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MICrOStrUCt.r. AND MECHANICAL BEHAVIOUr OF Al-Li-Zr AND Al-Li-Cu-Mg-Zr ALLOYS

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Acta Metallurgica Sinica(English Lett.r.) 1989年第2期2卷 130-136页

作者： K.t.aust G.C.WEAtHErLY University of t.r.nto TorontoONTCanada

the aging response,tensile and impact properties of two kinds of Al-Li based alloys have been *** microstruct.r.,deformation as well as fract.r. behaviour in the alloys were observed with SEM and *** was found that the mechanisms of deformation and fract.r. for different heat-treated alloys with the same chemical composition are quite *** causes leading to the drop of ductility,toughness as well as anisotropy in peak-aged alloys have been ***,possible methods to improve the ductility and toughness of the al- loys have been discussed.

关键词： Al-Li based alloy microstruct.r. mechanical properties

Value of histomorphometric tumour thickness and smoothelin for conventional m-classification in early oesophageal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2017年第11期9卷 444-451页

作者： Katharina Endhardt Bruno Markl Andreas Probst tina Schaller Daniela aust Institute of Pathology Klinikum Augsburg Department of Gastroent.r.logy Klinikum Augsburg Institute of Pathology Universitatsklinikum Dresden

AIM to test the validity of tumour thickness measurement in distinguishing between the different infiltration depths, especially when the duplication of muscularis mucosae cannot be demarcated clearly. MEtHODS We re-evaluated 100 completely embedded Barrett's adenocarcinomas regarding m-classification, maximum tumour thickness, and muscularis mucosae duplication. For validation, smoothelin staining was performed on a subset of cases. rESULtS the m1-, m2-and m3-classified adenocarcinomasshowed a significant lower tumour thickness compared to the m4-and sm1-classified lesions(P thelin staining det.r.ined a clear muscularis mucosae duplication in 64% of the tested samples and enabled the differentiation of the two layers in diffuse and merged splits. CONCLUSION tumour thickness in early oesophageal adenocarcinoma significantly correlates with the depth of infiltration and demonstrates its worth as an accurate p t classification in non-polypoid lesions. We created a new algorithm, which combines histomorphology with morphometric analyses. It is noteworthy that it facilitates the assessment of mucosal vs submucosal infiltration depth. the smoothelin staining strengthened our results of the tumour thickness evaluation and can be used in cases of doubt.

关键词： Smoothelin Endoscopic submucosal dissection Muscularis mucosae Barrett's carcinoma

Expression profiling of gastric cancer samples by oligonucleotide microarray analysis reveals low degree of intra-tumor variability

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World Journal of Gastroent.r.logy 2005年第38期11卷 5993-5996页

作者： Karolin trautmann Christine Steudel Dana Grossmann Daniela aust Gerhard Ehninger Stephan Miehike Christian thiede Medical Department Ⅰ Department of Pathology

AIM： Gene expression profiling provides an unique opportunity to gain insight into the development of different types of gastric cancer. tumor sample het.r.geneity is thought to decrease the sensitivity and tumor specificity of microarray analysis. thus, microdissection and preamplification of rNA is frequently performed. However, this technique may also induce considerable changes to the expression profile. to assess the effect of gastric tumor het.r.geneity on expression profiling results, we measured the variation in gene expression within the same gasbic cancer sample by performing a gene chip analysis with two rNA preparations extracted from the same tumor specimen. MEtHODS： tumor samples from six intestinal t2 gastric tumors were dissected under liquid nitrogen and rNA was prepared from two separate tumor fragments. Each extraction was individually processed and hybridized to an Affymetrix U133A gene chip covering approximately 18 000 human gene transcripts. Expression profiles were analyzed using Microarray Suite 5.0 （Affymetrix） and GeneSpring 6.0 （Silicon Genetics）. rESULtS： All gastric cancers showed little variance in expression profiles between different.r.gions of the same tumor sample. In this case, gene chips displayed mean pair wise correlation coefficients of 0.94±0.02 （mean±SD）, compared to values of 0.61±0.1 for different tumor samples. Expression of the variance between the two expression profiles as a percentage of “total change” （Affymetrix） revealed a remarkably low average value of 1.18±0.78 for comparing fragments of the same tumor sample. In contrast, comparison of fragments from different tumors revealed a percentage of 24.4±4.5. CONCLUSION： Our study indicates a low degree of expression profile variability within gastric tumor samples isolated from one patient. these data suggest that tumor tissue het.r.geneity is not a dominant source of error for microarray analysis of larger tumor samples, making total rNA extraction an appropria

关键词： Gastric cancer Microarray analysis tissue het.r.geneity

Music in depression: Neural correlates of emotional experience in remitted depression

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World Journal of Psychiatry 2013年第2期3卷 8-17页

作者： Sabine aust Karin Filip Stefan Koelsch Simone Grimm Malek Bajbouj Clust.r.of Excellence "Languages of Emotion" and Dahlem Institute for Neuroimaging of Emotion Freie Universitat Berlin Department of Psychiatry Charité University Medicine BerlinCampus Benjamin Franklin14150 BerlinGermany Department of Medicine Justus Liebig University Giessen

