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Development of NK cell-based cancer immunotherapies through receptor engineering

Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： audrey Page Nicolas Chuvin Jenny Valladeau-Guilemond Stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer treatment.Early clinical trials have shown promising outcomes,alongside satisfactory product efficacy and safety.Recent developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic capacities.This review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future directions.Most approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen restriction.This approach has increased the precision and potency of NK-mediated recognition and elimination of cancer cells.In addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target peptides.Indirect tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and signaling.Indeed,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular cytotoxicity.The ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been explored.Receptor-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced immunosuppression.Overall,receptor engineering has led to significant advances in NK cell-based cancer immunotherapies.As technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

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Vonoprazan-amoxicillin dual regimen with Saccharomyces boulardii as a rescue therapy for Helicobacter pylori:Current perspectives and implications

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World Journal of Gastroenterology 2024年第10期30卷 1280-1286页

作者： Valerie Josephine Dirjayanto Jessica audrey Daniel Martin Simadibrata Faculty of Medicine Universitas IndonesiaJakarta Pusat 10430DKI JakartaIndonesia Division of Gastroenterology and Hepatology Mayo ClinicRochesterMinnesota 55905United States Nuffield Department of Population Health University of OxfordOxford OX37LFUnited Kingdom

Yu et al’s study in the World Journal of Gastroenterology(2023)introduced a novel regimen of Vonoprazan-amoxicillin dual therapy combined with Saccharomyces boulardii(S.boulardii)for the rescue therapy against Helicobacter pylori(H.pylori),a pathogen responsible for peptic ulcers and gastric cancer.Vonoprazan is a potassium-competitive acid blocker renowned for its rapid and long-lasting acid suppression,which is minimally affected by mealtime.Compared to proton pump inhibitors,which bind irreversibly to cysteine residues in the H+/K+-ATPase pump,Vonoprazan competes with the K+ions,prevents the ions from binding to the pump and blocks acid secretion.Concerns with increasing antibiotic resistance,effects on the gut microbiota,patient compliance,and side effects have led to the advent of a dual regimen for H.pylori.Previous studies suggested that S.boulardii plays a role in stabilizing the gut barrier which improves H.pylori eradication rate.With an acceptable safety profile,the dual-adjunct regimen was effective regardless of prior treatment failure and antibiotic resistance profile,thereby strengthening the applicability in clinical settings.Nonetheless,S.boulardii comes in various formulations and dosages,warranting further exploration into the optimal dosage for supplementation in rescue therapy.Additionally,larger,randomized,double-blinded controlled trials are warranted to confirm these promising results.

关键词： Vonoprazan Saccharomyces boulardii Helicobacter pylori Rescue therapy Eradication rate

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Massive abdominal muscle atrophy during prolonged mechanical ventilation: Implications for tracheostomy removal

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Journal of Intensive Medicine 2024年第1期4卷 133-135页

作者： Pascal Beuret Florian Michelin audrey Tientcheu Laurane Chalvet Benedicte Philippon-Jouve Jean-Charles Chakarian Xavier Fabre Service de Réanimation et Soins continus Centre Hospitalier de RoanneRoanneFrance

Introduction Maintaining the functional integrity of respiratory muscles is crucial for critically ill patients to be weaned from mechanical ventilation and decannulated if tracheotomized.Dysfunction of the diaphragm is frequent in patients under mechanical ventilation and has been associated with a longer duration of weaning.[1,2]Studies on expiratory muscles are scarce.Two recent studies demonstrated the feasibility and reproducibility of ultrasound in measuring the thickness of abdominal muscles,[3,4]with one study showing abdominal muscle atrophy in 22%of mechanically ventilated critically ill patients during the first week of mechanical ventilation.[4]

关键词： critically mechanical abdominal

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Newegg Is Taking Various Measures to Help Chinese Businesses Go Abroad Digitally—Interview with Anthony Chow,CEO of Newegg Commerce

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China's Foreign Trade 2024年第1期 35-38页

作者： audrey Guo 不详

The CES 2024(International Consumer Electronics Show)was held this January in Las Vegas,USA.Newegg Commerce,Inc.,a global well-known e-commerce platform for science and technology companies,officially collaborated with TikTok to report at the CES 2024 and introduced new representative products from high-quality Chinese tech brands to both on-site visitors and online followers via TikTok’s live streaming service,helping these tech products attract a lot of fans.

