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Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer

World Journal of Gastrointestinal Oncology 2016年第12期8卷 826-834页

作者： audrey H Calderwood Karen E Lasser Hemant K Roy Section of Gastroenterology Depart-ment of MedicineDartmouth-Hitchcock Medical Center Section of General Internal Medicine Depart-ment of MedicineBoston University School of Medicine Section of Gastroenterology Department of MedicineBoston University School of Medicine

AIMTo review the evidence on the association between specific colon adenoma features and the risk of future colonic neoplasia [adenomas and colorectal cancer (CRC)]. METHODSWe performed a literature search using the National Library of Medicine through PubMed from 1/1/2003 to 5/30/2015. Specific Medical Subject Headings terms (colon, colon polyps, adenomatous polyps, epidemiology, natural history, growth, cancer screening, colonoscopy, CRC) were used in conjunction with subject headings/key words (surveillance, adenoma surveillance, polypectomy surveillance, and serrated adenoma). We defined non-advanced adenomas as 1-2 adenomas each 25% villous histology or high-grade dysplasia. A combined endpoint of advanced neoplasia included advanced adenomas and invasive CRC. RESULTSOur search strategy identified 592 candidate articles of which 8 met inclusion criteria and were relevant for assessment of histology (low grade vs high grade dysplasia, villous features) and adenoma size. Six of these studies met the accepted quality indicator threshold for overall adenoma detection rate > 25% among study patients. We found 254 articles of which 7 met inclusion criteria for the evaluation of multiple adenomas. Lastly, our search revealed 222 candidate articles of which 6 met inclusion criteria for evaluation of serrated polyps. Our review found that villous features, high grade dysplasia, larger adenoma size, and having ≥ 3 adenomas at baseline are associated with an increased risk of future colonic neoplasia in some but not all studies. Serrated polyps in the proximal colon are associated with an increased risk of future colonic neoplasia, comparable to having a baseline advanced adenoma. CONCLUSIONData on adenoma features and risk of future adenomas and CRC are compelling yet modest in absolute effect size. Future research should refine this risk stratification.

关键词： Colon adenoma Colorectal cancer screening Surveillance Colonoscopy

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A Cross-sectional Real-life Study of the Prevalence,Severity,and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1377-1386页

作者： Quentin Binet audrey Loumaye Michel P Hermans Nicolas Lanthier Service d’Hépato-Gastroentérologie Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium Service d’Endocrinologie et Nutrition Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium

Background and Aims:Most data on liver assessment in type 2 diabetes mellitus(T2DM)patients are from retrospective cohorts with selection *** aimed at appraising the feasibility,results,and benefits of an outpatient systematic noninvasive screening for metabolic dysfunction-associated fatty liver disease(MAFLD)severity and determinants in T2DM ***:We conducted a 50-week crosssectional study enrolling adult T2DM outpatients from a diabetes *** algorithm based on guidelines was applied using simple bioclinical scores and,if applicable,ultrasound and/or ***:Two hundred and thirteen patients were *** age and body mass index were 62 years and 31 kg/m^(2) and 29% of patients had abnormal transaminase *** acceptance rate of additional liver examinations was 92%.The prevalence of MAFLD,advanced fibrosis and cirrhosis was 87%,11%,and 4%,*** than half of the cases of advanced fibrosis had not been suspected and were detected by this *** was associated with poor glycemic control,elevated transaminases,low HDL-C and the absence of peripheral arterial *** fibrosis was linked to high waist circumference and excessive alcohol consumption,which should be interpreted with caution owing to the small number of patients reporting excessive ***:Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity,with high adherence of high-risk patients to subsequent noninvasive exams.

关键词： Noninvasive tests MAFLD Outpatient Steatosis Fibrosis

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Impacts of increased α-synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases

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Neural Regeneration Research 2018年第4期13卷 647-648页

作者： audrey T.Medeiros Luigi Bubacco Jennifer R.Morgan The Eugene Bell Center for Regenerative Biology and Tissue Engineering Marine Biological Laboratory Department of Biology University of Padova

α-Synuclein causes synaptic pathologies in several neurodegenerative diseases：Parkinson’s disease（PD）is a neurodegenerative disease that impacts the lives of millions of people worldwide.A pathological hallmark of PD,as well as dementia with Lewy bodies（DLB）and several Alzheimer’s disease variants,is the appearanceof intracellular inclusions called Lewy bodies, which contain high levels of aggregated α-synuclein,

关键词： synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases Impacts of increased

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Pulmonary Metastases in Colorectal Cancer: Review on Diagnosis,Management and Prognosis

Pulmonary Metastases in Colorectal Cancer: Review on Diagnos...

