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First Asian record of Panthera(Leo)fossilis(Mammalia,Carnivora,Felidae)in the Early Pleistocene of Western Siberia,Russia

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Integrative Zoology 2014年第4期9卷 517-530页

作者： marina V.SOTNIKOVA Irina V.FORONOVA Geological Institute of Russian Academy of Sciences MoscowRussia V.S.Sobolev Institute of Geology and Mineralogy Siberian Branch of Russian Academy of SciencesNovosibirskRussia

A lion-like pantherine felid is described as Panthera(Leo)fossilis from the late Early Pleistocene sediments of the Kuznetsk Basin(Western Siberia,Russia).The find of *** first recorded in Asia considerably extends the current notion of the eastward expansion of the most ancient *** Siberian lion is geologically the oldest form and is dimensionally among the largest members of the group of fossil lions on the Eurasian conti*** known by mandibular remains only,it is readily distinguished from Panthera(Leo)spelaea by a heavy built mandibular corpus with rectangular profile in the cheek teeth area,a deep,well-outlined and narrow anterior section of the masseteric fossa,and a largeр4 supported by a big unreduced anterior *** Siberian lion shares these features with the European Middle Pleistocene *** and the American Late Pleistocene P.(Leo)atrox,which suggests their close *** originated from *** and was isolated in North America south of the Late Pleistocene ice *** explains why the American lion has retained more primitive features than the coeval Eurasian cave lion P.(L.)spelaea.

关键词： Early Pleistocene evolution Panthera fossilis relationships Western Siberia

Effect of yttrium on photosynthesis and water relations in young maize plants

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Journal of Rare Earths 2014年第4期32卷 371-378页

作者： Ivana Maksimovi Rudolf Kastori marina Putnik-Deli Milan Boriev Faculty of Agriculture University of Novi Sad Department of Biology and Ecology Faculty of SciencesUniversity of Novi Sad

Despite an increase in spectrum of industrial applications of yttrium （Y） and the fact that it is widely present in the soils and plants, some of which are agronomically important crops, its effects on plant growth and metabolism are still obscure. Therefore, the aim of this work was to examine the effect of different concentrations of Y on its accumulation and distribution, photosynthetic responses, water relations, free proline concentration and growth of young maize plants. The experiment was done with maize （Zea mays L., hybrid NS-640）, in water cultures, under semi-controlled conditions of a greenhouse. Plants were supplied with half-strength complete Hoagland nutrient solution, to which was added either 0 （control）, 10-5, 10-4 or 10-3 mol/L Y, in the form of Y（NO）3·5H2O. Each variant was set in thirteen replications, with six plants in each replication. Plants were grown for 21 d and they were at the stage of 3 and 4 leaves when they were analyzed. The presence of Y reduced maize growth and photosynthetic performance. Dimensions of stomata significantly decreased while their density significantly increased on both adaxial and abaxial epidermis. Plant height, root length, total leaf area and dry mass also declined. Concentration of photosynthetic pigments （chl a and b and carotenoids） and free proline decreased. Photosynthesis and transpiration were impaired in the presence of Y-their intensities were also reduced, and the same stands for stomatal conductance of water vapor, photosynthetic water use efficiency （WUE） and water content. Although the highest concentration of Y was found in maize roots in each treatment, Y concentration in the second leaf and shoot also significantly increased with an increase in Y concentration in the nutrient solution. Albeit Y concentration was much higher in roots than in shoots, shoot metabolism and growth were much more disrupted. The results demonstrated that young maize plants accumulated significant amount of Y and that th

关键词： yttrium maize photosynthesis water use efficiency rare earths

Selective sorptive removal of Methyl Red from individual and binary component solutions by mesoporous organosilicas of MCM-41 type

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Journal of Environmental Sciences 2021年第1期33卷 59-71页

作者： Nadiia V.Roik Lyudmila A.Belyakova marina O.Dziazko Chuiko Institute of Surface Chemistry of NAS of Ukraine 17 General Naumov Str.Kyiv 03164Ukraine

Organosilicas with chemically immobilized 3-aminopropyl and Methyl Red-containing surface groups were prepared by sol-gel condensation of tetraethyl orthosilicate and(3-aminopropyl)triethoxysilane in the presence of dye as part of the mixed micelles or dyecontaining silane as silica *** hexagonally arranged mesoporous structure of synthesized materials was confirmed by low-temperature nitrogen adsorption-desorption,xray diffraction,and TEM *** composition of MCM-41-type organosilicas was established by FT-IR spectroscopy and chemical analysis of surface *** of Methyl Red by organosilicas was studied from diluted phosphate buffer solutions in dependence of medium p H,duration of contact,and equilibrium concentration of *** was found that effective removal of Methyl Red takes place at p H values within a range of *** curves of Methyl Red sorption on organosilicas were analyzed by the Lagergren,Ho-McKey,and Weber-Morris kinetic *** was found that the pseudo-second-order model fits the kinetics of Methyl Red sorption on all synthesized materials and the intraparticle diffusion is not the only one mechanism controlling the rate of Methyl Red sorptive *** parameters of equilibrium sorption of Methyl Red on organosilicas of MCM-41 type were calculated using Langmuir,Freundlich,Redlich-Peterson,and Brunauer-Emmett-Teller *** of acid dyes with geometry similar or substantially different from Methyl Red on mesoporous silicas was studied from single and binary component mixtures in aqueous solutions with p H 4.8 and *** was found that selective sorption process is highly dependent on the structural characteristics and protolytic state of silica surface as well as acid dye.

