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Role of doxycycline in the treatment of dengue infection: An open-label, randomized, controlled, pilot trial

Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 160-165页

作者： Banothu Vinod Kumar Kajal Kamboj Ashok Kumar Pannu Ashok Kumar Yadav Mandip Bhatia atul saroch Department of Internal Medicine PGIMER ChandigarhIndia Department of Experimental Medicine&Biotechnology PGIMER ChandigarhIndia

Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and C reactive protein(CRP)]levels in patients with dengue ***:A single-centre,open-label,parallel-group randomized controlled trial was done in PGIMER Chandigarh from June 2021 to October *** were randomized using a simple randomization process into two groups:the doxycycline treatment group(n=35)and the control group(n=34).Patients in the treatment group were given oral doxycycline 100 mg twice daily for five days along with standard treatment,whereas patients in the control group received only standard *** objective was to measure the effect of doxycycline on inflammatory markers in dengue ***:On comparative analysis at day 5,there was a statistically significant reduction in the median values of ferritin and CRP in cases compared to the control group(ferritin:P=0.006 and CRP:P=0.006).No significant reduction was noted in the levels of IL-6 and TNF-α.Conclusions:Doxycycline treatment led to a reduction of inflammatory markers in dengue infection.

关键词： Dengue Cytokine Doxycycline Serum ferritin C reactive protein

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Circulatory and hepatic failure at admission predicts mortality of severe scrub typhus patients: A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 209-213页

作者： Ashok Kumar Pannu atul saroch Saurabh Chandrabhan Sharda Manoj Kumar Debnath Manisha Biswal Navneet Sharma Department of Internal Medicine Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Medical Microbiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on ***:This was a prospective observational cohort study conducted between July 2017 and October 2020 at the medical emergency centre of PGIMER,Chandigarh,*** hundred and twenty-six patients aged≥13 years were diagnosed with scrub *** disease was defined as the presence of organ failure based on the Sequential Organ Failure Assessment(SOFA)score on ***:About two-thirds of the patients were from geographic regions outside the endemic sub-Himalayan ***(99.21%)and dyspnea(79.36%)were the most frequent *** failure(81.75%)was the most common organ failure,followed by hepatic(52.38%),coagulative(47.62%),circulatory(33.33%),renal(21.43%),and cerebral dysfunction(13.49%).The median(Q1,Q3)SOFA score was 8(6,9),and 48.41%of the patients had a quick-SOFA score≥*** supports with invasive ventilation(40.48%),vasopressors(36.51%),and renal replacement therapy(7.14%)were frequently *** in-hospital mortality was 11.90% and was independently predicted by circulatory and hepatic failures on multivariate logistic regression(OR 11.12,95%CI 1.73-71.31 and OR 8.49,95%CI 1.18-61.41,respectively).Conclusions:Most patients had pulmonary dysfunction;circulatory or hepatic failure on admission strongly predicts death.

关键词： Scrub typhus Orientia tsutsugamushi Organ failure Mortality Prognosis

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