关键词： companies service streaming

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The Inbound Tourism Market Has Accelerated Recovery

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China's Foreign Trade 2024年第1期 22-24页

作者： audrey Guo 不详

This year,with the approach of the Spring Festival,the inbound tourism market also ushered in a recovery.According to Ctrip data,as of mid-January 2024,the booking volume of outbound air tickets during the Spring Festival travel rush in 2024 increased by 460%compared with that in the Spring Festival travel rush in 2023,and the booking volume of inbound air tickets in the Spring Festival travel rush in 2024 increased by 819%compared with that in the Spring Festival travel rush in 2023.

关键词： Spring Recovery travel

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Global variation in skin injures and skincare practices in extremely preterm infants

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World Journal of Pediatrics 2023年第2期19卷 139-157页

作者： Pranav Jani Umesh Mishra Julia Buchmayer Rajesh Maheshwari Daphne D’Çruz Karen Walker Duygu Gözen Krista Lowe audrey wright James Marceau Mihaela Culcer Archana Priyadarshi Adrienne Kirby James EMoore Ju Lee Oei Vibhuti Shah Umesh Vaidya Abdelmoneim Khashana Sunit Godambe Fook Choe Cheah Wen-Hao Zhou Xiao-Jing Hu Muneerah Satardien Faculty of Medicine and Health The University of SydneySydneyNSWAustralia Department of Neonatology Westmead HospitalWestmeadNSW2145Australia Comprehensive Center for Pediatrics Department of Pediatrics and Adolescent MedicineDivision of NeonatologyPediatric Intensive Care and NeuropediatricsMedical University of ViennaViennaAustria Department of Newborn Care Royal Prince Alfred HospitalCamperdownNSWAustralia Council of International Neonatal Nurses BostonMAUSA The George Institute for Global Health SydneyNSWAustralia Sydney Institute for Women Children and Their FamiliesSydneyNSWAustralia Pediatric Nursing Department Florence Nightingale Faculty of Nursingİstanbul University-CerrahpaşaIstanbulTurkey The National Health and Medical Research Council Clinical Trials Centre University of SydneySydneyNSWAustralia Connecticut Children’s Division of Neonatal-Perinatal Medicine Connecticut Children’s Medical CenterHartfordCTUSA UCONN School of Medicine FarmingtonCTUSA The Royal Hospital for Women RandwickNSWAustralia School of Women’s and Children’s Health University of New South WalesRandwickNSWAustralia Department of Paediatrics and Institute of Health Policy Management and EvaluationMount Sinai HospitalTorontoCanada Department of Pediatrics King Edward Memorial HospitalPuneIndia Pediatrics Suez Canal UniversityIsmailiaEgypt Divisional Director for Clinical Governance Women’sChildren’s and Clinical SupportImperial College Healthcare NHS TrustLondonUK Department of Pediatrics Faculty of MedicineUniversiti KebangsaanBangiMalaysia Hospital Canselor Tuanku Muhriz Jalan Yaacob LatifBandar Tun RazakKuala LumpurMalaysia Department of Neonatology and Vice President Children’s Hospital of Fudan UniversityShanghaiChina Vice Director of Nursing Department Children’s Hospital of Fudan UniversityShanghaiChina Department of Paediatrics and Child Health Tygerberg HospitalCape TownSouth Africa University of Stellenbosch Cape TownSouth Africa

