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αV integrin:A new gastrin target in human pancreatic cancer cells

World Journal of Gastroenterology 2011年第40期17卷 4488-4495页

作者： Celine Cayrol Claudine Bertrand Aline Kowalski-Chauvel Laurence Daulhac Elizabeth Cohen-Jonathan-Moyal audrey Ferrand Catherine Seva INSERM UMR1037-Cancer Research Center of Toulouse Paul Sabatier University Toulouse Ⅲ 31432 Toulouse cedex 4 France INSERM U766 Department of pharma-cology Clermont 1 University of Pharmacy 63001 Clermont-Ferrand France

AIM： To analyse αv integrin expression induced by gas- trin in pancreatic cancer ***： αv integrin mRNA expression in human pan- creatic cancer cells was analysed using a ＂cancer genes＂ array and confirmed by real-time reverse transcription- polymerase chain reaction （PCR）. Western blotting and semi-quantitative immunohistochemistry were used to examine protein levels in human pancreatic cancer cell lines and pancreatic tissues, respectively, The role of αv integrin on gastrin-induced cell adhesion was examined using blocking anti-αv integrin monoclonal antibodies. Adherent cells were quantified by staining with crystal ***： Using a ＂cancer genes＂ array we identi- fied c^v integrin as a new gastrin target gene in human pancreatic cancer cells. A quantitative real-time PCR approach was used to confirm αv integrin gene expression. We also demonstrate that Src family kinases and the PI 3-kinase, two signalling pathways specifically activated by the CCK-2 receptor （CCK2R）, are involved in gastrin-mediated αv integrin expression. In contrast, inhibition of the ERK pathway was without any effect on αv integrin expression induced by gastrin. Our results also show that gastrin modulates cell adhesion via αv integrins. Indeed, in vitro adhesion assays performed on fibronectin show that gastrin significantly increases adhesion of pancreatic cancer cells. The use of blocking anti-αv integrin monoclonal antibodies completely reversed the increase in cell-substrate adhesion induced by gastrin. In addition, we showed in vivo that the targeted CCK2R expression in the pancreas of Elas-CCK2 mice, leads to the overexpression of αv integrin. This process may contribute to pancreatic turnout development observed in these transgenic ***： αv integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion.

关键词： v integrin Cell adhesion CCK-2 receptor Gastrin Pancreatic cancer

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Determination of Cusp Number and Occlusal Groove Pattern in Mandibular Molars:A Preliminary Epidemiological Study in an Indian Population

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Journal of Forensic Science and Medicine 2016年第2期2卷 98-101页

作者： Urvashi Ashwin Shetty Pushparaja Shetty audrey Madonna D’Cruz Departments of Oral Pathology and Microbiology and 1Public Health Dentistry A.B.Shetty Memorial Institute of Dental ScienceNitte UniversityMangaloreKarnatakaIndia

Teeth are excellent material in living and nonliving populations for anthropological,genetic,odontologic,and forensic *** present study aims to study the number of a number of cusps in the first and second mandibular molar and to assess the frequency and expression of different types of occlusal groove *** cross‑sectional study is carried *** hundred patients attending the Outpatient Department of the hospital were recruited for the study based on exclusion and inclusion *** examination was done,and the morphological details of the crown(the number of cusps)were *** casts of the mandibular teeth were *** occlusal grooves were highlighted by using Indian ink and observed under the 2×magnification for the groove pattern(+or y type).Descriptive statistics were carried out for the *** the case of mandibular first molar,the 5 cusp form was the most frequent occlusal configuration(82%)followed by 6 cusp variety(12%)and 4 cusp variety(4%)*** predominant occlusal groove pattern seen in mandibular first molar was“y”shape(65%)followed by“+”pattern(28%).Hence,the most frequent occlusal surface configuration in case of first mandibular molar was“y5”*** the case of mandibular second molar,the 4 cusp form was the most frequent occlusal configuration(86%),followed by 5 cusp type(12%)*** predominant occlusal groove pattern seen in mandibular second molar was a“+”shape(85%)followed by“y”pattern(11%).Hence,the most frequent occlusal surface configuration in case of mandibular second molar was“+4”*** study of dental morphological characteristics is important in forensic and anthropological research as it can provide information on the phylogenetic relationship between species,as well as variation and diversities within a population.

