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Small-for-size syndrome in liver transplantation:Definition,pathophysiology and management

Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 334-341页

作者： Yuichi Masuda Kazuki Yoshizawa Yasunari Ohno atsuyoshi mita Akira Shimizu Yuji Soejima Division of Gastroenterological Hepato-Biliary-PancreaticTransplantation and Pediatric SurgeryDepartment of SurgeryShinshu University School of Medicine3-1-1 AsahiMatsumotoNaganoJapan

Background:Since the first success in an adult patient,living donor liver transplantation(LDLT)has become an universally used ***-for-size syndrome(SFSS)is a well-known complication after partial LT,especially in cases of adult-to-adult *** definition of SFSS slightly varies among transplant *** use of a partial liver graft has risks of SFSS *** portal vein(PV)hypertension and PV hyper-perfusion after LT were identified as the main ***,various approaches were explored to modulate PV flow and decrease PV pressure in order to alleviate this ***,the definition,clinical symptoms,pathophysiology,basic research,as well as preventive and treatment strategies for SFSS are reviewed based on an extensive review of the literature and on our own *** sources:The articles were collected through PubMed using search terms“liver transplantation”,“living donor liver transplantation”,“living liver donation”,“partial graft”,“small-for-size graft”,“small-forsize syndrome”,“graft volume”,“remnant liver”,“standard liver volume”,“graft to recipient body weight ratio”,“sarcopenia”,“porcine”,“swine”,and“rat”.English publications published before March 31,2020 were included in this ***:Many transplant surgeons performed PV flow modulation,including portocaval shunt,splenic artery ligation and *** these techniques,patient outcome has been improved even when using a"small"*** factors,such as preoperative recipients’nutritional and skeletal muscle status,graft congestion,and donor factors,were also identified as risk factors which all have been addressed using various ***:The surgical approach controlling PV flow and pressure could help to prevent SFSS especially in severely ill *** the absence of efficacious medications to resolve SFSS,conservative treatments,including aggressive fluid balance correction for massive ascites,anti-microbiological therapy t

关键词： Liver transplantation Living donor liver transplantation Small-for-size graft Small-for-size syndrome

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Quantitative approach for damage detection of reinforced concrete frames

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Earthquake Engineering and Engineering Vibration 2003年第1期2卷 147-158页

作者： Yoshio Kaneko Akira mita Hirozo Mihashi Dept.of Architecture & Building Science Tohoku UniversitySendai 980-8579Japan Associate Professor Dept.of System Design Engineering Keio UniversityYokohama 223-8522Japan Professor

The objective of this paper is to provide an analytical basis for the quantitative evaluation of damage to a reinforced concrete structure based on the vibration data obtained by using the damage detection technique. A partial reinforced concrete system of a weak beam/strong column moment frame is chosen as an example. A pushover analysis is carried out in order to numerically examine both the story shear-relative displacement characteristics and the associated damage level. In the analysis, a two dimensional nonlinear finite element analysis is employed considering several constitutive models. As a result, the degradation of the stiffness at the damaged story is characterized in association with the story relative displacement. It is also pointed out that the rotation angle of the column-base is highly correlated with the story relative displacement. Based on the analytical findings, quantitative approaches for a structural health monitoring system are suggested considering both the current sensor technologies and those available in the future. Keywords nonlinear FEM analysis - structural health monitoring - reinforced concrete structure - story stiffness - rotation angle of column-base Supported by: Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (Base Research (c) (1), Research No. 14550555)

关键词： nonlinear FEM analysis structural health monitoring reinforced concrete structure story stiffness rotation angle of column-base

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Aeromagnetic signatures of Precambrian shield and suture zones of Peninsular India

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Geoscience Frontiers 2014年第1期5卷 3-15页

作者： mita Rajaram S.P.Anand Indian Institute of Geomagnetism New PanvelNavi Mumbai 410218 India

