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ACSL4,PUFA,and ferroptosis:new arsenal in anti-tumor immunity

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1363-1365页

作者： boyi gan Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA

In a recent study published in Cancer Cell,Liao et al.1 identified CD8+T-cell-derived interferon(IFN)γin combination with polyunsaturated fatty acids(PUFAs)as a natural ferroptosis inducer(FIN)to trigger tumor ferroptosis and promote anti-tumor immunity in an acyl-coenzyme A synthetase long-chain family member 4(ACSL4)-dependent *** refers to a form of regulated cell death triggered by excessive iron-dependent peroxidation of PUFA-containing phospholipids(PUFA-PLs)in the cellular membrane.

关键词： immunity peroxidation

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会理出土战汉时期铜矛的铅料来源分析

光谱学与光谱分析 2024年第2期44卷 446-451页

作者：徐军平杨颖东王晓婷杜靖唐翔罗武干山东省文物保护修复中心山东济南250100 成都文物考古研究院四川成都610042 中国科学院大学考古学与人类学系北京100049 中国科学院古脊椎动物与古人类研究所北京100044 国家文物局考古研究中心北京100013 会理县文物管理所四川会理615100

凉山州会理地区自先秦时期已成为金沙江中游进入云南的重要门户。会理青铜文化显示了浓厚的本地原始文化基础,且在历史发展进程中与金沙江以南等区域文化曾发生过不同程度的交流互动。铜矛是中国西南地区青铜文化墓葬中普遍出土的一类... 详细信息

凉山州会理地区自先秦时期已成为金沙江中游进入云南的重要门户。会理青铜文化显示了浓厚的本地原始文化基础,且在历史发展进程中与金沙江以南等区域文化曾发生过不同程度的交流互动。铜矛是中国西南地区青铜文化墓葬中普遍出土的一类青铜兵器,通常带有杀伐功能和礼仪性,此外因其具有独特的类型学特征,可以作为区别文化因素的特殊器物。由于青铜的冶炼受冶金技术和金属矿料供应的制约,青铜兵器的制作技术和矿料来源是讨论西南地方青铜文化与周边文化交流的良好例证。在此背景下,为探讨战国至西汉早期会理地区出土青铜矛的矿源以及其与周边文化的互动等问题,本研究利用便携式X射线荧光光谱仪(pXRF)、多接收电感耦合等离子质谱仪(MC-ICP-MS)等设备对会理郭家堡墓地出土的四件铜矛进行了成分与铅同位素比值测定。铜矛样品均为柳叶形矛叶,且中部略起脊,骹部无耳,通体素面,这种形制的铜矛属于典型的本地风格特征。科技分析结果显示,铜矛样品的合金成分组成差异较大,有铜铅合金、铜锡铅合金及铜铅锑合金。因为所有样品的铅含量都高于2%,所以铜器中的铅料系人为添加。铅同位素比值分析结果则揭示了本批铜矛样品矿源分为普通铅和高放射性成因铅截然不同的两组。通过比较周边地区的铅矿石铅同位素数据,可知会理青铜矛不仅采用了当地的铅料,而且还使用了云南东北部会泽金沙厂一带的铅矿料。在战国至秦汉时期,云南东北部属于古夜郎青铜文化的控制区域。结合该分析结果与两地考古遗物的发现,可以推测会理青铜文化与夜郎青铜文化曾发生过紧密的交流与联系。

关键词：铜矛铅同位素比值铅料会理

Effect of specimen gauge reduction on uniaxial tension properties of reinforcing steel

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Journal of Iron and Steel Research International 2020年第8期27卷 964-971页

作者： A.Triwiyono A.L.Han A.Aryanto S.Tudjono b.S.gan Civil Engineering Department Gadjah Mada UniversitySleman 55283YogyakartaIndonesia Civil Engineering Department Diponegoro UniversityTembalang 50275SemarangIndonesia Civil Engineering Department Bandung Institute of TechnologyCoblong 40132BandungIndonesia Department of Architecture College of EngineeringNihon UniversityKoriyama 963-8642Fukushima PrefectureJapan

