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Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia

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Asian Journal of Urology 2024年第1期11卷 26-32页

作者： awad elsid o.man Sahar Alharbi Atif Ali Ahmed Asim Ali Elbagir Pathology and Clinical Laboratory management Department(PCLM) King Fahad Medical CityRiyadhSaudi Arabia Department of Pathology and Laboratory Medicine University of Missouri at Children's Mercy HospitalKansas CityMOUSA

objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically ***: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using Taqman® minor groove binder polymerase chain reaction ***: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (potype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.

关键词： Prostatecancer Saudi Singlenucleotide polymorphism Allele

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Unusual cause of syncopal episodes

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open Journal of Internal Medicine 2012年第4期2卷 187-189页

作者： Raymond Farah Rola Khamisy-Farah Jamal awad Department of Internal Medicine “B” Ziv Medical Center Safed Israel Internal Medicine “A” Department Western Galilee Hospital Nahariya Israel obstetrics and Gynecology Western Galilee Hospital Nahariya Israel

We report a 43-year-old man who had been experiencing recurrent attacks of syncope for several years, and a search for the causes behind these lapses in consciousness was fruitless for many years. The patient was admitted to our department of internal medicine because of the symptoms flushing, hypotension and episodes of syncope. After a careful anamnesis and then a comprehensive investigation, we reached the definitive diagnosis of the infrequent disease “systemic mastocytosis”.

关键词： Syncope Hypotension Flushing Mastocytosis

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Unusual Cause of Stridor in an Adult man, Selective Immunoglobulin A Deficiency

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open Journal of Respiratory Diseases 2021年第2期11卷 76-83页

作者： Safwat A. M. Eldaboosy Amgad awad Ayman Ghoneim Almoosa Specialist Hospital Al-Ahsa Saudi Arabia Department of Chest Diseases Al Azhar Faculty of Medicine Al-Azhar University Cairo Egypt Department of Internal Medicine Al Azhar Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiothoracic Surgery Al Azhar Faculty of Medicine Cairo Egypt

The common causes of stridor in adults are abscesses or swelling of the upper airway, tumors, paralysis, or malfunction of vocal cords. Tracheitis due to immunoglobulin deficiency may be a rare explanation for stridor in adults, although occasionally reported in children. We report an adult man having stridor secondary to isolated immunoglobulin A deficiency. We did an in-depth review of the literature to seek out no reported cases of stridor thanks to immunoglobulin deficiency in adults. This case underlines the very fact that a standard symptom like stridor rarely occurs thanks to uncommon causes. This case is exclusive because it reports the presence of stridor associated with isolated immunoglobulin A deficiency in an adult patient. The explanation for the stridor was an intraluminal narrowing of the upper part of the extrathoracic trachea.

关键词： Stridor Tracheitis Immunoglobulin A Deficiency

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