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Journal of Thermal Science 2009年第1期18卷 54-57页

作者： Manabu TAKAO Hideki KUMA Takao MAEDA Yasunari KAMADA Michiaki OKI atsushi minoda Department of Mechanical Engineering Matsue National College of Technology Department of Mechanical Engineering Mie University

The objective of this study is to show the effect of guide vane geometry on the performance. In order to overcomethe disadvantages of vertical axis wind turbine, a straight-bladed vertical axis wind turbine (S-VAWT) witha directed guide vane row has been proposed and tested by the authors. According to previous studies, it wasclarified that the performance of the turbine can be improved by means of the directed guide vane row. However,the guide vane geometry of S-VAWT has not been optimized so far. In order to clarify the effect of guide vanegeometry, the effects of setting angle and gap between rotor blade and guide vane on power coefficient and startingcharacteristic were investigated in the experiments. The experimental study of the proposed wind turbinewas carried out by a wind tunnel. The wind tunnel with a diameter of 1.8m is open jet type. The wind velocityis 8 m/s in the experiments. The rotor has three straight blades with a profide of NACA0018 and a chord lengthof 100 mm, a diameter of 0.6 m and a blade height of 0.7 m. The guide vane row consists of 3 arc plates.

关键词：换热计算涡轮叶片湍流模型函数计算

Detection of RB Germline Mutations Using Exon-by-exon Heteroduplex Analysis Compared with SSCP

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Eye Science 1996年第3期16卷 151-157页

作者： Kensei minoda Department of Ophthalmology Teikyo University Ichihara Hospital

Purpose: To compare heteroduplex analysis with SSCP and to develop a simple and effective method for mutational screening of RB *** and Methods: Leukocyte DNA was prepared from 12 unrelated Japanese patients with hereditary retinoblstoma. PCR combined with simultaneous nonisotopic heteroduplex and SSCP analysis was used to screen leukocyte DNA for such mutations, exon-by-exon, without the use of restriction endonu-clease digestion. PCR was conducted using 28 pairs of primers flanking all 27 ex-ons and the promoter region of the RB gene, with PCR products ranging from 159bp to 326bp. Mutations were identified by ***: Heterozygous germline mutations were detected in 8 of 12 Japanese patients. The mutations were identified by sequencing as follows; G→C/acceptor of exon 11, T insertion/codon 389, C→T/codon 455, 33bp insertion/codon 455 (C GA), G→T/codon 533, C→T/codon 579, C deletion/codon 674, and C→T/ codon ***: Our results suggest that small RB gene mutations

关键词： retinoblastoma gene mutation SSCP heteroduplex

CONTROLLED SYNTHESIS OF AMPHIPHILIC BLOCK POLYMERS HAVING GLUCOSE RESIDUES AND THEIR STRUCTURE FORMATION

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Chinese Journal of Polymer Science 1999年第1期17卷 21-26页

作者： Takeaki Miyamoto Masahiko minoda Yoshinobu Tsujii Institute for Chemical Research Kyoto University Uji Kyoto 611 JapanInstitute for Chemical Research Kyoto University Uji Kyoto 611 JapanInstitute for Chemical Research Kyoto University Uji Kyoto 611 Japan

Vinyl ether (VE)-based amphiphilic block copolymers with D-glucose residues as hydrophilicpendants were synthesized by CH_3 CH(OiBu)Cl/ZnI_2-initiated sequential living cationic copolymerization of3-O-(vinyloxy)ethyl-1, 2:5, 6-di-O-isopropylidene-D-glucofuranose (IGVE) and isobutyl VE (IBVE ) andsubsequent deprotection. The precursor block copolymers had a narrow molecular weight distribution(M_w/M_n～1.1) and a controlled segmental composition. The solubility characteristics of the amphiphiliccopolymer depended strongly on composition. Their solvent-cast thin films were examined, under atransmission electron microscope, and could be seen to exhibit various microphase-separated surfacemorphologies such as spheres, cylinders, and lamellae, depending on composition. The amphiphiliccopolymers with the appropriate segmental composition were found to form a stable monolayer at the air-water interface, which was successfully transferred onto a substrate by the Langmuir-Blodgett (LB)technique. The layered strucfure of the built-up LB films was controlled by blending the homopolymer.

