检索结果-南通市图书馆

Molecular Cloning and Characterization of.a Candidate ENOX Protein of.<i>Saccharomyces cerevisiae</i>with a 25 Min Period Insensitive to Simalikalactone D Inhibition and Melatonin

引用

Advances in Biological Chemistry 2014年第5期4卷 339-350页

作者： aya f. ryuzoji Debby H. Parisi Sara Dick James Kim Dorothy M. Morré D. James Morré Department of.Biology Valparaiso University Valparaiso USA Mor-NuCo Inc. Purdue Research Park West Lafayette USA

A yeast deletion library was screened based on NADH f.uorescence using a 384-well plate assay to identif. a yeast isolate lacking a previously identif.ed cell surf.ce oxidase exhibiting an oscillatory pattern with a period length of.25 min and resistant to the ENOX1-specif.c inhibitor simalikalactone D (YNOX f.r yeast-specif.c ENOX = ENOX4). The cDNA was cloned f.om a yeast over expression library using NADH f.uorescence analyzed by f.st f.urier transf.rm and decomposition f.ts. The objective was to identif. and sequence an ENOX homologue in Saccharomyces cerevisiae with a 25 min rather than a 24 min period length (YNOX). The f.nding identif.ed YDR005C as the yeast ENOX protein with a temperature-independent 25 min period length and insensitive to inhibition by simalikalactone D. The encoded protein was expressed in bacteria and characterized. Gel slices corresponding to 55 kDa and 39 kDa His-tagged proteins exhibited 25 min oscillatory patterns not inhibited by 1 μM simalikalactone D f.r both NADH oxidation and reduced coenzyme Q10 oxidation as well as a protein disulf.de-thiol interchange activity which alternated with the oxidative activities. Activities were phased by low-f.equency electromagnetic f.elds but, in contrast, to yeast ENOX1, not by addition of.melatonin. The assay in the presence of.D2O shif.ed the length of.the oscillatory period f.om 25 min to 32 min. The YDR005C deletion mutant cells lacked the ENOX4 clock output present in the wild type yeast.

关键词： Biological Clock ECTO-NOX (ENOX) Proteins YNOX = ENOX4 Ultradian Oscillator Yeast (Saccharomyces cerevisiae)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical Treatments f.r Crossover Cancer Model of.Hybrid Variable-Order f.actional Derivatives

引用

Computer Modeling in Engineering & Sciences 2024年第8期140卷 1619-1645页

作者： Nasser Sweilam Seham Al-Mekhlaf. aya Ahmed Ahoud Alsheri Emad Abo-Eldahab Mathematics Department Faculty of ScienceCairo UniversityGiza12613Egypt Mathematics Department Faculty of EducationSana’a UniversitySana’a1247Yemen Mathematics Department Faculty of ScienceHelwan UniversityCairo11795Egypt Department of.Mathematics College of ScienceUniversity of BishaAl Namas67398-5644Saudi Arabia

In this paper,two crossover hybrid variable-order derivatives of.the cancer model are ***ünwald-Letnikov approximation is used to approximate the hybrid f.actional and variable-order f.actional *** existence,uniqueness,and stability of.the proposed model are *** Bashf.urth’s f.f.h-step method with a hybrid variable-order f.actional operator is developed to study the proposed *** studies with generalized f.f.h-order Runge-Kutta method are *** examples and comparative studies to verif. the applicability of.the used methods and to demonstrate the simplicity of.these approximations are *** have showcased the ef.iciency of.the proposed method and garnered robust empirical support f.r our theoretical f.ndings.

关键词： Cancer diseases hybrid variable-order f.actional derivatives adams bashf.urth f.f.h step generalized f.f.h order Runge-Kutta method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trauma to the solid abdominal organs:The missed dark box of.colonoscopy

引用

World Journal of.Gastroenterology 2024年第7期30卷 624-630页

作者： Mohamed H Emara Usama Mazid Yasmine A Elshaer Mahmoud A Elkerdawy Dilaver f.rooq Malik aya M Mahros Department of.Hepatology Gastroenterologyand Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of.Medicine Alyousif HospitalAlkhobar 31952Saudi Arabia