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作者： audrey Marietta（应明洁）重庆医科大学

学位级别：硕士

Colorectal cancer is the third most common incidence of malignant tumor and fourth deadliest in the *** better understanding of tumor biology and development of surgical technique,present available regional control of the disease is already quite ***,major concerns still remain for the control of the progressive disease,especially late stage cancer with distant organ *** is the most common distant organ metastases after the liver from the primary colorectal *** is the first organ reached by circulatory pathway beside the liver because of its vascular anatomy and circulatory *** distant site of metastases such as brain and bone are proven most commonly accompanied with lung metastases in latest SEER *** of lung metastases are recommended to be confirmed with routine chest CT and tumor marker level detection,especially *** examination technique that can be run as supportive test such as MRI for other soft tissue and lymph node assessment,genetic and immunology testing may also be beneficial in confirmation and prognosis prediction of the *** pre-surgery assessment must be done with consensus discussion in a Multidisciplinary Team meeting,mainly to decide whether lung lesion can be defined as metastatic lesion and confirmed its *** til today,the most effective management for resectable metastatic lesion is surgical removal via thoracotomy or *** local control of micronodule and other multiple oligometastatic nodule limited to the lung,image-assisted thermal ablation such as RFA,cryoablation and MWA or even *** locoregional and systemic control,combination of chemoregiments are still used as first *** testing and molecular detection plays important role for systemic treatment selection,therefore it must be done especially in patient with non-resectable lesion and/or patient considered for adjuvant *** factor of the overall survival in patient

关键词： colorectal cancer metastases lung metastases pulmonary metastasectomy prognosis

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CO2 Injection for Enhanced Oil Recovery in Tight Oil Reservoirs （CMG）

CO2 Injection for Enhanced Oil Recovery in Tight Oil Reservo...

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作者： KATO audrey ROXANE 中国石油大学(北京)

学位级别：硕士

There are basically four different techniques to enhance oil recovery and extract30-60%of the stock,rather than the 20-40%recoverable with conventional *** of all,it's possible to inject gases（natural gas,nitrogen,CO）into the well to extend the pressure and,sometimes,reduce the viscosity of the *** injected gases remain trapped within the *** system can therefore combine increased oil recovery and geological storage of *** solutions of diluent or surfactant may also be wont to reduce surface tensions and capillary pressure in oil *** injection of selected microorganisms could be a means of reducing the length of the carbon chains while generating in place surfactants and COwhich reduce the viscosity of the ***,the injection of steam reduces the viscosity and vaporizes a fraction of the *** process to understand the COinjection into a reservoir is an important step COinjection was investigated in the Bakken reservoir,which is rich in tight ***,it is significant to investigate about the potential of applying Enhanced Oil Recovery methods to increase the oil recovery *** we know,it is a subject which is not understood properly in unconventional reservoirs such as the *** that,a compositional simulator called CMG GEM will be ***,the fluid model is built by using CMG Winprop,the components are distributed into 7,with their different compositional data for the Peng-Robinson EOS in the Bakken *** is used to determine the PVT properties,also know the Minimum Miscibility *** after,the result is saving with GEM EOS Model,and will be imported to CMG GEM for the reservoir *** the case,we set up the reservoir with 4 effective hydraulic fractures,after that,the Huff-n-Puff *** total production of the well is 30 ***,the investigation of different parameters such as:fracture width,half-length,injection pressure,injection rate,length of soaking period is liste

关键词： CO2huff-n-puff Enhanced Oil Recovery the Minimum Miscibility Pressure

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Open land-use map:a regional land-use mapping strategy for incorporating OpenStreetMap with earth observations

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Geo-Spatial Information Science 2017年第3期20卷 269-281页

作者： Di Yang Chiung-Shiuan Fu audrey C.Smith Qiang Yu Department of Geography University of FloridaGainesvilleFLUSA Land Use and Environmental Change Institute University of FloridaGainesvilleFLUSA Beijing Key Laboratory of Precision Forestry Beijing Forestry UniversityBeijingChina

A land-use map at the regional scale is a heavy computation task yet is critical to most landowners,researchers,and decision-makers,enabling them to make informed decisions for varying *** are two major difficulties in generating land classification maps at the regional scale:the necessity of large data-sets of training points and the expensive computation cost in terms of both money and *** Geographic Information opens a new era in mapping and visualizing the physical world by providing an open-access database valuable georeferenced information collected by volunteer *** one of the most well-known VGI initiatives,OpenStreetMap(OSM),contributes not only to road network distribution information but also to the potential for using these data to justify and delineate land ***,most large-scale mapping approaches-including regional and national scales–confuse“land cover”and“land-use”,or build up the land-use database based on modeled land cover data-sets,in this study,we clearly distinguished and differentiated land-use from land *** focusing on our prime objective of mapping land-use and management practices,a robust regional land-use mapping approach was developed by integrating OSM data with the earth observation remote sensing *** novel approach incorporates a vital temporal component to large-scale land-use mapping while effectively eliminating the typically burdensome computation and time/money demands of such ***,our novel approach in regional scale land-use mapping produced robust results in our study area:the overall internal accuracy of the classifier was 95.2%and the external accuracy of the classifier was measured at 74.8%.

