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世界地震工程 1982年第2期 35-44页

作者： avtax s.pall Cedric Marsh Paul Fazio 刘河先

地震的地面运动在结构物上产生横向振动荷载,使结构来回摆动,其振幅与输入能量成正比。如果在结构运动过程中,输入能量能被控制并消耗掉其大部,结构的破坏程度就可大为降低。在钢构架或现浇混凝土结构中,当结构承受非弹性变形的时候,主... 详细信息

地震的地面运动在结构物上产生横向振动荷载,使结构来回摆动,其振幅与输入能量成正比。如果在结构运动过程中,输入能量能被控制并消耗掉其大部,结构的破坏程度就可大为降低。在钢构架或现浇混凝土结构中,当结构承受非弹性变形的时候,主要依靠其延

关键词：滑动荷载地震强度法向应力侧移能量耗散正应力大板结构地震反应

Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-sanchis Pedro AAvila-López Iva Tic David Valle-García Marta Ribalta-Vilella Luis Labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRs UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(sAMP8)control mice and sAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the sAMP8 group treated with G9a inhibitor than in the sAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG sAMP8

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Pancreatitis: Preventing catastrophic haemorrhage

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World Journal of Gastroenterology 2017年第30期23卷 5460-5468页

作者： Richard PT Evans Moustafa Mabrouk Mourad Gunraj pall simon G Fisher simon R Bramhall Russel’s Hall Hospital Department of surgery the Wye Valley NHS Trust

Pancreatitis represents nearly 3% of acute admissions to general surgery in United Kingdom hospitals and has a mortality of around 1%-7% which increases to around 10%-18% in patients with severe pancreatitis. Patients at greatest risk were those identified to have infected pancreatic necrosis and/or organ failure. This review seeks to highlight the potential vascular complications associated with pancreatitis that despite being relatively uncommon are associated with mortality in the region of 34%-52%. We examine the current evidence base to determine the most appropriate method by which to image and treat pseudo-aneurysms that arise as the result of acute and chronic inflammation of pancreas. We identify how early recognition of the presence of a pseudo-aneurysm can facilitate expedited care in an expert centre of a complex pathology that may require angiographic, percutaneous, endoscopic or surgical intervention to prevent catastrophic haemorrhage.

关键词： Complication of pancreatitis splenicartery Pancreatitis Haemorrhage Pseudoaneurysm

Gastrotomy closure with a new tissue anchoring device:A porcine survival study

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World Journal of Gastroenterology 2011年第13期17卷 1732-1738页

作者： Carlos Guarner-Argente Henry Córdova Graciela Martínez-pallí Ricard Navarro-Ripoll Antonio Rodríguez-d’Jesús Cristina Rodríguez de Miguel Mireia Beltrán Gloria Fernández-Esparrach Endoscopy Unit Hospital Clínic CIBERehd Barcelona 08026 Spain Anesthesiology Department Hospital Clínic CIBERehd Barcelona 08026 Spain

AIM: To evaluate the feasibility, reproducibility and efficacy of a new tissue anchoring device in a porcine survival model. METHODs: Gastrotomies were performed using a needle-knife and balloon dilator in 10 female Yorkshire pigs weighing 30-35 kg. Gastric closure was attempted using a new tissue anchoring device. The tightness of the closure was confirmed by means of air insufflation and the ability to maintain gastric distension with stability in peritoneal pressure measured with a Veress needle. All animals were monitored daily for signs of peritonitis and sepsis over 14 d. During necropsy, the peritoneal cavity and the gastric access site were ***: Transgastric access, closure and 14 d survival was achieved in all pigs. The mean closure time was 18.1 ± 19.2 min and a mean of 2.1 ± 1 devices were used. supplementary clips were necessary in 2 cases. The closure time was progressively reduced (24.8 ± 13.9 min in the first 5 pigs vs 11.4 ± 5.9 min in the last 5, P = Ns). At necropsy, the gastric access site was correctly closed in all cases with all brace-bars present. One device was misplaced in the mesocolon. Minimal adhesions were observed in 3 pigs and signs of mild peritonitis and adhesions in one. CONCLUsIONs: The use of this new tissue anchoring device in porcine stomachs is feasible, reproducible and effective and requires a short learning curve.