The Standard Test Methods for Tension Testing of Metallic Materials (ASTM E8) mandates a specimen gauge reduction for obtaining the tensile properties of reinforcing steel bars. The standard outlines the specimen preparation requirements and methods to ensure that test results well represent the material properties. On the other hand, some codes differ regarding the approach to specimen preparation. They do not apply gauging, for both deformed and plain steel bars. Thus, the effect of specimen gauge reduction on the tensile properties of reinforcing steel bars was evaluated, and the interconnection of properties to the layer hardness was analysed. The experiment governed a range of deformed hot-rolled bar sizes, tested in tension using precision instruments. The Rockwell hardness test was implemented layerwise on the specimen’s cross section, and the hardness number (HRC) was measured as a function of the layer distance to the centre. A finite element model was constructed to study the stress concentrations induced by a constant indentation, simulating the HRCs, and to numerically construct the stress–strain relationship of ungauged steel bars based on the core properties and the section HRC relationship. Scanning electron microscopy readings were performed to visually and chemically justify the results. It was shown that the specimen gauge reduction significantly influenced the resulting stress–strain behaviour of the material, and the yield and ultimate strengths were reduced. It was also demonstrated that the hardness response is proportional to the distance to the specimen’s axes. The corresponding yield and ultimate strengths thus increased accordingly, from the inner to the outer layers of the bar. Testing a gauged specimen will therefore result in lower strength than that of an ungauged steel bar.

关键词： Tensile property Specimen gauge reduction Rockwell hardness number Finite element model Reinforcing steel

Dynamic crossover in [VIO^(2+)][Tf_(2)N-]_(2) ionic liquid

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Chinese Physics b 2021年第1期30卷 374-379页

作者： gan Ren Departments of Physics&Key Laboratory of Photonic and Optical Detection in Civil Aviation Civil Aviation Flight University of ChinaGuanghan 618307China

Ionic liquids usually behave as fragile liquids,and the temperature dependence of their dynamic properties obeys supper-Arrhenius *** this work,a dynamic crossover is observed in([VIO^(2+)][Tf_(2)N-]_(2)) ionic liquid at the temperature of 240-800 *** diffusion coefficient does not obey a single Arrhenius law or a Vogel-Fulcher-Tammann(VFT) relation,but can be well fitted by three Arrhenius laws or a combination of a VFT relation and an Arrhenius *** origin of the dynamic crossover is analyzed from correlation,structure,and *** gets a stronger backward correlation at a lower temperature,as shown by the fractal dimension of the random *** temperature dependence function of fractal dimension,heterogeneity order parameter,and thermodynamic data can be separated into three regions similar to that observed in the diffusion *** two crossover temperatures observed in the three types of data are almost the same as that in diffusion coefficient fitted by three Arrhenius *** results indicate that the dynamic crossover of[VIO2+][Tf2 N-]2 is attributed to the heterogeneous structure when it undergoes cooling.

关键词： ionic liquids dynamic crossover heterogeneity order parameter fractal dimension fragile

基于改进多目标平衡优化器算法的点焊机器人路径规划

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机床与液压 2024年第5期52卷 8-14页

作者：赵云涛甘镭李维刚武汉科技大学冶金自动化与检测技术教育部工程研究中心湖北武汉430081

点焊机器人在工业领域内被广泛应用,合理的焊接顺序可以提高生产效率。为了实现点焊机器人的路径最优规划,针对点焊路径和工作时间建立多目标问题模型,提出一种融合改进快速非支配排序的多目标平衡优化器算法(DMONEO)。加入快速非支配排... 详细信息

点焊机器人在工业领域内被广泛应用,合理的焊接顺序可以提高生产效率。为了实现点焊机器人的路径最优规划,针对点焊路径和工作时间建立多目标问题模型,提出一种融合改进快速非支配排序的多目标平衡优化器算法(DMONEO)。加入快速非支配排序,并采用生存评分策略替代拥挤度因子,可以更好地保持种群的多样性,防止DMONEO过早收敛。TSPLIb基准实验结果表明,DMONEO算法相比于其他算法性能表现更好。最后在实际点焊机器人的路径规划应用中进行仿真实验并与其他算法对比,结果表明提出的算法得到的优化效果更好,耗时更短。

关键词：平衡优化器算法快速非支配排序多目标优化点焊机器人路径规划

The Chemistry of Fullerene-Mixed Peroxides

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Chinese Journal of Chemistry 2018年第11期36卷 991-994页

作者： Liangbing gan College of Chemistry and Molecular Engineering Peking University Bei- jing 200871 China

