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Ocular Manifestations during Rheumatoid Arthritis in Conakry

Open Journal of Ophthalmology 2022年第4期12卷 373-381页

作者： Alpha Ibrahima Balde Aly Badra Kamissoko Fremba Camara Sonassa Diane Emmanuel Yombouno Adel Lelano mohamed awada Ophthalmology Department of the Inter-Army Medical and Surgical Centre (CMCIA/BQG) of Camp Samory Touré in Conakry Co-nakry Guinea Rheumatology Department of the National Ignace Deen Hospital CHU of Conakry Conakry Guinea Regional Hospital of Kankan Kankan Guinea

Rheumatoid arthritis (RA) is a systemic inflammatory disease that primarily affects the joints and may also manifest with extra-articular symptoms. Ocular involvement is common in patients with rheumatoid arthritis and may represent the main clinical manifestation of the disease. Aim: To study the epidemiological and therapeutic particularities of ocular manifestations during rheumatoid arthritis in Conakry. Material and Methods: This was a descriptive cross-sectional study of 6 months duration from 1 January to 30 June 2018 on patients with RA. All patients with chronic inflammatory rheumatism in whom the diagnosis of rheumatoid arthritis had been made according to the diagnostic criteria of the American College of Rheumatology (ACR) 2010 and these patients benefited from a complete ophthalmologic examination. Results: We enrolled 22 patients. The mean age was 43.45 ± 16.07 years (range 21 and 79 years). The mean age at onset of symptoms was 39.4 years with a mean time to diagnosis of RA of 3.9 years. Females dominated with 77.27% of cases with a sex ratio of 0.22 M/F. Photophobia (39.29%), xerophthalmia (31.82%), lacrimation and decreased vision 5 cases or 22.73 each, pruritus (9.09%), foreign body sensation and red eye with 2 cases each or 9.09% were the most frequent symptoms. The different ophthalmological diagnoses found were dry eye 19 cases or 86.36%, allergic conjunctivitis 4 cases or 18.18%, ametropia 3 cases or 13.64%, cataract 2 cases or 9.09%, superficial punctate keratitis 2 cases or 9.09% and chronic glaucoma 1 case or 4.55%. The management of dry eye was based on tear substitutes. Cataract cases (9.09%) required surgical intervention while patients with ametropia (13.04%) received optical correction. Cases of allergic conjunctivitis (18.18%) were reported. Conclusion: Good coordination between the ophthalmologist and the rheumatologist is necessary to optimize the management of patients with rheumatoid arthritis.

关键词： Rheumatoid Arthritis Ocular Involvement Conakry

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Spondyloarthritis Associated with Inflammatory Bowel Disease: Study of 15 Observations in Guinea

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第2期11卷 89-95页

作者： Condé Kaba awada mohamed Carlos Othon Guelngar Adjibaye Emmanuel Sanni Yaya Aminou Mamadou Hady Diallo Touré Moriba Kamissoko Aly Badra Konaté Ibrahima Sory Fodé Abass Cissé Department of Rheumatology Academic Hospital University of Conakry Guinea Department of Neurology Academic Hospital University of Conakry Guinea Department of infectious disease Reference Hospital Ndjamena Chad

Objective: Rheumatologic disorders of chronic inflammatory bowel disease (IBD) and reactive arthritis with a digestive origin are part of the spondyloarthritis family. In black Africa, the prevalence of SpA associated with IBD is not clearly established. Thus the objective of our study was to describe the clinical and radiological characteristics of spondyloarthritis associated with IBD. Patients and Method: We carried out a prospective study in the rheumatology department of CHU Ignace Deen between January and December 2019. The diagnosis of SpA was based on clinical and biological arguments in accordance with the criteria of Amor and ASAS. Results: Fifteen observations of spondyloarthritis associated with IBD were collected in patients mean age 52 years with extremes of 32 and 65 years. 9 (53.33%) were female. Ten patients had Crohn’s disease (CD) and 5 had ulcerative colitis (UC). The mean number of pushes was 2.5 ± 1.2. The average diagnostic time was 46 months. Sacroiliitis was present in 73.3% of cases and the mean mSASSS score at diagnosis was 32.11/72. In total, corticosteroids were used in 9 (60%) of patients, NSAIDs in 26.6% while DMARDs salazopyrine and methotrexate in 33.3% and 20% of patients, respectively. Conclusion: The MICI and SpA association is undoubtedly underestimated in our regions. Better collaboration between rheumatologists and gastroenterologists could facilitate diagnosis and improve care.

