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Impact of Thyroglobulin on Survival and Prognosis of Differentiated Thyroid Cancer

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Journal of Cancer Therapy 2018年第9期9卷 706-713页

作者： Hanan Ahmed Wahba Hend Ahmed El-Hadaad Abeer hussien Anter Alaa M. Wafa Ahmed Negm Clinical Oncology & Nuclear Medicine Department Faculty of Medicine Mansoura University Hospital Mansoura Egypt Internal Medicine Department Faculty of Medicine Mansoura University Hospital Mansoura Egypt General Surgery Department Faculty of Medicine Mansoura University Hospital Mansoura Egypt

Proper assessment of risk factors contributes to the principle management of differentiated thyroid carcinoma post operatively. Aim of the study: to investigate the effect of Thyroglobulin (Tg) levels on prognosis together with other risk factors for Differentiated Thyroid Cancer (DTC). Patients and methods: Medical records of all patients with DTC presented to Clinical Oncology and Nuclear Medicine Department referred from Diabetes & Endocrine unit (Internal Medicine Hospital) and Surgery Department Mansoura University from 2011-2016 were retrospectively reviewed. Patients with distant metastasis or who lost follow-up were excluded. So data of 220 patients were analyzed. Data collected included pre-surgical assessment, also surgical interference either total or near total thyroidectomy with or without lymph node neck dissection were reviewed. Different prognostic factors that affect progression free survival (PFS) include age, umorsize, ymph node status, ex, multifocality, capsular infiltration, vascular invasion and Tg level were evaluated through multivariate analysis. Results: Most of the patients included were <45 years (69.1%). Incidence of the disease was higher in female (80%) with papillary type predominance (80.9%). About 59.5% of cases presented with tumor size ≤ 2 cm and multifocality was reported in 13.6%. While 30% had lymph node metastasis, 11% had vascular invasion. Capsular infiltration was observed in 15% and most of them showed Tg level ≤ 10 ng/ml (68.2%). About 70% received ablative radioiodine. The 5-year Progression Free Survival (PFS) was 85%. On multivariate analysis of variable prognostic factors on PFS, we found that tumor size, age, lymph node status, capsular infiltration, Tg level and vascular invasion significantly affected PFS (P = 0.01, 0.005, 0.004, 0.005, 0.02, 0.003) respectively. While sex, pathological type and multifocality were not (P = 0.9, 0.4, 0.6) respectively. Conclusion: Postoperative Tg level is a statistically significa

关键词： Thyroglobulin Thyroid Cancer Differentiated Thyroid Cancer Risky Factors

Angiogenesis Factors Associated with New Breast Cancer Cell Line AMJ13 Cultured <i>in Vitro</i>

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Advances in Breast Cancer Research 2015年第4期4卷 100-108页

作者： Ahmed Majeed Al-Shammari Worod Jawad Kadhim Allak Mahfoodha Umran Nahi Y. Yaseen ay.an hussien Experimental Therapy Department Iraqi Center for Cancer and Medical Genetic Research Al-Mustansiriyah University Baghdad Iraq Biotechnology Department Collage of Science Baghdad University Baghdad Iraq

Background: AMJ13 is a new breast cancer cell line that has been established from a 70-year-old Iraqi woman with a histological diagnosis of infiltrating ductal carcinoma. It is the first for an Iraqi population. In breast cancer, angiogenesis provides the tumor tissue, which is rapidly proliferated with oxygen and nutrients, removes wastes and increases the opportunity of cancer cells to invade other organs. Methods: The AMJ13 breast cancer cell line was represented at three different passages and incubated for interval times. Microarray panel of 43 different angiogenesis markers was used to scan the supernatant for the factors. ELISA was used to quantify some of the important angiogenesis factors released in the culture medium and to confirm absence of those who was not detected by the antibody array. RT-PCR was used to confirm the gene expression (mRNA) of studied factors. Results: Microarray.analysis showed that TIMP1 and two secreted at highest levels compared to the rest of the factors with low presence of endostatin. Other non-detectable factors by microarray examined by ELISA assay that showed highest expression level of VEGF-A were obtained at earliest passage, while the highest levels of FGF-b were obtained at late passage. The VEGF-D secretion was shown low concentrations at all studied passages. There is no detectable level of EGF protein in different passages and times interval tested. There are no significant differences in secretion of sICAM between different passages and incubation periods. Conclusion is that AMJ13 cell line depends on VEGF-A as main angiogenesis factor to induce micro-vessels supported by low levels of VEGF-D for lymphatic vessels formation. AMJ13 cell line depends on FGF as growth factors as in late passages it was shifted to depend mainly on FGF completely. All of this process may be regulated by TGF-β. TIMP-1 has proangiogentic effect and has feedback talk with TIMP-2. Understanding the angiogenesis process for breast cancer can