关键词： MCM-41 Sol-gel synthesis Methyl Red Chemical modification Selective sorption

Primary malignant tumors of bone surface:a review with emphasis in differential diagnosis

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 632-646页

作者： marina Pacheco Alberto Righi Department of Pathology IRCCS Istituto Ortopedico RizzoliBologna 40136Italy

Surface tumors of the bone are broadly defined as a diverse group of osteogenic and chondrogenic benign and malignant neoplasms that arise adjacent to the outer surface of cortical *** may be a cause of diagnostic difficulty due to a degree of histological overlap,rarity,and *** this review we summarize the different histological types of primary malignant tumors of bone surface,namely,secondary peripheral chondrosarcoma,periosteal chondrosarcoma,parosteal osteosarcoma,dedifferentiated parosteal osteosarcoma,periosteal osteosarcoma,and high-grade surface *** provide a comprehensive updated review of their pathogenesis and highlight radiological,macroscopic,and histopathological features and recently available ancillary diagnostic tools that may aid in the differential diagnosis.

关键词： Secondary peripheral chondrosarcoma periosteal chondrosarcoma parosteal osteosarcoma periosteal osteosarcoma high-grade surface osteosarcoma

Helicobacter pylori in gastric cancer: Features of infection and their correlations with long-term results of treatment

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World Journal of Gastroenterology 2021年第37期27卷 6290-6305页

作者： marina A Senchukova Olesya Tomchuk Elena I Shurygina Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia Department of Histology CytologyEmbryologyOrenburg State Medical UniversityOrenburg 460000Russia Department of Pathology Orenburg State Medical UniversityOrenburg 460000Russia

BACKGROUND Helicobacter pylori(***)is a spiral-shaped bacterium responsible for the development of chronic gastritis,gastric ulcer,gastric cancer(GC),and MALTlymphoma of the *** can be present in the gastric mucosa(GM)in both spiral and coccoid ***,it is not known whether the severity of GM contamination by various vegetative forms of *** is associated with clinical and morphological characteristics and long-term results of GC *** To establish the features of *** infection in patients with GC and their correlations with clinical and morphological characteristics of diseases and long-term results of *** Of 109 patients with GC were included in a prospective cohort *** in the GM and tumor was determined by rapid urease test and by immunohistochemically using the antibody to *** results obtained were compared with the clinical and morphological characteristics and prognosis of *** analysis was performed using the Statistica 10.0 *** *** was detected in the adjacent to the tumor GM in 84.5%of cases,of which a high degree of contamination was noted in 50.4%of the *** forms of *** were detected in 93.4%of infected patients,and only coccoid-in 68.9%.It was found that a high degree of GM contamination by the coccoid forms of *** was observed significantly more often in diffuse type of GC(P=0.024),in poorly differentiated GC(P=0.011),in stage T3-4(P=0.04)and in N1(P=0.011).In cases of moderate and marked concentrations of *** in GM,a decrease in 10-year relapse free and overall survival from 55.6%to 26.3%was observed(P=0.02 and P=0.07,respectively).The relationship between the severity of the GM contamination by the spiral-shaped forms of *** and the clinical and morphological characteristics and prognosis of GC was not *** The data obtained indicates that *** may be associated not only with induction but also wit

关键词： Gastric cancer Helicobacter pylori Coccoid and spiral forms of bacteria Rapid urease test Relapse free survival Overall survival

Colon and rectal cancer:An emergent public health problem

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World Journal of Gastroenterology 2024年第7期30卷 644-651页

作者： marina Pinheiro David Nascimento Moreira Michele Ghidini LAQV REQUIMTEDepartment of ChemistryFaculty of PharmacyUniversity of Porto4050-313 PortoPortugal Unidade de Saúde Pública Unidade Local de Saúde Barcelos/EsposendeBarcelinhos 4755-069BragaPortugal Medical Oncology Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy

Colorectal cancer ranks third globally,with a high mortality *** the United States,and different countries in Europe,organized population screenings exist and include people between 50 and 74 years of *** screenings have allowed an early diagnosis and consequently an improvement in health *** and rectal cancer(CRC)is a disease of particular interest due to the high global burden associated with it and the role attributed to prevention and early diagnosis in reducing morbidity and *** study is a review of CRC pathology and includes the most recent scientific evidence regarding this pathology,as well as a diagnosis of the epidemiological situation of ***,the recommendation from a public health perspective will be discussed in detail taking into account the context and the most current recommendations.

