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Vibrioharveyi: a serious pathogen offish and invertebrates in mariculture

marine Life Science & technology 2020年第3期2卷 231-245页

作者： Xiao-Hua Zhang Xinxin He Brian austin mOE Key Laboratory of marine Genetics and Breeding College of Marine Lite Sciences.Ocean University of ChinaQingdao 266003China Laboratory for marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Frontiers Science Center for Deep Ocean multispheres and Earth System Ocean University of ChinaQingdao 266100China Institute of Aquaculture University of StirlingStirling FK94LAScotlandUK

Vibrio harveyi,which belongs to family Vibrionaceae of class G cunmap rote obacte ria,includes the species *** char iae and *** as its junior *** organism is a well-recognized and serious bacterial pathogen of marine fish and invertebrates,including penaeid shrimp,in *** fish may exhibit a range of lesions,including eye lesions/blindness,gastro-enteritis,muscle necrosis,skin ulcers,and tail rot *** shrimp,*** is regarded as the etiological agent of luminous vibriosis in which affected animals glow in the *** is a second condition of shrimp known as Bolitas negricans where the digestive tract is filled with spheres of sloughed-off *** is recognized that the pathogenicity mechanisms of *** may be different in fish and penaeid *** shrimp,the pathogenicity mechanisms involved the endotoxin lipopolysaccharide,and extracellular proteases,and interaction with *** fish,the pathogenicity mechanisms involved extracellular hemolysin(encoded by duplicate hemolysin genes),which was identified as a phospholipase B and could inactivate fish cells by apoptosis,via the caspase activation *** may enter the so-called viable but nonculturable(VBNC)state,and resuscitation of the VBNC cells may be an important reason for vibriosis outbreaks in *** control measures center on dietary supplements(including probiotics),nonspecific immunostimulants,and vaccines and to a lesser extent antibiotics and other antimicrobial compounds.

关键词： Vibrio harveyi Pathogen Fish Invertebrates Aquaculture

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Relative carcinogenicity of tacrolimus vs mycophenolate after solid organ transplantation and its implications for liver transplant care

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World Journal of Hepatology 2024年第4期16卷 650-660页

作者： Dorothy Liu mark m Youssef Josephine A Grace marie Sinclair Department of Gastroenterology Austin HealthMelbourne 3084VictoriaAustralia Victorian Liver transplant Unit Austin HealthMelbourne 3084VictoriaAustralia Department of medicine University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND De novo malignancy is a leading cause of late morbidity and mortality in liver transplant *** immunosuppression has been shown to contribute to post-transplant malignancy(Ptm)*** is emerging evidence on the differential carcinogenic risk profile of individual immunosuppressive drugs,independent of the net effect of *** inhibitors such as tacrolimus may prom.t. tumourigenesis,whereas mycophenolic acid(mPA),the active m.t.bolite of mycophenolate mofetil,may lim.t.tumour *** transplantation(Lt)is relatively unique among solid organ transplantation in that immunosuppression monotherapy with either tacrolimus or mPA is often achievable,which makes careful consideration of the risk-benefit profile of these immunosuppression agents particularly relevant for this ***,there is lim.t.d clinical data on this subject in both Lt and other solid organ transplant *** to investigate the relative carcinogenicity of tacrolimus and mPA in solid organ *** A literature search was conducted using mEDLINE and Embase databases using the key terms“solid organ transplantation”,“tacrolimus”,“mycophenolic acid”,and“carcinogenicity”,in order to identify relevant articles published in English between 1st January 2002 to 11th August *** terms,synonyms and explosion of meSH terms,Boolean operators and truncations were also utilised in the *** lists of retrieved articles were also reviewed to identify any additional *** duplicates,abstracts from 1230 records were screened by a single reviewer,whereby 31 records were reviewed in ***-text articles were assessed for eligibility based on pre-specified inclusion and exclusion *** A total of 6 studies were included in this *** studies were large population registries or cohort studies,which varied in transplant era,type of organ transplanted and immunosuppression protocol us

关键词： Immunosuppression Solid organ transplantation Liver transplantation Carcinogenicity tacrolimus mycophenolate