关键词： Angiogenesis Factors Breast Cancer Cell AMJ13 Tumor Tissue

Determination of Clopidogrel Carboxylic Acid in Human Plasma by LC-MS/MS

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American Journal of Analytical Chemistry 2011年第4期2卷 447-455页

作者： Mohamed El-Husseiny El-Sadek Samia Mahmoud Moustafa hussien Omar Kadi Abdul Moneim Ali Al-Hakami 不详

Background: Clopidogrel, is a thienopyridine derivative labeled for use to prevent thrombosis after coronary artery stenting. Pharmacokinetics of clopidogrel is studied indirectly by quantification of carboxylic acid which is a major metabolite of Clopidogrel. Objective: The aim of this work is to develop and validate a rapid, simple and sensitive LC/MS/MS assay method for the determination of Clopidogrel carboxylic acid in human plasma using Clopidogrel-D4-carboxylic acid as internal standard. Methods: Analytes was extracted from 200 μl of plasma by a simple liquid-liquid extraction using diethyl ether – n-hexane (80:20, v/v). The chromatographic separations were achieved on a C18 column using Methanol, de-ionized water and formic acid as a mobile phase at flow rate of 0.5 ml/minute. Analysis was monitored by multiple reactions monitoring mode based on m/z transition of 308.10→113 for Clopidogrel carboxylic acid and 312.10→129 for internal standard. Result: The method had a total run time of about 4 minutes. The lower limit of quantification (LLOQ) was 25 ng/ml showing good linearity over the working range of 25 – 3000 ng/ml (r ≥ 0.999). The intra- and inter day accuracies were 90% - 98% and 92.138% - 96.889% respectively (deviation within acceptable range ≤ 10%).Conclusion: It was shown that this method is suitable for pharmacokinetic study following oral administration of Clopidogrel and can be successfully applied to the therapeutic drug monitoring of Clopidogrel in Clopidogrel-treated patients.

关键词： Clopidogrel Clopidogrel Carboxylic Acid Liquid Chromatography Tandem Mass Spectrometry

Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics

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World Journal of Hepatology 2023年第2期15卷 216-224页

作者： Mohamed H Emara Mariam Zaghloul Ibrahim F Amer aya M Mahros Mohammed hussien Ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M Ahmed Rasheda Tarik I Zaher Mona Talaat Haseeb Emad Hassan Emara Hassan Elbatae Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Internal Medicine Gastroenterology UnitSecurity Forces HospitalRiyadh 11481Saudi Arabia Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Diagnostic and Interventional Radiology Kafrelsheikh UniversityKafr-Elshikh 33516Egypt

Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive *** cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT.

关键词： Sonographic Gallbladder wall thickness Prediction Esophageal varices Portal hypertension Esophago-gastro-duodenoscopy

Factors Influencing Academic Motivation among UOS Medical Students

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Journal of Health Science 2017年第4期5卷 177-180页

作者： Khalid Sawalha Mai Al Ali Ahmad Sawalha Hu Ko Ikram Abdelli Salwa El Shawish Amal hussien College of Medicine University of Sharjah Sharjah 27272 United Arab Emirates

Motivation has been found to play a major role in determining student performance in the academic process. The aim of this study is to identify the intrinsic ＆ extrinsic motivational factors among medical students in the University of Sharjah. A Cross Sectional Study was conducted among university students of medical colleges in the period between February 2011 and March 2011. A total of 452 students （337 females and 115 males） were selected using the Quota sampling method equally between each college. A self-administered questionnaire consisting of 13 demographic questions, an agreement scale of 32 questions about the motivational factors and an open ended question asking students about what the university can do to help motivate them were developed. The most common intrinsic factors chosen by students were grade expectation （94%）, interest in material （92%） and leading an honorable life （88%）. While on the other hand the most common extrinsic factors were upcoming exams （88%）, family expectations （88%） and praise （82%）. The most common factors were similar between all students regardless of their major, gender, or performance. However, differences were visible in other factors such as in high performing students; rewards scored a 71.4% while low performing students scored it at 50%. It also shows that females consider praise as an important factor （86%） on the contrary males gave it a 72%. While the most common intrinsic factors showed to be grades, interest in material and leading an honorable life, the most common extrinsic factors on the other hand were upcoming exams, family expectations and praise.

