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Missed opportunities for hepatitis C treatment at a tertiary care hospital in South Australia

World Journal of Hepatology 2022年第8期14卷 1576-1583页

作者： Sreecanth Sibhi Raja Suzanne edwards Jeffrey Stewart Dep Huynh Department of Gastroenterology The Queen Elizabeth HospitalWoodville 5011South AustraliaAustralia Department of Statistician School of Public HealthUniversity of AdelaideAdelaide 5000South AustraliaAustralia

BACKGROUND Hepatitis C is a global epidemic and an estimated 230000 Australians were living with chronic hepatitis C in *** effective public health policy and state commitment,Australia has utilised the advent of direct acting antiviral(DAA)therapy to transform the therapeutic landscape for hepatitis C virus(HCV).However,treatment rates are falling and novel public health approaches are required to maintain momentum for HCV *** discourse in cascades of care have focused on expanding testing capabilities but less attention has been given to linking previously diagnosed patients back to *** simple and focused study rests on the premise that hospital admissions are an excellent opportunity to identify and refer previously diagnosed patients for HCV *** To assess whether inpatients with HCV are appropriately referred on for *** We conducted a retrospective single centre cohort study that examined all patients with HCV presenting to The Queen Elizabeth Hospital(QEH)inpatient service between January 1 and December 31,*** is a tertiary care hospital in South *** main inclusion criteria were patients with active HCV infection who were eligible for DAA *** study cohort was identified using a comprehensive list of diagnosis based on international classification of diseases-10 AM codes for chronic viral *** were excluded from the analysis if they had previously received DAA therapy or spontaneously cleared *** presenting with decompensated liver cirrhosis or other systemic medical conditions conferring poor short-term prognosis were also excluded from the *** primary outcome of our study was referral of patients for HCV *** outcomes included assessment of factors predicting treatment *** There were 309 inpatients identified with hepatitis C as a principal or additional diagnosis between January 1 and December 31,*** these patients,

关键词： Hepatitis C Viral hepatitis Treatment cascade Hepatology Public health Missed opportunities

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Isolating type-specific phenologies through spectral unmixing of satellite time series

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International Journal of Digital Earth 2018年第3期11卷 233-245页

作者： Jyoteshwar R.Nagol Joseph O.Sexton Anupam Anand Ritvik Sahajpal Thomas C.edwards Global Land Cover Facility Department of Geographical SciencesUniversity of MarylandCollege ParkMDUSA USGS Utah Cooperative Fish and Wildlife Research Unit Department of Wildland ResourcesCollege of Natural ResourcesUtah State UniversityLoganUTUSA

Vegetation phenology is commonly studied using time series of multispectral vegetation indices derived from satellite *** in reflectance among land-cover and/or plant functional types are obscured by sub-pixel mixing,and so phenological analyses have typically sought to maximize the compositional purity of input satellite data by increasing spatial *** present an alternative method to mitigate this‘mixed-pixel problem’and extract the phenological behavior of individual land-cover types inferentially,by inverting the linear mixture model traditionally used for sub-pixel land-cover *** using genetic algorithms,the method takes advantage of the discriminating capacity of calibrated surface reflectance measurements in red,near infrared,and short-wave infrared wavelengths,as well as the Normalized Difference Vegetation Index(NDVI)and the Normalized Difference Water *** simulation,the unmixing procedure reproduced the reflectances and phenological signals of grass,crop,and deciduous forests with high fidelity(RMSE<0.007 NDVI);and in empirical tests,the algorithm extracted the phenological characteristics of evergreen trees and seasonal grasses in a semi-arid *** approach shows potential for a wide range of ecological applications,including detection of differential responses to climate,soil,or other factors among vegetation types.

关键词： Spectral unmixing landsurface phenology NDVI genetic algorithms

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Development of a surgical procedure for removal of a placentome from a pregnant ewe during gestation

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Journal of Animal Science and Biotechnology 2020年第4期11卷 986-992页

作者： Colleen A.Lambo Ashley K.edwards Fuller W.Bazer Kathrin Dunlap M.Carey Satterfield Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical Sciences Texas A&M UniversityCollege StationTX 77843USA Department of Animal Science Texas A&M University2471 TAMUCollege StationTX 77843USA.

