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Impact of conditioning regimen on peripheral blood hematopoietic cell transplant

World journal of Clinical Oncology 2019年第2期10卷 86-97页

作者： Michael Burns Anurag K Singh Carrie C Hoefer Yali Zhang Paul K Wallace George L Chen Alexis Platek Timothy B Winslow austin j iovoli Christopher Choi Maureen Ross Philip L McCarthy Theresa Hahn Department of Medicine Roswell Park Comprehensive Cancer Center Department of Radiation Medicine Roswell Park Comprehensive Cancer Center Department of Flow Cytometry Roswell Park Comprehensive Cancer Center Center for Immunotherapy Roswell Park Comprehensive Cancer Center

AIM To investigate infused hematopoietic cell doses and their interaction with conditioning regimen intensity +/-total body irradiation(TBI) on outcomes after peripheral blood hematopoietic cell transplant(PBHCT).METHODS Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT and treated between 2001 and2012. Correlations were calculated using the Pearson product-moment correlation coefficient. Overall survival and progression free survival curves were generated using the Kaplan-Meier method and compared using the log-rank *** Neutrophil engraftment was significantly faster after reduced intensity TBI based conditioning [reduced intensity conditioning(RIC) + TBI] and > 4 × 10~6 CD34+cells/kg infused. A higher total nucleated cell dose led to a higher incidence of grade II-IV acute graft-versus-host disease in the myeloablative + TBI regimen group(P = 0.03), but no significant difference in grade III-IV graft-versus-host disease. A higher total nucleated cell dose was also associated with increased incidence of moderate/severe chronic graft-versus-host disease, regardless ofconditioning regimen. Overall and progression-free survival were significantly better in patients with a RIC + TBI regimen and total nucleated cell dose > 8 ×10~8/kg(3 years, overall survival: 70% vs 38%, P = 0.02, 3 years, progression free survival: 64% vs 38%, P = 0.02).CONCLUSION TBI and conditioning intensity may alter the relationship between infused cell doses and outcomes after PBHCT. Immune cell subsets may predict improved survival after unmanipulated PBHCT.

关键词： Total body radiation Peripheral blood hematopoietic cell transplant Total nucleated dose Neutrophil engraftment Graft-versus-host-disease

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Ca^(2+) signalling in cardiovascular disease:the role of the plasma membrane calcium pumps

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Science China(Life Sciences) 2011年第8期54卷 691-698页

作者： Elizabeth j.CARTWRIGHT Delvac OCEANDY Clare austin Ludwig NEYSES Cardiovascular Medicine Research Group Manchester Academic Health Science CentreUniversity of Manchester

The plasma membrane calcium ATPases(PMCA) are a family of genes which extrude Ca2+from the cell and are involved in the maintenance of intracellular free calcium levels and/or with Ca2+signalling,depending on the cell *** the cardiovascular system,Ca2+ is not only essential for contraction and relaxation but also has a vital role as a second messenger in signal transduction pathways.A complex array of mechanisms regulate intracellular free calcium levels in the heart and vasculature and a failure in these systems to maintain normal Ca2+homeostasis has been linked to both heart failure and *** article focuses on the functions of PMCA,in particular isoform 4(PMCA4) ,in the heart and vasculature and the reported links between PMCAs and contractile function,cardiac hypertrophy,cardiac rhythm and sudden cardiac death,and blood pressure control and *** is becoming clear that this family of calcium extrusion pumps have essential roles in both cardiovascular health and disease.

关键词： plasma membrane calcium/calmodulin-dependent ATPase Ca2+ homeostasis Ca2+ signalling heart failure hypertension

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Spectral operator representations

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npj Computational Materials 2024年第1期10卷 269-280页

作者： austin Zadoks Antimo Marrazzo Nicola Marzari Theory and Simulation of Materials(THEOS) École Polytechnique Fédérale de LausanneCH-1015 LausanneSwitzerland Dipartimento di Fisica Universitàdi TriesteI-34151 TriesteItaly Scuola Internazionale Superiore di Studi Avanzati(SISSA) I-34136 TriesteItaly National Centre for Computational Design and Discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneCH-1015 LausanneSwitzerland Laboratory for Materials Simulations(LMS) Paul Scherrer InstitutCH-5232 VilligenSwitzerland

Machine learning in atomistic materials science has grown to become a powerful tool,with most approaches focusing on atomic geometry,typically decomposed into local atomic *** approach,while well-suited for machine-learned interatomic potentials,is conceptually at odds with learning complex intrinsic properties of materials,often driven by spectral properties commonly represented in reciprocal space(e.g.,band gaps ormobilities)which cannot be readily partitioned in real *** such applications,methods that represent the electronic rather than the atomic structure could bemore *** thiswork,we present a general framework focused on electronic-structure descriptors that take advantage of the natural symmetries and inherent interpretability of physical *** apply this framework first to material similarity and then to accelerated screening,where a model trained on 217materials correctly labels 75%of entries in theMaterialsCloud 3Ddatabase,which meet common screening criteria for promising transparent-conducting materials.

