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Generalized Baumslag-Solitar Graphs with Soluble Fundamental Groups

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Algebra Colloquium 2014年第1期21卷 53-58页

作者： Alberto L. Delgado Derek j.S. robinson Mathew Timm vDepartment of Mathematics illinois State University Normal IL 61790 USA Department of Mathematics University of Illinois at Urbana-Champaign Urbana IL 61801 USA Department of Mathematics Bradley University Peoria IL 61625 USA

It is shown that the generalized Baumslag-Solitar graphs which have soluble fundamental groups can be constructed from four simple types of graph by a process of decoration. The method of proof is elementary and emplo... 详细信息

关键词： generalized Baumslag-Solitar graph soluble fundamental group

A time for cocktails and inclusion

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Neural Regeneration Research 2018年第6期13卷 987-988页

作者： Shenandoah robinson Frances j.Northington Lauren L.jantzie Division of Pediatric Neurosurgery Johns Hopkins University School of Medicine Division of Neonatology Department of Pediatrics Johns Hopkins University School of Medicine Departments of Pediatrics and Neurosciences University of New Mexico School of Medicine

Perinatal brain injury（PBI）is one of the most important causes of lifelong deficits in cognition,behavior,social interaction and motor skills,as well as *** encompasses,but is not limited to,hypoxic-ischemic encepha... 详细信息

关键词： PBI www HIE EPO A time for cocktails and inclusion

Numerical modelling of structural controls on fluid flow and mineralization

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Geoscience Frontiers 2011年第3期2卷 449-461页

作者： j.robinson P.M.Schaubs CSIRO Earth Sciences and Resource Engineering PO Box 1130BentleyWA 6102Australia

This paper presents the results of a set of numerical models focussing on structural controls on hydrothermal mineralization. We first give an overview of natural phenomena of structurally-controlled ore formation and the background theory and mechanisms for such controls. We then provide the results of a group of simple 2D numerical models validated through comparison with Cu-vein structure observed near the Shilu Copper deposit （Yangchun, Guangdong Province, China） and finally a case study of 3D numerical modelling applied to the Hodgkinson Province in North Queensland （Australia）. Two modelling approaches, discrete deformation modelling and continuum coupled deformation and fluid flow modelling, are involved. The 2D model-derived patterns are remarkably consistent with the Cu-vein structure from the Shilu Copper deposit, and show that both modelling approaches can realistically simulate the mechanical behaviours of shear and dilatant fractures. The continuum coupled deformation and fluid flow model indicates that pattern of the Cu- veins near the Shilu deposit is the result of shear strain localization, development of dilation and fluid focussing into the dilatant fracture segments. The 3D case-study models （with deformation and fluid flow coupling） on the Hodgkinson Province generated a number of potential gold mineralization

关键词： Structural control Dilation Fluid flow Mineralization Numerical modelling Shilu Cu-deposit Hodgkinson Province

肼酞嗪对蛋白激酶A和蛋白激酶G的体外抑制作用(英文)

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中国药理学报 1995年第3期16卷 278-280页

作者：孙刚 PhilIip j robinson Now in Department of Neurobiology The Second Military Medical University Shanghai 200433 China Endocrine Unit John Hunter HospitalNewcastleNSW 2310 Australia

目的:研究血管扩张药肼酞嗪和KRN2391对蛋白激酶的直接作用以探讨其作用机制.方法:采用层析纯化的蛋白激酶进行体外活性测定.结果:肼酞嗪可以抑制PKA和PKG的活性(0.01-10 mmol·L^(-1)),其IC_(50)分别为1.2和2.5 mmol·L^(-1),而对PKC... 详细信息

目的:研究血管扩张药肼酞嗪和KRN2391对蛋白激酶的直接作用以探讨其作用机制.方法:采用层析纯化的蛋白激酶进行体外活性测定.结果:肼酞嗪可以抑制PKA和PKG的活性(0.01-10 mmol·L^(-1)),其IC_(50)分别为1.2和2.5 mmol·L^(-1),而对PKC作用很小.KRN2391(1—1000μmol·L^(-1))对PKA,PKG和PKC活性均无明显影响.结论:肼酞嗪对PKA和PKG的直接作用可能是其扩张血管的机制之一.