Background Globally,are skincare practices and skin injuries in extremely preterm infants comparable?This study describes skin injuries,variation in skincare practices and investigates any association between them.Methods A web-based survey was conducted between February 2019 and August 2021.Quantifying skin injuries and describing skincare practices in extremely preterm infants were the main outcomes.The association between skin injuries and skincare practices was established using binary multivariable logistic regression adjusted for regions.Results Responses from 848 neonatal intensive care units,representing all geographic regions and income status groups were received.Diaper dermatitis(331/840,39%)and medical adhesive-related skin injuries(319/838,38%)were the most common injuries.Following a local skincare guideline reduced skin injuries[medical adhesive-related injuries:adjusted odds ratios(aOR)=0.63,95%confidence interval(CI)=0.45–0.88;perineal injuries:aOR=0.66,95%CI=0.45–0.96;local skin infections:OR=0.41,95%CI=0.26–0.65;chemical burns:OR=0.46,95%CI=0.26–0.83;thermal burns:OR=0.51,95%CI=0.27–0.96].Performing skin assessments at least every four hours reduced skin injuries(abrasion:aOR=0.48,95%CI=0.33–0.67;pressure:aOR=0.51,95%CI=0.34–0.78;diaper dermatitis:aOR=0.71,95%CI=0.51–0.99;perineal:aOR=0.52,95%CI=0.36–0.75).Regional and resource settings-based variations in skin injuries and skincare practices were observed.Conclusions Skin injuries were common in extremely preterm infants.Consistency in practice and improved surveillance appears to reduce the occurrence of these injuries.Better evidence regarding optimal practices is needed to reduce skin injuries and minimize practice variations.

关键词： Extremely premature infants Injuries Neonatal intensive care unit Skin care Wounds

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Evaluation of Procedural Pain in Neonates in Cameroon

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Open Journal of Pediatrics 2024年第3期14卷 568-578页

作者： Claude-audrey Meguieze Rose Bidias Etouckey Georges Eric Nseme Koki Ndombo Paul Olivier Pediatrics Department Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Morphologic Sciences Department Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon

Introduction: Acute pain associated with caregiving is a major cause of pain among neonates. Left untreated, it can lead to long-term neurosensory and psychoaffective consequences. In Cameroon, this subject has been scarcely explored, thus constituting an impediment to the management of care-induced pain. Objective: Assess procedural pain in neonates in Yaoundé. Material and Methods: We conducted a cross sectional study with prospective data collection over a period of eight months (October 2022 to May 2023) in three hospitals. We included neonates who were being cared for and were not crying prior to the onset of healthcare, whose parents consented to the study. Assessments were done using the DAN scale, which is specific to care-induced pain. Data was entered and analyzed using SPSS 23.0 software. Results: A total of 161 newborns were included. The hospital prevalence of care-induced pain in neonates was 85%. Neonatal sepsis was the main cause for admission (96.6%). The most common procedures were venous blood sampling (94.4%) and insertion of peripheral venous lines (93.8%). The pain intensity for these procedures was severe (83.9%). The most painful procedure was lumbar tap, followed by venous access procedures. Conclusion: Neonates in hospitals are subjected to many painful procedures. The pain experienced during these procedures is severe. The most nociceptive procedure is a lumbar puncture.

关键词： Assessment Procedural Pain Neonate Yaoundé Cameroon

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Early Quality Life Impairment in Alzheimer Disease’s Patients in Geriatric Department: About 214 Cases in Pitié Salpêtrière Hospital of Paris (France)

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Open Journal of Internal Medicine 2024年第1期14卷 30-42页

作者： Andia Abdoulkader audrey Rouet Benedicte Dieudonné Jacque Boaddert Charlotte Tomeo Sandrine Greffard Marc Verny Department of Geriatric of Pitie Salpetrière Hospital 47-83 Boulevard de l’H&ocircpital Paris France

