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Sigmoid colon endometriosis treated with laparoscopy-assisted sigmoidectomy:Significance of preoperative diagnosis

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World Journal of Gastroenterology 2007年第40期13卷 5400-5402页

作者： Motohira yoshida Yuji Watanabe atsushi Horiuchi Yuji Yamamoto Hiroki Sugishita Kanji Kawachi Department of Organ Regenerative Surgery Ehime University Graduate School of MedicineShitsukawaToonEhime 791-0295Japan

We present a female patient with sigmoid colon endometriosis who was diagnosed correctly preoperatively and underwent minimally invasive surgery. She was admitted to our hospital with rectal bleeding and constipation. We performed several workups. Colonoscopy and endoscopic ultrasonography showed sigmoid colon stenosis caused by submucosal tumor, and magnetic resonance imaging revealed a sigmoid colon tumor displaying signal hy- pointensity on both T1- and T2-weighted imaging. However, colonoscopic ultrasonography-assisted needle aspiration biopsy could not specify tumor characteristics. From these examinations, the lesion was diagnosed as sigmoid colon endometriosis and laparoscopy-assisted sigmoidectomy was performed. Pathological diagnosis from the resected specimen was identical to preoperative diagnosis, i.e., colonic endometriosis. Since differential diagnosis of intestinal endometriosis seems difficult, a cautious preoperative diagnosis is required to select treatments including minimally invasive surgery.

关键词： Intestinal endometriosis Preoperative diagnosis Laparoscopy-assisted surgery

Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer

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World Journal of Gastroenterology 2016年第8期22卷 2503-2511页

作者： Dai Shida Satoru Inoue Yuki yoshida atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji Colorectal Surgery Division National Cancer Center Hospital Department of Surgery Tokyo Metropolitan Bokutoh Hospital Department of Microbiology Hoshi University School of Pharmaceutical Sciences

AIM: To examine the expression of SphK1, an oncogenic kinase that produces sphingosine 1-phosphate (S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid (LPA) receptor overexpressed in various cancers, in human colorectal ***: Real-time reverse-transcription polymerase chain reaction was used to measure the mRNA expression of SphK1, LPAR2, and the three major S1P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of SphK1 and ***: Colorectal cancer tissue in 22 of 27 patients had higher levels of SphK1 mRNA than in normal tissue. In two-thirds of the samples, SphK1 mRNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 mRNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between SphK1 and LPAR2 expression [Pearson’s correlation coefficient (r) = 0.784 and P < 0.01]. The mRNA levels of SphK1 and LPAR2 did not correlate with TNM ***: Our findings suggest that S1P and LPA may play important roles in the development of colorectal cancer via the upregulation of SphK1 and LPAR2, both of which could serve as new therapeutic targets in the treatment of colorectal cancer.

关键词： Sphingosine kinase 1 Lysophosphatidic acid receptor 2 Carcinogenesis Colorectal cancer Sphingosine 1-phosphate

New insights into the roles for DYRK family in mammalian development and congenital diseases

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Genes & Diseases 2023年第3期10卷 758-770页

作者： Saishu yoshida Kiyotsugu yoshida Department of Biochemistry The Jikei University School of MedicineMinato-kuTokyo 1058461Japan

The dual-specificity tyrosine-regulated kinase (DYRK) family is evolutionarily conserved from invertebrate to mammals. DYRKs regulate cell proliferation, apoptosis, survival, and differentiation by modifying the protein activation state, cellular localization, and turnover. In contrast to several studies in cellular models, the available evidence regarding the in vivo roles of DYRKs in mammalian development is limited. This review summarizes the in vivo studies on Dyrks which provide insight into their roles in mammalian tissue development and congenital diseases. In vivo evidence obtained using knockout and genetically modified animals helps to understand and develop novel clinical therapies and drug for human congenital diseases, such as Down syndrome and neuronal disorders (associated with DYRK1A) and skeletal ciliopathies (associated with DYRK2).

关键词： Ciliopathies Development Down syndr ome DYRKS Embryogenesis

Evaluation of prognostic factors and scoring system in colonic perforation

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World Journal of Gastroenterology 2007年第23期13卷 3228-3231页

作者： atsushi Horiuchi Yuji Watanabe Takashi Doi Kouichi Sato Syungo Yukumi Motohira yoshida Yuji Yamamoto Hiroki Sugishita Kanji Kawachi Department of Surgery 2 Ehime University School of Medicine

