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Traditional uses,phytochemistry and pharmacology of Clerodendron glandulosum Coleb - a review

Asian Pacific Journal of Tropical Medicine 2012年第1期5卷 1-6页

作者： Ravirajsinh N Jadeja Menaka C Thounaojam Thouchom Brojendro Singh Ranjitsinh V Devkar av ramachandran Division of Phytotherapeutics and Metabolic Endocrinology Department of ZoologyFaculty of ScienceThe MS University of BarodaVadodara-390002GujaratIndia Department of Chemistry Oriental CollegeImphal-795001ManipurIndia

Present review for the first time provides a complete botanical description and information on ethnomcdicinal uses of Clerodendron ***(CG:***).Recent studies conducted from our laborator) provide pharmacological evidence for its anti-hypertensive,antidiabetic and anti-obesity ***,its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hcpatoprotective and free radical scavenging abilities along with its acute and sub- chronic toxicologiesl evaluations are also reported from our *** keeping with its traditional uses,CG extract was capable of ameliorating experimentally induced hypertension,diabetes and *** beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging ***—toxic nature of CG leaf extract further provides added merit to its reported pharmacological *** present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension,diabetes and obesity along with anti oxidant potential and beneficial elicits against non alcoholic steatohepatitis.

关键词： Clerodendron glandulosum.Coleb Hypertension Hyperlipidemia Insulin resistance Obesity Atherosclerosis

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“Burnt-Out” Endomyocardial Fibrosis—An Overview

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Case Reports in Clinical Medicine 2016年第11期5卷 437-493页

作者： ramachandran Muthiah Thoothukudi Medical College Hospital Thoothukudi India

Tropical endomyocardial fibrosis (EMF) is a public health problem affecting the children, young adults and elderly individuals in an epidemic fashion in the coastal districts of south India. Due to lack of resources for research in these endemic areas, its etiology remains elusive and hypotheses ranging from infections and allergic causes to malnutrition and toxins have not been tested rigorously. The disease is characterized by endocardial fibrosis and the right ventricle is the cardiac chamber most frequently affected. Patients may present clinically with heart failure and an associated av (atrioventricular) valve regurgitation is common. Several features of the advanced disease called as “burnt-out” stage of endomyocardial fibrosis (EMF) are not fully understood. Background of these case studies described the clinical presentation, echocardiographic features and management of this late stage of the disease.

关键词： Endomyocardial Fibrosis Burnt-Out Stage Pericardial Effusion Endocardial Calcification “Cobra-Head” Fibrosis

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Ebstein's Anomaly—An Overview

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Case Reports in Clinical Medicine 2018年第2期7卷 90-125页

作者： ramachandran Muthiah Thoothukudi Medical College Hospital Thoothukudi India

Aim: To present the various echocardiographic spectrum of Ebstein’s mal-formation in adolescence and adults. Introduction: Ebstein’s anomaly has different anatomic and hemodynamic variables with clinical manifestations of cyanosis, right-sided heart failure and arrhythmias. The leaflet tethering and dysplasia, together with dilatation of the tricuspid valve ring, constitute the anatomic cause of tricuspid regurgitation observed in this condition. Case Reports: The spectrum of leaflet tethering from mild to extreme with varying degrees of tricuspid regurgitation were documented by echocardiography in a 16-year-old cyanotic male with Ebstein’s anomaly associated with an atrial septal defect and mild low tricuspid regurgitation (TR), 22-year-old acyanotic male with right-sided heart failure due to severe tricuspid regurgitation and an intact atrial septum, 55-year-old asymptomatic female with moderate high tricuspid regurgitation. The extreme form was described as an “atretic” mem-brane in a 28-year-old cyanotic male and as a “blanket” of leaflet tissue in a 30-year-old cyanotic male. Conclusion: Ebstein’s anomaly has to be sus-pected clinically in presence of cyanosis with a WPW (Wolf-Parkinson-White) or atrioventricular (av) block pattern of ECG and its management is complex and must be individualized. RV (right ventricular) exclusion procedures are preferred in advanced cases.

关键词： “Sail-Like” Deformity “Atretic” Ebstein’s Anomaly Inverted Ebstein’s Anomaly Ebstein’s Mitral Valve Kay Annuloplasty

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Rheumatic “Taussig-Bing Heart”: A Case Report

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Case Reports in Clinical Medicine 2018年第1期7卷 7-36页

作者： ramachandran Muthiah Thoothukudi Medical College Hospital Thoothukudi India

Aim: To report a case of acyanotic Taussig-Bing heart, anatomically consistent with L-transposition and rheumatic Left av valve regurgitation associated with complete av block in an adolescent male. Introduction: Taussig-Bing heart is one of the conotruncal malformation, characterized by double-outlet right ventricle (DORV) and a subpulmonary VSD. Embryologically, abnormal cardiac looping with malalignment of conotruncal septum result its complexity and great artery relationships. Case Report: A 14-year old acyanotic boy presented with severe left-sided av valve regurgitation and bradycardia. ECG revealed left sided morphologic right ventricular hypertrophy (RVH) as evidenced by a loss of septal Q waves in left precordial leads suggesting ventricular inversion. X-ray chest revealed a straight upper right cardiac border due to loss of normal relationship of great vessels and cardiomegaly due to both left atrial and morphologic right ventricular enlargements suggesting a left-sided regurgitant lesion. Echocardiography revealed the ventricular inversion, primary origin of both L-transposed great arteries from the left-sided morphologic right ventricle suggesting a “double-outlet morphologic right ventricle” with “double discordance” and a subpulmonary VSD of Taussig-Bing type. The left-sided morphologic tricuspid valve is severely regurgitant due to rheumatic process resulting in heart failure which was improved with anti-failure measures and penicillin prophylaxis. Conclusion: The presence of left-sided regurgitation associated with bradycardia is a suspicion of “double discordance” and “double switch” procedure remains the mainstay of its surgical correction. Left av valve replacement with intraventricular repair is preferred in this child since the malformation is consistent with Taussing-Bing type of DORV with L-transposition.

关键词： Double-Outlet Right Ventricle Ventricular Inversion Subpulmonary VSD L-Transposition Left-Sided Ebstein’s Anomaly

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