关键词： Anthropology cusp dentistry forensic occlusal groove teeth

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INVISTA Launches Engineering Polymers Business in China

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China Chemical Reporter 2010年第9期21卷 7-7页

作者： audrey Rong

INVISTA launches an engineering polymersbusiness in China to meet growing industrialdemand for nylon 6,6 across a range ofapplications. The global leading chemicalintermediates, polymers and fibers manufacturersaid April 19th at ChinaPlas 2010in Shanghai, reflecting INVISTA’s commitmentto the Chinese market while supportingits objective of becoming a worldwideleader in the market development and productionof nylon 6,6 for engineeringpolymers.

关键词： nylon becoming reflecting bringing customers intro

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FOCAC:A Typical Model for South-South Cooperation——An exclusive interview with *** Msimang,Ambassador of South Africa to China

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China's Foreign Trade 2018年第5期 25-26页

作者： audrey Guo

“Since the establishment of FOCAC in 2000, China-Africa cooperation has yielded fruitful results. It has become a successful example of South-South coop-eration and has attracted world *** Beijing Summit of the Forum on China-Africa Cooperation will further promote China-Africa relations and give the two sides the opportunity to discuss how to integrate Africa into the actual mechanism of the Belt and Road Initia-tive. Te Belt and Road Initiative focuses on China-Africa trade and economics. Te integration of the African continent into this initiative will accelerate China’s com-mitment to Africa,” commented Dorana Msiman, the South African Ambassador to China, in an exclusive interview with China’s Foreign Trade. She also emphasized that the summit will inject new and pow-erful impetus into China-Africa mutually benefcial cooperation and push the Chi-na-Africa comprehensive strategic partner-ship to a new level.

关键词：中国典型模型南非非洲合作南方道路集成

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The failed invasion of Harmonia axyridis in the Azores, Portugal: Climatic restriction or wrong population origin?

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Insect Science 2021年第1期28卷 238-250页

作者： Alberto J.Alaniz Antonio OSoares Pablo M.Vergara Eduardo Brito de Azevedo audrey A.Grez Laboratorio de Ecologia de Ambientes Fragmentados Departamento de Ciencias Biologicas AnimatesFacultad de Ciencias VeterinariasPecuariasUniversidad de ChileChile Centro de Estudios en Ecologia Espacial y Medio Ambiente EcogeografiaSantiagoChile Departamento de Gestion Agra ria Facultad TecnologicaUniversidad de Santiago de ChileChile Center for Ecology Evolution and Environmental Changes and Azorean Biodiversity GroupFaculty of Sciences and TechnologyUniversity of the AzoresPonta DelgadaPortugal Center of Climate Departamento de Ciencias AgrariasMeteorology and Global Change of the University of the Azores(CCMMG-CITA-A)Universidade dos AzoresAngra do HeroismoPortugal

We tested two questions:(i)whether the climatic conditions of the Azorean Islands in Portugal may have restricted the invasion of Harmonia axyridis across this archipelago and(ii)determine what population of this species could have a higher probability of invading the *** used MaxEnt to project the climate requirements of different *** populations from three regions of the world,and the potential global niche of the species in the Azorean *** we assessed the suitability of the islands for each of the three *** populations and global potential niche through histograms analysis,Principal Component Analysis(PCA)of climate variables,and a variable-by-variable assessment of the suitability response curves compared with the climatic conditions of the *** conditions of the Azores are less suitable for the *** native Asian populations of ***,and more suitable for European populations and the global potential *** PCA showed that the climatic conditions of the islands differed from the climatic requirements of *** difference is mainly explained by precipitation of the wettest month,isothermality,and the minimum temperature of the coldest *** concluded that the climatic conditions of the Azores could have influenced the establishment and spread of *** on these islands from *** results showed that abiotic resistance represented by the climate of the potentially colonizable zones could hinder the establishment of invasive insects,but it could vary depending of the origin of the colonizing population.