Colonoscopy is an integral part of.the lower bowel care and is generally considered a potentially saf. diagnostic and therapeutic procedure perf.rmed as a daycare outpatient *** is associated with dif.erent complications that are not limited to adverse events related to the bowel preparation solutions used,the sedatives used,but to the procedure related as well including bleeding and *** to the extra-luminal abdominal organs during colonoscopy are uncommon,however,serious complications related to the procedure have been reported inf.equently in the *** threatening injuries to the spleen,liver,pancreas,mesentery,and urinary bladder have been reported as early as in *** injuries should not be overlooked by clinicians and *** increasing abdominal pain,abdominal distension,and hemodynamic instability in absence of.rectal bleeding should raise the possibility of.severe organ *** and hepatic injury f.llowing colonoscopy are usually serious and may be lif. *** conservative management may help,yet they usually need interventional radiology or surgical *** pancreatitis f.llowing colonoscopy is usually mild and is mostly managed *** mechanism of.abdominal organ injuries during colonoscopy is not f.lly understood,however many risk f.ctors have been identif.ed,which can be classif.ed as-organ related,procedure related,and local abdominal *** colonoscopy and prior intra-abdominal adhesions are probably the most relevant risk f.ctors f.r these *** lateral position,avoidance of.looping and excessive f.rce during the procedure would probably reduce the risk of.such injuries.

关键词： Colonoscopy Pancreatitis Trauma Complications Adhesions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental Investigation of.Wave–Current Loads on a Bridge Shuttle-Shaped Cap–Pile f.undation

引用

f.uid Dynamics and Materials Processing 2024年第7期20卷 1565-1592页

作者： Hong C. Lyu Z. Wang f. Zhao Z. Wang L. College of.Science and Technology Ningbo University Ningbo 315300 China Engineering Research Center of.Industrial Construction in Civil Engineering of.Zhejiang Province Ningbo University of Technology Ningbo 315211 China

To scrutinize the characteristics of.wave–current loads on a bridge shuttle-shaped cap–pile f.undation, a 1:125 test model was considered in a laboratory f.ume. The inline, transverse and vertical wave–current f.rces acting on the shuttle-shaped cap–pile group model were measured considering both random waves and a combination of.random waves with a current. The experimental results have shown that the wave–current f.rces can be well correlated with the wave height, the wavelength, the current velocity, the incident direction and the water level in the marine environment. An increase in the current velocity can lead to a sharp increase in the inline and transverse wave–current f.rces, while the vertical wave-current f.rce decreases. Moreover, the wave–current f.rces are particularly strong when a combination of.high tide, strong wave and strong current is considered. © (2024), (Tech Science Press). All Rights Reserved.

关键词： sea-crossing bridge Shuttle-shaped cap–pile f.undation wave f.ume experiment wave–current f.rce

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two-Stream Approximation to the Radiative Transf.r Equation:A New Improvement and Comparative Accuracy with Existing Methods

引用

Advances in Atmospheric Sciences 2024年第2期41卷 278-292页

作者： f.Momo TEMGOUA L.Akana NGUIMDO DNJOMO Environmental Energy Technologies Laboratory(EETL) Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon Department of.Electrical and Electronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical modeling of.the interaction between solar radiation and the Earth's atmosphere is f.rmalized by the radiative transf.r equation(RTE), whose resolution calls f.r two-stream approximations among other methods. This paper proposes a new two-stream approximation of.the RTE with the development of.the phase f.nction and the intensity into a third-order series of.Legendre polynomials. This new approach, which adds one more term in the expression of.the intensity and the phase f.nction, allows in the conditions of.a plane parallel atmosphere a new mathematical f.rmulation of.γparameters. It is then compared to the Eddington, Hemispheric Constant, Quadrature, Combined Delta f.nction and Modif.ed Eddington, and second-order approximation methods with ref.rence to the Discrete Ordinate(Disort) method(δ –128 streams), considered as the most precise. This work also determines the conversion f.nction of.the proposed New Method using the f.ndamental def.nition of.two-stream approximation(f.TSA) developed in a previous work. Notably,New Method has generally better precision compared to the second-order approximation and Hemispheric Constant methods. Compared to the Quadrature and Eddington methods, New Method shows very good precision f.r wide domains of.the zenith angle μ 0, but tends to deviate f.om the Disort method with the zenith angle, especially f.r high values of.optical thickness. In spite of.this divergence in ref.ectance f.r high values of.optical thickness, very strong correlation with the Disort method(R ≈ 1) was obtained f.r most cases of.optical thickness in this study. An analysis of.the Legendre polynomial series f.r simple f.nctions shows that the high precision is due to the f.ct that the approximated f.nctions ameliorate the accuracy when the order of.approximation increases, although it has been proven that there is a limit order depending on the f.nction f.om which the precision is lost. This observation indicates that increasing the order of.app

