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Inverse correlation between reactive oxygen species in unwashed semen and sperm motion parameters as measured by a computer-assisted semen analyzer

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Asian Journal of Andrology 2017年第3期19卷 350-354页

作者： Teppei Takeshima Yasushi Yumura Kengo yasuda Hiroyuki Sanjo Shinnosuke Kuroda Hiroyuki Yamanaka Akira Iwasaki Department of Urology Reproductive Center Yokohama City University Medical Center Yokohama Kanagawa Japan YMRAC Urology Office Yokohama Kanagawa Japan.

This study investigated the correlation between sperm motion parameters obtained by a computer-assisted semen analyzer and levels of reactive oxygen species in unwashed semen. In total, 847 patients, except for azoospermic patients were investigated. At the time of each patient＇s first consultation, semen parameters were measured using SMASTM or CellSoft 3000TM, and production of reactive oxygen species was measured using a computer-driven LKB Wallac Luminometer 1251 Analyzer. The patients were divided into two groups： reactive oxygen species - positive and negative. The semen parameters within each group were measured using one of the two computer-assisted semen analyzer systems and then compared. Correlations between reactive oxygen species levels and sperm motion parameters in semen from the reactive oxygen species - positive group were also investigated. Reactive oxygen species were detected in semen samples of 282 cases （33.3%）. Sperm concentration （P 〈 0.01; P 〈 0.01）, motility （P 〈 0.01; P 〈 0.05）, and progressive motility （P 〈 0.01; P 〈 0.01） were markedly lower in the reactive oxygen species - positive group than in the reactive oxygen species - negative group. Among the sperm motion parameters in the reactive oxygen species - positive group, sperm concentration （P 〈 0.01; P 〈 0.01）, motility （P 〈 0.05; P 〈 0.01）, mALH （P 〈 0.05; P 〈 0.01）, and progressive motility （P 〈 0.05; P 〈 0.01） also showed inverse correlations with the logarithmic transformed reactive oxygen species levels. Therefore, this study demonstrated that excessive reactive oxygen species in semen damage sperm concentration, motility, and other sperm motion parameters.

关键词： oxidative stress reactive oxygen species semen analysis sperm motility

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Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: A case report

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World Journal of Gastroenterology 2008年第35期14卷 5474-5477页

作者： atsushi Takahashi Yukiko Kanno Yuta Takahashi Natsumi Sakamoto Kyoko Monoe Hironobu Saito Kazumichi Abe Junko Yokokawa atsushi Irisawa Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University School of MedicineFukushimaJapan

A 43-year-old woman with multiple sclerosis （MS） was treated with pulsed methylprednisolone and interferon 13 at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis （AIH）. She was successfully treated with corticosteroids. As ataxia developed after i year, she was treated with pulsed methylprednisolone for 3 days, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.

关键词： Multiple sclerosis Autoimmune hepatitis Pulsed methylprednisolone

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Multi-temporal monitoring of wheat growth by using images from satellite and unmanned aerial vehicle

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International Journal of Agricultural and Biological Engineering 2017年第5期10卷 1-13页

作者： Du Mengmeng Noguchi Noboru Itoh atsushi Shibuya Yukinori Graduate School of Agriculture Hokkaido UniversitySapporo 065-8589HokkaidoJapan Research Faculty of Agriculture Hokkaido UniversitySapporo 065-8589HokkaidoJapan Hokkaido Agricultural Research Center Memuro 082-0081HokkaidoJapan

Recently near-ground remote sensing using unmanned aerial vehicles(UAV)witnessed wide applications in obtaining field *** this research,four Rapideye satellite images and eight RGB images acquired from UAV were used from early June to the end of July,2015 covering two experimental winter wheat fields,in order to monitor wheat canopy growth status and analyze the correlation among satellite images based normalized difference vegetation index(NDVI)with UAV’s RGB images based visible-band difference vegetation index(VDVI)and ground variables of the sampled grain protein ***,through image interpretation of UAV’s multi-temporal RGB images with fine spatial resolution,the wheat canopy color changes could be intuitively and clearly ***,by monitoring the changes of satellite images based NDVI as well as VDVI values and UAV’s RGB images based VDVI values,the conclusions were made that these three vegetation indices demonstrated the same and synchronized trend of increasing at the early stage of wheat growth season,reaching up to peak values at the same timing,and starting to decrease since *** results of the correlation analysis between NDVI of satellite images and sampled grain protein contents show that NDVI has good predicative capability for mapping grain protein content before ripening growth stage around June7,2015,while the reliability of using satellite image based NDVI to predict grain protein contents becomes worse as ripening stage *** regression analysis between UAV’s RGB image based VDVI and satellite image based VDVI as well as NDVI showed good coefficients of *** is concluded that it is feasible and practical to temporally complement satellite remote sensing by using UAV’s RGB images based vegetation indices to monitor wheat growth status and to map within-field spatial variations of grain protein contents for small scale farmlands.