关键词： operator apply partitioned

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CO2 activation on bimetallic CuNi nanoparticles

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Progress in Natural Science:Materials International 2016年第5期26卷 487-492页

作者： Natalie austin Brandon Butina Giannis Mpourmpakis Department of Chemical Engineering University of Pittsburgh

Density functional theory calculations have been performed to investigate the structural, electronic, and CO2adsorption properties of 55-atom bimetallic Cu Ni nanoparticles（NPs） in core-shell and decorated architectures,as well as of their monometallic counterparts. Our results revealed that with respect to the monometallic Cu55and Ni55parents, the formation of decorated Cu12Ni43and core-shell Cu42Ni13are energetically favorable. We found that CO2chemisorbs on monometallic Ni55, core-shell Cu13Ni42, and decorated Cu12Ni43and Cu43Ni12,whereas, it physisorbs on monometallic Cu55and core-shell Cu42Ni13. The presence of surface Ni on the NPs is key in strongly adsorbing and activating the CO2molecule（linear to bent transition and elongation of C=O bonds）. This activation occurs through a charge transfer from the NPs to the CO2molecule, where the local metal d-orbital density localization on surface Ni plays a pivotal role. This work identifies insightful structureproperty relationships for CO2activation and highlights the importance of keeping a balance between NP stability and CO2adsorption behavior in designing catalytic bimetallic NPs that activate CO2.

关键词： Density functional theory Alloys CO2adsorption Catalysis Stability

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Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery

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Engineered Regeneration 2020年第1期1卷 35-50页

作者： Thomas Malachowski austin Hassel Department of Biomedical Engineering Stony Brook UniversityUnited States

Nanotechnology has recently gained traction in the medical field as a method of targeted delivery and timed release of therapeutic *** interest in this field grows,design considerations of the selected nanotechnology and extensive knowledge of the human immune system are necessary to design an effective system for drug *** and control of an immune response has become an achievable outcome to ensure efficient treatment of target tissues through careful selection of materials and immune *** review outlines the immune system,the challenges created by its inherent functions,biocompatible materials that are presently being used to construct nanoparticles,and molecules and techniques used to manipulate the immune response to nanoparticles.

关键词： Immunomanipulation Inflammation Nanoparticle cloaking Biodegradable materials Immune responses

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High surface area biocarbon monoliths for methane storage

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Green Energy & Environment 2023年第5期8卷 1308-1324页

作者： Elizabeth Michaelis Renfeng Nie Douglas austin Yanfeng Yue Department of Chemistry Delaware State UniversityDoverDE 19901United States College of Chemical Engineering Zhengzhou UniversityZhengzhouHenan450001China

New energy sources that reduce the volume of harmful gases such as SO_(x)and NO_(x)released into the atmosphere are in constant *** gas,primarily made up of methane,is being widely used as one reliable energy source for heating and electricity generation due to its high combustion ***,natural gas accounts for a large portion of electricity generation and chemical feedstock in manufacturing plastics and other commercially important organic *** the near future,natural gas will be widely used as a fuel for ***,a practical storage device for its storage and transportation is very beneficial to the deployment of natural gas as an energy source for new *** this tutorial review,biomaterials-based carbon monoliths(CMs),one kind of carbonaceous material,was reviewed as an adsorbent for natural gas(methane)adsorption and storage.

关键词： Activated carbon Carbon monolith Methane storage High surface area Activation agent

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A novel method to fabricate TiAl intermetallic alloy 3D parts using additive manufacturing

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Defence Technology（防务技术） 2017年第2期13卷 72-76页

作者： j.j.S. Dilip H. Miyanaji austin Lassell Thomas L. Starr Brent Stucker Rapid Prototyping Center Department of Industrial EngineeringUniversity of LouisvilleLouisvilleKY 40292USA Department of Chemical Engineering University of LouisvilleLouisvilleKY 40292USA 3DSIM 1794 Olympic ParkwaySuite 110Park CityUT 84098USA

The present work explores the feasibility of fabricating porous 3D parts in TiAl intermetallic alloy directly from Tie6Ale4V and Al powders. This approach uses a binder jetting additive manufacturing process followed by reactive sintering. The results demonstrate that the present approach is successful for realizing parts in TiAl intermetallic alloy.