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Pleckstrin Homology-Like Domain, Family A, member 1 (PHLDA1): A multifaceted Cell Survival Factor that Drives m.t.bolic Disease

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Engineering 2023年第1期20卷 9-18页

作者： tamana Yousof Jae Hyun Byun Jack Chen Richard C.austin Department of medicine Division of NephrologyMcMaster UniversityThe Research Institute of St.Joe’s Hamilton and the Hamilton Centre for Kidney ResearchHamiltonOntarioL8N 4A6Canada

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular protein belonging to the evolutionarily conserved pleckstrin homology-related domain family. Its murine homologue, t-cell death-associated 51 (tDAG51) gene, was initially discovered for its role in activation-induced apoptosis in t-cell hybridomas. In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence also supports its role in endoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell proliferation. In this review, the current knowledge of PHLDA1 gene and protein regulation, localization, and function is summarized. this review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of m.t.bolic diseases.

关键词： ER-stress m.t.bolism Apoptosis Cell survival PHLDA1

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Effects of gamma-ray irradiation on electronic and non-electronic equipment of Large Helical Device

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Plasma Science and technology 2017年第2期19卷 95-100页

作者： K OGAWA t NISHItANI m ISOBE m SAtO m YOKOtA H HAYASHI t KOBUCHI t NISHImURA National Institute for Fusion Science National Institutes of Natural Sciences322-6 0roshi-choToki 509-5292Japan SOKENDAI(the Graduate University for Advanced Studies) School of Physical Sciences322-6 Oroshi-choTold 509-5292Japan

In a deuterium operation on the Large Helical Device, the measurement and control equipment placed in the toms hall must survive under an environment of radiation, to study the effects of gamma-ray irradiation on the equipment, an irradiation experiment is performed at the Cobalt-60 irradiation facility of Nagoya University. transient and permanent effects on a personal computer, media converters, programmable logic controllers, isolation amplifiers, a web camera, optical flow m.t.rs, and water sealing gaskets are experimentally surveyed. transient noise appears on the web camera. Offset of the signal increases with an increase of the integrated dose on the programmable logic controller. the DeviceNet module on the programmable logic controller is broken at the integrated dose of 72 Gy, which is the expected range of the integrated dose of the toms hall. the other equipment can survive under the gamma-ray field in the toms hall.