关键词： satellite remote sensing,UAV remote sensing,wheat growth monitoring,wheat lodging wheat protein content,multi-temporal images,NDVI

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Application of FEM Analysis to Braced Excavation

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Tsinghua Science and Technology 2008年第S1期13卷 40-45页

作者：李明飞 atsushi Nakamura 蔡飞 Keizo Ugai FORUM8 Co. Ltd. Department of Civil and Environmental Engineering Gunma University

It is becoming possible to do detailed numerical analyses for the various mechanical behavior of braced excavation by researching and developing the numerical analysis technique such as the finite element method (FEM). However, the mechanical behavior of braced excavation has not been clarified fully both in theory and in experience. Therefore, improving the prediction accuracy during the prior design is very important for making the observational method of braced excavation more effective. In this paper, FEM analyses were performed for a model of braced excavation by using Geotechnical Finite Element Elasto-plastic Analysis Software, GeoFEAS (2D). As the constitutive law of ground, MC-DP model, and Duncan-Chang model were applied. The results were compared and discussed with that of a site measurement, and the effects of the constitutive law of ground on the analyzed result were verified. For the difference between the results, the reason was investigated by the analyses adjusting the elastic modulus of ground, and the appropriate application of the constitutive law was researched.

关键词： numerical analysis retaining wall finite element method (FEM) constitutive law

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Diagnosis and therapeutic strategies for small bowel vascular lesions

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World Journal of Gastroenterology 2019年第22期25卷 2720-2733页

作者： Eiji Sakai Ken Ohata atsushi Nakajima Nobuyuki Matsuhashi Department of Gastroenterology NTT Medical Center TokyoTokyo 141-8625Japan Division of Gastroenterology and Hepatology Yokohama City University School of MedicineYokohama 236-0004Japan

Small bowel vascular lesions, including angioectasia (AE), Dieulafoy’s lesion (DL) and arteriovenous malformation (AVM), are the most common causes of obscure gastrointestinal bleeding. Since AE are considered to be venous lesions, they usually manifest as a chronic, well-compensated condition. Subsequent to video capsule endoscopy, deep enteroscopy can be applied to control active bleeding or to improve anemia necessitating blood transfusion. Despite the initial treatment efficacy of argon plasma coagulation (APC), many patients experience re-bleeding, probably because of recurrent or missed AEs. Pharmacological treatments can be considered for patients who have not responded well to other types of treatment or in whom endoscopy is contraindicated. Meanwhile, a conservative approach with iron supplementation remains an option for patients with mild anemia. DL and AVM are considered to be arterial lesions;therefore, these lesions frequently cause acute life-threatening hemorrhage. Mechanical hemostasis using endoclips is recommended to treat DLs, considering the high re-bleeding rate after primary APC cauterization. Meanwhile, most small bowel AVMs are large and susceptible to re-bleeding therefore, they usually require surgical resection. To achieve optimal diagnostic and therapeutic approaches for each type of small bowel lesion, the differences in their epidemiology, pathology and clinical presentation must be understood.