关键词： Spondyloarthritis Chronic Inflammatory Bowel Disease Guinea

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Profile of Juvenile Idiopathic Arthritis in Guinea

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第1期11卷 1-8页

作者： Kaba Condé Mamadou Ciré Barry Carlos Othon Guelngar Igue Kadidjatou Mamadou Hady Karinka Diawara Konaté Mamady Touré Moriba D. Granga D awada mohamed Fodé Abass Cissé Department of Neurology Academic Hospital University of Conakry Conakry Guinea Department of Rheumatology Academic Hospital University of Conakry Conakry Guinea Department of Pediatric Academic Hospital University of Conakry Conakry Guinea Department of Pediatric Mother and Child Hospital Ndjamena Chad

Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatoid disease in children. In Sub-Saharan Africa, little data is available on the prevalence of JIA. The objective of our study was to determine the frequency and describe the clinical profile of JIA in Guinean children seen at the Department of Neurology, Academic Hospital, University of Conakry (Guinea). Patients and Method: This was a retrospective study carried out at the Ignace Deen Academic Hospital, Conakry between January 2016 and December 2018. Patients were recruited through the Rheumatology and Paediatrics Department. Results: We collected forty (40) observations of JIA in 22 girls (55%) and 18 boys (45%). The median age at diagnosis was 14 years (range 7 - 18 years), compared to 7 years at onset (range 5 and 13 years). There were 3 cases of systemic arthritis (7.5%), 16 (40%) patients with persistent oligoarthritis, 3 patients (7.5%) that had extensive oligoarthritis, polyarthritis with positive RF in 8 cases (20%) and with negative RF in 4 cases (10%), psoriatic arthritis in 3 cases (7.5%), and enthesitis related arthritis in 2 cases (5%). There was one case of undifferentiated arthritis. A total of 23 (57.5%) received methotrexate, 9 (22.5%) were treated with salazopyrin. Conclusion: The profile of JIA in our study is different from that described in African studies with a predominance of oligoarticular JIA.

关键词： JIA Clinical Forms Guinea SSA

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Secondary Hypertrophic Osteoarthropathy or Pierre-Marie Syndrome Bamberger: Clinical Case and Literature Review

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第2期11卷 73-78页

作者： Kaba Condé Carlos Othon Guelngar awada mohamed Igué Kadidjatou Douna Granga Daouya Mamadou Ciré Barry Mamadou Hady Diallo Karinka Diawara Konaté Mamady Touré Moriba Fodé Abass Cissé Department of Rheumatology Academic Hospital University of Conakry Conakry Guinea Department of Neurology Academic Hospital University of Conakry Conakry Guinea Department of Pediatric Mother and child Hospital Ndjamena Chad Department of Pediatric Academic Hospital University of Conakry Conakry Guinea

Secondary hypertrophic osteoarthropathy, or Pierre-Marie Bamberger syndrome, is characterized by the association of digital clubbing, polyarthritis and periostitis affecting the long bones. Most commonly it is a paraneoplastic syndrome associated with lung cancer in 80% of cases. We report the case of a 49-year-old female patient who is actively smoking, one pack per day for 20 years. Seen in consultation for pain and swelling of the hands, elbows, knees, ankles, and feet evolving for about 5 months, associated with a poorly differentiated pulmonary adenocarcinoma. On history, she told us about a weight loss of about 8 kg, no fever, no cough, no family history of inflammatory rheumatism or cancer. Bilateral digital clubbing was noted. The diagnosis was based on imaging and histology. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and chemo-radiotherapy was started.

