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Journal of Surface Engineered Materials and Advanced Technology 2013年第4期3卷 36-42页

作者： Sho Hidaka Osamu Nikaido Shoichi Kiyosaki atsushi ikai Toshiya Osada Department of Life Science Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology Yokohama Japan Innovation Laboratory Tokyo Institute of Technology Yokohama Japan.

In our previous study, the specific interaction between P-factor, a peptide pheromone and its receptor, Mam2, on the cell surface of the fission yeast Schizosaccharomyces pombe was investigated by two methods, an atomic force microscope (AFM) and a GFP reporter assay. The removal of Leu at C-terminal of P-factor resulted in an inactivation of P-factor function to bind Mam2 and induce the signal transduction pathway. Here, we used truncated P-factor derivatives lacking N-terminal of P-factor (P12 ~ P22: 12 ~ 22 amino acid residues from C-terminal) as ligands for Mam2. From the dose-dependent analysis of the GFP reporter assay ranging from 1 nM to 100 μM of the peptide concentration, the peptides can be classified into three groups based on EC50 and maximal GFP production level, group1 (P-factor), group2 (P17 ~ 22), and group3 (P12 ~ P16). At 0.1 μM, only P-factor induced the signal transduction pathway. At 1 μM, peptides from group2 partially induced the pathway and peptides from group3 induced the pathway a little. At 10 μM, all peptides induced the pathway mostly depending on the length of peptides. We also performed AFM experiments using P-factor and peptides from group3 to investigate the interaction between the peptides and Mam2 for comparison between the two methods.

关键词： GPCR Mam2 Pheromone GFP AFM Yeast

新型糖基聚合物的合成及其作为高效液相色谱手性固定相的应用(英文)

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色谱 2016年第1期34卷 4-9页

作者： Tomoyuki ikai Takayuki YAMADA Graduate School of Natural Science and Technology Kanazawa University

Two novel polymers containing glucose units as the main-chain that only differ in terms of their regioregularity were synthesized to evaluate their chiral recognition abilities as chiral stationary phases(CSPs)for high performance liquid chromatography(HPLC).The regioregular polymer(poly-5)shows clear resolution ability for the racemate of cobalt(Ⅲ)acetylacetonate(Co(acac)3),whereas the corresponding regioirregular polymer(poly-3)does not show any chiral recognition for Co(acac)*** regioregular polymer main-chain seems to play an important role not only in providing an efficient interaction with the racemate but also in expressing the chiral recognition ability as a CSP for HPLC.

关键词：金属有机骨架化合物手性分离对映异构体选择性苇墩

Appropriate Heart Rate in a Patient with Repaired Tetralogy of Fallot

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Congenital Heart Disease 2022年第6期17卷 647-652页

作者： Aya Miyazaki Hideki Uemura Yasuyo Takeuchi Junya Tomida Yasuo Ono Yoshifumi Fujimoto Norie Mitsushita Akio ikai Department of Transitional Medicine Division of Congenital Heart DiseaseShizuoka General HospitalShizuokaJapan Congenital Heart Disease Center Nara Medical UniversityKashiharaJapan Department of Cardiology Shizuoka General HospitalShizuokaJapan Department of Clinical Engineering Shizuoka General HospitalShizuokaJapan

Appropriate heart rate in a failing pulmonary ventricle remains unknown, particularly in congenital heart diseasewith unique hemodynamics. A 71-year-old male with repaired tetralogy of Fallot and a pacemaker for a sinusnode dysfunction suffered from heart failure symptoms with preserved left ventricular function. Simply changingthe pacemaker’s lower rate from 60 to 75 bpm, New York Heart Association classification improved from III to II,and hemodynamic parameters drastically improved. We regarded this case as informative. Appropriate heart ratecould be higher in congenital patients with failing right and non-failing left ventricles than in adults with malfunctioningLV.

关键词： Heart rate repaired tetralogy of Fallot failing right ventricle pacemaker lower rate the right-left ventricular interaction

IMMOBILIZATION AND CHIRAL RECOGNITION OF REGIOSELECTIVE AMYLOSE DERIVATIVES AS CHIRAL PACKING MATERIALS FOR HPLC

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IMMOBILIZATION AND CHIRAL RECOGNITION OF REGIOSELECTIVE AMYL...