关键词： large helical device gamma-ray irradiation radiation effect

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Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： Cao, Zhen Aharonian, F. Axikegu Bai, Y.X. Bao, Y.W. Bastieri, D. Bi, X.J. Bi, Y.J. Bian, W. Bukevich, A.V. Cao, Q. Cao, W.Y. Cao, Zhe Chang, J. Chang, J.F. Chen, A.m. Chen, E.S. Chen, H.X. Chen, Liang Chen, Lin Chen, Long Chen, m.J. Chen, m.L. Chen, Q.H. Chen, S. Chen, S.H. Chen, S.Z. Chen, t.L. Chen, Y. Cheng, N. Cheng, Y.D. Cui, m.Y. Cui, S.W. Cui, X.H. Cui, Y.D. Dai, B.Z. Dai, H.L. Dai, Z.G. Danzengluobu Dong, X.Q. Duan, K.K. Fan, J.H. Fan, Y.Z. Fang, J. Fang, J.H. Fang, K. Feng, C.F. Feng, H. Feng, L. Feng, S.H. Feng, X.t. Feng, Y. Feng, Y.L. Gabici, S. Gao, B. Gao, C.D. Gao, Q. Gao, W. Gao, W.K. Ge, m.m. Geng, L.S. Giacinti, G. Gong, G.H. Gou, Q.B. Gu, m.H. Guo, F.L. Guo, X.L. Guo, Y.Q. Guo, Y.Y. Han, Y.A. Hasan, m. He, H.H. He, H.N. He, J.Y. He, Y. Hor, Y.K. Hou, B.W. Hou, C. Hou, X. Hu, H.B. Hu, Q. Hu, S.C. Huang, D.H. Huang, t.Q. Huang, W.J. Huang, X.t. Huang, X.Y. Huang, Y. Ji, X.L. Jia, H.Y. Jia, K. Jiang, K. Jiang, X.W. Jiang, Z.J. Jin, m. Kang, m.m. Karpikov, I. Kuleshov, D. Kurinov, K. Li, B.B. Li, C.m. Li, Cheng Li, Cong Li, D. Li, F. Li, H.B. Li, H.C. Li, Jian Li, Jie Li, K. Li, S.D. Li, W.L. Li, X.R. Li, Xin Li, Y.Z. Li, Zhe Li, Zhuo Liang, E.W. Liang, Y.F. Lin, S.J. Liu, B. Liu, C. Liu, D. Liu, D.B. Liu, H. Liu, H.D. Liu, J. Liu, J.L. Liu, m.Y. Liu, R.Y. Liu, S.m. Liu, W. Liu, Y. Liu, Y.N. Luo, Q. Luo, Y. Lv, H.K. ma, B.Q. ma, L.L. ma, X.H. mao, J.R. min, Z. m.t.humsiri, W. mu, H.J. Nan, Y.C. Neronov, A. Ou, L.J. Pattarakijwanich, P. Pei, Z.Y. Qi, J.C. Qi, m.Y. Qiao, B.Q. Qin, J.J. Raza, A. Ruffolo, D. Sáiz, A. Saeed, m. Semikoz, D. Shao, L. Shchegolev, O. Sheng, X.D. Shu, F.W. Song, H.C. Stenkin, Yu.V. Stepanov, V. Su, Y. Sun, D.X. Sun, Q.N. Sun, X.N. Sun, Z.B. takata, J. tam, P.H.t. Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China University of Chinese Academy of Sciences Beijing 100049 China tIANFU Cosmic Ray Research Center Chengdu China Dublin Institute for Advanced Studies 31 Fitzwilliam Place 2 Dublin Ireland max-Planck-Institut for Nuclear Physics P.O. Box 103980 Heidelberg 69029 Germany School of Physical Science and technology & School of Inform.t.on Science and technology Southwest Jiaotong University Chengdu 610031 China School of Astronomy and Space Science Nanjing University Nanjing 210023 China Center for Astrophysics Guangzhou University Guangzhou 510006 China tsung-Dao Lee Institute & School of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312 Russia Hebei Normal University Shijiazhuang 050024 China University of Science and technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark m.t.er and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 China Research Center for Astronomical Computing Zhejiang Laboratory Hangzhou 311121 China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China School of Physics and Astronomy Yunnan University Kunming 650091 China Key Laboratory of Cosmic Rays (tibet University) Ministry of Education Lhasa 850000 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100101 China School of Physics and Astronomy (Zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and technology (Zhuhai) Sun Yat-sen University Zhuhai 519000 & Guangzhou 510275 Guangdong China Institute of Frontier and

the γ-ray emission from.t.e W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays (CRs) accelerated by the shock of supernova remnant (SNR) W51C and the dense molecular clouds in the adjacent star-forming region, W51B. However, the maximum acceleration capability of W51C for CRs remains elusive. Based on observations conducted with the Large High Altitude Air Shower Observatory (LHAASO), we report a significant detection of γ rays emanating from.t.e W51 complex, with energies from 2 to 200 teV. the LHAASO measurements, for the first time, extend the γ-ray emission from.t.e W51 complex beyond 100 teV and reveal a significant spectrum bending at tens of teV. By combining the "π0-decay bump" featured data from Fermi-LAt, the broadband γ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision model. the observed spectral bending feature suggests an exponential cutoff at ∼400 teV or a power-law break at ∼200 teV in the CR proton spectrum, most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV regime. Additionally, two young star clusters within W51B could also be theoretically viable to produce the most energetic γ rays observed by LHAASO. Our findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs. © 2024 Science China Press

关键词： Cosmic rays

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Line of sight waypoint guidance for a container ship based on frequency domain identification of Nom.t. model of vessel

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Journal of Central South University 2016年第8期23卷 1944-1953页

作者： m.t.Ghorbani Instituto Superior tecnico Torre Norte-8.17 1049-001 Lisboa Portugal

CIFER software is used to identify steering and roll dynamics of a container ship. In this software, advanced features such as the Chirp-Z transform(CZt) and composite window optimization are applied to the time history of steering and roll dynamics to extract high quality frequency responses. From.t.e extracted frequency responses, two linear transfer functions of Nom.t. model are fitted for yaw and roll dynamics of the vessel. Based on the identified Nom.t. model, a PID heading controller and a Kalman filter observer are constructed. the simulation results of heading controller for line of sight(LOS) waypoint guidance show excellent tracking of pilot inputs in the presence of wave induced m.t.ons and forces.