Background: In recent decades, there has been a growing interest in the impact of insults during pregnancy on postnatal health and disease. It is known that changes in placental development can impact fetal growth and subsequent susceptibility to adult onset diseases;however, a method to collect sufficient placental tissues for both histological and gene expression analyses during gestation without compromising the pregnancy has not been described. The ewe is an established biomedical model for the study of fetal development. Due to its cotyledonary placental type, the sheep has potential for surgical removal of materno-fetal exchange tissues, i.e., placentomes. A novel surgical procedure was developed in well-fed control ewes to excise a single placentome at ***: A follow-up study was performed in a cohort of nutrient-restricted ewes to investigate rapid placental changes in response to undernutrition. The surgery averaged 19 min, and there were no viability differences between control and sham ewes. Nutrient restricted fetuses were smaller than controls(4.7 ± 0.1 kg vs. 5.6 ± 0.2 kg;P < 0.05), with greater dam weight loss(-32.4 ± 1.3 kg vs. 14.2 ± 2.2 kg;P < 0.01), and smaller placentomes at necropsy(5.7 ± 0.3 g vs. 7.2 ± 0.9 g;P < 0.05). Weight of sampled placentomes and placentome numbers did not ***: With this technique, gestational studies in the sheep model will provide insight into the onset and complexity of changes in gene expression in placentomes resulting from undernutrition(as described in our study),overnutrition, alcohol or substance abuse, and environmental or disease factors of relevance and concern regarding the reproductive health and developmental origins of health and disease in humans and in animals.

关键词： Developmental biology Fetal development IUGR Ovine/sheep Placenta Placental transport

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Demonstration of Covalent Sidewall Functionalization of Single Wall Carbon Nanotubes by NMR Spectroscopy:Side Chain Length Dependence on the Observation of the Sidewall sp^(3)Carbons

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Nano Research 2008年第1期1卷 72-88页

作者： Liling Zeng Lawrence B.Alemany Christopher L.edwards Andrew R.Barron Richard E.Smalley Institute for Nanoscale Science and Technology and Department of Chemistry Rice UniversityHoustonTX 77005USA

Carboxylic acid-functionalized single walled carbon nanotubes(SWNTs)prepared via the reaction of an amino acid,NH2(CH2)nCO2H where n=1(glycine,GLY),5(6-aminohexanoic acid,AHA),10(11-aminoundecanoic acid,AUDA),with fl uorinated single walled carbon nanotubes(F-SWNTs)have been characterized by MAS 13C NMR *** ease of observing the aliphatic CH2 groups and the resolution of the signal are dependent on the length of the amino acid’s aliphatic *** have proposed that where substituent chains are short(making NMR data collection difficult)chemical modification to extend the chain length should alleviate analysis *** this regard,we have investigated the esterifi cation of the carboxylic acid *** amino acid-functionalized SWNTs were esterified with an appropriate alcohol to ensure parity of the overall substituent length,i.e.,GLY-SWNT(C1)+1-dodecanol(C_(12))=DOD-GLY-SWNT(1),AHA-SWNT(C_(5))+1-octanol(C_(8))=OCT-AHA-SWNT(2),and AUDA-SWNT(C_(10))+1-propanol(C_(3))=PRO-AUDA-SWNT(3).The 13C NMR shift for the sp3 nitrogen-substituted carbon atoms of the SWNT sidewall is observed atδ≈75 *** the length of SWNT sidewall functional groups enhances the ability to observe the sidewall sp^(3)*** methylene carbon signal intensity is less attenuated in the dipolar dephasing spectrum of the ester-functionalized SWNTs than their associated amino acid derivatives,suggesting more motional freedom of the side chain in the solid *** confi rmation of the dipolar dephasing spectral effects was assisted by the characterization of the ester of AUDA-SWNT with 1,3-propanediol:PPD-AUDA-SWNT(4).

关键词： Single walled carbon nanotube(SWNT) nuclear magnetic resonance(NMR) esterification amino acid functionalization

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Does playing a sports active video game improve object control skills of children with autism spectrum disorder?

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Journal of Sport and Health Science 2017年第1期6卷 17-24,127页

作者： Jacqueline edwards Sarah Jeffrey Tamara May Nicole J.Rinehart Lisa M.Barnett School of Health and Social Development Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Department of Paediatrics Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneParkvilleVIC 3052Australia School of Psychology Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Murdoch Childrens Research Institute ParkvilleVIC 3052Australia

Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar *** was a secondary ***: Actual(Test of Gross Motor Development) and perceived OC skills(Pictorial Scale of Perceived Movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was ***: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities.

关键词： Autism spectrum disorder Child Exergaming Fundamental movement skills Physical self-perception Xbox

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Sources of matrix-bound phosphine in advanced wastewater treatment system

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Chinese Science Bulletin 2005年第12期50卷 1274-1276页

作者： DINGLili LIANGHanwen ZHUYixin MOWeiheng WANGQiang RENHongqiang WANGXiaorong M.edwards D.Glindemann StateKeyLaboratoryofPollutionControlandResourceReuse SchoolofEnvironmentNanjingUniversityNanjing210093China VirginiaPolytechnicInstituteandStateUniversity 418DurhamHall(0246)BlacksburgVA24061USA

Investigates different wastewater treatment stages from a full scale advanced wastewater treatment plant for the potential existence of matrix-bound phosphine. Variation of matrix-bound protein with the change of sampling season and location; Effect of hydrogen ion on phosphine production; Comparison of the concentrations of matrix-bound phosphine in aerobic sludge to anoxic sludge.