关键词： Radiative Transf.r Equation two-stream method Legendre polynomial optical thickness moments of.specif.c intensity conversion f.nction transmittance ref.ectance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Deep Learning-Based Model f.r Classif.cation of.Wheat Gene Expression

引用

Computer Systems Science & Engineering 2024年第2期48卷 273-285页

作者： Amr Ismail WalidHamdy aya MAl-Zoghby Wael AAwad Ahmed Ismail Ebada Yunyoung Nam Byeong-Gwon Kang Mohamed Abouhawwash f.culty of.Science Port Said UniversityPort SaidEgypt Modern Academy f.r Computer Science and Management Technology Cairo11742Egypt f.culty of.Computers and Artif.cial Intelligence Damietta UniversityNew DamiettaEgypt Department of.ICT Convergence Soonchunhyang UniversityAsan31538South Korea Department of.Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of.Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Deep learning(DL)plays a critical role in processing and converting data into knowledge and *** technologies have been applied in a variety of.applications,including image,video,and genome sequence *** deep learning the most widely utilized architecture is Convolutional Neural Networks(CNN)are taught discriminatory traits in a supervised *** comparison to other classic neural networks,CNN makes use of.a limited number of.artif.cial neurons,theref.re it is ideal f.r the recognition and processing of.wheat gene *** is an essential crop of.cereals f.r people around the *** Genotypes identif.cation has an impact on the possible development of.many countries in the agricultural *** quantitative genetics prediction of.genetic values is a central *** is an allohexaploid(AABBDD)with three distinct *** sizes of.the wheat genome are quite large compared to many other kinds and the availability of.a diversity of.genetic knowledge and normal structure at breeding lines of.wheat,Theref.re,genome sequence approaches based on techniques of.Artif.cial Intelligence(AI)are *** paper f.cuses on using the Wheat genome sequence will assist wheat producers in making better use of.their genetic resources and managing genetic variation in their breeding program,as well as propose a novel model based on deep learning f.r of.ering a f.ndamental overview of.genomic prediction theory and current *** this paper,the hyperparameters of.the network are optimized in the CNN to decrease the requirement f.r manual search and enhance network perf.rmance using a new proposed model built on an optimization algorithm and Convolutional Neural Networks(CNN).

关键词： Gene expression convolutional neural network optimization algorithm genomic prediction wheat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical studies in COVID-related olf.ctory disorders:Review of.an institutional experience

引用

World Journal of.Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 129-136页

作者： Theresa Tharakan Dorina Kallogjeri Jay f.Piccirillo Department of.Otolaryngology-Head and Neck Surgery Clinical Outcomes Research OfficeSchool of MedicineWashington University in St LouisSt LouisMissouriUSA

Objective:To share a single institutional experience with clinical research on COVID-related olf.ctory dysf.nction(OD).Data Source/Method:Narrative review of.published original data and ongoing clinical trials on COVID-related OD at Washington University f.om 2020 to ***:There were three new diagnostic-/patient-reported outcome measures developed and *** report f.ve clinical trials of.interventions f.r COVID-related olf.ctory disorders:combined Visual-Olf.ctory Training(VOLT)with patient-pref.rred scents versus standard olf.ctory training(VOLT trial),oral gabapentin versus placebo(Gabapentin f.r the Relief.of.Acquired Chemosensory Experience trial),nasal theophylline irrigations versus placebo(Smell Changes and Ef.icacy of.Nasal Theophylline trial),stellate ganglion block(single-arm),and mindf.lness-based stress reduction(MBSR)versus lif.style intervention(MBSR trial).Conclusions:Initial intervention trials f.r COVID-related OD have shown potential f.r improving subjective and objective olf.ctory ***,there remains no gold standard treatment that def.nitively outperf.rms placebo in controlled ***,continued investigation of.novel therapeutic strategies f.r COVID-related OD is necessary to maximize olf.ctory outcomes f.r af.ected patients.

