检索结果-南通市图书馆

气候资料高精度模拟与土地利用动力学方法在中国水文规划中的应用(论文摘编)(英文)

在线全文

学校读者我要写书评

暂无评论

长江流域资源与环境 2006年第5期15卷 649-649页

作者： axel thomas Institute of Greography Johannes Gutenberg University D-55099 Mainz Germany

Modelling landscapes with GIS provides a powerful tool to analyze and model terrestrial ecosystems for land use planning. In order to gain realistic results, input data has to represent the natural environment as realistically as possible. While some of the fundamental data layers such as topography and soils are more or less static, climatic data is variable both in space and time.

关键词：气候资料高精度模拟土地利用动力学方法中国水文规划

在线全文

学校读者我要写书评

暂无评论

基于PC的控制增强自动化的可能性

现代制造 2014年第5期 42-42,44,45页

作者： axel BUCH thomas LAUDENBERG

PC自动化控制在运用和解决方案方面的功能远远超出了传统式控制所甚现的功能。为了实现效益好、功能强的解决办案，PC自动化控制的运用要准确覆盖自动化的任务。

关键词：自动化控制 PC 功能传统式

Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

Microglia:a promising therapeutic target in spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第41期25卷 6238-6247页

作者： Colin Markus Kruger Ulrich Adam thomas Adam axel Kramer Claus D Heidecke Frank Makowiec Hartwig Riediger Department of Surgery Immanuel Hospital RüdersdorfBerlin 15562Germany Department of General Surgery Vivantes-Humboldt hospitalBerlin 13503Germany Department of Microbiology Labor Berlin GmbHBerlin 13353Germany Institute of Hygiene and Environmental Medicine University Medicine GreifswaldGreifswald 17495Mecklenburg VorpommernGermany Department of Surgery Clinic of GeneralVisceralVascular and Thoracic SurgeryUniversity Medicine GreifswaldGreifswald 17475Mecklenburg VorpommernGermany Section of clinical risk assessment University hospital of FreiburgFreiburg 79106Baden-WürttembergGermany

BACKGROUND Jaundice or preoperative cholestasis(PC)are typical symptoms of pancreatic *** 50%of patients undergo preoperative biliary drainage(PBD)*** is a common cause of bacterobilia(BB)and is a known surgical site infection risk *** adjustment of preoperative antibiotic prophylaxis(PAP)may be reasonable according to the profile of *** this,we examined the microbiological findings in routine series of *** To investigate the incidence and profile of biliary bacterial colonization in patients undergoing pancreatic head *** In the period from January 2009 to December 2015,285 consecutive pancreatic head resections were *** for surgery were malignancy(71%),chronic pancreatitis(18%),and others(11%).A PBD was in 51%and PC was in 42%.The standard PAP was ampicillin/***,a smear was taken from the hepatic *** analysis of the isolated species and resistograms was *** were categorized according to the presence or absence of PC(PC+/PC-)and PBD(PBD+/PBD-)into four *** efficiency was analyzed for standard PAP and possible *** BB was present in 150 patients(53%).BB was significantly more frequent in PBD+(n=120)than in PBD-(n=30),P<*** was present both in patients with PC and without PC:(PBD-/PC-:18%,PBD-/PC+:30%,PBD+/PC-:88%,PBD+/PC+:80%).BB was more frequent in malignancy(56%)than in chronic pancreatitis(45%).PBD,however,was the only independent risk factor in multivariate *** total,357 pathogens(342 bacteria and 15 fungi)were *** five most common groups(n=256,74.8%)were Enterococcus spp.(28.4%),Streptococcus spp.(16.9%),Klebsiella spp.(12.6%),Escherichia coli(10.5%),and Enterobacter spp.(6.4%).A polymicrobial BB(PBD+:77% vs PBD-:40%,P<0.01)and a more frequent detection of Enterococcus(P<0.05)was significantly associated with PBD+.In PBD+,the efficiency of imipenem and piperacillin/tazobactam was significantl

关键词： Pancreatic surgery Bacteriobilia Antibiotic prophylaxis Cholestasis Cholangiopancreatography Endoscopic retrograde

Reduction and carburization of iron oxides for Fischer–Tropsch synthesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2020年第12期29卷 48-61页

