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Fabrication and in vivo 2-photon microscopy validation of transparent PEDOT:PSS microelectrode arrays

Microsystems & Nanoengineering 2022年第4期8卷 183-190页

作者： Gerwin Dijk attila kaszas Jolien Pas Rodney Philip O’Connor Mines Saint-Etienne Centre CMPDepartment of BioelectronicsGardanne 13541France Panaxium SAS Aix-en-Provence 13100France

Transparent microelectrode arrays enable simultaneous electrical recording and optical imaging of neuronal networks in the *** made of the conducting polymer poly(3,4-ethylenedioxythiophene)doped with polystyrene sulfonate(PEDOT:PSS)are transparent;however,device fabrication necessitates specific processes to avoid deterioration of the organic ***,we present an innovative fabrication scheme for a neural probe that consists of transparent PEDOT:PSS electrodes and demonstrate its compatibility with 2-photon *** electrodes show suitable impedance to record local field potentials from the cortex of mice and sufficient transparency to visualize GCaMP6f-expressing neurons underneath the PEDOT:PSS *** results validate the performance of the neural probe,which paves the way to study the complex dynamics of in vivo neuronal activity with both a high spatial and temporal resolution to better understand the brain.

关键词： material. transparent microelectrode

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Integrating flexible electronics for pulsed electric field delivery in a vascularized 3D glioblastoma model

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npj Flexible Electronics 2021年第1期5卷 150-158页

作者： Marie C.Lefevre Gerwin Dijk attila kaszas Martin Baca David Moreau Rodney P.O’Connor Mines Saint-Etienne Centre CMPDepartment of BioelectronicsGardanneFrance.2Panaxium SASAix-en-ProvenceFrance

Glioblastoma is a highly aggressive brain tumor,very invasive and thus difficult to eradicate with standard oncology *** treatments based on pulsed electric fields have proven to be a successful method to treat cancerous ***,they rely on stiff electrodes,which cause acute and chronic injuries,especially in soft tissues like the *** we demonstrate the feasibility of delivering pulsed electric fields with flexible electronics using an in ovo vascularized tumor *** show with fluorescence widefield and multiphoton microscopy that pulsed electric fields induce vasoconstriction of blood vessels and evoke calcium signals in vascularized glioblastoma spheroids stably expressing a genetically encoded fluorescence *** of the electric field delivery are compared with the measured influence of electric field effects on cell membrane integrity in exposed tumor *** results confirm the feasibility of flexible electronics as a means of delivering intense pulsed electric fields to tumors in an intravital 3D vascularized model of human glioblastoma.

关键词： injuries electronics stiff

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