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Pazopanib Induced Hand-Foot Syndrome in a Patient Previously Treated with Sunitinib: A Possible Cumulative Skin Toxicity?

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Pharmacology & Pharmacy 2016年第8期7卷 354-357页

作者： Emanuele Cozzani Sanja Javor Stefano Ottoboni aurora parodi Department of Endocrinological and Metabolic Sciences Section of Dermatology University of Genoa Genoa Italy Department of Chirurgic and Diagnostic Sciences (DISC) University of Genoa Genoa Italy

Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia, is a skin toxicity that could be observed during target therapies such as with tyrosine-kinase inhibitors (TKI). It usually develops within the first 2 - 4 weeks of drug administration. We present a case of HFS induced by Pazopanib after 2 months of treatment, in patients previously treated with Sunitinib, suggesting a possible cumulative toxicity of two drugs. The clinical and therapeutic management of skin adverse reactions during TKI therapy usually requires 25% dose reduction and adequate local treatment. It is important for the clinicians to recognize clinical signs and symptoms of such skin toxicities. Attention should be paid especially when two or more drugs from the same class are used in combined treatment.

关键词： Hand-Foot Syndrome Pazopanib Sunitinib Tyrosine-Kinase Inhibitors Cumulative Toxicity 1.

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Complete Kawasaki Disease in a 21-Year-Old Caucasian Patient

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Case Reports in Clinical Medicine 2015年第5期4卷 175-178页

作者： Francesco Drago Sanja Javor Giulia Ciccarese Emanuele Cozzani aurora parodi Department of Endocrinological and Metabolic Sciences Section of Dermatology University of Genoa Genoa Italy

Kawasaki disease is a rare condition in adults and it may remain unrecognized because many pa-tients do not fulfil all the diagnostic criteria for the diagnosis of “complete” Kawasaki disease. The authors report a case of 21-year-old male Caucasian patient complaining fever and presenting a diffuse maculopapular and erythema multiforme-like eruption, erythema and edema of the hands, feet and ears, non-exudative bilateral conjunctivitis, injected lips, strawberry tongue and symmetrical widespread lymphadenopathy. On the basis of clinical presentation, laboratory results and diagnostic criteria, a diagnosis of complete Kawasaki disease has been done. After treatment with systemic corticosteroids and aspirin (100 mg trice daily), the patient showed clinical improvement with typical large scale desquamation of the hands. The patient did not present any complication during one month follow-up. It is important to be familiar with the signs and symptoms of Kawasaki disease, because early diagnosis and adequate treatment is crucial for the prevention of cardiovascular morbidity and mortality.

关键词： Kawasaki Disease Adult Patient Classification

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