AIM: To study the significance of scoring systems assessing severity and prognostic factors in patients with colonic perforation. METHODS: A total of 26 patients (9 men, 17 women; mean age 72.7 ± 11.6 years) underwent emergency operation for colorectal perforation in our institution between 1993 and 2005. Several clinical factors were measured preoperatively and 24 h postoperatively. Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), Mannheim peritonitis index (MPI) and peritonitis index of Altona (PIA Ⅱ) scores were calculated preoperatively. RESULTS: Overall postoperative mortality rate was 23.1% (6 patients). Compared with survivors, non- survivors displayed low blood pressure, low serum protein and high serum creatinine preoperatively, and low blood pressure, low white blood cell count, low pH, low PaO2/FiO2, and high serum creatinine postoperatively. APACHE Ⅱ score was significantly lower in survivors than in non-survivors (10.4 ± 3.84 vs 19.3 ± 2.87, P = 0.00003). Non-survivors tended to display high MPI score and low PIA Ⅱ score, but no signif icant difference was identif ied. CONCLUSION: Pre- and postoperative blood pressure and serum creatinine level appear related to prognosis of colonic perforation. APACHE Ⅱ score is most associated with prognosis and scores ≥ 20 are associated with signif icantly increased mortality rate.

关键词： Scoring system Colonic perforation Prognostic factor

Incidence and localization of lymphoid follicles in early colorectal neoplasms

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World Journal of Gastroenterology 2005年第43期11卷 6863-6866页

作者： Kuang-I Fu Yasushi Sano Shigeharu Kato Takahiro Fujii Ikura Koba Takayuki Yoshino atsushi Ochiai Shigeaki yoshida Takahiro Fujimori Division of Gastrointestinal Oncology and Digestive Endoscopy Division of Pathology Department of Surgical and Molecular Pathology

AIM： TO investigate the incidence and Iocalizations of lymphoid follicles （LFs） in early colorectal neoplasms in human beings. METHODS： From July 1992 to September 1999, a total of 1 324 early colorectal neoplasms were removed endoscopically or surgically at our hospital; 1 031 （77.9%） were available for analysis in this study. Localization of LFs was defined histologically： as submucosal LFs, if located under the muscularis mucosa; and as intramucosal LFs, if located across or over the muscularis RESULTS： Histologically, the materials included 903 intramucosal neoplasms and 128 submucosal cancers. Overall incidence of LFs was 27.2% （280/1 031）. The incidence of LFs was significantly higher in females （33.6% vs 24.9%, P = 0.0064）, the right-sided colon （32.2% vs 25.6%, P = 0.0403） and in flat or depressed type lesions （34.6% vs 25.2%, P〈O.O001） as compared to males, left-sided colon and protruding type lesions, respectively. The incidences of intramucosal neoplasms and submucosal cancers were 24.3% and 43.8%, respectively （P〈O.O001）. Localizations of LFs （intramucosal LF/submucosal LF） in depressed, flat, and protruding types were 1/24, 14/36, and 131/74, respectively. CONCLUSION： The incidence of LFs in early human colorectal neoplasms significantly differs by gender, location, macroscopic type, and histology. Moreover,localization significantly differs by macroscopic type.

关键词： Lymphoid follicle Early colorectal neoplasm Carcinogenesis

Clinical characteristics and management of gastric tube cancer with endoscopic submucosal dissection

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World Journal of Gastroenterology 2015年第3期21卷 919-925页

作者： Michita Mukasa Hidetoshi Takedatsu Ken Matsuo Hiroaki Sumie Hikaru yoshida atsushi Hinosaka Yasutomo Watanabe Osamu Tsuruta Takuji Torimura Division of Gastroenterology Department of MedicineKurume University School of Medicine67 Asahi-machiKurumeFukuoka 830-0011Japan

AIM:To identify the characteristics of gastric tube cancer(GTC) and the complications associated with endoscopic submucosal dissection(ESD) for ***:Between 2007 and 2012,11 individualswith early gastric cancer in the reconstructed gastric tube after esophagectomy who underwent ESD in this hospital were *** characteristics of GTC were identified,and the complications of ESD for GTC were analyzed at three phases:preoperative,intraoperative,and ***:A total of 11 consecutive patients with 11 GTCs were selected for this *** cases underwent en bloc resections by *** median procedure time was 142 *** average GTC diameter was 26.1 mm,and the average size of the resected lesions was 45.5 *** histopathological diagnosis in all cases was a differentiated *** the preoperative phase,anastomotic strictures(5/11,45%) and food residues(4/11,36.4%) in the gastric tube were the main *** the intraoperative phase,bleeding was observed in 5 cases(45%).The postoperative complications observed were delayed bleeding in 2 cases(18.2%) and stenosis in one case(9.1%).The case with stenosis was successfully treated using endoscopic balloon ***:Minor complications were frequently ***,all GTCs underwent en bloc resection with ESD without any serious *** is considered a useful treatment for GTC.

