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Journal of Earth Science 2013年第2期24卷 145-156页

作者： ito Tsuyoshi 张磊冯庆来 matsuoka atsushi State Key Laboratory for Geological Processes and mineral Resources China University of Geosciences Graduate School of Science and Technology Niigata University Department of Geology Faculty of ScienceNiigata University

The Gujingling （古井岭） Section in Xiaodong （小董）, Guangxi （广西） Zhuang Autonomous Region, China, consists of cherts and siliceous siltstones, which belongs to the Bancheng （板城）Formation of the Qinzhou （钦州） allochthon. Three successive radiolarian assemblage-zones related to the Guadalupian （middle Permian） appear in the section in the following ascending order： Pseudoalbaillella sp. aff. Pseudoaibailleila longicornis-Pseudoalbaillella fusiformis, Follicucuilus monacanthus, and Follicucuilus scholasticus-Foilicucullus porrectus. The radiolarian content in this section is generally greater than that of sponge spicules. The radiolarian fauna commonly consists of abundant Albaillellaria and spherical radiolaria with minor Latentifistularia and Entactinaria. The sponge fauna is composed mainly of hexactinellids with minor demosponges. These siliceous fossil faunal features, comparable with those in a deep basin of the western belt of the Phosphoria Basin in the western United States, indicate that the Bancheng Formation in the Gujingling Section was deposited in a basin deeper than 1 000 m. The siliceous siltstones in the section are characterized by inclusion of silt-sized quartz and no inclusion of sand-sized materials, suggesting that the Gujingling Section was located at least a few hundred kilometers from the South China Block in the Guadalupian.

关键词： radiolarian fossil sponge spicule Guadalupian (middle Permian) Bancheng Formation Qinzhou allochthon paleobathymerry.

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Wind Tunnel Study on Wind and Turbulence Intensity Profiles in Wind Turbine Wake

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Journal of Thermal Science 2011年第2期20卷 127-132页

作者： Takao mAEDA Yasunari KAmADA Junsuke mURATA Sayaka YONEKURA Takafumi ito atsushi OKAWA Tetsuya KOGAKI Division of mechanical Engineering Mie University National Institute of Advanced Industrial Science and Technology

In recent years, there has been a rapid development of the wind farms in Japan. It becomes very important to investigate the wind turbine arrangement in wind farm, in order that the wake of one wind turbine does not to interfere with the flow in other wind turbines. In such a case, in order to achieve the highest possible efficiency from the wind, and to install as many as possible wind turbines within a limited area, it becomes a necessity to study the mutual interference of the wake developed by wind turbines. However, there is no report related to the effect of the turbulence intensity of the external flow on the wake behind a wind turbine generated in the wind tunnel. In this paper, the measurement results of the averaged wind profile and turbulence intensity profile in the wake in the wind tunnel are shown when the turbulence intensity of the external wind was changed. The wind tunnel experiment is performed with 500mm-diameter two-bladed horizontal axis wind turbine and the wind velocity in wake is measured by an I-type hot wire probe. As a result, it is clarified that high turbulence intensities enable to the entrainment of the main flow and the wake and to recover quickly the velocity in the wake.

关键词： Horizontal axis wind turbine Wake Wind profile Turbulence intensity Power output

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Excitation mechanism of Surface Plasmon Polaritons for Surface Plasmon Sensor With 1D metal Grating Structure for High Refractive Index medium

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Photonic Sensors 2019年第1期9卷 11-18页

作者： atsushi mOTOGAito Yusuke ito Graduate School of Engineering Mie UniversityMie 514-8507Japan Iga Satellite Mie UniversityMie 518-0131Japan

The excitation mechanism of surface plasmon polaritons(SPPs)in a surface plasmon sensor with a one-dimensional(1D)Au diffraction grating on a glass substrate is studied *** sensitivity of the sensor for application to a refractometer is also *** SPPs are excited at the following two types of interface:one between the Au grating and the glass substrate and the other between the Au grating and the *** simulation data for the transmittance spectra and the transmittance mapping are consistent With the experimental data even when the refractive index of the solution medium is ***,the excitation mechanism of the SPPs in a surface plasmon sensor is capable of detecting the medium(n=1.700),in which the sensor is used and clarified.

关键词： Surface plasmon diffraction grating high refractive index chemical sensor

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Conversion of glycerol to acrolein by mesoporous sulfated zirconia-silica catalyst

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Chinese Journal of Catalysis 2017年第3期38卷 420-425页

作者： Hirokazu Kobayashi Shogo ito Kenji Hara atsushi Fukuoka 北海道大学触媒科学研究所日本北海道札幌001-0021 北海道大学综合化学院日本北海道札幌060-8628 东京工科大学工学部日本东京八王子192-0982

A mesoporous sulfated zirconia-silica catalyst bearing only Br？nsted acid sites converted glycerol to acrolein in 81%yield with 82% *** time yield as high as 9.0 mmol h^（-1） g_（cat）^（-1） was achieved even at a low reaction temperature of 523 *** catalytic activity and selectivity were higher than those of typical sulfated *** is proposed that the milder acidity due to dilution of zirconium species by silica and large pore size for faster diffusion contributed towards the better catalytic performance.

关键词： Acrolein Glycerol mesopore Sulfated zirconia

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词： Galerkin methods