Peroxy radicals such as butOO· add to fullerenes efficiently to form isomerically pure multiadducts, for example, C60(OObut)6. The fullerene‐ mixed peroxides exhibit rich chemical reactivity. Further transformation of the peroxy groups has resulted in fullereneols, open‐cage fullerenes, aza‐ and oxafullerenes and/or fulleroids. Practical applications such as photoinitiator remain to be explored for these fullerene‐mixed peroxides. In this account, I highlight some of our progress toward the design/fabrication of nanostructured fullerene‐mixed peroxides, which have been shown to be good precursors for open‐cage, heterofullerenes and fullerenols. [AbSTRACT FROM AUTHOR]

关键词： aromaticity fullerene heterofullerene open‐cage peroxide radical

Proactive eviction of flow entry for SDN based on hidden Markov model

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Frontiers of Computer Science 2020年第4期14卷 107-116页

作者： gan HUANG Hee Yong YOUN College of Software Sungkyunkwan UniversitySuwon440746Korea

With the fast development of software defined network(SDN),numerous researches have been conducted for maximizing the performance of ***,flow tables are utilized in OpenFlows witch for *** to the space limitation of flow table and switch capacity,various issues exist in dealing with the *** existing schemes typically employ reactive approach such that the selection of evicted entries occurs when timeout or table miss *** this paper a proactive approach is proposed based on the prediction of the probability of matching of the *** eviction occurs proactively when the utilization of flow table exceeds a threshold,and the flow entry of the lowest matching probability is *** matching probability is estimated using hidden Markov model(HMM).Computersimulation reveals that it significantly enhances the prediction accuracy and decreases the number of table misses compared to the standard Hard timeout scheme and Flow master scheme.

关键词： SDN OpenFlow flow entry eviction HMM matching probability

适宜儿童主动游戏的幼儿园学习环境:要素与创设策略

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幼儿教育 2024年第21期 37-41页

作者：贾云甘子路江苏第二师范学院江苏南京211200 南京市溧水区小太阳幼儿园江苏南京211200

主动游戏是3一6岁儿童的首要学习方式。幼儿园学习环境的创设应当适宜这一学习方式。适宜儿童主动游戏的物质环境应包含尊重儿童的主体性、可选择的多样性、兼具灵活性的稳定性、规则性和挑战性五大要素。适宜儿童主动游戏的社会环境包... 详细信息

主动游戏是3一6岁儿童的首要学习方式。幼儿园学习环境的创设应当适宜这一学习方式。适宜儿童主动游戏的物质环境应包含尊重儿童的主体性、可选择的多样性、兼具灵活性的稳定性、规则性和挑战性五大要素。适宜儿童主动游戏的社会环境包含智慧的教师角色和良好的师幼关系。

关键词：学习方式学习环境主动游戏教师角色师幼关系

Novel DDS based OFDM Transmitter Structure without IFFT and Interpolation Filter

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China Communications 2021年第12期18卷 219-229页

作者： Sanjun Liu Guangming gan School of Information Engineering Hubei Minzu UniversityEnshi 445000China School of physics and electronic information engineering Hubei Engineering UniversityWuhan 432003China

The traditional orthogonal frequency divi-sion multiplexing(OFDM)transmitter is implemented by inverse fast Fourier transform(IFFT),up-sampling and low pass shaping filter(LPSF),which occupy a large number of hardware resources and have long *** further meet the 5G and future 6G commu-nication requirements,this paper proposes a novel di-rect digital synthesis(DDS)based OFDM transmitter structure that can replace these *** to the strong parallelism of the system structure,it is very suitable for implementation on field programable gate array(FPGA)*** making two special sim-plifications to the primary structure,the refined struc-ture becomes very simple compared with the tradi-tional *** attractively,the proposed struc-ture has the following three advantages that i)the data transformation from frequency domain to time domain has zero latency,ii)the transformation length does not need to be an integer power of 2 and iii)the struc-ture does not even need to use any multiplier,thus leading to low implementation complexity and high *** experiments are carried out on Intel FPGA platform which show that our DDS based structure can save more than half of the resources com-pared with the traditional structures and can provide the same bit error rate(bER)performance under the condition without using any LPSF.

关键词： OFDM transmitter direct digital synthe-sis(DDS) fast Fourier transform(FFT)