关键词： Additive manufacturing Binder jetting Intermetallic Titanium aluminide Reactive sintering

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No evidence of predator odor avoidance in a North American bird community

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Avian Research 2024年第1期15卷 133-138页

作者： austin Dotta Batur Yaman Alex Van Huynh Department of Biology DeSales University2755 Station AvenueCenter ValleyPAUSA

Recent advances in our understanding of avian chemical communication have highlighted the importance of olfaction in many aspects of avian *** studies investigating predator avoidance behaviors in response to predator odor cues have produced mixed results across species and *** we assess if a community of birds in eastern Pennsylvania displays avoidance behaviors towards predator odor cues in a natural foraging *** use clay caterpillars to measure foraging activity by birds in the presence of predator(bobcat)urine,non-predator(rabbit)urine,and water controls in two different environmental contexts(field ***).Although we detected a weak trend for birds to forage less at predator urine-treated sites,we found no significant difference in avian foraging between the site *** did find that foraging rates between environmental contexts changed significantly over the course of the experiment,with forest sites showing decreasing foraging rates and field sites showing increasing foraging *** results reinforce the published literature that avoidance of predator odors by birds may not be ubiquitous across contexts and species.

关键词： Foraging Odor Olfaction Predation Predator-avoidance

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Identifying candidate hosts for quantum defects via data mining

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npj Computational Materials 2020年第1期6卷 595-600页

作者： austin M.Ferrenti Nathalie Pde Leon jeff D.Thompson Robert j.Cava Department of Chemistry Princeton UniversityPrincetonNJ 08544USA Department of Electrical Engineering Princeton UniversityPrincetonNJ 08544USA

Atom-like defects in solid-state hosts are promising candidates for the development of quantum information systems,but despite their importance,the host substrate/defect combinations currently under study have almost exclusively been found *** we systematically evaluate the suitability of host materials by applying a combined four-stage data mining and manual screening process to all entries in the Materials Project database,with literature-based experimental confirmation of band gap values.

关键词： quantum applying suitability

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Protein profiles of enzymatically isolated rumen epithelium in sheep fed a fibrous diet

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journal of Animal Science and Biotechnology 2019年第2期10卷 449-462页

作者： j.j.Bond A.j.Donaldson j.V.F.Coumans K.austin D.Ebert D.Wheeler V.H.Oddy NSW Department of Primary Industries Extensive Livestock Industry CentreUniversity of New EnglandTrevenna RdArmidaleNSW 2351Australia School of Rural Medicine University of New EnglandArmidaleNSW 2351Australia NSW Department of Primary Industries Orange Agricultural InstituteOrangeNSW 2800Australia.

Background: The rumen wall plays a major role in efficient transfer of digested nutrients in the rumen to peripheral tissues through the portal venous system. Some of these substrates are metabolised in the epithelium during this process. To identify the specific proteins involved in these processes, we used proteomic technologies. Protein extracts were prepared from ventral rumen tissue of six sheep fed a fibrous diet at 1.5× maintenance energy *** a newly developed method, we were able to enzymatically isolate the epithelial cells from underlying tissue layers, thus allowing cytosol and membrane fractions to be independently analysed using liquid chromatography tandem mass spectrometry(LC MS/MS).Results: Using our procedure we identified 570 epithelial proteins in the Ovis aries sequence database. Subcellular locations were largely cytosolic(n = 221) and extracellular(n = 85). However, a quarter of the proteins identified were assigned to the plasma membrane or organelle membranes, some of which transport nutrients and metabolites. Of these 91 were transmembrane proteins(TMHMM), 27 had an N-terminal signal peptide(signalP) and TMHMM motif,13 had a glycosylphosphatidylinositol(GPI) anchor and signalP sequence, 67 had beta(β) strands or 17 β strands and a transit peptide sequence, indicating the identified proteins were integral or peripheral membrane proteins. Subunits of the 5 protein complexes involved in mitochondrial cellular energy production were well represented. Structural proteins(15%), proteins involved in the metabolism of lipids and proteins(26%) and those with steroid or cytokine action were a feature of the ***: Our research has developed a procedure to isolate rumen epithelium proteins from the underlying tissue layers so that they may be profiled using proteomic technologies. The approach improves the number of proteins that can be profiled that are specific to the epithelium of the rumen wall. It provides new insights

关键词： Epithelium Metabolism Nutrition Proteome Rumen Sheep

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