关键词： climatic suitability Harlequin ladybird Invasibility invasive alien species Niche analysis Species Distribution Model

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Intelligence Plus Application Makes Data Protection More Important

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China's Foreign Trade 2019年第3期 38-39页

作者： audrey Guo 不详

During the China International Fair for Trade in Services at the end of May 2019,many people in the industry gathered at the'2019 China Intelligent Industry Forum'and discussed the future innovation and integration of China’s intelligence *** would become another grand event in the field of artificial intelligence(AI),and it strongly promoted the development of China’s industry of AI.

关键词： Intelligence Plus Application Makes Data Protection More Important

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Chinese Investment Emigration is Surging

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China's Foreign Trade 2014年第8期 24-25页

作者： audrey Guo

Education,pollution and food safety concerns are three main reasons for *** Angeles,San Francisco and Vancouver are top overseas real estate investments for Chinese.66%of those who have emigrated,or are applying or co... 详细信息

关键词： overseas Vancouver estate investments doing gettin

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China-Pakistan will Keep Strengthening the Bilateral Relationship

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China's Foreign Trade 2017年第4期 35-37页

作者： audrey Guo

2017 is the 66th anniversary of the establishment of diplomatic relations between China and *** then,China and Pakistan have established friendship and carried out all-round cooperation,as well as bringing tangible benefits to the two countries people and promoting regional peace,stability and *** the 2015 China President Xi Jinping’s visit to Pakistan,the two countries issued the joint statement between People’s Republic of

关键词：巴基斯坦中国中华人民共和国双边伙伴关系习近平伊斯兰

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Effective Integration Makes 1+1＞2

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China's Foreign Trade 2012年第5期 10-12页

作者： audrey Guo

On the sixth Chinese Enterprises Outbound Investment Conference,*** Guoqiang,Minister of the Department of Foreign Economic Research under the Development Research Center of the State Council,gave his opinions on the ... 详细信息

关键词：国务院发展研究中心整合对外投资经济全球化中国企业对外经济经济结构产业升级

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Accuracy between clinical and radiological diagnoses compared to surgical orbital biopsies

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 616-622页

作者： audrey Tang Helen Hoi-Lam Ng Taras Gout Bernard Chang Nabil El-Hindy George Kalantzis School of Medicine Faculty of Medicine and HealthUniversity of LeedsLeedsLS2.9 JTUnited Kingdom Department of Ophthalmology St.James’s University HospitalLeeds Teaching Hospitals NHS TrustBeckett StreetLeedsLS97TFUnited Kingdom

AIM:To assess the concordance between diagnosing orbital lesions by clinical examination,orbital imaging,and histological evaluation,in order to help guide future research and clinical ***:A retrospective analysis was undertaken at a large regional tertiary referral centre of all surgical orbital biopsies performed over a 5-year period,from 1st January 2015 until 31st December *** and concordance between clinical,radiological and histological diagnoses are reported as percentage sensitivity and positive predictive ***:A total of 128 operations involving 111 patients were ***,sensitivities of 47.7%for clinical and 37.3%for radiological diagnoses were found when compared to the histological gold *** lesions that have characteristic clinical and radiological features had the highest sensitivity at 71.4%and 57.1%,*** conditions showed the lowest sensitivity in both clinical(30.3%)and radiological(18.2%)*** PPV for inflammatory conditions were 47.6%for clinical and 30.0%for radiological ***:Accurate diagnoses are difficult to reach by relying on clinical examination and imaging *** orbital biopsy with histological diagnosis should remain the gold standard approach for definitively identifying orbital *** larger scale prospective studies would help further refine concordance and guide future research avenues.

关键词： orbital biopsy orbital lesion histological diagnosis radiological diagnosis clinical diagnosis

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