关键词： Colon and rectal neoplasia Colon and rectal tumor Mortality Morbidity

Maneuvering Angle Rigid Formations With Global Convergence Guarantees

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IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1464-1475页

作者： Liangming Chen Zhiyun Lin Hector Garcia de marina Zhiyong Sun Mir Feroskhan School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Computer Architecture and Technology and also with CITICUniversity of Granada18014 GranadaSpain Department of Electrical Engineering Eindhoven University of Technology5600 MB Eindhoventhe Netherlands

Angle rigid multi-agent formations can simultaneously undergo translational,rotational,and scaling maneuvering,therefore combining the maneuvering capabilities of both distance and bearing rigid ***,maneuvering angle rigid formations in 2D or 3D with global convergence guarantees is shown to be a challenging problem in the existing literature even when relative position measurements are *** by angle-induced linear equations in 2D triangles and 3D tetrahedra,this paper aims to solve this challenging problem in both 2D and3D under a leader-follower *** the 2D case where the leaders have constant velocities,by using local relative position and velocity measurements,a formation maneuvering law is designed for the followers governed by double-integrator *** the leaders have time-varying velocities,a sliding mode formation maneuvering law is proposed by using the same *** the 3D case,to establish an angle-induced linear equation for each tetrahedron,we assume that all the followers'coordinate frames share a common Z ***,a formation maneuvering law is proposed for the followers to globally maneuver Z-weakly angle rigid formations in *** extension to Lagrangian agent dynamics and the construction of the desired rigid formations by using the minimum number of angle constraints are also *** examples are provided to validate the effectiveness of the proposed algorithms.

关键词： Index Terms—Angle rigid formations formation control formation maneuvering global convergence multi-agent systems

Observation of the hyperfine structure and anticrossings of hyperfine levels in the luminescence spectra of LiYF4:Ho3+

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Light(Science & Applications) 2022年第9期11卷 2155-2165页

作者： KIRILL N.BOLDYREV BORIS Z.MALKIN marina N.POPOVA Institute of Spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Kazan Federal University Kazan 420008Russia

Resolved hyperfine structure and narrow inhomogeneously broadened lines in the optical spectra of a rare-earth-doped crystal are favorable for the implementation of various ***,a well-resolved hyperfine structure in the photoluminescence spectra of LiYF4:Ho single crystals and the anticrossings of hyperfine levels in a magnetic field are demonstrated using a self-made setup based on a Bruker 125HR high-resolution Fourier *** is the first observation of the resolved hyperfine structure and anticrossing hyperfine levels in the luminescence spectra of a *** narrowest spectral linewidth is only 0.0022 *** fact together with a large value of the magnetic g factor of several crystal-field states creates prerequisites for developing magnetic field sensors,which can be in demand in modern quantum information technology devices operating at low *** small random lattice strains characterizing the quality of a crystal can be detected using anticrossing points.

关键词： spectra luminescence hyperfine

Resistance to energy metabolism-targeted therapy of AML cells residual in the bone marrow microenvironment

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Cancer Drug Resistance 2023年第1期6卷 138-150页

作者： Yoko Tabe marina Konopleva Department of Laboratory Medicine Juntendo UniversityTokyo 112-8421Japan Department of Medicine(Oncology)and Molecular Pharmacology Albert Einstein College of MedicineBronxNY 10461USA Department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

In response to the changing availability of nutrients and oxygen in the bone marrow microenvironment,acute myeloid leukemia(AML)cells continuously adjust their metabolic *** meet the biochemical demands of their increased proliferation,AML cells strongly depend on mitochondrial oxidative phosphorylation(OXPHOS).Recent data indicate that a subset of AML cells remains quiescent and survives through metabolic activation of fatty acid oxidation(FAO),which causes uncoupling of mitochondrial OXPHOS and facilitates *** targeting these metabolic vulnerabilities of AML cells,inhibitors of OXPHOS and FAO have been developed and investigated for their therapeutic *** experimental and clinical evidence has revealed that drug-resistant AML cells and leukemic stem cells rewire metabolic pathways through interaction with BM stromal cells,enabling them to acquire resistance against OXPHOS and FAO *** acquired resistance mechanisms compensate for the metabolic targeting by *** chemotherapy/targeted therapy regimens in combination with OXPHOS and FAO inhibitors are under development to target these compensatory pathways.

关键词： Bone marrow microenvironment acute myeloid leukemia mitochondria oxidative phosphorylation fatty acid oxidation energy metabolism