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effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2006年第36期12卷 5813-5819页

作者： e Louise Thomas audrey e brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson The Robert Steiner MR Unit MRC Clinical Sciences Centre Department of Nutrition and Dietetics The Robert Steiner MR Unit MRC Clinical Sciences Centre Faculty of Medicine Imperial College London Hammersmith Hospital Du Cane Rd London W12 0HS United Kingdom and Histopathology Department Faculty of Medicine Imperial College London St Mary's Hospital Praed Street London W2 1NY United Kingdom Faculty of Medicine Faculty of Medicine Imperial College London St Mary's Hospital Praed Street London W2 1NY United Kingdom

AIM： To assess the effectiveness of the current UK clinical practice in reducing hepatic fat （IHCL）.MeTHODS： Whole body MRI and IH MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease （NAFLD）.ReSULTS： A 500 Kcal-restricted diet resulted in an average weight loss of 4% （-3.4 kg,） accompanied by significant reductions in most adipose tissue （AT） depots, including subcutaneous （-9.9%）, abdominal subcutaneous （-10.2%） and intra-abdominal- AT （-11.4%）. Intramyocellular lipids （IMCL） were significantly reduced in the tibialis muscle （-28.2%）. Decreases in both IHCL （-39.9%） and soleus IMCL （-12.2%） content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests： serum aspartate aminotransferase （AST） and alanine aminotransferase （ALT）. Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION： This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LeTs.

关键词： Intra-abdominal adipose tissue Intrahepatic fat Intramyocellular lipids Weiqht loss Magnetic resonance imaging

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Newegg Is Taking Various Measures to Help Chinese Businesses Go Abroad Digitally—Interview with Anthony Chow,CeO of Newegg Commerce

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China's Foreign Trade 2024年第1期 35-38页

作者： audrey Guo 不详

The CeS 2024(International Consumer electronics Show)was held this January in Las Vegas,*** Commerce,Inc.,a global well-known e-commerce platform for science and technology companies,officially collaborated with TikTok to report at the CeS 2024 and introduced new representative products from high-quality Chinese tech brands to both on-site visitors and online followers via TikTok’s live streaming service,helping these tech products attract a lot of fans.

关键词： companies service streaming

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Acceptance and experience of HIV-Infected Adolescents in Two Hospitals in Yaoundé

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Open Journal of Pediatrics 2024年第2期14卷 435-443页

作者： Isabelle Mekone Nkwele Nelly Kamgaing Pierrette Amanda emah Manga Jeannette Épée Ngoué Hélène Kamo Sélangai Claude audrey Meguieze Nsoh Ndeh-Fofang Serge Tchoukoua Jean-Baptiste Fotso Djemo Paul Koki Ndombo Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Institut Supérieur des Sciences de la Santé de Bangangté Université des Montagnes Bangangté Cameroon Faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon

Introduction: Access to antiretroviral drugs has improved the survival of children infected with the Human Immunodeficiency Virus (HIV). As they reach adolescence, they are confronted with various constraints related to the infection and its treatment, in addition to those of the growth period they are going through. The main aim of the study was to assess the acceptance and describe the experience of HIV infection by infected adolescents but also to investigate the factors associated with good acceptance and a positive experience. Methodology: The cross-sectional analytic study concerned HIV-infected adolescents aged 15 to 19 followed up at the Chantal Biya Foundation-Mother and Child Centre (CMe-FCB) and the Yaoundé University Hospital Centre (CHUY) between February 2020 and June 2020. The study saw participants complete a questionnaire containing socio-demographic data and assessing acceptance and experience with the infection. Data analysis was accomplished using epi info software version 7.***.2.6. Results: One hundred and thirteen HIV-infected adolescents were included in the study. The sex ratio was 0.68 and the mean age was 17 years. More than half of the adolescents had a good acceptance and positive experience with the infection. Related factors were the adolescent’s perception of good health and participation in an association with other infected adolescents. Conclusion: emphasizing the psychological and educational follow-up of infected adolescents and encouraging their participation in associations for adolescents living with HIV could reduce the consequences of poor acceptance and ensure a better transition to adulthood. .

关键词： HIV Adolescent Acceptance experience

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Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer

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World Journal of Gastrointestinal Oncology 2016年第12期8卷 826-834页

作者： audrey H Calderwood Karen e Lasser Hemant K Roy Section of Gastroenterology Depart-ment of MedicineDartmouth-Hitchcock Medical Center Section of General Internal Medicine Depart-ment of MedicineBoston University School of Medicine Section of Gastroenterology Department of MedicineBoston University School of Medicine

