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CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis

Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 75-80页

作者： Tadafumi Asaoka atsushi miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda Mitsugu Sekimoto Shoji Nakamori Department of Surgery National Hospital Organization Osaka National Hospital

Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from ***: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December *** patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate ***: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL.

关键词： Pancreatic cancer CA19-9 Para-aortic lymph node

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Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients:A pilot study

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World Journal of Gastroenterology 2014年第30期20卷 10512-10517页

作者： Hirotoshi Ishiwatari Tsuyoshi Hayashi Makoto Yoshida Michihiro Ono Hiroyuki Masuko Tsutomu Sato Koji Miyanishi Yasushi Sato Rishu Takimoto Masayoshi Kobune atsushi miyamoto Tomoko Sonoda Junji Kato Department of Medical Oncology and Hematology Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Hospital Pharmacy Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Public Health Sapporo Medical University School of MedicineSapporo 0600061Japan

AIM: To investigate the effectiveness of phenol for the relief of cancer pain by endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN).

关键词： Celiac plexus neurolysis Celiac plexus blockade Endoscopic ultrasound Phenol Pain management Upper gastrointestinal cancer

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Comparison of 4-Weekly vs 3-Weekly Gemcitabine as Adjuvant Chemotherapy Following Curative Resection for Biliary Tract Cancer: A Prospective Randomized Controlled Trial

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Journal of Cancer Therapy 2011年第5期2卷 703-709页

作者： Shogo Kobayashi atsushi miyamoto Junzo Shimizu Masaki Kashiwazaki Yutaka Takeda Shigeyuki Ueshima Yongkook Kim Toru Kitagawa Keizo Dono Masaki Mori Yuichiro Doki Hiroaki Nagano 不详

Background: Surgery for biliary tract cancer, including pancreatoduodenectomy and major hepatectomy, is too aggressive and does not allow postoperative gemcitabine to be administered by the usual dosage protocol. We hypothesized that the feasibility of 3-weekly protocol (days 1 and 8, every 3 weeks) of adjuvant gemcitabine therapy may be superior to the usual 4-weekly protocol (days 1, 8, and 15 every 4 weeks). Method: We compared the outcomes of 6 cycles of the 4-weekly protocol and 9 cycles of the 3-weekly protocol in a prospective randomized setting. The primary endpoint was the completion rate, and the secondary endpoints were the adverse events and the recurrence-free survival rate. Results: Totally, 27 patients were enrolled. The protocol could be completed without any omittances and/or dose modifications in two patients (14%) of the 4-weekly protocol, and three patients (23%) of the 3-weekly protocol (p = 0.8099);grade 3/4 neutropenia occurred in almost all the remaining (70%) patients. The relative dose intensity was 72% in the 4-weekly protocol and 78% in the 3-weekly protocol. There was no significant difference in the recurrence-free survival rate. Conclusion: The 3-weekly protocol did not yield superior completion, adverse events or recurrence-free survival rates as compared to the 4-week protocol. Trial Registration: UMIN-CTR, UMIN000001020.

关键词： Biliary Tract Cancer Adjuvant Therapy Gemcitabine

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Imaging characteristics of hypervascular focal nodular hyperplasialike lesions in patients with chronic alcoholic liver disease

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World Journal of Gastroenterology 2025年第2期31卷 61-70页