关键词： Glucose-substituted amphiphilic block polymer Controlled structure

Advances in Management of Retinoblastoma

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眼科学报 1992年第1期8卷 28-33页

作者： Kensei minoda Department of Ophthalmology Ichihara HospitalTeikyo University 3426-3 AnesakiIchihara-CityChiba 299-01Japan

Retinobiastoma is a highly malignant intraocular tumor of children that requires accurate diagnosis to prompt treatment. This article reviewed clinical, pathological and follow-up data on 1 147 cases of retinobiastoma registered in Japan from 1975 to 1982. It is obvious that the prognosis of children with retinobiastoma has improved remarkably in recent years. The current advances in the management of the retinobiastoma were discussed.

关键词： Retinoblaslroma extraocular invasion cumulative incidence.

Single 5'green-3'red Hybrid Gene in Protanopia

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Eye Science 1996年第1期16卷 5-9页

作者： Kensei minoda Dapartment of Ophthalmology Teikyo University Ichihara HospitalJapan.

Purpose: To disclose the structure of visual pigment gene for a protanopia with specific ***: Exon 5 fragments of the red andgreen visual pigment genes from the protanopia with specific varnation as well as controls were amplified by poly-merase chain reaction (PCR). The PCR products were put through heteroduplex-SSCP analysis and PCR-RFLP (restriction fragement length polymorphism) analysis to clarify the specific variation. The specific variation of the exon 5 DNA fragment from the protanopia was identified by ***: A novel 5’green-3’red hybrid gene fragment without the normal red and green visual pigment gene was discovered in the protanopia. He should only have a single visual pigment gene, 5’green-3’red hybrid gene, on his X chromosome. The fusion point is between codon 285 and codon 296 in exon 5. Conclusion : Unequal intragenic recombination may occur in exon 5 as well as its upstream. A 5’green-3’red hybrid gene may present independently on the X chromosome without

关键词： color vision defects hybrid gene sequence

温轧细化亚晶7475铝合金板材的力学性能(英文)

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Transactions of Nonferrous Metals Society of China 2014年第7期24卷 2187-2195页

作者： Hiroki TANAKA Tadashi minoda Research and Development Center Sumitomo Light Metal Ind. Ltd.

研究了温轧下过渡元素对7475铝合金板材晶粒细化的影响。经350°C温轧、480°C固溶热处理后,用Zr代替Cr的7475铝合金具有稳定亚晶超细组织;平均亚晶直径接近3μm。结果表明,溶液中的Zr能稳定亚晶是因为温轧中析出了细小的Al3Zr粒子;另... 详细信息

研究了温轧下过渡元素对7475铝合金板材晶粒细化的影响。经350°C温轧、480°C固溶热处理后,用Zr代替Cr的7475铝合金具有稳定亚晶超细组织;平均亚晶直径接近3μm。结果表明,溶液中的Zr能稳定亚晶是因为温轧中析出了细小的Al3Zr粒子;另一方面,含Cr粒子化合物在温轧之前析出,并且在温轧过程中会变粗大。与传统冷轧7475铝合金板材相比,温轧细化亚晶板材具有独特的性能。固溶处理后的温轧板材,在厚度截面的亚晶组织具有高比例小于15°的小角度晶界;温轧T6态合金板材的强度高于传统7475铝合金板材强度10%。温轧铝合金板材最显著的特点是,在与轧制方向呈45°时高Lankford(r)值为3.5,而其平均Lankford(r)值为2.2。高Lankford(r)值有利于组织演变为β-fiber织构,特别是强{011}?211?黄铜部分。同时,温轧板材也具有高的抗应力腐蚀开裂性能(SCC)。根据Kikuchi线和透射电镜分析,温轧T6板材形成的小角度晶界导致无沉淀析出带(PFZs)难以形成,这是导致抗应力腐蚀开裂性能提高的重要因素,其原因是晶界和晶内的电化学性能存在差异。

关键词：温轧 Al-Zn-Mg-Cu 晶粒细化应力腐蚀开裂

全膝关节置换术中个性化截骨导板的设计改进提高了胫骨假体在冠状面和轴向平面上的对齐准确性

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中华医学杂志 2022年第1期102卷 20-20页

作者： Yamamura K minoda Y Sugama R 王鑫光(编译) 何宜蓁(编译) 田华(编译) 不详北京大学第三医院骨科

假体安放位置是影响全膝关节置换术(TKA)术后长期临床结果的最重要因素之一。为了改善假体安放位置,近年来基于患者MRI或CT数据的个性化截骨导板(PSI)被用于辅助TKA。但目前对于PSI的准确性仍然存在争议,尤其在胫骨假体安放方面,结论不... 详细信息

假体安放位置是影响全膝关节置换术(TKA)术后长期临床结果的最重要因素之一。为了改善假体安放位置,近年来基于患者MRI或CT数据的个性化截骨导板(PSI)被用于辅助TKA。但目前对于PSI的准确性仍然存在争议,尤其在胫骨假体安放方面,结论不一。在本项研究中,为了提高胫骨假体的安放准确性,对传统的PSI进行了以下3方面的改进:增加了胫骨与PSI之间的接触面积;在PSI上增加旋转定位标记.