中国化学会第三届全国分子手性学术研讨会

作者： Tomoyuki ikai Yoshio Okamoto Nagoya University Furo-choChikusa-kuNagoya 464-8603Japan College of Material Science and Chemical Engineering Harbin Engineering University

＜正＞Polysaccharide-based CPMs for high-performance liquid chromatography（HPLC）,especially those based on phenylcarbamate and benzoate derivatives of cellulose and amylose,are wellknown to exhibit a high chiral recognition to a wide range of *** on the method of regioselective esterification at 2-position of amylose reported by Dicke,we have

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皮肤中的前列腺素D_2

国外医学（皮肤性病学分册） 1989年第5期15卷 284-287页

作者： ikai K. 宋力夫

前列腺素(PGs)是一类具有活性的物质,在酶作用下,由二十碳的花生四烯酸经由花生四烯酸氧化途径产生。皮肤合成、降解 PGs。多种皮肤病与 PGs 及其衍生物有关。前列腺素 D_2(PGD_2)是 PGs 中一种,许多组织和细胞中均能合成;在各种生理、... 详细信息

前列腺素(PGs)是一类具有活性的物质,在酶作用下,由二十碳的花生四烯酸经由花生四烯酸氧化途径产生。皮肤合成、降解 PGs。多种皮肤病与 PGs 及其衍生物有关。前列腺素 D_2(PGD_2)是 PGs 中一种,许多组织和细胞中均能合成;在各种生理、病理条件下,调节这些组织、细胞的功能。正常皮肤中的

关键词：皮肤前列腺素花生四烯酸

Influence of Ozone Injection on Corrosion Behavior of Steel in Water Ballast Tank

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Journal of Shipping and Ocean Engineering 2014年第11期4卷 327-337页

作者： Ryuji Kojima Michiaki ikai Jinsun Liao Yoichi Mori Department of Marine Environment and Engine Systems National Maritime Research Institute Tokyo 1810004 Japan Technology Development Division Kurimoto Ltd. Osaka 5590021 Japan

Ozone is the principal active substances and usually employed in ballast water management systems. In the present study, the corrosion protective effect of ozone was conducted by immersion test and electrochemical techniques. It was found that corrosion protective effect was revealed in the range of 2.0 to 2.7 ppm of ozone concentration in seawater. The ratio of the rust area of specimen became 20% in that concentration region. The rusted area is strongly influenced by the ozone concentration and the flow rate determined by FEM （finite element method）. Ozone has a good influence for ballast tanks, i.e., ozone can delay the rust of ballast tanks, provided that the suitable concentration of ozone is selected. In this case, ozone may stop the corrosion at the defects, if a part of the paint in ballast tank is peeled off. However, ozone may also promote the corrosion of steel when the ozone concentration is very high, e.g., 10 ppm. Attention should be paid to the ozone concentration, if we use ozone as an active substance for ballast water management systems.

关键词： Ozone corrosion protective effect water ballast tank coating film electrochemical measurement FEM analysis.

Deterioration of Water Ballast Tank Coating Systems by Active Substances in Ballast Water Management Systems

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Journal of Shipping and Ocean Engineering 2014年第9期4卷 229-235页

作者： Ryuji Kojima Michiaki ikai Toshiaki Shibata Koichi Ueda Department of Marine Environment and Engine Systems National Mazitime Research Institute Tokyo 1810004 Japan

Sodium hypochlorite and ozone are the principal active substances and usually employed in ballast water management systems. In the present study, the authors focus on the effect of these active substances to the maaix polymer of coating. In order to obtain such information, the authors investigated the penetration of active substances to the polymer from cross section of specimens introduced by SAICAS （surface and interracial cutting analysis system）, followed by FT-IR-ATR （Fourier transform infrared and attenuated total reflectance） spectroscopy analysis from Z direction of cross section. The corrosion test of coating panels by these active substances （control as artificial seawater） has been conducted for 120 days. The results show that the depth profile of each active substance is around few dozens of micrometers from coating surface. The criteria of corrosion test cannot be determined by these results due to lacking in actual corrosion data immersed for 15 years under active substances. However, the authors evaluated the effect on ballast tank coating systems by active substances using analytical methods of SAICAS and FT-IR-ATR spectroscopy.

关键词： Ozone sodium hypochlorite SAICAS FT-IR-ATR epoxy resin PSPC ballast water management systems.

