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Different characteristics of 40 kinds of free amino acids and 5-amino levulinic acid between wines and sakes(Japanese rice wines)

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Journal of Future Foods 2024年第4期4卷 361-368页

作者： Tohru kimura Laboratory of Animal Science Joint Faculty of Veterinary MedicineYamaguchi UniversityYamaguchi 753-8515Japan

Based on a systemic analysis for the globa1 burden of disease study from 1990 to 2016,the Global Burden of Diseases(GBD)2016 Alcohol Collaborators reported that alcohol use was a 1eading nisk factor for globa1 disease burden and caused substantial health ***,alcoholic dnink(wines and sakes)contains abundant nutrients,particularly fermentable amino acids denived from grapes and *** acid nutrition and metabolism is strongly associated with health and preventiom against various *** purpose of this study was to elucidate 40 kinds of free amino acid(FAA)profles in wines and *** addition,the present study also provided the contents of 5-aminolevulinic acid(5-AI A)involved in the vital functionality of *** were detected and analyzed by use of an automatic amino acid *** amino acid,branched chain amino acid and Fischer ratio were calculated for each ***1 FAAs showed significant differences between wines and *** abundantly contained almost all FAAs whereas wines had just a lttle content in some *** were rich in arginine,glycine,alanine,valine,glutamic acid and leucine,while wines were remarkably nich in proline(Pro).Wines showed increased FAA levels in 6 kinds of variables(4-hydroxyproline,3-methy1 histidine,B-alanine,a-aminobutyric acid,Pro and a.-aminoadipic acid).In functionally characteristic FAAs,both wines and sakes were considerably abundant in y aminobutynic acid and 5-AI A The total amount of aromatic amino acid and branched chain amino acid were markedly higher in sakes than in *** results revealed that there were the apparent different characteristics in FAA profiles between wines and *** difference resulted from fermentation process in wines(single fermentation)and sakes(paralle1 double fermentation).Forty kinds of FAA profiles are more usefu1 in investigating characteristics of the taste of wines and *** future,detailed FAA analysis has the potential to fi

关键词： Fermentation 5-Amino levulinic acid Free anino acids γ-Aminobutyric acid Sake Wine

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Rate of social anxiety disorder, its comorbidity with depression and paroxetine effects in outpatients in Japan

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Open Journal of Psychiatry 2013年第1期3卷 191-194页

作者： Yukihiko Shirayama Michio Takahashi Masatoshi Suzuki atsushi kimura Koichi Sato Department of Psychiatry Teikyo University Chiba Medical Center Ichihara Japan

The prevalence of persons with social anxiety disorder (SAD) in Japan remains unknown. This study examined 293 patients with age between 20 and 60 at first visit on the outpatient clinic of psychiatry by the section of social phobia of M.I.N.I. and DSM-IV. After that, 10 patients with both SAD out of 16 patients (trial recruited) completed 12 weeks of treatment with paroxetine. Among 63 patients with 4 points and 40 patients with 3 points on the M.I.N.I., 21 patients (33%) and 16 patients (40%) were diagnosed as SAD on DSM-IV criteria, respectively. Together, 37 patients (12.6%) were diagnosed as SAD out of the 293 outpatients. Among 37 patients with SAD, 23 patients (62%) had comorbid depression. As for 10 patients after treatment with paroxetine, 8 patients improved from the point of recovery of depression (HAM-D scores below 10), whereas only 4 patients improved from the point of recovery of social phobia (L-SAS scores below 30). Three points as well as 4 points on the M.I.N.I. is meaningful for the diagnosis of SAD. For a while, paroxetine exerted less beneficial effects on SAD rather than on depression.

关键词： Social Anxiety Disorder Depression Paroxetine Comorbidity

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用于旋翼飞机开发研究的多分野解析框架

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第1期41卷 43-52页

作者： TANABE Yasutada SUGAWARA Hideaki kimura Keita 日本宇宙航空研究开发机构航空技术部日本东京181-0015

介绍了日本宇宙航空研究开发机构研发的用于旋翼飞机的多分野解析框架。Heli Design是在各种旋翼飞机初期概念设计时使用的软件;rFlight可以提供在各种飞行条件下的平衡解析和线性化飞行模型;rBET/RMT是基于叶片要素理论的低保真度空力... 详细信息

