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NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.Schafer Sudena Wang Michael J.Schmeisser axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Considerations for determining optimal mouse caging density

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中国比较医学杂志 2008年第1期18卷 26-26页

作者： Charmaine Foltz Larry Carbone David DeLong Bernard E. Rollin Pascalle Van Loo Julia Whitaker axel wolff Division of Veterinary Resources National Institutes of Health Bethesda MD. University of California San Francisco San Francisco CA. Veterinary Medical Unit VA Medical Center Minneapolis MN. Colorado State University Fort Collins CO. Utrecht University The Netherlands. Department of Pathology and Laboratory Medicine Division of Laboratory Animal Medicine University of North Carolina Chapel Hill NC. Division of Compliance Oversight OLAW National Institutes of Health Bethesda MD. Correspondence should be addressed to Charmaine Foltz DVM

Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders

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World Journal of Gastroenterology 2015年第15期21卷 4466-4490页

作者： Rolf Teschke Albrecht wolff Christian Frenzel axel Eickhoff Johannes Schulze Department of Internal Medicine Ⅱ Division of Gastroenterology and Hepatology Klinikum Hanau Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/Main Department of Internal Medicine Ⅱ Division of Gastroenterology Hepatology and Infectious DiseasesFriedrich Schiller University Jena Department of Medicine I University Medical Center Hamburg Eppendorf Institute of Industrial Environmental and Social Medicine Medical Faculty of the Goethe University Frankfurt/Main

Herbal traditional Chinese medicine(TCM) is used to treat several ailments, but its efficiency is poorly documented and hence debated, as opposed to modern medicine commonly providinge ffective therapies. The aim of this review article is to present a practical reference guide on the role of herbal TCM in managing gastrointestinal disorders, supported by systematic reviews and evidence based trials. A literature search using herbal TCM combined with terms for gastrointestinal disorders in Pub Med and the Cochrane database identified publications of herbal TCM trials. Results were analyzed for study type, inclusion criteria, and outcome parameters. Quality of placebo controlled, randomized, double-blind clinical trials was poor, mostly neglecting stringent evidence based diagnostic and therapeutic criteria. Accordingly, appropriate Cochrane reviews and meta-analyses were limited and failed to support valid, clinically relevant evidence based efficiency of herbal TCM in gastrointestinal diseases, including gastroesophageal reflux disease, gastric or duodenal ulcer, dyspepsia, irritable bowel syndrome, ulcerative colitis, and Crohn's disease. In conclusion, the use of herbal TCM to treat various diseases has an interesting philosophical background with a long history, but it received increasing skepticism due to the lack of evidence based efficiency as shown by high quality trials; this has now been summarized for gastrointestinal disorders, with TCM not recommended for most gastrointestinal diseases. Future studies should focus on placebo controlled, randomized, double-blind clinical trials, herbal product quality and standard criteria for diagnosis, treatment, outcome, and assessment of adverse herb reactions. This approach will provide figures of risk/benefit profiles that hopefully are positive for at least some treatment modalities of herbal TCM. Proponents of modern herbal TCM best face these promising challenges of pragmaticmodern medicine by bridging the gap be

关键词： Evidence based trials Traditional Chinesemedicine Herbal traditional Chinese medicine Gastrointestinaldisorders

Drug and herb induced liver injury: Council for International Organizations of Medical Sciences scale for causality assessment

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World Journal of Hepatology 2014年第1期6卷 17-32页

作者： Rolf Teschke Albrecht wolff Christian Frenzel Alexander Schwarzenboeck Johannes Schulze axel Eickhoff Department of Internal Medicine Ⅱ Klinikum Hanau Academic Teaching Hospital of the Medical Faculty of the Goethe University of Frankfurt/Main Department of Internal Medicine Ⅱ Division of Gastroenterology Hepatology and Infectious Diseases Friedrich Schiller University Jena Department of Medicine Ⅰ University Medical Center Hamburg Eppendorf Institute of Industrial Environmental and Social Medicine Medical Faculty Goethe University

Causality assessment of suspected drug induced liver injury(DILI) and herb induced liver injury(HILI) is hampered by the lack of a standardized approach to be used by attending physicians and at various subsequent evaluating levels. The aim of this review was to analyze the suitability of the liver specific Council for International Organizations of Medical Sciences(CIOMS) scale as a standard tool for causality assessment in DILI and HILI cases. PubMed database was searched for the following terms: drug induced liver injury; herb induced liver injury; DILI causality assessment; and HILI causality assessment. The strength of the CIOMS lies in its potential as a standardized scale for DILI and HILI causality assessment. Other advantages include its liver specificity and its validation for hepatotoxicity with excellent sensitivity, specificity and predictive validity, based on cases with a positive reexposure test. This scale allows prospective collection of all relevant data required for a valid causality assessment. It does not require expert knowledge in hepatotoxicity and its results may subsequently be refined. Weaknesses of the CIOMS scale include the limited exclusion of alternative causes and qualitatively graded risk factors. In conclusion, CIOMS appears to be suitable as a standard scale for attending physicians, regulatory agencies, expert panels and other scientists to provide a standardized, reproducible causality assessment in suspected DILI and HILI cases, applicable primarily at all assessing levels involved. 2014 Baishideng Publishing Group Co., Limited. All

关键词： Drug induced liver injury Drug hepatotox-icity Herb induced liver injury Herbal hepatotoxicity Causality assessment

Exactly Solvable Combinations of Scalar and Vector Potentials for the Dirac Equation Interrelated by Riccati Equations

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Chinese Physics Letters 2006年第6期23卷 1365-1368页

作者： axel Schulze-Halberg Department of Science University of Colima Bernal Diaz del Castillo 340 Col. Villas San Sebastian C.P. 28045 Colima Col. Mexico

New classes of solvable scalar and vector potentials for the Dirac equation are obtained, together with the associated exact Dirac spinors. The method of derivation is based on an a priori constraint between the solutions, leading to an interrelation between the scalar and vector potential in the form ofa Riccati equation. The present note generalizes a series of former articles.