关键词：肼肽嗪蛋白激酶类体外抑制作用

Perturbations of the ileal mycobiota by necrotic enteritis in broiler chickens

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journal of Animal Science and Biotechnology 2022年第2期13卷 520-535页

作者： Qing Yang jing Liu Kelsy j.robinson Melanie A.Whitmore Sydney N.Stewart Guolong Zhang Department of Animal and Food Sciences Oklahoma State UniversityStillwaterOKUSA Poultry Production and Product Safety Research Unit USDA-Agricultural Research ServiceFayettevilleARUSA Safety and Security Division Institute for Public ResearchCNAArlingtonVAUSA

Background:Intestinal microbiota is critical for maintaining animal health and ***,involvement of the fungal community,also known as the mycobiota,in animal health and disease is poorly *** study was aimed to examine the association between the intestinal mycobiota and the severity of necrotic enteritis(NE),an economically significant poultry ***:A total of 90 day-of-hatch Cobb broilers were infected with Eimeria maxima on d 10,followed by an oral challenge with *** on d 14 to induce NE,while another 10 broilers were served as mock-infected *** d 17,the lesions in the jejunum were scored,and the ileal digesta were subjected to DNA isolation and real-time PCR quantification of total bacterial and fungi *** transcribed spacer 2(ITS2)amplicon sequencing was also performed to profile the ileal mycobiota *** in the ileal mycobiota in response to NE were *** correlation analysis was further conducted to identify the correlations between relative abundances of individual ileal fungi and the severity of ***:While the total bacterial population in the ileum was increased by 2-to 3-fold in NE chickens,the total fungal population was progressively declined in more exacerbated NE,with the most severely infected chickens showing a nearly 50-fold reduction relative to mock-infected *** of the ileal mycobiota also tended to reduce in chickens with NE(P=0.06).Compositionally,among 30 most abundant fungal amplicon sequence variants(ASVs),11 were diminished and 7 were enriched(P0.05).Multiple Wallemia and Aspergillus species were markedly diminished in NE(P<0.05)and also showed a significant negative correlation with NE severity(P<0.05).Conclusions:Dysbiosis of the ileal mycobiota is induced evidently by NE and the extent of the dysbiosis is positively correlated with disease ***

关键词： Antimicrobial resistance C.perfringens Dysbiosis ITS sequencing Microbiome Mycobiota Necrotic enteritis Poultry

Experimental Investigation of the Decay from A Ship’s Propeller

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China Ocean Engineering 2011年第2期25卷 265-284页

作者： W.Lam G.A.Hamill 宋永臣 D.j.robinson S.Raghunathan Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of Technology Queen's University Belfast

In the present study, an experimental investigation of the decay of the maximum velocity and its turbulent characteristics behind a ship propeller, in ＂bollard pull＂ condition （zero speed of advance）, is reported. Velocity measurements were performed in laboratory by use of a Laser Doppler Anemometry （LDA） measurement system. Earlier researchers described that the maximum axial velocity is constant at the initial stage of a ship＇s propeller jet （Fuehrer and Romisch, 1977; Blaauw and van de Kaa, 1978; Berger et al, 1981; Verhey, 1983） as reported in a pure water jet （Albertson et al., 1950; Lee et al., 2002; Dai, 2005）, but a number of researchers disagreed with the constant velocity assumption. The present study found that the maximum axial velocity decays in the zone of flow establishment and the zone of established flow with different rates. The investigation provides an insight into the decays of both the maximum velocity and the maximum turbulent fluctuation in axial, tangential and radial components and the decay of the maximum turbulent kinetic energy. Empirical equations are proposed to allow coastal engineers to estimate the jet characteristics from a ship＇s propeller.

关键词： ship's propeller jet Laser Doppler Anemometry (LDA) maximum velocity decay

Real-time four-dimensional scanning transmission electron microscopy through sparse sampling

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Chinese Physics B 2024年第11期33卷 34-38页

作者： A W robinson j Wells A Moshtaghpour D Nicholls C Huang A Velazco-Torrejon G Nicotra A I Kirkland N D Browning 无 SenseAI Innovations Ltd. LiverpoolUK Centre for Doctoral Training University of LiverpoolLiverpoolUK Correlative Imaging Group Rosalind Franklin InstituteOxfordUK CNR-IMM Z.I.VIII Strada 5Catania95121Italy Department of Mechanical Materialsand Aerospace EngineeringUniversity of LiverpoolLiverpoolUK