关键词： Academic motivation motivational factors College of Medicine University of Sharjah.

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埃及大学生汉语学习动机调查研究

埃及大学生汉语学习动机调查研究

作者：李晓芳（FATMAELZHRAA ATEF GOMAA hussien ELTIAR）北京外国语大学

学位级别：硕士

在外语学习过程当中,学习者的学习动机是决定学习外语成败的最重要因素之一。动机研究肇始于加拿大。近年来越来越多的外语教师和研究者关注到这个问题。而随着动机研究的发展和深入,“去动机（动机削弱）”Demotivation的概念也逐渐进... 详细信息

在外语学习过程当中,学习者的学习动机是决定学习外语成败的最重要因素之一。动机研究肇始于加拿大。近年来越来越多的外语教师和研究者关注到这个问题。而随着动机研究的发展和深入,“去动机（动机削弱）”Demotivation的概念也逐渐进入研究者的视野。大量研究结果体现了教师对学习者动机的影响在教学过程当中起到非常重要的作用。其实学习者的学习动机是动态变化的,可能增强,也可能减弱。而学习动机一旦减弱,会导致学习者的学习兴趣下降、学习效率下降,效果随之变差,最终会影响外语学习甚至有的学习者可能会选择放弃外语学习。笔者在前人研究的基础上,分析导致学习者学习外语动机削弱的重要因素——学习者本身、教师、其他外部因素。随着“一带一路”倡议的推进,许多埃及学生将中文选为大学本科专业,笔者以埃及中文专业学生的汉语学习动机为研究对象,通过调查问卷与访谈研究这类学生的学习动机情况。本文主要内容如下:首先,本文将为“外语学习动机”下定义并综述国内外的第二外语学习动机研究成果以及汉语学习动机研究成果。其次,本文将详细介绍埃及汉语学习者的汉语学习动机的调查研究过程,如相关问题的提出、调查问卷的设计、调查样本的选择、研究的过程、数据的分析整理过程最后,本文通过数据分析和整理发现了埃及汉语学习者的汉语学习动机削弱的现象。进而,本文将分析“动机削弱”产生的原因,并为如何提高或进一步激发埃及汉语学习者的汉语学习动机提出教学建议。本文分为五章节:第一章:要简单解释“动机”的定义,并解释选题源起、选题背景,明确本研究的对象和要点。第二章:研究综述,第二语言教学中的动机和去动机化研究文献综述。第三章:本章将展示调查对象的详细信息,以及研究方法和对学生、教师的访谈结果。埃及汉语学习者学习动机调查研究。通过对埃及汉语学习者的学习动机进行调查研究,笔者发现去动机化的现象存在,并发现了学习动机削弱（去动机化）的影响因素。第四章:通过对以上的调查结果进行的分析,本文为汉语教师提供一些改进教学的方法。第五章:结论。本文的结论为:埃及汉语学习者语言层面的动机很强,但在学习过程中遇到一些外部因素导致部分学生汉语学习兴趣下降。

关键词：动机动机削弱埃及汉语学习者

锆—钽—钛种植材料的表面性质对抗菌活性的影响

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锆—钽—钛种植材料的表面性质对抗菌活性的影响

作者：查松海（Juaim Akram Nasser hussien）中南大学

学位级别：硕士

钛及其合金Ti6Al4V是牙科和骨科植入物中最常用的合金,具有优异的机械性能和生物相容性,但是仍存在许多问题,如它们的弹性模量显著高于骨骼,可能导致植入物周围的应力屏蔽效应和骨质流失;合金中铝和钒释放可引起细胞毒性和过敏反应,而... 详细信息