Alzheimer’s disease (AD) is the most common neurodegenerative disease causing an alteration of life quality in the terminal stage. The purpose was to report 14 years of experience about the early impact on the quality of life of patients with AD. Methodology: Descriptive retrospective study over 14 years in the geriatric department of Pitié Salpêtrière Hospital, using the activity of daily living, Instrumental activity of daily living, neuropsychological inventory and Hoen Yahr scale evaluated at the time of diagnosis of AD according to the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer Disease’s and Related Disorders Association diagnostic criteria. Results: A total of 214 exploitable files had been listed. At the moment of diagnosis, the mean age was 82.1 years with extremes 68 to 95 with sex ratio 1.6 in women’s favor. The mean socio-cultural level was 4.9 with extremes about 0 to 7. There was poly pathology with a mean Cumulative Illness Rate Scale = 4.6 with extremes 0 to 16. the mean cognitive status was moderate = 22.5 with extremes 0 to 30. Quality life showed moderate impairment of IADL = 9.2 with extreme 3 to 11 compared to activity of daily living. The activity of daily living was more affected in 68 - 80-year-olds, while poly pathology impacted more on IADL in men. The cognitive impairment was more deficient in IADL when the MMSE test was low. The common disorders at the NPI were psychological, behavioral and psychotic. Conclusion: At the early diagnosis of Alzheimer’s Disease cognitive deficiencies were predominant and influenced on global Instrumental activity and psychological, behavioral disorders.

关键词： Alzheimer’s Disease IADL ADL NPI Paris France

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Actors of Psychoactive Drug Initiation among Adolescents in Yaoundé-Cameroon

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Open Journal of Pediatrics 2024年第2期14卷 246-254页

作者： Claude-audrey Meguieze Atabe Ngwene Neri Ngole Georges Eric Nseme Etouckey Paul Olivier Koki Ndombo Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Morphologic Sciences Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Introduction: Actors of psychoactive drug initiation refer to those who introduce others to psychoactive drug use (initiators) and those who are introduced to psychoactive drugs (users). By identifying their features, better prevention and intervention programs can be developed to reduce psychoactive drug use among adolescents. This article describes the role of actors of psychoactive drug initiation among teenagers in secondary schools in Yaoundé (Cameroon). Methodology: A cross sectional study was carried out in twelve secondary schools in Yaoundé from October 2022 to May 2023. Adolescents from Form four to upper sixth, who assented to participate in the study and received parental consent were included. Data were collected in a structured self-reported questionnaire and analyzed using SPSS 23. Quantitative variables were expressed using means, standard deviations, median and interquartile ranges depending on the distribution of data. Qualitative variables were expressed in the form of frequency and percentages. Results: Drug use was more prevalent among male adolescents (55.3%) from nuclear families (91.4%) who received relatively high pocket money. The main sources of drug exposure were non-family members (49.7%), especially friends outside school. The most frequent place of initiation was snack bars (33.1%). Conclusion: The study revealed the importance of the family, friends and leisure places in the initiation process of drug use in teenagers. Based on these results, parents and school authorities should work together to create a safe and supportive environment that fosters communication, education to prevent drug abuse among adolescents in Yaoundé.

关键词： Initiators Drug Users Adolescents Cameroon

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小老鼠、红草莓和大饿熊

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阅读 2024年第44期 14-19页

作者： Don audrey Wood

绘本导读：欢乐的“六一”儿童节，你打算和伙伴们一起做点什么呢？不如跟着绘本来玩一场有意思的游戏吧！你看，有一只小老鼠，他一大早就跑去摘了一颗熟透了的红草莓，辛苦地扛回了家。可是，竟然有个声音一直对他说：有一只饥饿的大...

绘本导读：欢乐的“六一”儿童节，你打算和伙伴们一起做点什么呢？不如跟着绘本来玩一场有意思的游戏吧！你看，有一只小老鼠，他一大早就跑去摘了一颗熟透了的红草莓，辛苦地扛回了家。可是，竟然有个声音一直对他说：有一只饥饿的大坏熊，离得老远就能闻到草莓的香气，正准备冲过来抢走红草莓呢！于是，一场关于红草莓的“保卫战”开始了……

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