关键词：三氢化磷矩阵废水处理生物化学

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Long-term trend and abrupt events of the Holocene Asian monsoon inferred from a stalagmiteδ^(18)O record from Shennongjia in Central China

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Chinese Science Bulletin 2006年第2期51卷 221-228页

作者： SHAO Xiaohua WANG Yongjin CHENG Hai KONG Xinggong WU Jiangying edwards R. Lawrence College of Geography Science Nanjing Normal University Nanjing 210097 China Department of Geology and Geophysics Minnesota University MN 55455 USA

A high-resolution oxygen-isotope record from a thorium-uranium-dated stalagmite from Shanbao Cave at Shennongjia reflects variations in the amount of monsoon precipitation for the period from 11.5 to 2.1 ka (1 ka = 1000 cal aBP). Between 11.5 and 9.3 ka, a sharp decrease in δ18O indicates a rapid increase in monsoon precipitation. An interval of generally high monsoon precipitation is observed between 9.3 and 4.4 ka. An arid period has prevailed between 4.4 and 2.1 ka. The long-term trend of Shanbao record appears to follow summer insolation at 33°N latitude. An abrupt decrease in monsoon precipitation around 4.3 ka is synchronous with the collapse of Neolithic culture in central China. This abrupt change could have resulted from the amplifi- cation of the gradually decreased summer insolation by the positive vegetation-atmosphere-aerosol feed- back. The weakened Asian monsoon events were in concert with decreased Greenland temperature dur- ing the early Holocene, centered at 8.2, 8.6, 9.3, 10.2 and 11.0 ka. This correlation suggests that changes in low-latitude monsoon are connected with climate change in high-latitude polar region.

关键词：全新世亚洲季风长期趋势突发事件古气候氧同位素中国神龙架石笋

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Great flood in the middle-lower Yellow River reaches at 4000 a BP inferred from accurately-dated stalagmite records

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Science Bulletin 2018年第4期63卷 206-208页

作者： Liangcheng Tan Chuan-Chou Shen Yanjun Cai Hai Cheng R.Lawrence edwards State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Open Studio for Oceanic-Continental Climate and Environment Changes Qingdao National Laboratory for Marine Science and Technology Institute of Global Environmental Change Xi’an Jiaotong University High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC) Department of Geosciences Taiwan University Department of Earth Sciences University of Minnesota

Recently,Wu et al.[1]suggested an earthquake-induced landslide dam outburst flood on the eastern Tibetan Plateau at 1920BCE(3870 a BP,BP denotes year before 1950 CE)caused the Great Flood in the middle-lower Yellow River reaches,and resulted in the founding of Xia Dynasty at 3850 a *** age is$150–300younger than the previously estimated age of the Xia Dynasty[2].While the geological evidence of the outburst flood。

关键词：石笋记录活动范围大洪水 BP 黄河黄土高原 BCE 幻灯片

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Joint Contact Forces with Changes in Running Stride Length and Midsole Stiffness

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Journal of Science in Sport and Exercise 2020年第1期2卷 69-76页

作者： Joshua M.Thomas WBrent edwards Timothy R.Derrick Department of Health Wellnessand SportUniversity of DubuqueDubuqueIA 52001USA Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Kinesiology Iowa State University111L Forker BuildingAmesIA 50011USA

The purpose of this study was to determine if lower extremity joint loading was influenced by stride length or shoe midsole *** subjects completed 10 trials of overground running at an average speed of 4.43 m/s in each of three condi-tions:normal running,running with a stride length(SL)reduced by 10%of normal,and running with a cushioned midsole stiffness(i.e.,mechanical impact reduction of 13.7-10.9 g).Reaction forces calculated from inverse dynamics were summed with muscle forces estimated from a musculoskeletal model using static optimization to obtain joint contact forces at the hip,knee and ankle *** components of the contact forces[axial,anterior-posterior,and medial-lateral(ML)]were examined using parametric statistics(α=0.05).Reducing stride length resulted in significant decreases in absolute peak ankle contact forces in the axial direction(normal:-14.5±1.5 BW;reduced SL:-14.0±1.6 BW)and the ML direction(normal:0.67±0.23 BW;reduced SL:0.61±0.21 BW).Reducing stride length also reduced the peak absolute axial forces at the knee(normal:-10.6±1.3 BW;reduced SL:-9.8±1.2 BW)and the hip(normal:-7.26±2.24 BW;reduced SL:-6.75±2.10 BW).The cushioned shoe did not statistically reduce the peak absolute contact forces from the normal stride condition at any of the *** hoc stress analysis suggested that the observed changes in anterior hip force would increase stress more than any of the other statistically significant *** in stride length appear to decrease some joint contact variables but cushioning in the heel region of the shoe does not.

关键词： Gait Injury Compressive force Shear force Cushioning Strain

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Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang Hasini AKalpage Yongwei Su Holly edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

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