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A novel indocyanine green-based fluorescent marker for guiding surgical tumor resection

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 77-87页

作者： Jiawei Ge Justin D.Opfermann Hamed Saeidi Katherine A.Huenerberg Christopher D.Badger Jaepyeong Cha Martin J.Schnermann Arjun S.Joshi axel krieger Department of Mechanical Engineering Johns Hopkins University BaltimoreMD 21218USA Department of Mechanical Engineering University of Maryland College Park MD 20742USA Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Hospital WashingtonDC 20010USA Department of Pathology George Washington University WashingtonDC 20052USA Division of Otolaryngology-Head and Neck Surgery George Washington University Washington DC 20052USA Chemical Biology Laboratory Center for Cancer Research National Cancer InstituteNational Institutes of HealthFrederickMD 21702USA

Surgical tumor resection is a common approach to cancer *** Ink tattoos are widely used to aid tumor resection by localizing and mapping the tumor edge at the ***,India Ink tattoos are easily obscured during electrosurgical resection,and fade in intensity over *** this work,a novel near-infrared(NIR)fluorescent marker is introduced as an *** NIR marker was made by mixing indocyanine green(ICG),biocompatible cyanoacrylate,and *** marking strategy was evaluated in a chronic ex vivo feasibility study using porcine tissues,followed by a chronic in vivo mouse study while compared with India *** both studies,signal-to-noise(SNR)ratios and dimensions of the NIR markers and/or India Ink over the study period were calculated and *** was performed on the last day of the mouse study after mice were euthanized,and SNR ratios and dimensions were quantified and *** was performed at all injection sites and slides were examined by a *** proposed NIR marker achieved(i)consistent visibility in the 26-day feasibility study and(ii)improved durability,visibility,and biocompatibility when compared to traditional India Ink over the six-week period in an in vivo mouse *** effects persist after electrocautery whereas the India Ink markers were *** use of a NIR fluorescent presurgical marking strategy has the potential for intraoperative tracking during long-term treatment protocols.

关键词： Near-infrared fluorescent marker surgical tumor resection fluorescence-guided sur-gery electrosurgery India ink

从濒危边缘救回一度近乎灭绝的象海豹正在寻找新的家园

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空中英语教室（高级版．彭蒙惠英语） 2024年第8期 30-31,47页

作者： Lisa M.krieger 不详

世界各地的野生动物正在逐渐消失,其数量正在以人类历史上前所未有的速度急剧下降象海豹就是其中之一。曾经濒临灭绝的象海豹正在向北扩展,进入加利福尼亚海岸的新繁殖地,将空旷已久的海滩变成了喧闹之地。

关键词：象海豹繁殖地野生动物濒临灭绝加利福尼亚

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电子皮肤与高效率会议

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 34-36,49,50页

作者： Lisa M.krieger Steven I.Weiss 不详

29斯坦福大学团队研发出具有触觉的电子皮肤斯坦福大学的科学家研发出了一种柔软又可伸展的电子皮肤,而且能够模仿真实皮肤的感觉反馈,并直接传送给大脑。这项发明所用的技术如果进一步改善,有可能为数百万装义肢的人士带来希望.

关键词：斯坦福大学电子皮肤直接传送高效率

Molecular elements of pheromone detection in the female moth, Hefiothis virescens

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Insect Science 2018年第3期25卷 389-400页

作者： Monika Zielonka Heinz Breer Jürgen krieger Institute of Physiology University of Hohenheim Stuttgart Germany Department of Animal Physiology Institute of BiologylZoology Martin Luther University Halle-Wittenberg Halle (Saale) Germany

Pheromones play pivotal roles in the reproductive behavior of moths, most prominently for the mate finding of male moths. Accordingly, the molecular basis for the detection of female-released pheromones by male moths has been studied in great detail. In contrast, little is known about how females can detect pheromone components released by themselves or by conspecifics. In this study, we assessed the antenna of female Helio- this virescens for elements of pheromone detection. In accordance with previous findings that female antennae respond to the sex pheromone component （Z）-9-tetradecenal, we identified olfactory sensory neurons that express its cognate receptor, the receptor type HR6. All HR6 cells coexpressed the ＂sensory neuron membrane protein 1＂（SNMP1） and were associated with supporting cells expressing the pheromone-binding proteins PBP1 and PBP2. These features are reminiscent to male antennae and point to congruent mechanisms for pheromone detection in the two sexes. Further analysis of the SNMP1- expressing cells revealed a higher number in females compared to males. Moreover, in females, the SNMP 1 neurons were arranged in clusters, which project their dendrites into a common sensillum, whereas in males there were only solitary SNMPl-neurons and only 1 per sensillum. Not all SNMP1 positive cells in female antennae expressed HR6 but instead the putative pheromone receptors HR11 and HR18, respectively. Neurons express- ing 1 of the 3 receptor types were assigned to different sensilla. Together the data indicate that on the antenna of females, sensory neurons in a subset of sensilla trichodea are equipped with molecular elements, which render them responsive to pheromones.

