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Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells

World Journal of Gastroenterology 2014年第15期20卷 4189-4196页

作者： Muriel Mathonnet aurelie perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot Department of Digestive Surgery Limoges University Hospital87042 LimogesFrance Homéostasie Cellulaire at Pathologies Faculty of MedicineUniversity of Limoges87025 LimogesFrance Institut 145 GEIST UMR CNRS 7276Faculty of MedicineUniversity of Limoges87025 LimogesFrance

Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human *** major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative *** properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers *** treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant ***,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like *** cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor *** stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor ***-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC ***,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show *** article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their *** personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy.

关键词： Colon cancer Stem cell Cancer stem-like cell Tumor-initiating cell Microenvironment

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