关键词： OpenStreetMap(OSM) Volunteered Geographic Information(VGI) crowdsourced data Random Forest Google Earth Engine(GEE)

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Analysis of Natural Allelic Variation Controlling Arabidopsis thaliana Seed Germinability in Response to Cold and Dark： Identification of Three Major Quantitative Trait Loci

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Molecular Plant 2008年第1期1卷 145-154页

作者： Ping-Hong Meng audrey Macquet Olivier Loudet Annie Marion-Poll Helen M. North Laboratoire de Biologie des Semences UMR 204 INRA AgroParisTech Institut Jean-Pierre Bourgin F-78026 Versailles Cedex France Station de Genetique et Amelioration des Plantes INRA Institut Jean-Pierre Bourgin F-78026 Versailles Cedex France Present address: Institute of Horticulture Guizhou Academy of Agricultural Sciences GuiYang Guizhou Province 550006 RR. China

Light and temperature are key external factors in the control of Arabidopsis thaliana seed germination and dormancy mechanisms. Perception and response to these stimuli have to ensure that seedling emergence and growth occur at the most advantageous time for correct establishment. Analysis of over 300 Arabidopsis accessions identified 14, from 12 different geographical locations, that were able to germinate to greater than 20% at 6℃ in the dark. This natural variation was exploited to identify genetic loci responsible for cold-tolerant, dark germination. A quantitative trait loci approach was used on recombinant inbred line progeny of a cross between Bay-0 and Shahdara. Six distinct quantitative trait loci were identified, three of which were major loci, each responsible for 17-25% of the phenotypic variability in this trait. Parental phenotypes indicated that the majority of the cold-tolerant, dark-germination characteristics are related to light responses. Validation of the three major loci using heterogeneous inbred families confirmed the feasibility of fine mapping and cloning the genes at the quantitative trait loci responsible for cold-tolerant, dark germination.

关键词： Three Major Quantitative Cold and Dark Natural Allelic Variation

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Interleukin 7 regulates switch transcription in developing B cells

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Cellular & Molecular Immunology 2021年第3期18卷 776-778页

作者： audrey Dauba Fatima-Zohra Braikia Chloe Oudinet Ahmed Amine Kham lichi Mnstitut de Pharmacologie et de Biologie Structurale IPBSUniversite de ToulouseCNRSUniversity Paul Sabatier31077 ToulouseFrance

Class switch recombination(CSR)enables activated mature B cells to change immunoglobulin(Ig)isotype expression from IgM to IgG,IgE,or *** process requires activation-induced cytidine deaminase(AID)expression and transcription of the target sequences at the Ig heavy chain(IgH)constant locus,which is composed of multiple constant(C_(H))genes,each specifying an Ig isotype.

关键词： Interleukin enable IgH

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The work of difference

The work of difference

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作者： audrey Wasser.

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Bumblebees adjust protein and lipid collection rules to the presence of brood

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Current Zoology 2019年第4期65卷 437-446页

作者： Stephane Kraus Tamara Gomez-Moracho Cristian Pasquaretta Gerard Latil audrey Dussutour Mathieu Lihoreau Research Center on Animal Cognition (CRCA) Center for Intergrative Biology (CBI)CNRS University Paul Sabatier Toulouse France

Animals have evolved foraging strategies to acquire blends of nutrients that maximize fitness traits. In social insects, nu trie nt regulation is complicated by the fact that few in dividuals, the foragers, must address the diverge nt nutritional n eeds of all colony members simulta neously, includi ng other workers, the reproductives, and the brood. Here we used 3D nutritional geometry design to examine how bumblebee workers regulate their collection of 3 major macronutrients in the presence and absenee of brood. We provided small colonies artificial nectars (liquid diets) and pollens (solid diets) varying in their compositions of proteins, lipids, and carbohydrates during 2 weeks. Colo nies give n a choice betwee n nutrition ally complementary diets self-selected foods to reach a target ratio of 71% proteins, 6% carbohydrates, and 23% lipids, irrespective of the presenee of brood. Whe n con fined to a single nutrition ally imbalanced solid diet, colonies without brood regulated lipid collection and over-collected protein relative to this target ratio, whereas colonies with brood regulated both lipid and protein collection. This brood effect on the regulation of nutrient collection by workers suggests that protein levels are critical for larval development. Our results highlight the importa nee of con sidering bee nu trition as a multidimensi onal phe no men on to better assess the effects of environmental impoverishment and malnutrition on population declines.

关键词： artificial diets Bombus terrestris bumble bees nutritional geometry rule of compromise

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