作者： atsushi Urase Masakatsu Tsurusaki Ryohei Kozuki atsushi Kono Keitaro Sofue Kazunari Ishii Department of Radiology Kindai UniversityFaculty of MedicineOsakasayama 589-8511OsakaJapan Department of Radiology Kansai Medical University Medical CenterMoriguchi 570-8507OsakaJapan Department of Radiology Kobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Focal nodular hyperplasia(FNH)-like lesions are hyperplastic formations in patients with micronodular cirrhosis and a history of alcohol *** pathologically similar to hepatocellular carcinoma(HCC)lesions,they are *** such,it is important to develop methods to distinguish between FNH-like lesions and *** To evaluate diagnostically differential radiological findings between FNH-like lesions and *** We studied pathologically confirmed FNH-like lesions in 13 patients with alco-holic cirrhosis[10 men and 3 women;mean age:54.5±12.5(33-72)years]who were negative for hepatitis-B surface antigen and hepatitis-C virus antibody and underwent dynamic computed tomography(CT)and magnetic resonance imaging(MRI),including superparamagnetic iron oxide(SPIO)and/or gadoxetic acid-enhanced *** patients also underwent angiography-assisted *** The evaluated lesion features included arterial enhancement pattern,washout appearance(low density compared with that of surrounding liver parenchyma),signal intensity on T1-weighted image(T1WI)and T2-weighted image(T2WI),central scar presence,chemical shift on in-and out-of-phase images,and uptake pattern on gadoxetic acid-enhanced MRI hepatobiliary phase and SPIO-enhanced *** patients had multiple small lesions(<1.5 cm).Radiological features of FNH-like lesions included hypervascularity despite small lesions,lack of“corona-like”enhancement in the late phase on CT during hepatic angiography(CTHA),high-intensity on T1WI,slightly high-or iso-intensity on T2WI,no signal decrease in out-of-phase images,and complete SPIO uptake or incomplete/partial uptake of gadoxetic ***,similar to HCC,FNH-like lesions showed many unpaired arteries and sinusoidal *** Overall,the present study showed that FNH-like lesions have unique radiological findings useful for differential ***,SPIO-and/or gadoxetic acid-enhanced MRI and CTHA features might facili

关键词： Focal nodular hyperplasia Alcoholic liver disease Hepatocellular carcinoma Magnetic resonance imaging Liver

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Comparison of 4-Weekly vs 3-Weekly Gemcitabine as Adjuvant Chemotherapy Following Curative Resection for Biliary Tract Cancer: A Prospective Randomized Controlled Trial

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Journal of Cancer Therapy 2011年第5期

作者： Shogo Kobayashi atsushi miyamoto Junzo Shimizu Masaki Kashiwazaki Yutaka Takeda Shigeyuki Ueshima Yongkook Kim Toru Kitagawa Keizo Dono Masaki Mori Yuichiro Doki Hiroaki Nagano

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Frontier of continuous structural health monitoring system for short&medium span bridges and condition assessment

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 569-604页

作者： Ayaho miyamoto Risto KIVILUOMA Akito YABE Department of Civil Engineering Aalto UniversityAaltoFinland Sustainable Solutions Dept. KOZO KEIKAKU Eng.Inc.TokyoJapan

It is becoming an important social problem to make maintenance and rehabilitation of existing short and medium span(10-20 m)bridges because there are a huge amount of short and medium span bridges in service in the *** kernel of such bridge management is to develop a method of safety(condition)assessment on items which include remaining life and load carrying *** health monitoring using information technology and sensors is capable of providing more accurate knowledge of bridge performance than traditional *** aim of this paper is to introduce a state-of-the-art on not only a rational bridge health monitoring system incorporating with the information and communication technologies for lifetime management of existing short and medium span bridges but also a continuous data collecting system designed for bridge health monitoring of mainly short and medium span *** this paper,although there are some useful monitoring methods for short and medium span bridges based on the qualitative or quantitative information,mainly two advanced structural health monitoring systems are described to review and analyse the potential of utilizing the long term health monitoring in safety assessment and management issues for short and medium span *** first is a special designed mobile in-situ loading device(vehicle)for short and medium span road bridges to assess the structural safety(performance)and derive optimal strategies for maintenance using reliability based *** second is a long term health monitoring method by using the public buses as part of a public transit system(called bus monitoring system)to be applied mainly to short and medium span bridges,along with safety indices,namely,"characteristic deflection"which is relatively free from the influence of dynamic disturbances due to such factors as the roughness of the road surface,and a structural anomaly parameter.

关键词： condition assessment short&medium span bridge structural health monitoring(SHM) long-term data collection system maintenance bridge performance information technology loading vehicle(public bus) in-situ loading

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Role and limitations of rehabilitation-induced neural network remodeling after stroke

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Neural Regeneration Research 2018年第12期13卷 2087-2088页

作者： Naohiko Okabe Osamu miyamoto Second Department of Physiology Kawasaki Medical School

There is plenty of evidence that proves the beneficial and reliable effects of rehabilitation therapy,making it the most common treatment for patients with chronic *** is believed that rehabilitation improves functional recovery through neural network remodeling,which is observed as a motor map reorganization or functional connectivity change assessed by intracortical microstimulation or functional magnetic resonance imaging（MRI）.