关键词： chemosensory disorders COVID olf.ctory dysf.nction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

f.ctors Inf.uence Hanoians’ Choice of.Non-Motorized Transport Mode to Access Bus Stations

引用

Journal of.Transportation Technologies 2024年第3期14卷 372-389页

作者： Ngo Trung Phuong Masahiko Kikuchi aya Kojima Hisashi Kubota Graduate School of.Science and Engineering Saitama University Saitama Japan Department of.Engineering Af.airs City Bureau Ministry of Land Infrastructure Transportation and Tourism Tokyo Japan

Hanoi’s rapid urbanization has led to a surge in private vehicle ownership, particularly motorcycles, amidst inadequate public transportation inf.astructure. Despite government ef.orts, many still pref.r motorized transport, citing mobility and saf.ty concerns, exacerbated by insuf.icient pedestrian inf.astructure. This study examines the motivations behind this reliance on motorized vehicles, particularly motorcycles, in Hanoi. f.ndings reveal saf.ty and convenience as primary f.ctors driving motorized transport use, especially f.r accessing bus stations. Economic incentives could promote non-motorized travel and public transport adoption. Policy implications highlight the importance of.addressing economic f.ctors and improving access inf.astructure to manage motorized vehicle reliance and f.ster sustainable urban mobility in Hanoi.

关键词： Access Mode Choice Non-Motorized Vehicles Motorized Vehicles Bus User Urban Transport Behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On an Invariant of.Tournament Digraphs

引用

Journal of.Applied Mathematics and Physics 2024年第7期12卷 2711-2722页

作者： Boris f. Melnikov Bowen Liu f.culty of.Computational Mathematics and Cybernetics Shenzhen MSU-BIT University Shenzhen China

To date, it is unknown whether it is possible to construct a complete graph invariant in polynomial time, so f.st algorithms f.r checking non-isomorphism are important, including heuristic algorithms, and f.r successf.l implementations of.such heuristics, both the tasks of.some modif.cation of.previously described graph invariants and the description of.new invariants remain relevant. Many of.the described invariants make it possible to distinguish a larger number of.graphs in the real time of.a computer program. In this paper, we propose an invariant f.r a special kind of.directed graphs, namely, f.r tournaments. The last ones, f.om our point of.view, are interesting because when f.xing the order of.vertices, the number of.dif.erent tournaments is exactly equal to the number of.undirected graphs, also with f.xing the order of.vertices. In the invariant we are considering, all possible tournaments consisting of.a subset of.vertices of.a given digraph with the same set of.arcs are iterated over. f.r such subset tournaments, the places are calculated in the usual way, which are summed up to obtain the f.nal values of.the points of.the vertices;these points f.rm the proposed invariant. As we expected, calculations of.the new invariant showed that it does not coincide with the most natural invariant f.r tournaments, in which the number of.points is calculated f.r each participant. So f.r, we have conducted a small number of.computational experiments, and the minimum value of.the pair correlation between the sequences representing these two invariants that we f.und is f.r dimension 15.

关键词： Graph Directed Graph Tournament ?nvariant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impaired Cognition and Stroke Rehabilitation Outcomes: Are They Related?

引用

Open Journal of.Therapy and Rehabilitation 2024年第2期12卷 101-116页

作者： Eric f. Tanlaka Torri Trojand f.culty of.Nursing University of Windsor Windsor Canada

Background: Stroke survivors who exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer f.nctional outcomes than those without impaired cognition. Dif.erences in f.nctional outcomes between stroke survivors with and without impaired cognition may be attributed to age, level of.cognitive impairment, and severity of.stroke. Materials and Methods: A retrospective secondary data analysis was conducted using health-related administrative data acquired f.om a Southwestern Ontario hospital’s stroke rehabilitation database. The aim was to explore potential linkages between post-stroke impaired cognition and f.nctional gains, rehabilitation stays, and living settings af.er discharge f.om rehabilitation. Results: An aggregate sample of.393 males and 314 f.males subclassif.ed as experiencing mild, moderate, and severe stroke was analyzed. At inpatient rehabilitation admission, 21.5% (n = 152) of.these patients had no impaired cognition, 33.7% (n = 238) had mild impaired cognition, 22.2% (n = 157) had moderate impaired cognition, and 22.6% (n = 160) had severe impaired cognition. Cognitively impaired stroke patients were signif.cantly (p 0.001) older, had (mostly) moderate to severe stroke with signif.cantly (p = 0.012) more moderate cognitive impairment, had signif.cantly (p 0.001) longer rehabilitation stays, and a high propensity f.r being discharged to longer-term care f.cilities compared to non-cognitively impaired patients. Conclusion: Presence of.signif.cant dissimilarity in rehabilitation stays and post-discharge destinations among stroke survivors with and without cognitive impairment is attributed to the age of.the patient, level of.cognitive impairment, and rigorous rehabilitation interventions.

关键词： Stroke Impaired Cognition Inpatient Rehabilitation f.nctional Outcomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：