关键词： Gastric tube cancer Endoscopic submucosal dissecti

Comparison of Damages on Tungsten Surface Exposed to Noble Gas Plasmas

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Plasma Science and Technology 2013年第3期15卷 282-286页

作者： Miyuki YAJIMA Masato YAMAGIWA Shin KAJITA Noriyasu OHNO Masayuki TOKITANI Arimichi TAKAYAMA Seiki SAITO atsushi M.ITO Hiroaki NAKAMURA Naoaki yoshida Department of Energy Engineering and Science Graduate School of EngineeringNagoya University EcoTopia Science Institute Research Institute for Applied Mechanics Kyushu University International Research Center for Nuclear Material Science Institute for Material ResearchTohoku University

Tungsten was exposed to pure Ar or Ne plasmas over 1550 K at several incident ion energies. Even under the irradiation condition that the tungsten nanostructure is formed by He plasma irradiation, holes/bubbles and fiberform nanostructures were not formed on the surface by exposure to Ar or Ne plasmas. In addition, the results from energy dispersive X-ray spectroscopy supported the facts that Ar and Ne did not remain in the sample. We will discuss the reason for the differences in the damage to the tungsten surface exposed to noble gas plasmas.

关键词： plasma-material interaction tungsten noble gas plasmas

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World Journal of Gastroenterology 2015年第33期21卷 9808-9816页

作者： Eriko Nakano atsushi Kanno atsushi Masamune Naoki yoshida Seiji Hongo Shin Miura Tetsuya Takikawa Shin Hamada Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Keisuke Nakayama Fumiyoshi Fujishima Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Division of Nephrology Endocrinology and Vascular MedicineTohoku University Graduate School of Medicine Department of Pathology Tohoku University Graduate School of Medicine

A 50-year-old male was referred to our hospital for the evaluation of *** positron emission tomography revealed high fluorodeoxyglucose uptake in the pancreas,bilateral lacrimal glands,submandibular glands,parotid glands,bilateral pulmonary hilar lymph nodes,and *** data showed an elevation of hepatobiliary enzymes,renal dysfunction,and remarkably high immunoglobulin(Ig) G levels,without elevated serum *** computed tomography revealed swelling of the pancreatic head and bilateral *** retrograde cholangiopancreatography showed an irregular narrowing of the main pancreatic duct in the pancreatic head and stricture of the lower common bile *** examination by endoscopic ultrasonography-guided fine-needle aspiration revealed findings of lymphoplasmacytic sclerosing pancreatitis without IgG4-positive plasma *** laboratory values and the swelling of several organs were improved by the treatment with *** patient was diagnosed as having type 1 autoimmune pancreatitis(AIP) based on the International Consensus Diagnostic ***,we encountered a case of compatible type 1 AIP without elevated levels of serum IgG4 or IgG4-positive plasma *** case suggests that AIP phenotypes are not always associated with IgG4.

关键词： IgG4-related disease Steroid Intestinal nephritis

Primary signet-ring cell carcinoma of the colon at early stage: A case report and a review of the literature

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World Journal of Gastroenterology 2006年第21期12卷 3446-3449页

作者： Kuang-I Fu Yasushi Sano Shigeharu Kato Hiroki Saito atsushi Ochiai Takahiro Fujimori Yutaka Saito Takahisa Matsuda Takahiro Fujii Shigeaki yoshida Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East KashiwaChiba 277-8577Japan Department of Surgical and Molecular PathologyDokkyo University School of Medicine880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East KashiwaChiba 277-8577Japan Division of Pathology National Cancer Center East Research Institute Chiba 277-8577Japan Department of Surgical and Molecular Pathology Dokkyo University School of Medicine 880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan Division of Endoscopy National Cancer Center Hospital TsukijiTokyo 104-0045Japan

A 67-year-old man, who had undergone surgery to resect multiple gastric cancers 4 years ago, visited our hospital for surveillance colonoscopy. Colonoscopy revealed a discolored, 7-mm in diameter, flat-elevated lesion with central depression in the transverse colon near the splenic flexure. Although the findings of endoscopy and barium enema were suggestive of submucosal invasion, the patient chose to undergo endoscopic mucosal resection. Pathological examination of the resected specimen revealed signet-ring cell carcinoma and a positive surgical margin. A second operation was performed, and no residual tumor or metastasis to lymph nodes was found in the resected specimens. Primary colorectal cancers composed of signet-ring cell carcinoma detected and treated at an early stage are extremely rare. We present a case and review the literature.

关键词： Signet-ring cell carcinoma Early colorectal cancer Endoscopic mucosal resection