关键词： Exactly Solvable Combinations Riccati Equations

The future of underground spatial planning and the resulting potential risks from the point of view of mining subsidence engineering

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International Journal of Mining Science and Technology 2020年第1期30卷 93-98页

作者： Carolina Brücker axel Preuβe Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in MiningRWTH Aachen UniversityWüllnerstr.2Aachen 52062Germany

The topic of ground movements in Germany has been studied extensively in the past,especially in the field of active *** active hard coal mines in Germany were finally shut down in 2018 and lignite mining is expected to take place only until *** so-called long-term liabilities of the mine operators in Germany include,among other things,the long-term guarantee of stability and thus the monitoring of ground *** far,the economic use of underground mining in Germany was mainly the supply of raw *** the future,the underground storage of compressed air,methane or hydrogen will play an important role in renewable energy supply and climate ***,the underground storage space will become more important and the spatial planning is essential to ensure availability of safe underground openings for the various options of environmentally friendly energy ***,this renewed usage of underground openings may also bring new and sometimes unknown challenges of geomechanical *** aftermath of hard coal and lignite mining will be an increasing challenge in mining subsidence *** the other hand,new possibilities due to underground spatial planning may lead to subsidence and/or heaving of the upper surface.

关键词： Mining Surveying Underground spatial planning Mining engineering Renewable energies

Buffered microclimate determines the presence of Salamandra corsica

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Journal of Forestry Research 2021年第3期32卷 1089-1093页

作者： Daniel Escoriza axel Hernandez GRECO Institute of Aquatic EcologyUniversity of Girona17071 GironaSpain Department of Environmental Sciences University Pasquale Paoli20250 CorteFrance

Numerous amphibian species occupy microhabitats with buffered thermal and moisture conditions,typically under forest ***,we assessed whether the insular endemic Salamandra corsica also uses this type of habitat,which could have important implications for its *** used data loggers to record the air temperature and air humidity at 4 h intervals over a period of 2 years,at 13 stations with a confirmed presence of *** data were compared with those recorded at Corsican weather stations and those generated by a climate model(WorldClim 2).The weather station data showed significant deviations from the probe data,by an average of-1.26℃(minimum temperature),+2.61℃(maximum temperature),and-0.04%(relative humidity).Similarly,the WorldClim 2 data showed significant deviations from the probe data,by an average of-2.49°C(minimum temperature)and+1.69℃(maximum temperature).These discrepancies refl ect the use of densely vegetated and topographically complex habitats by ***,which reduce temperature ***,our results highlight the importance of natural vegetal cover in the conservation of populations of this endemic salamander.

关键词： Fire salamander Island endemic Microclimate Probe Threatened species

Using hierarchical spatial models to assess the occurrence of an island endemism: the case of Salamandra corsica

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Ecological Processes 2019年第1期8卷 199-209页

作者： Daniel Escoriza axel Hernandez GRECO Institute of Aquatic EcologyUniversity of Girona17071 GironaSpain Department of Environmental Sciences University Pasquale Paoli20250 CorteFrance.

Background:Island species are vulnerable to rapid extinction,so it is important to develop accurate methods to determine their occurrence and habitat *** this study,we assessed two methods for modeling the occurrence of the Corsican endemic Salamandra corsica,based on macro-ecological and fine habitat *** expected that models based on habitat descriptors would better estimate *** occurrence,because its distribution could be influenced by micro-environmental *** occurrence of *** was modeled according to two ensembles of variables using random ***:Salamandra corsica was mainly found in forested habitats,with a complex vertical *** habitats are associated with more stable environmental *** model based on fine habitat descriptors was better able to predict occurrence,and gave no false *** model based on macro-ecological variables underestimated the occurrence of the species on its ecological boundary,which is important as such locations may facilitate interpopulation ***:Implementing fine spatial resolution models requires greater investment of resources,but this is advisable for study of microendemic species,where it is important to reduce type II error(false negatives).

关键词： Amphibian Corsica Mediterranean islands Microhabitat Salamander

Use of the area of main influence to fix a relevant boundary for mining damages in Germany

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International Journal of Mining Science and Technology 2018年第1期28卷 79-83页

作者： Denise Müller axel Preusse Faculty of Georesources and Materials Engineering Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining RWTH Aachen University

In 2010, the fracking discussion in Germany caused a number of changes in German law, which came into force in *** the production of gas had to be *** the legislation amendment, the Subsidence-Area Mining Regulation has been revised, *** changes expand the compensation of mining damages, especially to the extraction with drilling from the surface and underground *** the Subsidence-Area Mining Regulation has been revised, the area of main influence(subsidence of 10 cm)remains to determine a relevant boundary for mining *** determination and prediction of this boundary above caverns are presented in this *** addition, further elements of ground movements and their relevance to mine damages are *** usage of the area of main influence to fix a relevant boundary for mining damages does not correspond to the relevant elements of ground movements.A limit for differences in subsidence(tilt) or horizontal changes in length should be preferred to describe the relevance of mining damages on ***, this paper outlines the meaning of using the area of main influence to fix a relevant boundary for mining damages.

关键词： Ground movements Area of main influence Boundary for mining damages Subsidence-area mining regulation Subsidence detection Modeling above caverns