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Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality

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Neural Regeneration Research 2023年第3期18卷 497-502页

作者： Yulia Mitiagin Ari barzilai Department of Neurobiology the School of NeurobiologyBiophysicsMolecular Biology and BiochemistryGeorge S.WiseFaculty of Life SciencesTel Aviv UniversityTel AvivIsrael Sagol School of Neurosciences Tel Aviv UniversityTel AvivIsrael

Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic ***,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still *** this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar *** addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular *** discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox ***,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.

关键词： ataxia telangiectasia ATM cerebellum DNA damage response double-strand breaks mitochondrial dysfunction oxidative stress single-strand breaks

Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 155-165页

作者： Natalie Kaminsky Ofer Bihari Sivan Kanner Ari barzilai Department of Neurobiology George S.WiseFaculty of Life SciencesTel Aviv University Sagol School of Neuroscience Tel Aviv University

The DNA damage response（DDR） is a complex biological system activated by different types of DNA *** in certain components of the DDR machinery can lead to genomic instability disorders that culminate in tissue degeneration,premature aging,and various types of ***,malfunctioning DDR plays a role in the etiology of late onset brain degenerative disorders such as Parkinson＇s,Alzheimer＇s,and Huntington＇s *** many years,brain degenerative disorders were thought to result from aberrant neural *** we discuss the evidence that supports our novel hypothesis that brain degenerative diseases involve dysfunction of glial cells（astrocytes,microglia,and oligodendrocytes）.Impairment in the functionality of glial cells results in pathological neuro-glial interactions that,in turn,generate a ‘‘hostile＂ environment that impairs the functionality of neuronal *** events can lead to systematic neural demise on a scale that appears to be proportional to the severity of the neurological deficit.

关键词： DNA damage response Genomic instability Brain degenerative diseases Glial cells Astrocytes Microglia

UP REGULATION OF SEMAPHORIN EX-PRESSION IN RETINA OF GLAUCOMA- TOUS RABBITS

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国际眼科杂志 2003年第1期3卷 86-86页

作者： A.S.Solomon M.Kimron V.Holdengreber A.Shirvan A.barzilai Sheba Medical Center Tel-Aviv UniversityTel-Aviv UniversityNST Ltd. IsraelTel-Aviv University

Glaucoma is a term encompassing a variety of diseases that culminate in the death of retinal ganglion cells (RGC). Although a variety of factors can initiate the disease onset, increased intraocular pressure (IOP) is one of the major risk factors. In our previous study we found that semaphorins were causally involved in RGC death following axotomy. Since a common feature of

关键词：家兔青光眼视网膜信号肽表达调节

ANTI SEMA3A ANTIBODIES RESCUE RETINAL GANGLION CELLS FROM CELL DEATH FOLLOWING OPTIC NERVE AXO- TOMY

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国际眼科杂志 2003年第1期3卷 86-86页

作者： A.barzilai A.Shirvan M.Kimron V.Holdengreber I.Ziv Y Ben-Shaul S.Melamed E.Melamed A.S.Solomon Tel aviv University NST Ltd. Petach TiqvaTel Aviv UniversityTel Aviv UniversityNST Ltd. Petach TiqvaNST Ltd. Petach TiqvaTel Aviv UniversityGold-schleger Eye Research InstituteRabin Medical Center Is-raelGold-schleger Eye Research Institute

Damage to the optic nerve in mammals induces retrograde degeneration and apoptosis of the retinal ganglion cell (RGC) bodies. We have previously shown that semaphorins, axon guidance molecules with repulsive cues, are... 详细信息

关键词：视神经辅损伤视网膜神经节细胞死亡救治 Ⅲ型信号肽抗体