In many Precambrian provinces the understanding of the tectonic history is constrained by limited exposure and aeromagnetic data provide information below the surface cover of sediments, water, etc. and help build a tectonic model of the region. The advantage of using the aeromagnetic data is that the data set has uniform coverage and is independent of the accessibility of the region. In the present study, available reconnaissance scale aeromagnetic data over Peninsular India are analyzed to understand the magnetic signatures of the Precambrian shield and suture zones thereby throwing light on the tectonics of the region. Utilizing a combination of differential reduction to pole map, analytic signal, vertical and tilt derivative and upward continuation maps we are able to identify magnetic source distribution, tectonic elements, terrane boundaries, suture zones and metamorphic history of the region. The mag- netic sources in the region are mainly related to charnockites, iron ore and alkaline intrusives. Our analysis suggests that the Chitradurga boundary shear and Sileru shear are terrane boundaries while we interpret the signatures of Palghat Cauvery and Achankovil shears to represent suture zones. Processes like metamorphism leave their signatures on the magnetic data： prograde granulites （charnockites） and retrograde eclogites are known to have high susceptibility. We find that charnockites intruded by alkali plutons have higher magnetization compared to the retrogressed charnockites. We interpret that the Dharwar craton to the north of isograd representing greenschist to amphibolite facies transition, has been subjected to metamorphism under low geothermal conditions. Some recent studies suggest a plate tectonic model of subduction collision-accretion tectonics around the Palghat Cauvery shear zone （PCSZ）. Our analysis is able to identify several west to east trending high amplitude magnetic anomalies with deep sources in the region from Palghat Cauvery shear t

关键词： Aeromagnetic interpretation Southern Granulite Terrain Metamorphism Precambrian Subduction Collision

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A new protocol for concurrently allocating licensed spectrum to underlay cognitive users

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Digital Communications and Networks 2018年第3期4卷 200-208页

作者： Sabyasachi Chatterjee Prabir Banerjee mita Nasipuri Department of Electronics and Communication Engineering Heritage Institute of Technology Kolkata India Department of Computer Science Engineering Jadavpur university Kolkata India

Cognitive radio technology makes efficient use of the valuable radio frequency spectrum in a non-interfering manner to solve the problem of spectrum scarcity. This paper aims to design a scheme for the concurrent use of licensed frequencies by Underlay Cognitive Users （UCUs）. We develop a new receiver-initiated Medium Access Control （MAC） protocol to facilitate the selections of alternative reliable carrier frequencies. A circuit is designed to establish reliable carrier selections based on the Received Signal Strength Indicator （RSSI） at the receiving end. Based on both packet-level simulations and various performance parameters, a comparison is carried out among conventional techniques, including the Multiple Access with Collision Avoidance （MACA） and MACA by invitation（MACA-BI） techniques, and our scheme. The simulated results demonstrate that when conventional techniques are used, the system overhead time increases from 0.5 s on the first attempt to 16.5 s on the sixth attempt. In the proposed scheme under the same failure condition, overhead time varies from 0.5 s to 2 s. This improvement is due to the complete elimination of the exponential waiting time that occurs during failed transmissions. An average efficiency of 60% is achieved with our scheme while only 43% and 34% average efficiencies are achieved with the MACA and MACA-BI techniques, respectively. The throughput performance of our scheme on the fourth attempt is 7 Mbps, whereas for the MACA and MACA-BI protocols, it is 1.9 Mbps and 2.2 Mbps respectively.

关键词： Exponential back-off time Interference temperature limit Medium-access control protocol Received signal strength indicator Underlay cognitive user

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Gene expression analysis in the larval silk gland of the eri silkworm Samia ricini

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Insect Science 2016年第6期23卷 791-804页

作者： Takuya Tsubota Kimiko Yamamoto Kazuei mita Hideki Sezutsu Transgenic Silkworm Research Unit Ibaraki 305-8634Japan Insect Genome Research Unit National Institute of Agrobiological Sciences Ibaraki 305-8634Japan

