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Radiotherapy of Oligoprogressive Lesions in Castration-Resistant Prostate Cancer: Impact on Second-Generation Hormone Therapy

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Journal of Cancer Therapy 2021年第5期12卷 302-310页

作者： Kanta Ka Papa Macoumba Gaye awa sadikh badiane Ibrahima Thiam Mouhamadou Bachir Ba Papa Massamba Diene Maimouna Mané Lamine Niang Fatou Samba Ndiaye Radiotherapy Department of Centre Hospitalier National Universitaire Dalal Jamm Guédiawaye Senegal Cheikh Anta Diop University of Dakar Dakar Senegal Hematology Department of Centre Hospitalier Universitaire Dalal Jamm Guédiawaye Senegal

Background: The therapeutic standard for oligoprogressive prostate cancer resistant to castration is second-generation hormone therapy. This systemic treatment is expensive. There are oligoprogressive lesions accessible to radiotherapy. Objectives: To study the impact of radiotherapy of oligoprogressive lesions on the implementation of second generation hormone therapy. Patients and Methods: A retrospective study from 2012 to 2020 was carried out. All patients with oligoprogressive prostate cancer who had received radiotherapy on one or more lesions in progression were collated. Survival was calculated using the Kaplan-Meier method. Results: 8 patients were treated with stereotactic and conformational radiotherapy between August 2012 and August 2020 in the context of oligoprogressive prostate cancer resistant to castration. The median age at diagnosis of oligoprogression was 73 years with a median PSA level of 3.11 ng/ml. Nine lesions were diagnosed with PET scan PSMA. All the lesions were treated by radiotherapy with different regimens. After a median follow-up of 12.5 months, 7 patients showed a biochemical response to treatment with a median decrease in PSA of 67%. The median survival without clinical or biochemical progression was 7 months. The median survival without the need for further systemic treatment was 9 months. During the follow-up period, six patients received second-generation hormone therapy to treat their relapse, and

关键词： Ablative Radiotherapy Hormone Therapy Oligometastasis Prostate Castration-Resistant Cancer

Assessment of a Database Management System in a Mammogram Unit of a Radiologic Department in Fann Teaching Hospital (Senegal)

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第4期6卷 401-409页

作者： Mamour Gueye awa sadikh badiane Sokhna Ba Diop Mamadou Ly Mame Diarra Ndiaye Gueye Abdoulaye Dione Diop Abdoulaye Ndoye Diop Marame Fall Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Dakar Senegal Department or Radiology Fann Teaching Hospital Dakar Senegal

Objectives: To evaluate a medical data management system of a mammogram unit in a department of Radiology. Methods: This is a qualitative and quantitative assessment study in Fann Teaching Hospital between April 2014 and June 2015 one year after its implementation. The quantitative component consisted of the audit of the database to determine the socio-demographic characteristics of patients and the results of mammograms. The qualitative component assessed users’ experience. For analysis, quantitative data were extracted and transferred to Microsoft Excel. For scale variables, we calculated the averages and extremes. For qualitative variables, we established percentages. Results: During the study period, 433 patients underwent mammograms. The average age of patients was 48 years. The completion rate maintained above 85% was below 26% in the first two months of use. As to the completeness given examinations, it was still above 83%. The results of mammogram examinations were normal in the majority of cases: 96% for the right breast and 95.2% for the left breast. All users had a favourable opinion about the database. The reasons were better work organization, comprehensiveness, accessibility and standardization of information about the patient and especially the immediate availability of statistics. For 60% of these health professionals, complaints related to the use of the software were the time-consuming of filling data. Conclusion: This study mainly describes the perception of health professionals on the computerization of radiological examinations. It offers some advantages, proposes improvements and opens avenues for reflection on the globalization of the computerization of patient records in Radiology.

关键词： Electronic Medical Records Database Mammogram Radiology Dakar

Curative 3D Conformal Radiotherapy of Non-Operated Prostate Adenocarcinoma at Pointe-a-Pitre University Hospital (Guadeloupe): About 29 Cases

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Journal of Cancer Therapy 2021年第5期12卷 279-288页

作者： Ibrahima Thiam Kanta Ka awa sadikh badiane Mouhamadou Bachir Bâ El Hadj Amadou Sall Boucar Ndong Papa Ahmet Fall Mamadou Moustapha Dieng Papa Macoumba Gaye Joliot Curie Institute of Aristide Le Dantec Hospital Dakar Senegal Radiotherapy Department of the University Hospital Center of Dalal Jamm Guédiawaye Senegal Cheikh Anta Diop University Dakar Senegal Urology Department of the University Hospital Center of Dalal Jamm Guédiawaye Senegal

Context: Technological advances have improved the toxicities of radiotherapy. We are evaluating the 3D technique in prostate cancer. Materials and Methods: Retrospective study from January 2015 to December 2015 with 29 files. Survival was calculated by Kaplan-Meier method. Results: We collected 29 patient records over the study period. The median age was 75 years with the following extremes: 54 years and 83 years. The median PSA level was 12 ng/ml with a range of 3.05 to 79 ng/ml. Gleason score analysis showed 6 patients (20.69%) with a score of 6 (3 + 3), 23 patients (79.31%) with a score of 7 including 12 patients (41.38%) with grade 3 and 11 patients (37.93%) with grade 4. The median dose delivered was 74 Gy, with a mean dose of 73.79 Gy and extremes of 70 Gy for the minimum and 76 Gy for the maximum. Hormone therapy was combined with radiotherapy in 17 patients (58.62%). Seven patients (24.14%) had grade 1 acute bladder toxicity and one patient (3.45%) had grade 2 acute toxicity. Late bladder toxicity was grade 1 in 5 patients (17.24%), grade 2 in 3 patients (10.34%) and grade 3 in 1 patient (3.45%). Late rectal toxicity, grade 2 in 3 patients (10.34%), grade 3 in 1 patient, was noted. Overall survival at 2 years was 100% and 89.65% at 5 years. Relapse-free survival at 2 years was 82.76% and 62.07% at 5 years. There were 3 deaths (10.34%) of which only one was related to prostate cancer.

A Shoulder Mass Revealing a Metastatic Prostate Cancer

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