关键词： Angiodysplasia Angioectasia Dieulafoy's lesion Arteriovenous malformation Obscure gastrointestinal bleeding Video capsule endoscopy Deep enteroscopy Argon plasm coagulation

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Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells

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World Journal of Gastroenterology 2005年第22期11卷 3368-3374页

作者： atsushi Masamune Kazuhiro Kikuta Masahiro Satoh Noriaki Suzuki Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan

AIM: To clarify the effects of epigallocatechin-3-gallate (EGCG) on the platelet-derived growth factor (PDGF)-BB-induced proliferation and migration of pancreatic stellate cells (PSCs). METHODS: PSCs were isolated from rat pancreas tissue and used in their culture-activated, myofibroblast-like phenotype. Cell proliferation was assessed by measuring the incorporation of 5-bromo-2'-deoxyuridine. Cell migration was assessed using modified Boyden chambers. Cyclin D1, p21waf1, and p27kip1 expression and phosphorylation of PDGF β-receptor, extracellular signal-regulated kinase, and Akt were examined by Western blotting. Activation of phospha-tidylinositol 3-kinase was examined by kinase assay using phosphatidylinositol as a substrate. Cell cycle was assessed by flow cytometry after staining with propidium iodide. RESULTS: EGCG at non-cytotoxic concentrations inhibited PDGF-induced proliferation and migration. This effect was associated with the inhibition of cell cycle progression beyond the G1 phase, decreased cyclin Dl and increased p27kip1 expression. EGCG inhibited tyrosine phosphorylation of PDGF p-receptor and downstream activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/ Akt pathways. CONCLUSION: EGCG inhibited PDGFBB-induced proliferation and migration of PSCs through the inhibition of PDGFmediated signaling pathways.

关键词： Pancreatitis Pancreatic fibrosis Pancreatic stellate cells Epigallocatechin-3-gallate Green tea Platelet-derived growth factor Proliferation Migration

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中国与国际玉米价格的波动关系分析

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中国商论 2024年第1期 1-6页

作者：刘凯穆月英山崎雅人小池淳司商务部国际贸易经济合作研究院北京100710 中国农业大学经济管理学院北京100083 名古屋大学减灾合作研究中心日本名古屋4648601 神户大学工学部日本神户6578501

本文在政策分析的基础上,建立VAR-BEKK-GARCH模型进行实证分析。首先,国际玉米价格的波动幅度比中国价格波动幅度大,临储政策取消后,中国价格波动幅度变大。其次,临储期间,中国价格的预期波动可以影响国际价格的波动,而国际价格的随机... 详细信息

本文在政策分析的基础上,建立VAR-BEKK-GARCH模型进行实证分析。首先,国际玉米价格的波动幅度比中国价格波动幅度大,临储政策取消后,中国价格波动幅度变大。其次,临储期间,中国价格的预期波动可以影响国际价格的波动,而国际价格的随机波动可以影响中国价格的波动。在生产者补贴期间,中国价格的预期波动和随机波动均可影响国际价格的波动。再次,中国价格的影响力在中国市场和进口市场占据主导地位,与国产玉米供给本国市场的数量地位相符。最后,中国玉米进口的不断增加将降低对本国市场价格的主导能力,需重视通过“期货+保险”规避价格风险,并分散玉米进口源,以提高市场主导力。

关键词：玉米价格波动价格风险波动溢出 VAR-BEKK-GARCH模型

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DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus

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World Journal of Gastroenterology 2014年第14期20卷 3916-3926页

作者： Keisuke Matsusaka Sayaka Funata Masashi Fukayama atsushi Kaneda Department of Molecular Oncology Graduate School of MedicineChiba University Department of Pathology Graduate School of MedicineThe University of Tokyo CREST Japan Science and Technology Agency

Gastric cancer is a leading cause of cancer death worldwide,and significant effort has been focused on clarifying the pathology of gastric *** particular,the development of genome-wide analysis tools has enabled the detection of genetic and epigenetic alterations in gastric cancer;for example,aberrant DNA methylation in gene promoter regions is thought to play a crucial role in gastric *** etiological viewpoint is also essential for the study of gastric cancers,and two distinct pathogens,Helicobacter pylori(***)and Epstein-Barr virus(EBV),are known to participate in gastric *** inflammation of the gastric epithelium due to *** infection induces aberrant polyclonal methylation that may lead to an increased risk of gastric *** addition,EBV infection is known to cause extensive methylation,and EBV-positive gastric cancers display a high methylation epigenotype,in which aberrant methylation extends to not only Polycomb repressive complex(PRC)-target genes in embryonic stem cells but also non-PRC-target ***,we review aberrant DNA methylation in gastric cancer and the association between methylation and infection with *** and EBV.