AIMTo review the evidence on the association between specific colon adenoma features and the risk of future colonic neoplasia [adenomas and colorectal cancer (CRC)]. MeTHODSWe performed a literature search using the National Library of Medicine through PubMed from 1/1/2003 to 5/30/2015. Specific Medical Subject Headings terms (colon, colon polyps, adenomatous polyps, epidemiology, natural history, growth, cancer screening, colonoscopy, CRC) were used in conjunction with subject headings/key words (surveillance, adenoma surveillance, polypectomy surveillance, and serrated adenoma). We defined non-advanced adenomas as 1-2 adenomas each 25% villous histology or high-grade dysplasia. A combined endpoint of advanced neoplasia included advanced adenomas and invasive CRC. ReSULTSOur search strategy identified 592 candidate articles of which 8 met inclusion criteria and were relevant for assessment of histology (low grade vs high grade dysplasia, villous features) and adenoma size. Six of these studies met the accepted quality indicator threshold for overall adenoma detection rate > 25% among study patients. We found 254 articles of which 7 met inclusion criteria for the evaluation of multiple adenomas. Lastly, our search revealed 222 candidate articles of which 6 met inclusion criteria for evaluation of serrated polyps. Our review found that villous features, high grade dysplasia, larger adenoma size, and having ≥ 3 adenomas at baseline are associated with an increased risk of future colonic neoplasia in some but not all studies. Serrated polyps in the proximal colon are associated with an increased risk of future colonic neoplasia, comparable to having a baseline advanced adenoma. CONCLUSIONData on adenoma features and risk of future adenomas and CRC are compelling yet modest in absolute effect size. Future research should refine this risk stratification.

关键词： Colon adenoma Colorectal cancer screening Surveillance Colonoscopy

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Use of sub-micron sized resin particles for removal of endocrine disrupting compounds and pharmaceuticals from water and wastewater

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Journal of environmental Sciences 2017年第1期29卷 256-264页

作者： audrey Murray Banu rmeci edward P.C.Lai Department of Civil and environmental engineering Carleton University Department of Chemistry Carleton University

endocrine disrupting compounds（eDCs） and pharmaceuticals pose a challenge for water and wastewater treatment because they exist at very low concentrations in the presence of substances at much higher concentrations competing for adsorption ***-micron sized resin particles（approximately 300 nm in diameter）（SMR） were tested to evaluate their potential as a treatment for eDCs including：17-β estradiol（e2）,17-α ethinylestradiol（ee2）,estrone（e1）,bisphenol A（BPA）,and diethylstilbestrol（DeS） as well as 12 *** were able to remove 98%of spiked e2,80%of ee2,87%of BPA,and up to 97%of DeS from *** a 0.5 ppm mixture of e2,ee2,e1,BPA and DeS,the minimum removal was24%（e2） and the maximum was 49%（DeS）.They were also able to remove the pharmaceuticals from deionized water and ***,SMR are a promising advanced treatment for removal of both eDCs and pharmaceuticals.

关键词： Water treatment Wastewater treatment Pharmaceuticals endocrine disrupting compounds Micropollutants Adsorption

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Bioluminescent fungi from Peninsular Malaysia-a taxonomic and phylogenetic overview

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Fungal Diversity 2015年第1期70卷 149-187页

作者： audrey L.C.Chew Dennis e.Desjardin Yee-Shin Tan Md Yusoff Musa Vikineswary Sabaratnam Mushroom Research Centre University of Malaya50603 Kuala LumpurMalaysia Institute of Biological Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA

Fifteen bioluminescent fungi recently collected from Peninsular Malaysia are analysed *** phylogeny of the Malaysian bioluminescent fungi and closely related taxa were evaluated with molecular data from the nuclear ribosomal large subunit(LSU),RNA polymerase 2 second largest subunit(RPB2)and internal transcribed spacers(ITS)gene *** sequences data support the circumscription of species based on the morphological species concept,but was unable to fully support the current sectional delimitation of genus *** the 15 taxa analysed here,four are novel species described herein,*** gombakensis,***,*** and Panellus luxfilamentus;while four taxa of Mycena *** were recently described as *** species(***)represents a new distribution record to Peninsular Malaysia,and six species(Neonothopanus nambi,Filoboletus manipularis,***,Roridomyces pruinosoviscidus,*** and ***)have been previously *** pruinosoviscidus is accepted as a new combination based on morphological and phylogenetic *** morphology data indicate its potential for taxon delimitation as axenic cultures of each species produced unique and distinguishable *** descriptions,illustrations and photographs are provided on basidiome and culture morphology.A key to aid in species identification,comparisons with allied species and data on basidiome and mycelium luminescence are also *** study gives the first report on mycelial luminescence for ***,***,*** as well as all new species described *** reports in this study bring the total known luminescent fungi worldwide to 81 species.

关键词： Basidiomycete Biodiversity Culture morphology Filoboletus Mycena Neonothopanus Panellus Phylogeny Roridomyces Systematics Taxonomy

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Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium

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International Journal of Oral Science 2013年第2期5卷 75-84页

作者： audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen e Harris Department of Periodontics University of Texas Health Science Center at San Antonio Baylor College of Dentistry Texas A&M System University of Alabama School of Dentistry

Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey＇s fibers of the periodontal ligament （PDL）. However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 （Bmp2） in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-eGFP mouse model. Sp7-Cre-eGFP first becomes active at e18 in the first molar, with robust Cre activity at postnatal day 0 （PO）, followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2gene is removed from Sp7＋（Osterix＋） cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC （Nfic）, periostin and α-SMA＋ cells. Third, there is a failure to produce vascular endothelial growth factor A （VeGF-A） in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOsp7-cre＇eGFe. Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOsp7-cre＇eGFe. These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation.