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吡嘧黄隆及其相关化合物的选择除草活性

农药译丛 1992年第5期14卷 13-18页

作者： Susumu Yamamoto Takashi ikai 吴佩文日产化学工业公司中心研究所日产化学工业公司Shiraoka生物科学研究站

磺酰脲类除草剂例如氯黄隆和嘧黄隆为兼具芽前和芽后除草活性的新型化合物(图1),用量极低.笔者对此类化合物的结构及除草活性极感兴趣,正在努力开发兼具高活性和极佳作物安全性的新型化合物.磺酰脲类化合物由三个部分组成:芳基、磺酰脲... 详细信息

磺酰脲类除草剂例如氯黄隆和嘧黄隆为兼具芽前和芽后除草活性的新型化合物(图1),用量极低.笔者对此类化合物的结构及除草活性极感兴趣,正在努力开发兼具高活性和极佳作物安全性的新型化合物.磺酰脲类化合物由三个部分组成:芳基、磺酰脲桥以及杂环(图1).已经了解到芳基能维持除草活性,即使以杂环如噻吩和吡啶替代芳基也是如此.但是,其他部位结构改性一般都降低活性.

关键词：吡嘧黄隆农药除草剂

Relationship between Glucocorticoid-induced Osteoporosis and Vitamine D Receptor Genotypes

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第4期22卷 317-319页

作者：李裕明徐琳沈凌迅余立凯陈璐璐 DepartmentofInternalMedicine

By means of polym erase chain reaction- restriction fragment length polymorphism (PCR- RFL P) assay,the association between vitamine D receptor (VDR) genotypes and bone min- eral density (BMD) in the patients receiving long- term glucocorticoid therapy was *** clinical data and blood of71patients with rheumatosis who received long- term glucocorticoid ther- apy were *** was m easured by dual- energy X- ray *** gene frag- ment(about185 bp) was amplified by PCR from the extracted genomic DNA,then digested with restriction endonuclease Bsm *** genotypes were evaluated based on the fragment length fol- lowing endonuclease digestion and the association between genotypes and BMD or Z- score values was *** the 71cases,the detected genotypes were Bb and bb with the distribution frequency being 11.3% and 88.7% *** distribution frequency of the alleles was in agreement with the Hardy- Weinberg *** was no significant difference between the two genotypes in age,gender,body m ass index(BMI) ,disease duration,disease types,time of glucocorticoid administration and cumulative dosage(P>0 .0 5 ) .Osteoporosis rate of the patients with Bb or bb genotype was37.5 % and33.3% respectively,with the difference being notsignif- icant (χ2 =0 .0 5 ,P=0 .8) .The BMD and Z- score values at lumbar spine and femur in two geno- types were not similar,but the difference had no significant (P>0 .0 5 ) .The distribution frequen- cy of bb type of VDR genotypes in Han populations of China was m ore prevalent,followed by Bb and bb types in *** the patients receiving long- term glucocorticoid therapy,there was no sig- nificant difference in BMD between Bb and bb *** data suggest that the VDR geno- types may not be m eans of identifying patients at greater risk of glucocorticoid- induced osteoporo- sis,which await to be further confirmed by a large sample size.

关键词： glucocorticoid vitamine D receptor bone mineral density genotypes polymerase chain reaction- restriction fragm ent length polym orphism

CBA职业联赛京津主场球市开发的现状及策略

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体育成人教育学刊 2018年第4期34卷 55-57页

作者：闫育东关凯赵晶天津体育学院天津300381 天津市第七中学天津300000

从比赛成绩、观众、运动员、场馆、门票5个方面对CBA联赛京津赛区球市开发的现状进行了对比分析,并提出以下策略:提升球员技术能力,提高比赛观赏性;加大媒体宣传力度,营造球员明星效应;完善场馆设施建设,创造良好的观赛环境;丰富赛场表... 详细信息

从比赛成绩、观众、运动员、场馆、门票5个方面对CBA联赛京津赛区球市开发的现状进行了对比分析,并提出以下策略:提升球员技术能力,提高比赛观赏性;加大媒体宣传力度,营造球员明星效应;完善场馆设施建设,创造良好的观赛环境;丰富赛场表演形式,营造和谐的观赛氛围;加强俱乐部组织管理,提高市场服务策略。

关键词： CBA联赛篮球产业京津主场球市开发