关键词： container ship Nom.t. model Kalman filter frequency domain identification CIFER software

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Exploring trees Diversity and Ecological Value of mountain Forests in the Blue Nile Region of Sudan

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Open Journal of Ecology 2024年第3期14卷 245-256页

作者： Dafa-Alla m. Dafa-Alla Haytham H. Gibreel Ahmed A. H. Siddig Yousif E. Yagoub Hashim A. Abdelkarim Khatir H.t. Saeed Ahmed I. Abuelbashar Faculty of Forestry-Shambat University of Khartoum Khartoum Sudan Harvard Forest Harvard University Petersham MA USA Faculty of Forest Science and Wood technology University of Gezira Wad-Medani Sudan Department of Forestry and Range Sciences Faculty of Natural Resources and Environmental Studies Alsalam University Alfula Sudan Forest Research and Gum Arabic Centre Agricultural Research Corporation Khartoum-Soba Sudan

We carried out this research at Abu-Gaddaf Natural Forest Reserve (ANFR) which is located east of Blue Nile River, in Blue Nile State, Sudan. It aims at exploring tree composition assessing their diversity indices, and ecological importance values. For survey of types and estim.t.on of density of tree species in the forest, we randomly distributed 97 circular sample plots (0.1 hectare (ha)). In each sample plot we identified all trees to the species level, recorded their frequencies and computed species diversity and importance value indices (IVI). A total of 13 tree species, which belong to 12 genera and nine families, were identified in the tree layer of the forest. mean tree density in ANFR was 116 trees/ha, composed mainly of Boswellia papyrifera (Del.) Hochst. (48), followed by Combretum hartmannianu (19) and Lannea fruticosa (18). Fabaceae was the most common family followed by Combretaceae and malvaceae. B. papyrifera Delile Hochst was the most abundant while Acacia seyal was the least abundant species. Species richness (R = 1.71), evenness (E = 0.69), dominance (0.24) indices and Simpson’s Index of Diversity (D' = 0.76) suggest a moderate diversity, moderate numbers of individuals in each species and a moderate community stability. the research provides empirical results on diversity and ecological importance value of species, signifies the urging need to safeguard threatened species and to prioritize them for conservation, as well as the need to prom.t. management of abundant species to provide multiple forest ecosystem services.

关键词： tree Species Diversity Dry-Land Forest Sudan

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Synergistic fibroblast optimization: a novel nature-inspired computing algorithm

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Frontiers of Inform.t.on technology & Electronic Engineering 2018年第7期19卷 815-833页

作者： t t DHIVYAPRABHA P SUBASHINI m KRISHNAVENI Department of Computer Science Avinashilingam Institute for Home Science and Higher Education for Women

the evolutionary algorithm, a subset of computational intelligence techniques, is a generic population-based stochastic optimization algorithm which uses a mechanism m.t.vated by biological concepts. Bio-inspired computing can implement successful optimization m.t.ods and adaptation approaches, which are inspired by the natural evolution and collective behavior observed in species, respectively. Although all the m.t.-heuristic algorithms have different inspirational sources, their objective is to find the optimum(minimum or maximum), which is problem-specific. We propose and evaluate a novel synergistic fibroblast optimization(SFO) algorithm, which exhibits the behavior of a fibroblast cellular organism in the dermal wound-healing process. Various characteristics of benchmark suites are applied to validate the robustness, reliability, generalization, and comprehensibility of SFO in diverse and complex situations. the encouraging results suggest that the collaborative and self-adaptive behaviors of fibroblasts have intellectually found the optimum solution with several different features that can improve the effectiveness of optimization strategies for solving non-linear complicated problems.