Four-dimensional scanning transmission electron microscopy(4-D STEM)is a state-of-the-art image acquisition mode used to reveal high and low mass elements at atomic *** acquisition of the electron momenta at each real space probe location allows for various analyses to be performed from a single dataset,including virtual imaging,electric field analysis,as well as analytical or iterative extraction of the object induced phase ***,the limiting factor in 4-D STEM is the speed of acquisition which is bottlenecked by the read-out speed of the camera,which must capture a convergent beam electron diffraction(CBED)pattern at each probe position in the *** developments in sparse sampling and image inpainting(a branch of compressive sensing)for STEM have allowed for real-time recovery of sparsely acquired data from fixed monolithic detectors,Further developments in compressive sensing for 4-D STEM have also demonstrated that acquisition speeds can be increased,i.e.,live video rate 4-D imaging is now *** this work,we demonstrate the first practical implementations of compressive 4-D STEM for real-time inference on two different scanning transmission electron microscopes.

关键词： compressive sensing 4-D STEM inpainting

Stem cells, immortality, and the evolution of metastatic properties in breast cancer: telomere maintenance mechanisms and metastatic evolution

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journal of Cancer Metastasis and Treatment 2019年第5期4卷 32-40页

作者： Nathaniel j.robinson Derek j.Taylor William P.Schiemann Department of Pathology Case Western Reserve University School of MedicineClevelandOH 44106USA Department of Pharmacology Case Western Reserve University School of MedicineClevelandOH 44106USA Case Comprehensive Cancer Center Case Western Reserve UniversityClevelandOH 44106USA

Breast cancer is the most significant cause of cancer-related death in women around the *** vast majority of breast cancer-associated mortality stems from metastasis,which remains an incurable disease *** results from evolution of clones that possess the insidious properties required for dissemination and colonization of distant *** clonal populations are descended from breast cancer stem cells(CSCs),which are also responsible for their prolonged maintenance and continued *** impose a lifespan on cells that can be extended when they are actively elongated,as occurs in ***,changes in telomere structure serve to promote the survival of CSCs and subsequent metastatic *** selection of telomere maintenance mechanism(TMM)has important consequences not only for CSC survival and evolution,but also for their coordination of various signaling pathways that choreograph the metastatic *** the telomere maintenance machinery may therefore provide a boon to the treatment of metastatic breast *** we review the two major TMMs and the roles they play in the development of stem and metastatic breast cancer *** also highlight current and future approaches to targeting these mechanisms in clinical settings to alleviate metastatic breast cancers.

关键词： Breast cancer cancer evolution cancer stem cells metastasis telomerase

The Importance of Evidence for the Integration of Traditional and Complementary Medicine into Western Healthcare?

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World journal of Traditional Chinese Medicine 2016年第1期2卷 74-79页

作者： Nicola robinson Allied Health Sciences School of Health & Social Care London South Bank University

Policy makers should consider improving access to treatments normally considered outside of healthcare in the west, particularly given the recent WHO strategy. However, research on integrating traditional and complementary medicines(T&CM) into conventional health care is lacking. T& CM approaches, may provide a cost effective option given the increase in chronic diseases with evidence of effectiveness of T& CM being key if such approaches are to be offered as part of integrative patient care, in most countries, an integrated healthcare approach is unavailable to patients. Evidence based clinical guidelines on T& CM should influence care provision. However evidence that is available may not even be cited. Poor use of evidence may possibly be a reflection of lack of knowledge and/or biases of guideline developers but additionally stakeholders vary in their perceived need for evidence to implement health policy change. journal editors should focus on publishing high quality manuscripts, with clear rationales, design and reporting frameworks. Researchers should consider carrying out careful feasibility studies prior to conducting trials taking into account the UK Medical Research Council's framework on complex interventions. Examples of feasibility studies highlighting their importance for trial design are given in this paper. If preparation for more definitive studies is conducted this will in turn improve the quality of research being designed, executed and published and subsequently encourage the inclusion of evidence by guideline developers. Robust evidence is necessary in order to inform governments' health policies providing appropriate T&CM interventions which can ultimately help to provide best patient care.

关键词： Integrated medicine traditional and complementary medicine clinical guidelines evidence based medicine Delphi Technique acupuncture