关键词： Gastric cancer Epigenetics DNA methylation Epstein-Barr virus Helicobacter pylori

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Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells

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World Journal of Gastroenterology 2005年第22期11卷 3385-3391页

作者： atsushi Masamune Masahiro Satoh Kazuhiro Kikuta Noriaki Suzuki Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan

AM: To clarify the role of Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway in platelet-derived growth factor (PDGF) induced proliferation in activated pancreatic stellate cells (PSCs). METHODS: PSCs were isolated from rat pancreas tissue, and used in their culture-activated, myofibroblast-like phenotype. STAT-specific binding activity was assessed by electrophoretic mobility shift assay. Activation of Src, JAK2, STAT1, STAT3, and ERK was determined by Western blotting using anti-phosphospecific antibodies. Cell proliferation was assessed by measuring the incorporation of 5-bromo-2'-deoxyuridine. RESULTS: PDGF-BB induced STAT-specific binding activity, and activation of Src, JAK2, STAT1, STAB, and ERK. Ethanol and acetaldehyde at clinically relevant concentrations decreased basal activation of JAK2 and STAT3. PDGF-induced activation of STAT1 and STAT3 was inhibited by a Src inhibitor PP1 and a JAK2 inhibitor AG490, whereas PDGF-induced activation of ERK was inhibited by PP1, and not by AG490. PDGF-induced proliferation was inhibited by PP1 and AG490 as well as by STAT3 antisense oligonucleotide. CONCLUSION: PDGF-BB activated JAK2-STAT pathway via Src-dependent mechanism. Activation of 3AK2-STAT3 pathway, in addition to ERK, may play a role in PDGF-induced proliferation of PSCs.

关键词： Pancreatitis Pancreatic fibrosis Pancreatic stellate cells Platelet-derived growth factor Janus kinase Signal transducers and activators of transcription

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Establishment and characterization of a rat pancreatic stellate cell line by spontaneous immortalization

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World Journal of Gastroenterology 2003年第12期9卷 2751-2758页

作者： atsushi Masamune Masahiro Satoh Kazuhiro Kikuta Noriaki Suzuki Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendaiJapan A.M.and M.S.equally contributed to this work

AIM: Activated pancreatic stellate cells (PSCs) have been implicated in the pathogenesis of pancreatic fibrosis and inflammation. Primary PSCs can be subcultured only several times because of their limited growth potential. A continuous cell line may therefore be valuable in studying molecular mechanisms of these pancreatic disorders. The aim of this study was to establish a cell line of rat PSCs by spontaneous ***: PSCs were isolated from the pancreas of male Wistar rats, and conventional subcultivation was performed repeatedly. Telomerase activity was measured using the telomere repeat amplification protocol. Activation of transcription factors was assessed by electrophoretic mobility shift *** of mitogen-activated protein (MAP) kinases was examined by Western blotting using anti-phosphospecific antibodies. Expression of cytokine-induced neutrophil chemoattractant-1 was determined by enzyme ***: Conventional subcultivation yielded actively growing cells. One clone was obtained after limiting dilution,and designated as SIPS. This cell line has been passaged repeatedly more than 2 years, and is thus likely *** cells retained morphological characteristics of primary,culture-activated PSCs. SIPS expressed α-smooth muscle actin, glial acidic fibrillary protein, vimentin, desmin, type Ⅰ collagen, fibronectin, and prolyl hydroxylases. Telomerase activity and p53 expression were negative. Proliferation of SIPS cells was serum-dependent, and stimulated with platelet-derived growth factor-BB through the activation of extracellular signal-regulated kinase. Interleukin-1β activated nuclear factor-κB, activator protein-1, and MAP ***-1β induced cytokine-induced neutrophil chemoattractant-1 expression through the activation of nuclear factor-κB and MAP ***: SIPS cells can be useful for in vitro studies of cell biology and signal transduction of PSCs.

关键词： Animals Base Sequence Cell Culture Techniques Cell Line, Transformed Cells, Cultured Cystic Fibrosis Cytoskeletal Proteins Extracellular Matrix Proteins Immunohistochemistry NF-kappa B Oligonucleotide Probes Pancreas Rats Research Support, Non-U.S. Gov't Transcription Factor AP-1

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