钛及其合金Ti6Al4V是牙科和骨科植入物中最常用的合金,具有优异的机械性能和生物相容性,但是仍存在许多问题,如它们的弹性模量显著高于骨骼,可能导致植入物周围的应力屏蔽效应和骨质流失;合金中铝和钒释放可引起细胞毒性和过敏反应,而且这些材料的抗菌活性不足以预防植入物周围感染。为解决抗菌问题,研究通常采用表面修饰添加铜和银等抗菌元素或使用具有光敏活性的材料来改善植入物的抗菌活性,但这些技术存在细胞毒性、短期效应、不稳定性和高成本等缺点。为克服这些缺点,本研究采用等离子烧结技术制备了新合金Zr-30Ta和Zr-25Ta-5Ti,它们由对人体友好、无毒、不引起过敏反应的锆、钽和钛元素组成,具有良好的生物相容性,其弹性模量显著低于Ti及其合金(Zr-30Ta为99GPa,Zr-25Ta-5Ti为73GPa)。前期研究已证实了它们具有良好的机械性能和成骨活性。研究证实细菌直接与材料表面相互作用,但材料的表面性能因素,如元素组成、氧化膜形成、表面粗糙度、接触角和表面电荷等如何影响细菌附着和生长目前尚不清楚。因此本研究选择与种植体周围感染有关的变形链球菌和牙龈卟啉单胞菌,探索Zr-30Ta和Zr-25Ta-5Ti材料的抗菌活性和机制。1.材料与方法1.1.材料选择:前期对Zr-Ta合金研究发现Zr-30Ta合金具有最佳的机械性能和生物相容性,又发现向合金中添加钛后,Zr-25Ta-5Ti合金的机械性能显著提高,弹性模量降低。还发现这两种合金都具有优异的生物相容性和成骨活性。因此,选择Zr-30Ta和Zr-25Ta-5Ti合金进行抗菌评估。1.2.材料制备:使用放电等离子烧结粉末冶金技术制备Zr-30Ta和Zr-25Ta-5Ti合金样品,烧结过程在等离子烧结系统中进行,温度/压力为1600°C/40MPa。在本研究中,所用样品尺寸为10mm×10mm×2 mm,用同样参数制备的工业纯钛(CP-Ti)作为对照组。1.3.材料性能评估:1.3.1.材料显微结构评估:使用扫描电子显微镜在次级电子和背散射模式下分析Zr-30Ta和Zr-25Ta-5Ti合金表面形貌和相组成。采用能量色散谱(EDS)定量分析合金表面元素分布。1.3.2.电化学腐蚀评估:实验所用样品尺寸为6 mm×6 mm×6mm,利用三电极系统中的电化学工作站对其进行测试(图2-2)。为稳定其表面电位,将样品浸于Fusayama人工唾液(腐蚀液)中5小时后进行测试,采用电位动力学极化测试评估Zr-30Ta和Zr-25Ta-5Ti合金的抗腐蚀性,以商业纯钛作为对照组。使用扫描电子显微镜评估腐蚀后的表面形貌,并采用EDS分析确定元素组成以评估腐蚀液对合金表面的影响。1.3.3.表面粗糙度评估:使用Dektak XT探针式轮廓仪评估纳米级粗糙度。在实验之前,样品经过抛光、清洁和干燥处理,测量长度为3 mm。1.3.4.表面润湿性评价:使用DSA100滴形分析仪,通过静置法测量静态接触角以评价表面润湿性。于室温(22℃)和大气压下,将一滴水(d HO)置于样品表面,5秒后记录液滴形态。1.3.5.表面电荷评价:使用Surpass电化学分析仪,采用p H扫描法测量Zeta电位。实验所用样品尺寸为20 mm×10 mm×1 mm,测试溶液为0.001-M的氯化钾(KCl)电解质溶液,测试液的p H值在2.8-8.2之间,利用0.05-M的盐酸(HCl)和0.05 M的氢氧化钠(Na OH)调控。1.4.抗菌评价:评估Zr-30Ta和Zr-25Ta-5Ti样品对与口腔种植体周围感染相关细菌--变形链球菌、牙龈卟啉单胞菌的抗菌活性,CP-Ti为对照。细菌浓度均为1×10 CFU/孔。1.4.1.抑菌圈法:采用Kirby-Bauer抑菌圈试验改进法评估样品对细菌生长的影响。将细菌接种在含样品的琼脂平板上,标准条件下培养1天(变形链球菌)或7天(牙龈卟啉单胞菌),在所设时间内测量样品周围所形成的抑菌区。1.4.2.平板计数法:采用平板计数法评估样品对细菌附着和存活的影响。首先将细菌与样品在脑心浸液肉汤(Brain heart infusion broth(BHI))培养基中标准条件下孵育1天和3天,然后将样品上细菌分离至溶液中,10倍稀释后接种于琼脂平板上。根据中国标准GB/T4789.2-2010计数琼脂平板上的细菌菌落数,并计算Zr-30Ta和Zr-25Ta-5Ti样品的抗菌率(R),以CP-Ti为对照。1.4.3.活死染色法:采用活死染色法直接观察样品对细菌存活的影响。将细菌与样品在BHI液培养基中孵育1天和3天,将细菌溶液废弃后,PBS洗涤样品,并根据生产商说明使用细菌活力检测试剂盒染色。SYTO9将活细菌染成绿色,碘化丙啶(PI)将死亡细菌染成红色。去除多余染料后,使用倒置荧光显微镜观察染色样品。