Insects produce silk for a range of purposes. In the Lepidoptera, silk is utilized as a material for cocoon production and serves to protect larvae from adverse environmental conditions or predators. Species in the Saturniidae family produce an especially wide variety of cocoons, for example, large, golden colored cocoons and those with many small holes. Although gene expression in the silk gland of the domestic silkworm （Bombyx mori L.） has been extensively studied, considerably fewer investigations have focused on members of the saturniid family. Here, we established expression sequence tags from the silk gland of the eri silkworm （Samia ricini）, a saturniid species, and used these to analyze gene expression. Although we identified thefibroin heavy chain gene in the established library, genes for other major silk proteins, such asfibroin light chain andfibrohexamerin, were absent. This finding is consistent with previous reports that these latter proteins are lacking in saturniid silk. Recently, a series offibrohexamerin-like genes were identified in the Bombyx genome. We used this information to conduct a detailed analysis of the library established here. This analysis identified putative homologues of these genes. We also found several genes encoding small silk protein molecules that are also present in the silk of other Lepidoptera. Gene expression patterns were compared between eri and domestic silkworm, and both conserved and nonconserved expression patterns were identified for the tested genes. Such differential gene expression might be one of the major causes of the differences in silk properties between these species. We believe that our study can be of value as a basic catalogue for silk gland gene expression, which will yield to the further understanding of silk evolution.

关键词： domestic silkworm eri silkworm EST analysis Samia ricini silk gland

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Undergraduate nursing students’experiences of online learning:gaining access in resource-limited circumstances

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Frontiers of Nursing 2022年第1期9卷 47-54页

作者： Titan Ligita mita Murtilita Winarianti School of Nursing Faculty of MedicineUniversitas TanjungpuraPontianak 78124Indonesia

Background:In response to the need to mitigate the increase in Coronavirus Disease 2019(COVID-19)cases,nursing students undertake online learning in almost all nursing education institutions in *** students face distinctive learning experiences,which have not yet been identified in the Indonesian *** study aimed to explore students’experiences of online learning during the COVID-19 ***:We used a descriptive exploratory *** students from three nursing education institutions in Indonesia were interviewed through telephone calls or video conference ***:One main theme,Gaining access in resource-limited circumstances,was developed to describe students’experience of online learning during the COVID-19 *** theme was supported by five subthemes:struggling for internet connection;becoming familiar with the applications;flexibility;supported by others;and dealing with ***:This current study provides insights into what support should be provided for nursing students to manage limitations in the online learning process.

关键词： COVID-19 pandemic descriptive exploratory experiences Indonesia nursing students online learning

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Effects of docosahexaenoic acid or arachidonic acid supplementation on gene expression and contractile force of rat cardiomyocytes in primary culture

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BIOCELL 2021年第5期45卷 1213-1229页

作者： MIZUNA YANO YUTA UMEHARA TOMOKAZU KUDO TAKAO NAKAMURA TADASHI KOSAWADA atsuyoshi NISHINA MASAKI SAZUKA DAISUKE SATO ZHONGGANG FENG Graduate School of Science and Engineering Yamagata UniversityYonezawa9928510Japan Graduate School of Medical Science Yamagata UniversityYamagata9909585Japan Department of Materials and Applied Chemistry College of Science and TechnologyNihon UniversityTokyo1018308Japan Department of Health and Nutrition Yamagata Prefectural Yonezawa University of Nutrition SciencesYonezawa9920025Japan

While fatty acids play essential roles in the physiology of the myocardium,conventional culture media contain little *** previously revealed that rat neonatal myocardium mainly contains docosahexaenoic(DHA),linoleic(LA),and arachidonic(AA)acids as polyunsaturated fatty acids(PUFAs),and these contents in cultured cardiomyocytes derived from fetal rats were markedly lower than those in the neonatal *** this study,we first assessed the effects of supplementation of DHA,LA,or AA on the fatty acid contents and the percentage change of contractile area in primarily cultured rat *** on this assessment,we then evaluated the effects of DHA or AA supplementation on mRNA expression and further directly measured the contractile force of cardiomyocytes with the *** study revealed that percentage change of contractile area was maximized under 20μM DHA or 50μM AA supplementation while LA supplementation did not affect this contraction index,and that a widespread upregulation tendency of the mRNA expression related to differentiation,maturity,fatty acid metabolism,and cell adhesion was seen in the cultured cardiomyocytes with supplementation of DHA or *** particular,upregulation of the gene expression of cellular adhesion molecules connexin43 and N-cadherin were remarkable,whereas the effects on differentiation and maturation were less ***,the increase of the percentage change of the contractile area of cardiomyocyte clusters in culture dishes with the supplementations was significant,whereas the enhancement of the contractile force was *** results suggest that supplementation of DHA or AA to the fetal cardiomyocyte culture may play effective roles in preventing the de-differentiation of the cardiomyocytes in culture and that the enhancement of the contractile performance may be mainly attributed to the improvement of intercellular connection.