关键词： Synergistic fibroblast optimization (SFO) Fitness analysis Convergence Benchmark suite monk's dataset

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the Impact of a Prior Norwood Procedure on Cardiac transplantation in Failed Fontan Physiology

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Congenital Heart Disease 2024年第3期19卷 257-266页

作者： Ryan G.mcQueen Nikki m.Singh Ronald K.Woods medical College of Wisconsin Herma Heart Institute at Children’s WisconsinMilwaukeeUSA Division of Pediatric Cardiology Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA Division of Pediatric Cardiothoracic Surgery Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA

Objective:the objective of this study was to compare cardiac transplant operative and postoperative courses of patients with failed Fontan physiology who were initially palliated with a Norwood(FFN)to those without a prior Norwood(FF).m.t.ods:A single-institution retrospective review of all patients with Fontan failure who under-went cardiac transplantation from 2003–2021 was completed-22 underwent prior Norwood(FFN)and 11 did not(FF).Descriptive and inferential statistics were calculated for operative course and patient ***:the operative course of the FFN cohort appeared to be more complex(not statistically significant,but clinically relevant)-this group exclusively experienced sternal re-entry events(3 of 22 patients)and concom.t.nt neo-aor-tic reconstruction(6 patients),had a longer duration of surgery(median of 682 min vs.575.5 min),more time on circulatory arrest(median of 25.5 min vs.12.5 min),and more frequent use of open sternal management[50%of patients(11/22)vs.27.3%of patients(3/11)].Postoperatively,these patients underwent more mediastinal explora-tions[other than sternal closure;40.9%of patients(9/22)vs.18.2%of patients(2/11)],spent more time on mechanical ventilation(median of 5 days vs.2 days),had a longer length of stay(median of 30 days vs.19 days),and required more catheter-based re-interventions[22.7%of patients(5/22)vs.9.1%of patients(1/11)].Conclu-sion:Although underpowered,our results suggest that the operative course of FFN patients is more challenging,based mostly on neo-aortic arch *** turn,this likely leads to a more complex postoperative *** are currently collaborating with other institutions to increase the cohort size and power of the study.

关键词： Fontan Fontan failure Norwood cardiac transplantation

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the dual role of microglia in ischemic stroke and its modulation via extracellular vesicles and stem cells

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Neuroprotection 2024年第1期2卷 4-15页

作者： m.t.eo Haupt Stefan t.Gerner thorsten R.Doeppner Department of Neurology University of Gottingen Medical SchoolGottingenGermany Department of Neurology University Hospital GiessenGiessenGermany Center for mind Brain and Behavior(CMBB)University of Marburg and Justus Liebig University GiessenMarburgGermany Department of Anatomy and Cell Biology Medical University of VarnaVarnaBulgaria medipol University Istanbul Research InstituteforHealthSciencesand Technologies(SABITA)IstanbulTurkey

Stem cell-based therapies and extracellular vesicle(EV)treatment have demonstrated significant potential for neuroprotection against ischemic *** the neuroprotective mechanisms are not yet fully under-stood,targeting microglia is central to prom.t.ng *** are the resident immune cells of the central nervous *** cells are crucial in the pathogenesis of ischemic *** respond rapidly to the site of injury by releasing pro-inflamm.t.ry cytokines,phagocytizing dead cells and debris,and recruiting peripheral immune cells to the ischemic *** these responses are essential for clearing damage and initiating tissue repair,excessive or prolonged microglial activation can exacerbate brain injury,leading to secondary neuroinflamm.t.on and ***,microglia exhibit a dynamic range of activation states with the so-called m1 pro-inflamm.t.ry and m2 anti-inflamm.t.ry phenotypes,representing the two ends of the *** delivery of both EVs and stem cells modulates microglial activation,suppressing pro-inflamm.t.ry genes,influencing the expression of transcription factors,and altering receptor expression,ultim.t.ly contributing to *** findings underscore the importance of understanding the complex and dynamic role of microglia in the development of effective neuroprotective strategies to reduce the effects of ischemic *** this review,we examine the current state of knowledge regarding the role of microglia in ischemic stroke,including their molecular and cellular mechanisms,activation states,and interactions with other *** also discuss the multifaceted contributions of microglia to stem cell-and EV-based neuroprotection during an ischemic stroke to provide a comprehensive understanding of microglial functions and their potential implications in stroke therapies.

关键词： extracellular vesicle microglia neuroprotection stroke stem cells

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