关键词： Hypertrophic Osteoarthropathy Pulmonary Adenocarcinoma Guinea

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Tuberculous Sacroiliitis with Secondary Psoas Abscess: A Case Report

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第2期11卷 48-52页

作者： Kaba Condé Carlos Othon Guelngar Igué Kadidjatou D. D. Granga Mamadou Ciré Barry Mamadou Hady Karinka Diawara Konaté Mamady Touré Moriba awada mohamed Fodé Abass Cissé Department of Neurology Academic Hospital University of Conakry Conakry Guinea Department of Rheumatology Academic Hospital University of Conakry Conakry Guinea Department of Pediatric Mother and child Hospital Ndjamena Chad Department of Pediatric Academic Hospital University of Conakry Conakry Guinea

Tuberculous sacroiliitis secondary to a psoas abscess is rare, only a few sporadic cases were reported in the literature. Tuberculous sacroiliitis is rare, usually unilateral, its symptomatology is misleading, its diagnosis is often delayed or even confused with damage to the hip or lumbosacral hinge, most often related to difficulties exploration of the sacroiliac joint. We report the case of a 66-year-old diabetic patient with low back pain, unilateral right with inflammatory appearance, insidious installation, evolving for about 8 months. The diagnosis of tuberculous sacroiliitis was made after biopsy of the sacroiliac joint. CT and MRI are necessary for lesion diagnosis. Tuberculosis treatment was started and the abscess was surgically drained. The aim of this work was to describe the diagnostic pathway of a patient with tuberculous sacroiliitis in a tropical environment. Conclusion: Tuberculous sacroiliitis, secondary to an abscess of the psoas muscle is an unusual cause of hip pain and is likely to be overlooked due to its atypical presentation.

关键词： Tuberculous Sacroiliitis Psoas Abscess Guinea

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Contribution of ARV Treatment in the Correction of Anemia in People Living with HIV during the First Semester in the Hematology Department of Conakry University Hospital

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World Journal of AIDS 2021年第4期11卷 143-151页

作者： Diakite Mamady Kante Ansoumane Sayon Keita Fatimata Ouendouno Soumana Camara Toumin Diallo Abdoul Goudoussy Kourouma Mamadou Sylla Mouctar Camara Fatou awada mohamed Traore Fodé Amara Magassouba Aboubacar Sidiki Sidikiba Sidibé Abdoulaye Touré Department of Hematology Conakry University Hospital Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Dermatology-MST Conakry University Hospital Conakry Guinea Department of Internal Medicine Conakry University Hospital Conakry Guinea Department of Infectious and Tropical Diseases Conakry University Hospital Conakry Guinea Public Health Department CHU Conakry Guinea

Introduction: Anemia is frequently associated with the natural course of people living with HIV (PLWHIV). The objective was to describe the evolution of anemia in PLWHIV during the first 6 months of ART and to identify the associated factors in the hematology service of the Ignace Deen national hospital of the Conakry University Hospital. Methods: This was a prospective, observational descriptive and analytical study lasting one year from August 1, 2019 to July 31, 2020. It focused on PLWHIV who were newly included in ART during the period of study in the Hematology Department of Ignace Deen Hospital. Results: Of 45 PLWHIV, 40 presented with anemia of 88.89%. The mean age was 40.16 years ± 12.29 years and extremes of 22 and 71 years. The female sex represented 65% of cases with a sex ratio of 0.54. Prolonged fever was the main reason for consultation, 97.5%. The HIV-1 serotype was represented in all anemic patients. At least one OI was found in 24 patients, 60%. MO anemia was severe (28.9%), moderate (44.4%) and mild (26.7%). At M6 it was moderate (5.9%) and light (94.1%). It was normochromic normocytic in 55%. At M0, statistical analysis was significant between anemia and OIs, WHO stage and CD4 count, but the link was not established at M6. Conclusion: Anemia is frequently associated with HIV infection linked to delayed treatment. Its development would be better with the establishment of good support. Specific actions should be taken to better identify the factors involved.

关键词： PLWHIV ART Treatment Anemia CHU Conakry

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