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A novel mechanism of EAE resistance highlights the conflicting roles of progranulin-mediated immunosuppression and antigen processing

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Cellular & Molecular Immunology 2021年第2期18卷 506-507页

作者： aubryanna hettinghouse Guanmin Gao Chuan-ju Liu Department of Orthopaedic Surgery New York University Medical CenterNew YorkNY10003USA Department of Cell Biology New York University School of MedicineNew YorkNY10016USA

Progranulin(PGRN)is a secreted growth-factor-like molecule with multiple biological functions;elevated PGRN expression correlates with the activity of various autoimmune diseases,including rheumatoid arthritis(RA),inflammatory bowel disease(IBD),and systemic lupus erythematosus(SLE).1,2,3,4 PGRN deficiency is associated with an enhanced inflammatory response and commonly results in increased susceptibility to the onset and progression of various autoimmune conditions in murine models,including inflammatory arthritis,4 inflammatory bowel diseases,5 and inflammatory skin diseases.6 In contrast,PGRN expression has been shown to aggravate some autoimmune conditions,including lupus nephritis.

关键词： autoimmune diseases elevated

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Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes

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Genes & Diseases 2017年第3期4卷 125-126页

作者： Jinlong Jian aubryanna hettinghouse Chuan-ju Liu Department of Orthopaedic Surgery New York University Medical CenterNew YorkNY10003USA Department of Cell Biology New York University School of MedicineNew YorkNY 10016USA

Multifunctional factor progranulin(PGRN)plays an important role in lysosomes,and its mutations and insufficiency are associated with lysosomal storage diseases,including neuronal ceroid lipofuscinosis and Gaucher disease(GD).The first breakthrough in understanding the molecular mechanisms of PGRN as regulator of lysosomal storage diseases came unexpectedly while investigating the role of PGRN in *** PGRN null mice displayed typical features of *** addition,GRN gene variants were identified in GD patients and the serum levels of PGRN were significantly lower in GD *** directly binds to and functions as a chaperone of the lysosomal enzyme β-glucocerebrosidase(GCaase),whose mutations cause *** addition,its C-terminus containing granulin E domain,termed Pcgin(PGRN C-terminus for GCase Interaction),is required for the association between PGRN and *** concept that PGRN acts as a chaperone of lysosomal enzymes was further supported and extended by a recent article showing that PGRN acts as a chaperone molecule of lysosomal enzyme cathepsin D(CSTD),and the association between PGRN and CSTD is also mediated by PGRN’s C-terminal granulin E ***,these reports suggest that PGRN may act as a shared chaperone and regulates multiple lysosomal enzymes.

关键词： β-glucocerebrosidase Cathepsin D Chaperone Lysosomal storage diseases Lysosomal trafficking Progranulin

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Repurposing FDA-approved drugs for SARS- CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction

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Protein & Cell 2021年第7期12卷 586-591页

作者： Wenyu Fu Yujianan Chen Kaidi Wang aubryanna hettinghouse Wenhuo Hu Jing-Quan Wang Zi-Ning Lei Zhe-Sheng Chen Kenneth A.Stapleford Chuan-ju Liu Department of Orthopaedic Surgery New York University Medical Center301 East 17th StreetNew YorkNY 10003USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Department of Pharmaceutical Science College of Pharmacy and Health SciencesSt.John’s UniversityNew YorkNY 11439USA Department of Microbiology New York University School of MedicineNew YorkNY 10016USA Department of Cell Biology New York University School of MedicineNew YorkNY 10016USA

Dear Editor,The ongoing coronavirus disease 2019(COVID-19)global pandemic is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which instigates severe and often fatal *** of September 4th,2020,more than 26 million cases of COVID-19 and almost 900,000 deaths have been reported to *** on Kissler and colleagues’modeled projections of future viral transmission scenarios,a resurgence in SARS-CoV-2 could occur over the next five years(Kissler et al.,2020).

关键词： ACE2 drugs acute

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