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钙三醇的临床前预防试验:干预阶段和治疗持续时间对口腔癌变的影响

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中国口腔颌面外科杂志 2019年第4期17卷 315-315页

作者： Vincent-Chong Vk DeJong H attwood k 赵泽亮不详

在临床前模型中广泛报道了1,25-二羟基维生素D3(1,25(OH)2D3或骨化三醇)的抗癌活性。然而,尚未对钙三醇对口腔癌发生谱的化学预防潜力进行系统研究。为了解决这方面的知识差距,我们在4-硝基喹啉-1-氧化物(4NQO)口腔癌发生模型中进行了... 详细信息

在临床前模型中广泛报道了1,25-二羟基维生素D3(1,25(OH)2D3或骨化三醇)的抗癌活性。然而,尚未对钙三醇对口腔癌发生谱的化学预防潜力进行系统研究。为了解决这方面的知识差距,我们在4-硝基喹啉-1-氧化物(4NQO)口腔癌发生模型中进行了钙三醇的临床前预防试验。将C57BL/6小鼠暴露于饮用水中的致癌物质4NQO 16周,并随机分配到对照组(仅4NQO)或钙三醇组。

关键词：口腔癌变预防试验钙三醇治疗持续时间临床前 4-硝基喹啉-1-氧化物 C57BL/6小鼠抗癌活性

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Current hurdles in the management of eosinophilic oesophagitis:The next steps

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World Journal of Gastroenterology 2013年第6期19卷 790-796页

作者： Stephen EA attwood Michael SJ Wilson Department of General Surgery North Tyneside HospitalRake LaneNorth ShieldsTyne and Wear NE29 8NHUnited Kingdom

Eosinophilic oesophagitis (EoE) is a chronic,antigen mediated disease of the disease of the oesophagus that may present in both adults and *** is characterised by intermittent dysphagia,food bolus obstruction and weight *** pathogenesis is incompletely understood but is thought to culminate in poor compliance,or reduced *** condition is being reported and studied in the literature with increasing incidence,although equally it is highly likely that the diagnosis is being missed altogether with alarming *** of the condition requires at least one oesophageal biopsy with an eosinophil count greater than 15 per high power *** features include trachealisation,furrows,white exudate,narrowing and in the most severe cases stricture formation although none are pathognomonic of the *** is often not required,but in the acute setting may take the form of dietary therapy or topical *** term maintenance therapy is usually only required in the most severe cases and the most effective treatment is the subject of ongoing *** are a number of hurdles to be overcome in the management of patients with *** include;improving our understanding of the aetiologyof the condition,investigating the individual causes,assessing the true disease severity and planning the best long term maintenance *** EoE from EoE gastro-oesophageal reflux disease is also a hurdle because the two conditions,both being common,can *** order to overcome these hurdles,a multifaceted approach is *** management of food bolus obstruction requires a management algorithm that is accepted and endorsed by a number of *** and international disease registers should be established in order to facilitate future research but more importantly to address areas where further education or increased diagnostic capabilities may be *** of disease severity should become a ke

关键词： Eosinophil oesophagitis Dysphagia Food bolus obstruction Therapy Gastroscopy

Natural history of Barrett's esophagus

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World Journal of Gastroenterology 2012年第27期18卷 3483-3491页

作者： Rao Milind Stephen E attwood Department of Surgery North Tyneside General HospitalNorth ShieldsTyne and Wear NE29 8NHUnited Kingdom

The natural history of Barrett's esophagus (BE) is difficult to quantify because,by definition,it should describe the course of the condition if left ***,we assume that patients with BE will receive symptomatic treatment with acid suppression,usually a proton pump inhibitor,to treat their *** paper describes the development of complications of stricture,ulcer,dysplasia and adenocarcinoma from this *** over the definition of BE and its implications in clinical practice are *** presence of intestinal metaplasia and its relevance to cancer risk is discussed,and the need to measure the extent of the Barrett's epithelium (long and short segments) using the Prague guidelines is *** and international consensus over the diagnosis and management of BE are being regularly *** need for expert consensus is important due to the lack of randomized trials in this *** searching the literature,we have tried to collate the important studies regarding progression of Barrett's to dysplasia and *** therapeutic studies yet reported show a clear reduction in the development of cancer in *** effect of pharmacological and surgical intervention on the natural history of Barrett's is a subject of ongoing research,including the Barrett's Oesophagus Surveillance Study and the aspirin and esomeprazole cancer chemoprevention trial with interesting *** geographical variation and the wide range of outcomes highlight the difficulty of providing an individualized risk profile to patients with *** studies on the interaction of genome wide abnormalities in Barrett's and their interaction with environmental factors may allow individualization of the risk of cancer developing in BE.

关键词： Barrett's esophagus Columnar lined esoph-agus Dysplasia Adenocarcinoma Gastroesophagealreflux Surgery

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERk1/2 nuclear export

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Cellular & Molecular Immunology 2024年第8期21卷 873-891页

作者： Saeed Daneshmandi Qi Yan Jee Eun Choi Eriko katsuta Cameron R.MacDonald Mounika Goruganthu Nathan Roberts Elizabeth A.Repasky Prashant k.Singh kristopher attwood Jianmin Wang Yosef Landesman Philip L.McCarthy Hemn Mohammadpour Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Cell Stress Biology Roswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Oncology Yokohama City UniversityGraduate School of MedicineYokohamaJapan Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Biostatistics&Bioinformatics Roswell Park Comprehensive Cancer CenterBuffaloNYUSA karyopharm Therapeutics NewtonMAUSA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNYUSA

Myeloid-derived suppressor cells(MDSCs)are a main driver of immunosuppression in *** the mechanisms that determine the development and immunosuppressive function of these cells could provide new therapeutic targets to improve antitumor ***,using preclinical murine models,we discovered that exportin 1(XPO1)expression is upregulated in tumor MDSCs and that this upregulation is induced by IL-6-induced STAT3 activation during MDSC ***1 blockade transforms MDSCs into T-cell-activating neutrophil-like cells,enhancing the antitumor immune response and restraining tumor ***,XPO1 inhibition leads to the nuclear entrapment of ERk1/2,resulting in the prevention of ERk1/2 phosphorylation following the IL-6-mediated activation of the MAPk signaling ***,XPO1 blockade in human MDSCs induces the formation of neutrophil-like cells with immunostimulatory ***,our findings revealed a critical role for XPO1 in MDSC differentiation and suppressive functions;exploiting these new discoveries revealed new targets for reprogramming immunosuppressive MDSCs to improve cancer therapeutic responses.

关键词： MDSCs Tumor Exportin 1 MAPk pathway

Block Copolymesrs of Ethylene Oxide and Styrene Oxide. New Copolymer Surfactants(Ⅱ)

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胶体与聚合物 2003年第2期21卷 23-26页

作者： Zhuo Yang Davod attwood Colin Booth FacultyofChemistryandMaterialsScience HubeiUniversityWuhan430062Chian SchoolofPharmacyandPharmaceuticalScience UniversityofManchesterManchesterM139PLUK DepartmentofChemistry UniversityofManchesterManchesterM139PLUK

1 IntroductionThe range and application, actual and potential, of water-soluble block-copoly (oxyalkylene)s have beenextensively reviewed in recent compilations by edited by Nace[1] and by Alexandridis and Lindman[2].

关键词：共聚烯烃乙烯基苯乙烯氧化物共聚物表面活性

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应用“One Health”策略解决复杂健康问题

2009年

作者： Greg attwood ... [et al.].

来源：畅想之星图书光盘版（南... 评论

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中华预防医学杂志 2014年第12期48卷 1025-1029页

作者： Xiao Zheng 陆家海 Sarah k.White Tara Sabo-attwood Gregory C.Gray College of Public Health and Health Professions and One Health Center of Excellence for Research and TrainingUniversity of FloridaGainesvilleFlorida 32610USA 中山大学公共卫生学院 Duke Infectious Diseases Duke Global Health InstituteDuke MedicineDurhamNC 27710USA

“One Health”意指多学科共同合作，为人类健康、动物健康、环境健康三者共同成为一个健康整体而进行的工作和努力。“One Health”是一个新的名词，但是这一概念是很早之前已经存在的。2003年4月7日，华盛顿邮报的Rick Weiss引证了兽... 详细信息

“One Health”意指多学科共同合作，为人类健康、动物健康、环境健康三者共同成为一个健康整体而进行的工作和努力。“One Health”是一个新的名词，但是这一概念是很早之前已经存在的。2003年4月7日，华盛顿邮报的Rick Weiss引证了兽医博士William karesh的话“人类和家禽或者野生动物的健康再也不能分开谈论了，世界上只有‘One Health’，所有的问题解决办法需要我们各个学科的工作人员共同努力，在不同的层面为问题的解决作出贡献。”其实，我国也一直是采用类似的策略来解决复杂的公共卫生与健康问题，只是没有提出相应新的“名词”，也没有进行系统地阐述。为此，我刊特邀美国杜克大学的 Gregory *** 教授撰写此文，以供国内同行借鉴。关于“One Health”，目前国内翻译的名称非常不一致，比如“唯一健康”、“共同健康”、“协同健康”，编者在此不做翻译，希望广大专家、读者广泛讨论，最终能够确定比较合适并广为接受的中文名称。

关键词：健康问题应用人类健康中文名称动物健康环境健康野生动物工作人员

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Advances in the development of new biomarkers for Alzheimer’s disease

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Translational Neurodegeneration 2022年第1期11卷 601-624页

作者： Timofey O.klyucherev Pawel Olszewski Alena A.Shalimova Vladimir N.Chubarev Vadim V.Tarasov Misty M.attwood Stina Syvänen Helgi B.Schiöth Department of Neuroscience Functional PharmacologyUniversity of Upp-salaUppsalaSweden Department of Pharmacology Institute of PharmacyI.M.Sechenov First Moscow State Medical UniversityMoscowRussia Institute of Translational Medicine and Biotechnology I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Department of Public Health and Caring Sciences Rudbeck LaboratoryUppsala UniversityUppsalaSweden.

Alzheimer’s disease(AD)is a complex,heterogeneous,progressive disease and is the most common type of neurodegenerative *** prevalence of AD is expected to increase as the population ages,placing an additional burden on national healthcare *** is a large need for new diagnostic tests that can detect AD at an early stage with high specificity at relatively low *** development of modern analytical diagnostic tools has made it possible to determine several biomarkers of AD with high specificity,including pathogenic proteins,markers of synaptic dysfunction,and markers of inflammation in the *** is a considerable potential in using microRNA(miRNA)as markers of AD,and diagnostic studies based on miRNA panels suggest that AD could potentially be determined with high accuracy for individual *** of the retina with improved methods of visualization of the fundus are also showing promising results for the potential diagnosis of the *** review focuses on the recent developments of blood,plasma,and ocular biomarkers for the diagnosis of AD.

关键词： Alzheimer’s disease Amyloid beta peptides Biomarkers Blood Cytokines Inflammation MicroRNA Ocular biomarkers

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