AIM: to investigate neural and behavioral correlates of emotional experiences as potential vulnerability markers in remitted depression. MEtHODS: Fourteen remitted participants with a hist.r. of major depression and fourteen closely matched healthy control participants took part in the study. We used two psychiatric int.r.iews(Hamilton Depression rating Scale, Montgomery-Asberg Depression rating Scale) and one self-report scale(Beck Depression Invent.r.) to assess remission. Healthy control participants were int.r.iewed by an experienced psychiatrist to exclude those who showed any current or lifetime psychiatric or neurological disorders. to explore psychosocialand cognitive-int.r.ersonal underpinnings of potential vulnerability markers of depression, early life stress, coping styles and alexithymia were also assessed. We induced pleasant and unpleasant emotional states using congruent combinations of music and human emotional faces to investigate neural and behavioral correlates of emotional experiences; neutral stimuli were used as a control condition. Brain responses were recorded using functional magnetic resonance imaging. Behavioral responses of pleasantness, arousal, joy and fear were measured via button-press inside the resonance imaging scanner. rESULtS: the mean age of the sample was 54.9(± 11.3) years. there were no differences between remitted depressed(rD)(n = 14; 9 females and 5 males) and healthy participants(n = 14; 8 females and 6 males) regarding age, current degree of depression, early life stress, coping styles and alexithymia. On a neural level, rD participants showed reduced activations in the pregenual ant.r.or cingulate cortex(pg ACC) in response to pleasant [paramet.r.estimates:-0.78 vs 0.32; t(26) =-3.41, P t [paramet.r.estimates:-0.88 vs 0.56; t(26)=-4.02, P tional stimuli. Linear regression analysis revealed that pg ACC activity was modulated by early life stress [β =-0.48; r2 = 0.23, F(1,27) = 7.83, P < 0

关键词： Mood disorders remission Emotion Ant.r.or cingulate cortex Early life stress Music Functional magnetic resonance imaging

Al-Li-Zr和Al-Li-Cu-Mg-Zr合金的显微组织和力学性能

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金属学报 1988年第5期 347-353页

作者：尹志民 K.t.aust G.C.WEAtHErLY 湖南长沙中南工业大学材料系 Univertsity of t.r.nto Canada Univertsity of t.r.nto Canada

研究了两种Al-Li基合金的时效硬化、拉伸和冲击等力学行为,用透射电镜和扫描电镜对合金的显微组织结构,变形和断裂的特征进行了分析。结果指出:同一成分、不同热处理态的合金变形和断裂的机制截然不同。分析了时效态合金韧性下降和产生... 详细信息

研究了两种Al-Li基合金的时效硬化、拉伸和冲击等力学行为,用透射电镜和扫描电镜对合金的显微组织结构,变形和断裂的特征进行了分析。结果指出:同一成分、不同热处理态的合金变形和断裂的机制截然不同。分析了时效态合金韧性下降和产生冲击各向异性的原因。讨论了改善Al-Li合金塑、韧性的可能途径。

关键词： Al-Li基合金显微组织力学性能

A NEUrAL NEtWOrK-BASED MODEL FOr PrEDICtION OF HOt.r.LLED austENItE GrAIN SIZE AND FLOW StrESS IN MICrOALLOY StEEL

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Acta Metallurgica Sinica(English Lett.r.) 2000年第2期13卷 521-530页

作者： J. t.Niu,L.J.Sun and P.Karjalainen 1) Harbin Institute of technology, Harbin 150001, China 2) University of Oulu, FIN-90571, Oulu, Finland

For the great significance of the prediction of control paramet.r. selected for hot.r.lling and the evaluation of hot.r.lling quality for the analysis of prod uction problems and production management, the selection of hot.r.lling control paramet.r. was studied for microalloy steel by following the neural network principle. An experimental scheme was first worked out for acquisition of sample data, in which a gleeble-1500 thermal simolat.r.was used to obtain rolling temperat.r., strain, stain rate, and stress-strain curves. And consequently the aust enite grain sizes was obtained t.r.ugh microscopic observation. the experimental data was then processed t.r.ugh regression. By using the training network of BP algorithm, the mapping relationship between the hotrooling control paramet.r. (rolling temperat.r., stain, and strain rate) and the microstruct.r.l paramete rs (austenite grain in size and flow stress) of microalloy steel was function appro ached for the establishment of a neural network-based model of the austeuite grain size and flow stress of microalloy steel. From the results of estimation made with the neural network based model, the hot.r.lling control paramet.r. can be effectively predicted.

关键词： microalloy steel controlled rolling austenite grain size flow stress neural network BP algorithm

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厚壁奥氏体焊缝超声波检测之探究(英文)

无损检测 2009年第11期31卷 837-841页

作者： Han t Y Khler B Schmitz V Zimmer A Langenberg K J 德国弗劳恩霍夫研究院无损检测研究所(分部) 德国弗劳恩霍夫研究院德国卡塞尔大学

由于奥氏体焊缝中材料性能的各向异性和微观组织结构的不同,奥氏体焊缝的超声波检测是非常困难的。超声波在奥氏体焊缝中会沿金属结晶方向发生偏转,并在焊缝边界上发生散射。过去十年来,人们开发了多种模拟各向异性材料中声波传播的仿... 详细信息

由于奥氏体焊缝中材料性能的各向异性和微观组织结构的不同,奥氏体焊缝的超声波检测是非常困难的。超声波在奥氏体焊缝中会沿金属结晶方向发生偏转,并在焊缝边界上发生散射。过去十年来,人们开发了多种模拟各向异性材料中声波传播的仿真工具。本文则以常规超声波检测方法为基础,将声线跟踪法和弹性动力学有限积分技术(EFIt)相结合,应用于含晶间应力腐蚀裂纹的厚壁奥氏体焊缝中,其结果显示声线跟踪法和弹性动力学有限积分技术(EFIt)结合应用,有助于超声波检测参数的选取。

关键词：奥氏体焊缝超声波检测弹性动力学有限积分技术仿真裂纹