作者： Monia Runge Nielsen Asger Barkholt Moss Anton Simon Bjrnlund Xi Liu axel Knop-Gericke Alexander YuKlyushin Jan-Dierk Grunwaldt thomas LSheppard Dmitry EDoronkin Anna Zimina thomas Eric Lyck Smitshuysen Christian Danvad Damsgaard Jakob Birkedal Wagner thomas Willum Hansen DTU Nanolab Technical University of DenmarkDK-2800Kgs.LyngbyDenmark Department of Physics Technical University of DenmarkDK-2800Kgs.LyngbyDenmark SynCat@Beijing Synfuels China Technology Co.LtdBeijing 101407China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Inorganic Chemistry Fritz Haber Institute of the Max Planck SocietyD-14195 BerlinGermany Research Group Heterogeneous Reactions.Max Planck Institute for Chemical Energy Conversion D-45470 MulheimGermany Research Group Catalysis for Energy Helmholtz-Zentrum Berlin for Materials and Energy(BESSYⅡ)D-12489 BerlinGermany Institute for Chemical Technology and Polymer Chemistry Karlsruhe Institute of TechnologyD-76131 KarlsruheGermany Institute of Catalysis Research and Technology Karlsruhe Institute of TechnologyD-76344 Eggenstein-LeopoldshafenGermany

The activation of iron oxide Fischer–Tropsch Synthesis(FTS) catalysts was investigated during pretreatment: reduction in hydrogen followed by carburization in either CO or syngas mixture, or simultaneously reduction and carburization in syngas. A combination of different complementary in situ techniques was used to gain insight into the behavior of Fe-based FTS catalysts during activation. In situ XRD was used to identify the crystalline structures present during both reduction in hydrogen and carburization. An increase in reduction rate was established when increasing the temperature. A complete reduction was demonstrated in the ETEM and a grain size dependency was proven, i.e. bigger grains need higher temperature in order to reduce. XPS and XAS both indicate the formation of a small amount of carbonaceous species at the surface of the bulk metallic iron during carburization.

关键词： In situ characterization Fischer–Tropsch Catalyst reduction and carburization Iron oxides

Development of German-Ukrainian cooperations for education and research in photogrammetry and laser scanning

在线全文

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2021年第1期24卷 152-159,I0016页

作者： thomas Luhmann Institute for Applied Sciences and Geoinformatics Jade University of Applied Sciences OldenburgOldenburgGermany

Since 2011 an intensive international cooperation has been in place between the Institute for Applied Photogrammetry and Geoinformatics(IAPG)at the Jade University of Applied Sciences in Oldenburg,Germany,and various Ukrainian *** an initial contact by *** Konecny,the first visit was organized,and was followed by many *** subsequent years an intensive cooperation was established particularly with the National University for Construction and Architecture(KNUCA)in *** addition to architects and civil engineers,KNUCA also trains geodesists,geo-information scientists and landscape *** cooperation today includes the reciprocal exchange of scientists and students,research projects,courses and cooperation at many other *** addition,a commercial company has been established,SPM3D LLC,which now employs more than 14 engineers in the field of 3D acquisition,point cloud processing and *** article summarizes the history of the cooperation and presents the results of associated student *** addition,results of joint work on the development of a virtual laser scanner are presented,part of a German-Ukrainian initiative to digitize teaching.

关键词： Internationalization technology transfer curricula reform photogrammetry laser scanning e-learning

Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2022年第6期42卷 517-535页

作者： Jian Shen Na Sun Philipp Zens thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger Sabina Berezowska axel Walch Research Unit Analytical Pathology Helmholtz Zentrum Munchen-German Research Center for Environmental HealthNeuherberg 85764Germany Institute of Pathology University of BernBern 3008Switzerland Graduate School for Health Sciences University of BernMittelstrasse 43Bern 3012Switzerland Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031P.R.China Department of Laboratory Medicine and Pathology Institute of PathologyLausanne University Hospital and University of LausanneLausanne 1011Switzerland

Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC *** spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with *** evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine ***:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with *** specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%*** contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,*** combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic *** multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic *** Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non

关键词： cancer metabolism machine learning mass spectrometry imaging metabolic classifier Nonsmall cell lung cancer prognosis spatial metabolomics treatment response