关键词： Bmp2 gene cementum dentinogenesis periodontium development root formation

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Imputation of single-cell gene expression with an autoencoder neural network

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Quantitative Biology 2020年第1期8卷 78-94页

作者： Md.Bahadur Badsha Rui Li Boxiang Liu Yang ILi Min Xian Nicholas eBanovich audrey Qiuyan Fu Department of Statistical Science Institute for Bioinformatics and Evolutionary StudiesInstitute for Modeling Collaboration&InnovationUniversity of IdahoMoscowID 83844USA Department of Biology Stanford UniversityStanfordCA 94305USA Section of Genetic Medicine University of ChicagoChicagoIL 60637USA Department of Computer Science University of IdahoIdaho FallsID 83401USA The Translational Genomics Research Institute PhoenixAZ 85004USA

Background:Single-cell RNA-sequencing(scRNA-seq)is a rapidly evolving technology that enables measurement of gene expression levels at an unprecedented *** the explosive growth in the number of cells that can be assayed by a single experiment,scRNA-seq still has several limitations,including high rates of dropouts,which result in a large number of genes having zero read count in the scRNA-seq data,and complicate downstream ***:To overcome this problem,we treat zeros as missing values and develop nonparametric deep learning methods for ***,our LATe(Learning with AuToencoder)method trains an autoencoder with random initial values of the parameters,whereas our TRANSLATe(TRANSfer learning with LATe)method further allows for the use of a reference gene expression data set to provide LATe with an initial set of parameter ***:On both simulated and real data,LATe and TRANSLATe outperform existing scRNA-seq imputation methods,achieving lower mean squared error in most cases,recovering nonlinear gene-gene relationships,and better separating cell *** are also highly scalable and can efficiently process over 1 million cells in just a few hours on a ***:We demonstrate that our nonparametric approach to imputation based on autoencoders is powerful and highly efficient.

关键词： single-cell gene expression deep learning autoencoder

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FOCAC:A Typical Model for South-South Cooperation——An exclusive interview with *** Msimang,Ambassador of South Africa to China

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China's Foreign Trade 2018年第5期 25-26页

作者： audrey Guo

“Since the establishment of FOCAC in 2000, China-Africa cooperation has yielded fruitful results. It has become a successful example of South-South coop-eration and has attracted world *** Beijing Summit of the Forum on China-Africa Cooperation will further promote China-Africa relations and give the two sides the opportunity to discuss how to integrate Africa into the actual mechanism of the Belt and Road Initia-tive. Te Belt and Road Initiative focuses on China-Africa trade and economics. Te integration of the African continent into this initiative will accelerate China’s com-mitment to Africa,” commented Dorana Msiman, the South African Ambassador to China, in an exclusive interview with China’s Foreign Trade. She also emphasized that the summit will inject new and pow-erful impetus into China-Africa mutually benefcial cooperation and push the Chi-na-Africa comprehensive strategic partner-ship to a new level.

关键词：中国典型模型南非非洲合作南方道路集成

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Colon cancer stemness as a reversible epigenetic state:Implications for anticancer therapies

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World Journal of Stem Cells 2019年第11期11卷 920-936页

作者： audrey Vincent Aicha Ouelkdite-Oumouchal Mouloud Souidi Julie Leclerc Bernadette Neve Isabelle Van Seuningen Lille University Institut National de la Sante et de la Recherche MédicaleCHU LilleUMR-S 1172-Jean-Pierre Aubert Research CenterLille F-59000France Department of Biochemistry and Molecular Biology Lille University HospitalLille F-59000France

The recent discovery of cancer cell plasticity,*** ability to reprogram into cancer stem cells(CSCs)either naturally or under chemotherapy and/or radiotherapy,has changed,once again,the way we consider cancer *** cancer stemness is a reversible epigenetic state rather than a genetic identity,opportunities will arise for therapeutic strategies that remodel epigenetic landscapes of ***,the systematic use of DNA methyltransferase and histone deacetylase inhibitors,alone or in combination,in advanced solid tumors including colorectal cancers,regardless of their molecular subtypes,does not seem to be the best *** this review,we first summarize the knowledge researchers have gathered on the epigenetic signatures of CSCs with the difficulty of isolating rare populations of *** raise questions about the relevant use of currently available epigenetic inhibitors(epidrugs)while the expression of numerous cancer stem cell markers are often repressed by epigenetic *** markers include the three cluster of differentiation CD133,CD44 and CD166 that have been extensively used for the isolation of colon ***,we describe current treatment strategies using epidrugs,and we hypothesize that,using correlation tools comparing associations of relevant CSC markers with chromatin modifier expression,we could identify better candidates for epienzyme targeting.

关键词： Cancer stem cells Colon cancer epigenetics Chromatin modifying enzymes CD44 CD133 CD166

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