关键词：胫骨假体安放位置临床结果全膝关节置换术冠状面定位标记 CT数据 TKA

Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 918-930页

作者： Mitsuru Esaki Kazuhiro Haraguchi Kazuya Akahoshi Naru Tomoeda Akira Aso Soichi Itaba Haruei Ogino Yusuke Kitagawa Hiroyuki Fujii Kazuhiko Nakamura Masaru Kubokawa Naohiko Harada Yosuke minoda Sho Suzuki Eikichi Ihara Yoshihiro Ogawa Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 8128582Japan Division of Gastroenterology and Hepatology Department of MedicineNihon University School of MedicineTokyo 1738610Japan Department of Gastroenterology Hara-Sanshin HospitalFukuoka 8120033Japan Department of Gastroenterology Aso Iizuka HospitalIizuka 8208502Japan Department of Gastroenterology Clinical Research InstituteNational Hospital Organization Kyushu Medical CenterFukuoka 8108564Japan Department of Gastroenterology Kitakyushu Municipal Medical CenterKitakyushu 8020077Japan Department of Gastroenterology Kyushu Rosai HospitalKitakyushu 8000296Japan Department of Internal Medicine Saiseikai Fukuoka General HospitalFukuoka 8100001Japan Department of Gastroenterology and Hepatology National Hospital Organization Fukuokahigashi Medical CenterKoga 81103195Japan Department of Gastroenterology and Metabolism Graduate School of Medicine SciencesKyushu UniversityFukuoka 8128582Japan

BACKGROUND The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors(SNADETs)is *** To compare the efficacy and safety of endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)for *** We retrospectively analyzed the data of patients with SNADETs from a database of endoscopic treatment for SNADETs,which included eight hospitals in Fukuoka,Japan,between April 2001 and October 2017.A total of 142 patients with SNADETs treated with EMR or ESD were *** score matching was performed to adjust for the differences in the patient characteristics between the two *** analyzed the treatment outcomes,including the rates of en bloc/complete resection,procedure time,adverse event rate,hospital stay,and local or metastatic *** Twenty-eight pairs of patients were *** characteristics of patients between the two groups were similar after *** EMR group had a significantly shorter procedure time and hospital stay than those of the ESD group[median procedure time(interquartile range):6(3-10.75)min vs 87.5(68.5-136.5)min,P<0.001,hospital stay:8(6-10.75)d vs 11(8.25-14.75)d,P=0.006].Other outcomes were not significantly different between the two groups(en bloc resection rate:82.1%vs 92.9%,P=0.42;complete resection rate:71.4%vs 89.3%,P=0.18;and adverse event rate:3.6%vs 17.9%,P=0.19,local recurrence rate:3.6%vs 0%,P=1;metastatic recurrence rate:0%in both).Only one patient in the ESD group underwent emergency surgery owing to intraoperative *** EMR has significantly shorter procedure time and hospital stay than ESD,and provides acceptable curability and safety compared to ***,EMR for SNADETs is associated with lower medical costs.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Superficial non-ampullary duodenal epithelial tumor Short-term Outcome Propensity score matching

Assistant skill in gastric endoscopic submucosal dissection using a clutch cutter

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World Journal of Gastrointestinal Surgery 2021年第2期13卷 116-126页

作者： Mitsuru Esaki Toshiki Horii Ryoji Ichijima Masafumi Wada Seiichiro Sakisaka Shuichi Abe Naru Tomoeda Yusuke Kitagawa Kei Nishioka Yosuke minoda Shinichi Tsuruta Sho Suzuki Hirotada Akiho Eikichi Ihara Yoshihiro Ogawa Takuji Gotoda Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Division of Gastroenterology and Hepatology Department of MedicineNihon University School of MedicineTokyo 101-8309Japan Department of Gastroenterology Kitakyushu Municipal Medical CenterKitakyushu 802-0077FukuokaJapan Department of Internal Medicine Saiseikai Fukuoka General HospitalFukuoka 810-0001Japan Department of Gastroenterology Hara-Sanshin HospitalFukuoka 812-0033Japan Department of Gastroenterology Clinical Research InstituteNational Hospital Organization Kyushu Medical CenterFukuoka 810-0065Japan Department of Anatomic Pathology Kyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology and Metabolism Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan

BACKGROUND A clutch cutter is a scissor-type knife used in endoscopic submucosal dissection(ESD)for gastrointestinal tract *** assistant during the ESD using a clutch cutter(ESD-C)needs to rotate the device and grasp the target tissue appropriately;therefore,the assistant’s skill may affect the technical outcomes of *** To determine how assistant skill level affected the technical outcomes of gastric ESD-C using an ex vivo porcine training *** In this pilot study,mock lesions of 15-30 mm in diameter were created in the middle or lower third of the porcine stomach.A total of 32 ESD-C procedures were performed by 16 *** trainee operator performed two ESD-C procedures;one ESD-C was assisted by an expert(ESD-C-E),and the other was assisted by a non-expert(ESD-C-NE).The total procedure time of the ESD was set as the primary outcome,and en bloc resection rate,complete procedure rate,perforation rate,and each procedure time/speed for mucosal incision or submucosal dissection were set as the secondary *** addition,we investigated factors associated with the difficulty of ESD including incompletion of ESD procedure,a long procedure time(≥20 min)or intraoperative *** The median total procedure time of the ESD-C-E was significantly shorter than that of the ESD-C-NE(12.9 min vs 21.9 min,P=0.001).The en bloc resection rate was 100%in both *** resection rates of the ESD-C-E and ESD-C-NE groups were 100%and 93.8%,*** intraoperative perforation was observed in both *** the multivariate analysis,assistant skill was significantly associated with the difficulty of ESD,with the highest odds ratio of *** Assistance by an expert is an important factor when trainees perform ESD-C procedures.

关键词： Endoscopic submucosal dissection Porcine training model Clutch cutter Assistant Skill level

Clutch Cutter knife efficacy in endoscopic submucosal dissection for early gastric neoplasms

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World Journal of Gastrointestinal Oncology 2018年第12期10卷 487-495页

作者： Yasuyo Hayashi Mitsuru Esaki Sho Suzuki Eikichi Ihara Azusa Yokoyama Seiichiro Sakisaka Taizo Hosokawa Yoshimasa Tanaka Takahiro Mizutani Shinichi Tsuruta Aya Iwao Shun Yamakawa Akira Irie Yosuke minoda Yoshitaka Hata Haruei Ogino Hirotada Akiho Yoshihiro Ogawa Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu University Department of Gastroenterology Kitakyushu Municipal Medical Center Division of Gastroenterology and Hepatology Department of MedicineNihon University School of Medicine Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University

AIM To compare the outcomes of endoscopic submucosal dissection(ESD) for gastric neoplasms using Clutch Cutter(ESD-C) or other knives(ESD-O).METHODS This was a single-center retrospective study. Gastric neoplasms treated by ESD between April 2016 and October 2017 at Kitakyushu Municipal Medical Center were reviewed. Multivariate analyses and propensity score matching were used to reduce biases. Covariates included factors that might affect outcomes of ESD, including age, sex, underlying disease, anti-thrombotic drugs use, tumor location, tumor position, tumor size, tumor depth, tumor morphology, tumor histology, ulcer(scar), and operator skill. The treatment outcomes were compared among two groups. The primary outcome was ESD procedure time. Secondary outcomes were en bloc, complete, and curative resection rates, and adverse events rates including perforation and delayed *** A total of 155 patients were included in this study; 44 pairs were created by propensity score matching. Background characteristics were quite similar among two groups after matching. Procedure time was significantly shorter for ESD-C(median; 49 min) than for ESD-O(median; 88.5 min)(P < 0.01). However, there was no significant difference in treatment outcomes between ESD-C and ESD-O including en bloc resection rate(100% in both groups), complete resection rate(100% in both groups), curative resection rate(86.4% vs 88.6%, P = 0.730), delayed bleeding(2.3% vs 6.8%, P = 0.62) and perforation(0% in both groups).CONCLUSION ESD-C achieved shorter procedure time without an increase in complication risk. Therefore, ESD-C could become an effective ESD option for gastric neoplasms.

关键词： Endoscopic submucosal dissection Clutch Cutter Gastric neoplasm Knife Propensity score