关键词： female insect moth olfaction pheromone detection

Advanced Microsoft Office Documents 2007 Edition Inside Out

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Importing Manganese into the Chloroplast： Many Membranes to Cross

2007年

作者： Stephanie krieger

来源：畅想之星图书光盘版（南... 评论

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Molecular Plant 2018年第9期11卷 1109-1111页

作者： Anja krieger-Liszkay Sebastien Thomine Institute for Integrative Biology of the Cell (12BC) CEA CNRS Universite Paris-Sud Universite Paris-Saclay Gif-sur-Yvette Cedex 91198 France

Manganese （Mn） plays a wealth of roles in living systems. It is ubiquitously involved in the antioxidant response because of its ability to catalyze the dismutation of superoxide anions. In eukaryotic cells, Mn also plays a role in protein glycosylation in the secretory system. However, arguably, in photosynthetic organisms, the most important role of Mn is in the oxygen evolving complex at photosystem IL （PS Ⅱ）. Atthe global level, atmospheric oxygen is derived from the splitting of water, a reaction that relies strictly on the tetra-manganese cluster （Mn405Ca） bound to photosystem II at the lumen side of the thylakoid membrane.

关键词： PHOTOSYSTEM-II HOMEOSTASIS PHOTOSYNTHESIS PROTEIN ARABIDOPSIS CELLS

Hydrotropism： Root Bending Does Not Require Auxin Redistribution

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Molecular Plant 2016年第5期9卷 757-759页

作者： Doron Shkolnik Gat krieger Roye Nuriel Hillel Fromm Department of Molecular Biology&Ecology of Plants Faculty of Life SciencesTel Aviv UniversityTel Aviv 69978Israel

Dear Editor The widely accepted Chotodny-Went theory posits that asym- metrical auxin redistribution is required for tropic growth of plant organs. We demonstrate, using the sensitive auxin-sensor protein DII-VENUS that, in the presence and absence of auxin polar transport inhibitors, root tropism toward moisture （hydrotro- pism） does not involve auxin redistribution. Moreover, highly specific auxin signaling antagonists accelerate hydrotropism. Thus, hydrotropism is an exception to the Cholodny-Went theory.

关键词： Bending Require Redistribution

A small number of male-biased candidate pheromone receptors are expressed in large subsets of the olfactory sensory neurons in the antennae of drones from the European honey bee Apis mellifera

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Insect Science 2022年第3期29卷 749-766页

作者： Joerg Fleischer Alexander Rausch Kathrin Dietze Silvio Erler Sina Cassau Jurgen krieger Martin Luther University Halle-Wittenberg Institute of Biologyl ZoologyDepartment of Animal PhysiologyHalle(Saale) Institute for Bee Protection Julius Kuhn Institute(JKI)-Federal Research Centre for Cultivated PlantsBraunschweigGermany

In the European honey bee(Apis mellifera),the olfactory system is essential for foraging and intraspecific communication via *** bees are equipped with a large repertoire of olfactory receptors belonging to the insect odorant receptor(OR)*** studies have indicated that the transcription level of a few OR types including OR11,a receptor activated by the queen-released pheromone compound(2£)-9-oxodecenoic acid(9-ODA),is significantly higher in the antenna of males(drones)than in female ***,the number and distribution of antennal cells expressing male-biased ORs is ***,we analyzed antennal sections from bees by in situ hybridization for the expression of the male-biased receptors OR11,OR18,and *** results demonstrate that these receptors are expressed in only moderate numbers of cells in the antennae of females(workers and queens),whereas substantially higher cell numbers express these ORs in ***,the reported male-biased transcript levels are due to sex-specific differences in the number of antennal cells expressing these *** analyses for OR11 and OR18 in drone antennae revealed expression in two distinct subsets of olfactory sensory neurons(OSNs)that in total account for approximately 69%of the OR-positive *** high percentages of OSNs expressing given receptors are reminiscent of male-biased ORs in moths that mediate the detection of female-released sex pheromone ***,our findings indicate remarkable similarities between male antennae of bees and moths and support the concept that male-biased ORs in bee drones serve the detection of female-emitted sex pheromones.

关键词： chemosensory odorant receptor olfaction pheromone detection sensilla placodea

A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40

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Cellular & Molecular Immunology 2020年第6期17卷 659-661页

作者： Andreas Spyrantis Jana krieger Katja Stifter Bernhard Otto Boehm Reinhold Schirmbeck Department of Internal Medicine I Ulm University Hospital/Albert Einstein Allee 2389081 UlmGermany Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Imperial College London LondonUK

Type 1 diabetes mellitus(T1D)is an autoimmune disease that is characterized by a progressive infiltration of autoreactive T cells into the pancreatic islets and the destruction of insulin-producing beta cells.1 It is generally assumed that T1D is initiated by yet unidentified T cells that escape from thymic negative selection2 and trigger an initial destruction of beta cells.3 These initial hits could generate suitable conditions in beta cells and/or in islets that favor the coactivation and amplification of autoreactive T cells directed against a broad spectrum of beta cell-specific antigens,such as GAD65,IGRP,and IA-2.

关键词： GPR40 islet directed