关键词： Role and limitations of rehabilitation-induced neural network remodeling after stroke

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Recovery of Tungsten Surface with Fiber-Form Nanostructure by Plasmas Exposures

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Plasma Science and Technology 2013年第2期15卷 161-165页

作者： Takanori miyamoto Shuichi TAKAMURA Hiroaki KURISHITA Department of Electrical Engineering Faculty of EngineeringAichi Institute of TechnologyToyota 470-0392Japan International Research Center for Nuclear Materials Science IMRTohoku UniversityOaraiIbaraki 311-1313 Japan

One of the serious concerns for tungsten materials in fusion devices is the radiation defects caused by helium plasma irradiation since helium is a fusion product. The fiber-formed nanostructure is thought to have a possible weakness against the plasma heat flux on the plasma- facing component and also may destroy the reflectivity of optical mirrors. In this paper an inter- esting method for the recovery of such tungsten surfaces is shown. The recovery process depends on the grade and manufacturing process of tungsten materials.

关键词： helium defects tungsten plasma-surface interaction fiber-form nanostruc-ture surface recovery

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CONTROLLED SYNTHESIS OF AMPHIPHILIC BLOCK POLYMERS HAVING GLUCOSE RESIDUES AND THEIR STRUCTURE FORMATION

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Chinese Journal of Polymer Science 1999年第1期17卷 21-26页

作者： Takeaki miyamoto Masahiko Minoda Yoshinobu Tsujii Institute for Chemical Research Kyoto University Uji Kyoto 611 JapanInstitute for Chemical Research Kyoto University Uji Kyoto 611 JapanInstitute for Chemical Research Kyoto University Uji Kyoto 611 Japan

Vinyl ether (VE)-based amphiphilic block copolymers with D-glucose residues as hydrophilicpendants were synthesized by CH_3 CH(OiBu)Cl/ZnI_2-initiated sequential living cationic copolymerization of3-O-(vinyloxy)ethyl-1, 2:5, 6-di-O-isopropylidene-D-glucofuranose (IGVE) and isobutyl VE (IBVE ) andsubsequent deprotection. The precursor block copolymers had a narrow molecular weight distribution(M_w/M_n～1.1) and a controlled segmental composition. The solubility characteristics of the amphiphiliccopolymer depended strongly on composition. Their solvent-cast thin films were examined, under atransmission electron microscope, and could be seen to exhibit various microphase-separated surfacemorphologies such as spheres, cylinders, and lamellae, depending on composition. The amphiphiliccopolymers with the appropriate segmental composition were found to form a stable monolayer at the air-water interface, which was successfully transferred onto a substrate by the Langmuir-Blodgett (LB)technique. The layered strucfure of the built-up LB films was controlled by blending the homopolymer.

关键词： Glucose-substituted amphiphilic block polymer Controlled structure

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Seismic Response of Magnetically Levitated House

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Open Journal of Earthquake Research 2022年第1期11卷 1-17页

作者： Yuji miyamoto Takaharu Nakano atsushi Shimamura Kentaro Sho Department of Architecture and Civil Engineering Fukui University of Technology Fukui Japan Graduate School of Engineering Osaka University Osaka Japan Development Department Chemical Grouting Company Tokyo Japan

This study explored the seismic response of a house supporting base sides with a polymeric displacement control material and by magnetically levitating the foundation base. In this paper, we explore the possibility and efficacy of a seismic-isolated detached house as described above from both a shaking table experiment of model and three-dimensional finite element analysis. The seismic-isolated model showed stable response and its acceleration response was significantly reduced compared to the base-fixed model in the shaking table test. Three-dimensional finite element analysis was possible to simulate the experimental results. In the seismic response analysis of a full-scale detached house, the seismic-isolated model showed response reduction and its residual displacement was smaller than that of the sliding-base isolation model.

关键词： Seismic Response Reduction Magnetic Levitation Shaking Table Test 3D FEM

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