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Revealing CO_(2)-Fixing SAR11 Bacteria in the Ocean by Raman-Based Single-Cell metabolic Profiling and Genomics

BioDesign Research 2022年第1期2022卷 52-67页

作者： Xiaoyan Jing Yanhai Gong Teng Xu Paul ADavison Craig macGregor-Chatwin cneil Hunter La Xu Yu meng Yuetong Ji Bo ma Jian Xu Wei E.Huang Single-Cell Center CAS Key Laboratory of BiofuelsShandong Key Laboratory of Energy Genetics and Shandong Institute of Energy ResearchQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdaoShandongChina Laboratory for marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandongChina University of Chinese Academy of Sciences BeijingChina Plants Photosynthesis and SoilSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK Disease and Fishery Drugs Research Center Marine Biology Institute of Shandong ProvinceQingdaoShandongChina Single-Cell Biotechnology LtdQingdaoShandongChina Department of Engineering Science University of OxfordParks RoadOX13PJ OxfordUK

The majority of marine microbes remain uncultured,which hinders the identification and mining of CO_(2)-fixing genes,pathways,and chassis from the ***,we investigated CO_(2)-fixing microbes in seawater from the euphotic zone of the Yellow Sea of China by detecting and tracking their ^(13)C-bicarbonate(^(13)C-HCO_(3)^(-))intake via single-cell Raman spectra(SCRS)*** target cells were then isolated by Raman-activated Gravity-driven Encapsulation(RAGE),and their genomes were amplified and sequenced at one-cell *** single-cell metabolism,phenotype and genome are *** identified a notyet-cultured Pelagibacter spp.,which actively assimilates ^(13)C-HCO_(3)^(-),and also possesses most of the genes encoding enzymes of the Calvin-Benson cycle for CO_(2) fixation,a complete gene set for a rhodopsin-based light-harvesting system,and the full genes necessary for carotenoid *** four proteorhodopsin(PR)genes identified in the Pelagibacter *** confirmed by heterologous expression in *** results suggest that hitherto uncultured Pelagibacter *** light-powered metabolism to contribute to global carbon cycling.

关键词： metabolism Benson hinder

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Prognostic Value of Lymphocyte Vascular Density and E-Cadherin in Inflammatory Breast Cancer

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Journal of Cancer Therapy 2014年第14期5卷 1380-1387页

作者： Paul H. Levine Heather J. Hoffman audra m.cneil Salman Hashmi Sherry X. Yang Stephen Hewitt Kenneth L. van Golen Sandra m. Swain Department of Epidemiology and Biostatistics Milken Institute School of Public Health The George Washington University Washington DC USA National Clinical Target Validation Laboratory Division of Cancer Treatment & Diagnosis National Cancer Institute Bethesda USA Laboratory of Pathology Center for Cancer Research National Cancer Institute Bethesda USA Department of Biological Sciences Center for Translational Cancer Research The University of Delaware Newark USA Washington Cancer Institute MedStar Washington Hospital Center Washington DC USA

Background: We recently evaluated four laboratory assays, vascular endothelial growth factor D (VEGF-D), E-cadherin, lymphatic vessel density (LVD) measured by podoplanin, and intra-lymphatic tumor emboli (ILTE), which showed notable differences between inflammatory breast cancer (IBC) and non-inflammatory locally advanced breast cancer (LABC). In this study we investigated the potential of the three most quantitatively measured markers, E-cadherin, LVD and VEGF-D, to predict survival in the IBC patients. materials and methods: This study involved the 100 cases identified in the Inflammatory Breast Cancer Registry (IBCR) whose tumors were previously evaluated for the four assays noted above. Living patients were recontacted and survival data were available for up to 17 years. Overall survival (OS) was analyzed through the Kaplan-meier method stratified by E-cadherin, LVD, VEGF-D, and response to chemotherapy. The differences in OS curves were compared using the log-rank test. Results: The median OS for patients with high LVD was 6.63 years (95% CI: 4.06 to 10.14), compared to median at 10 years not reached in those with low LVD (p = 0.03). There was a trend towards a longer median OS in patients with high E-cadherin (10.14, 95% CI: 6.63 to 11.67), compared with those with low E-cadherin (6.26, 95% CI: 3.42 to undeterminable). VEGF-D levels showed no correlation with survival. Conclusion: Low LVD significantly predicts better survival. High E-cadherin expression, as with non-IBC breast cancer and several other malignancies, tends to be associated with a better prognosis.

关键词： IBC Prognostic markers E-Cadherin Lymphocyte Vascular Density

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Prognostic Value of Lymphocyte Vascular Density and E-Cadherin in Inflammatory Breast Cancer

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Journal of Cancer Therapy（癌症治疗） 2014年第14期

作者： Paul H. Levine Heather J. Hoffman audra m.cneil Salman Hashmi Sherry X. Yang Stephen Hewitt Kenneth L. vanGolen Sandra m. Swain

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