关键词： Cardiomyocyte culture Polyunsaturated fatty acid mRNA expression Contractile force Intercellular connection

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Clinical development of reovirus for cancer therapy:An oncolytic virus with immune-mediated antitumor activity

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World Journal of Methodology 2016年第1期6卷 25-42页

作者： Jun Gong Esha Sachdev Alain C mita Monica M mita Department of Medical Oncology City of Hope National Medical Center Division of Experimental Therapeutics Program Samuel Oschin Com-prehensive Cancer Institute Cedars-Sinai Medical Center

Reovirus is a double-stranded RNA virus with demonstrated oncolysis or preferential replication in cancer cells. The oncolytic properties of reovirus appear to be dependent, in part, on activated Ras signaling. In addition, Ras-transformation promotes reovirus oncolysis by affecting several steps of the viral life cycle. Reovirusmediated immune responses can present barriers to tumor targeting, serve protective functions against reovirus systemic toxicity, and contribute to therapeutic efficacy through antitumor immune-mediated effects via innate and adaptive responses. Preclinical studies have demonstrated the broad anticancer activity of wild-type, unmodified type 3 Dearing strain reovirus（Reolysin） across a spectrum of malignancies. The development of reovirus as an anticancer agent and available clinical data reported from 22 clinical trials will be reviewed.

关键词： Reovirus Type 3 Dearing Oncolytic virus Ras Epidermal growth factor receptor Clinical trial Preclinical Immune modulation

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Hepatic portal venous gas in pancreatic solitary metastasis from an esophageal squamous cell carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 103-105页

作者： Takeshi Sawada Yasushi Adachi Manabu Noda Kimishige Akino Takefumi Kikuchi Hiroaki mita Yoshifumi Ishii Takao Endo Division of Gastroenterology Sapporo Shirakaba-dai Hospital Department of Pathology Sapporo Shirakaba-dai Hospital

BACKGROUND:Hepatic portal venous gas(HPVG) is a rare entity commonly associated with intestinal necrosis and fatal outcome,and various underlying diseases have been *** solitary metastasis without local extension is also rare in esophageal squamous cell ***:This report describes an interesting and unusual case of HPVG arising from pancreatic *** revealed pathogenesis of HPVG and synchronous tumors of the esophagus and ***:A 73-year-old man developed synchronous double tumor in the esophagus and pancreas several months before acute abdomen and his death,which were generated by *** revealed that HPVG was caused by gastric wall infarction owing to expansion of an isolated pancreatic metastasis from esophageal squamous cell ***:This is the first case of HPVG that was derived from pancreatic tumor *** he had been diagnosed with solitary pancreatic metastasis from esophageal squamous cell carcinoma in the first time,he might have an option for chemotherapy,which could let him live longer.

关键词： hepatic portal venous gas solitary pancreatic tumor metastasis

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Homeostasis Lighting Control System Using a Sensor Agent Robot

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Intelligent Control and Automation 2013年第2期4卷 138-153页

作者： Tatsuya Akiba Akira mita Department of System Design Engineering Keio University Yokohama Japan

In this study, “homeostasis”, the function by which living things keep their constancy, was emulated as a lighting control for a building space. The algorithm we developed mimics the mechanisms of the endocrine and immune systems. The endocrine system transmits information entirely, whereas the immune system transmits information with a concentration gradient. A lighting control system using the proposed algorithm was evaluated in a simulation and experiment using a sensor agent robot. In this algorithm, a robot recognizes a person’s behavior and uses it to decide his or her preference as to the illuminance. The results indicate that the algorithm can be used to realize a comfortable lighting control in several situations.

关键词： Homeostasis Lighting Control Sensor Agent Robot Human Tracking

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