关键词：锆钽钛种植体周围炎抗菌活性氧抗粘附

Evaluation of Actual Evapotranspiration and Crop Coefficient in Carrot by Remote Sensing Methodology Using Drainage and River Water to Overcome Reduced Water Availability

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Engineering（科研） 2023年第5期15卷 352-366页

作者： Ali H. Hommadi Nadhir Al-Ansari Hatem H. hussien Rafat N. Abd Algan Ghaith M. Ali Majed National Center for Water Resource Management Ministry of Water Resource Baghdad Iraq Luleå University of Technology Luleå Sweden

Searching for alternative methods for traditional irrigation is World trend at days due to a reduction in water and increased of drought due to climate changes therefore farmers need use modern methods of scheduling water and minimizing water losses while also increasing yield. To meet the future increasing demands water and food there is a need to utilize alternative methods to reduce evaporation, transpiration and deep percolation of water. Any countries use recycled water (drain and sewage) and desalination water from the sea or drains to irrigate crops plus computing actual crop evapotranspiration (ETc) so as to calculate the amount of water to apply to a crop. The paper aims to assess the actual evaporation and evaporation coefficient of carrots, by planting carrots in a field and the crop was exposed to several sources of water (DW and RW) and comparing ETc, Kc and production among plots of three sites (A, B and C). The study used two types of irrigation water (drain water (DW) and river water (RW)). The results were to monthly rate and accumulated actual evapotranspiration to C (irrigation by RW only) more than A (67% RW and 33% DW) and B (17% RW and 83% DW) via 7% and 58%, respectively. The yield to C more than A and B by 17% and 75%, respectively. In conclusion the use of DW can cause a reduction in crop consumptive of carrot crops also causes a reduction in yield, crop length, root length, root size, canopy of crop, number of leaves and biomass of the plant therefore, the drainage water needs to treated before irrigating crops And making use of it to irrigate the fields and fill the shortfall in the amount of water from the river. The drain water helped on filling the water shortage due to climate changes and giving production of carrot crop but less than river water.

关键词： Carrot Reference Evapotranspiration Actual Evapotranspiration (ETa) Marginal Water Crop Coefficient Landsat Satellite

Comparison of serum cardiac troponin-Ⅰ and creatine kinase MB isoenzyme concentrations in asphyxiated neonates

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海南医学院学报 2009年第1期15卷 31-36页

作者： Nouran F. hussien Eman A. Abdel Ghany Amany E.Elwan Yasser H.Kamel Dina K.Ali Pediatric Department Neonatology DepartmentCairo University Hospitals

Objective:To assess the correlation of signs of myocardial damage to serum cardiac troponin I(cTnI)and creatine kinase MB isoenzyme(CK-MB)***:Blood samples were collected from 25 term asphyxiated neonates and 25 controls at 12 h of age by *** asphyxiated neonates were followed up until discharge or ***:Asphyxiated neonates had significantly higher concentrations of cTnI and CK-MB than controls(P<0.001).Serum cTnI concentrations were significantly higher in asphyxiated neonates who developed hypotension,heart failure or those had low ejection fraction(P<0.01).Serum cTnI concentrations were significantly higher in asphyxiated who died than those who survived(P<0.01).There was no significant difference in serum CK-MB mass concentrations between asphyxiated neonates with and without these ***:Unlike CK-MB,serum cTnI concentrations are significantly higher in asphyxiated neonates who died or developed cardiac dysfunction.

关键词：肌钙蛋白肌酸激酶围产期心脏水肿