关键词： Gastrotomy Closure suture survival Porcine model Notes

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绩效考核在医院薪酬体系中的应用

江苏卫生事业管理 2018年第10期29卷 1102-1105页

作者：潘旭宁波市第六医院人事科浙江宁波315040

目的:构建一套科学、公平以及操作性强的绩效考核体系,希望对未来进一步完善新型医院绩效管理方案提供参考。方法:引入平衡计分卡设计思路,将医院的战略目标逐层分解为各种具体的绩效考核指标体系,并对其实现情况进行考核。结果:实施科... 详细信息

目的:构建一套科学、公平以及操作性强的绩效考核体系,希望对未来进一步完善新型医院绩效管理方案提供参考。方法:引入平衡计分卡设计思路,将医院的战略目标逐层分解为各种具体的绩效考核指标体系,并对其实现情况进行考核。结果:实施科学的绩效考核,合理地分配绩效工资,有效地激发员工的积极性,提高医院服务质量。结论:应在充分考虑各种影响因素的基础上,选择顺应卫生体制改革要求的适合本单位的绩效考核模式。全员参与和信息化的有力支撑是全面实施绩效考核的关键。

关键词：医院绩效考核薪酬体系应用

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Revisiting Port Regulatory Governance & substance: Towards a Holistic supply Chain Approach

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Journal of Environmental science and Engineering(B) 2023年第4期12卷 206-210页

作者： Constantınos Chlomoudıs Petros.pallıs Theodore stylıadıs Department of Maritime studies University of PiraeusPiraeus 18532Greece

The evolution and integration of ports in global logistics chains has altered their traditional role while has initiated restructuring processes in many ports worldwide. While most of the research addresses this issue by highlighting the need for re-positioning and redefining the role of the port within the supply chains, not much attention has been given to the structure, scope and reach as well as to the tools of regulation hat competent authorities could exploit in order to avert potential abusive actions of global powerful actors along the containerized transport chain, that would affect the competitive functioning of distinct segment or the integrity of supply chains. In this context, we propose the reconceptualization and reinforcement of the regulatory governance structures of ports on a national and international level as well as the extension of the scope of ports’ regulations along the supply chain to counterbalance the globalization, consolidation and integration of containerized transport actors.

关键词： Ports concentration supply chain integration regulation

Unrecorded Ethnomedicinal Uses of Biodiversity from Tadgarh-Raoli Wildlife sanctuary, Rajasthan, India

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云南植物研究 2007年第3期29卷 337-344页

作者： Anita JAIN s. s. KATEWA P. K. GALAV Ambika NAG Laboratory of Ethnobotany and Agrostology Department of Botany College of Science M. L. Sukhadia University Udaipur-313001 (Rajasthan) India.

Extensive ethnomedicinal survey was carried out during the year 2003-2005 to document the precious indigenous health care practices prevalent among the different ethnic groups (Bhil, Meena, Garasia, etc) of Tadgarh-Raoli wildlife sanctuary. This sanctuary is located in Rajsamand, Pali, and Ajmer districts of south-east Rajasthan, India. The tribals belonging to primitive or aboriginal culture possess a good deal of information about medicinal utility of biodiversity. During the survey, it was noted that plant or plant parts as well as animals and substances derived from animal origin were commonly used by the tribals to cure various diseases and disorders. Indigenous healthcare practices, provide low cost alternatives in situation where modern health care services are not available or too *** of data based on 85 remedies indicates that 70 remedies are based on 45 different species of plants belonging to 28 families and 17 remedies are based on several substances of animal origin to cure various ailments through indigenous health care practices. A list of plant and animal species along with their scientific name, parts used and the mode of administration for effective control in different ailments are given.

关键词：拉贾斯坦邦印度野生植物生物多样性民族药学植物药

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针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题

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英国医学杂志中文版 2020年第9期23卷 522-533页

作者： sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani pall Jonsson sarah Cumbers Adrian Jonas Katherine s L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary s Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) Alan Turing Institute Kings CrossLondonUK Departments of Mathematics and statistics University of WarwickCoventryUK Warwick Medical school University of WarwickCoventryUK Kings College Hospital Denmark HillLondonUK Department of statistical science University College LondonLondonUK University of Chicago ChicagoILUSA science Policy and Research National Institute for Health and Care ExcellenceManchesterUK Health and social Care Directorate National Institute for Health and Care ExcellenceLondonUK Data and Analytics Group National Institute for Health and Care ExcellenceLondonUK Clinical Practice Research Datalink Medicines and Healthcare products Regulatory AgencyLondonUK Medicines and Healthcare products Regulatory Agency LondonUK Julius Centre for Health sciences and Primary Care UMC UtrechtUtrecht UniversityUtrechtNetherlands UK EQUATOR Centre Centre for Statistics in MedicineNDORMSUniversity of OxfordOxfordUK Meta-Research Innovation Centre at stanford Stanford UniversityStanfordCAUSA Department of statistics University of OxfordOxford 0X13LBUK Health Data Research UK London University College LondonLondon.UK Institute of Health Informatics University College LondonLondonUK National Institute for Health Research University College London Hospitals Biomedical Research CentreUniversity College LondonLondonUK 深圳智影医疗公司首都医科大学附属北京安贞医院清华大学附属北京清华长庚医院皮肤科

机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、... 详细信息

机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。

关键词：人工智能研究机器学习同行评审数据资源缺乏透明度可重复性透明性跨学科团队