介绍了日本宇宙航空研究开发机构研发的用于旋翼飞机的多分野解析框架。Heli Design是在各种旋翼飞机初期概念设计时使用的软件;rFlight可以提供在各种飞行条件下的平衡解析和线性化飞行模型;rBET/RMT是基于叶片要素理论的低保真度空力解析软件,和rMode提供的结构模型结合,可以推测旋转翼的弹性变形和各种飞行条件下的空力负载;rFlow3D是基于CFD计算的高保真度数值模拟软件;rGrid系列自动网格构造工具为其提供简单的网格生成;基于rFlow3D的计算结果,r Noise可以预测在任何观测点的噪声。这些软件已经广泛地被应用在各种新型旋翼飞机的开发研究中,其计算精度也已被各种实验结果所应证。

关键词：旋翼飞机多分野解析高保真模拟设计工具

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NiCoZn/C@melamine sponge-derived carbon composites with high-performance electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2274-2286页

作者： Xiubo Xie Heshan Wang Hideo kimura Cui Ni Wei Du Guanglei Wu School of Environmental and Material Engineering Yantai University Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textiles College of Materials Science and Engineering Qingdao University

NiMZn/C@melamine sponge-derived carbon（MSDC） composites（M = Co, Fe, and Mn） were prepared by a vacuum pumping solution method followed by carbonization. A large number of carbon nanotubes（CNTs） homogeneously attached to the surfaces of the three-dimensional cross-linked of the sponge-derived carbon in the NiCoZn/C@MSDC composite, and CNTs were detected in the Ni Fe Zn/C@MSDC and NiMnZn/C@MSDC composites. Ni3ZnC0.7,Ni3Fe, and MnO in-situ formed in the NiFeZn/C@MSDC and Ni Mn Zn/C@MSDC composites. The CNTs in the NiCoZn/C@MSDC composite efficiently modulated its complex permittivity. Thus,the composite exhibited the best performance among the composites, with the minimum reflection loss(RLmin) of-33.1 dB at 18 GHz and thickness of 1.4 mm. The bandwidth for RL of ≤-10 dB was up to 5.04 GHz at the thickness of 1.7 mm and loading of 25wt%. The optimized impedance matching, enhanced interfacial and dipole polarization, remarkable conduction loss, and multiple reflections and scattering of the incident microwaves improved the microwave absorption performance. The effects of Co, Ni, and Fe on the phase and morphology provided an alternative way for developing highly efficient and broadband microwave absorbers.

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Combined laparoscopic and thoracoscopic repair of adult right-sided Bochdalek hernia with massive liver prolapse: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2420-2425页

作者： Shinya Mikami Sae kimura Yoshitsugu Tsukamoto Masaki Hiwatari Yasuhito Hisatsune Asako Fukuoka Tsunehisa Matsushita Takeharu Enomoto Takehito Otsubo Department of Gastrointestinal and General Surgery St.Marianna University School of MedicineKanagawa 216-8511Japan

BACKGROUND A Bochdalek hernia(BH)is a congenital diaphragmatic hernia that often develops in the neonatal *** typically occurs on the left side of the diaphragm.A right-sided BH in an adult is *** SUMMARY A 45-year-old man was referred to our hospital because of an abnormal shadow seen on chest radiography during a medical check-up.A chest radiograph showed elevation of the right *** tomography showed prolapse of multiple intraabdominal organs into the right thoracic cavity,corresponding to a right-sided *** herniated contents included the stomach,transverse colon,and left lobe of the *** left lobe of the liver was enlarged,particularly the medial *** surgery was ***,the left lobe of the liver was completely trapped in the thoracic ***,thoracoscopic manipulation had to be performed to return the liver to the abdominal *** hernia was repaired with interrupted nonabsorbable sutures and reinforced with *** Combined laparoscopic and thoracoscopic surgery was successfully performed for right-sided BH with massive liver prolapse and abnormal liver morphology.

关键词： Bochdalek hernia Right-sided Adult Laparoscopic and thoracoscopic repair Liver prolapse Abnormal liver morphology Case report

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日本食用菌菌种产业的现状

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食药用菌 2024年第2期32卷 88-94页

作者：木村荣一日本Kinokkusu株式会社

介绍日本食用菌生产及品种登记情况,菌株保藏的具体方法和解冻方式;指出复苏菌株可通过目视法、生理性方法、病毒基因诊断法和栽培试验法等确认菌株性能,并比较各方法优劣;简介现行菌株鉴定方法,分析菌种种性劣化的原因,指出菌种种性维... 详细信息

介绍日本食用菌生产及品种登记情况,菌株保藏的具体方法和解冻方式;指出复苏菌株可通过目视法、生理性方法、病毒基因诊断法和栽培试验法等确认菌株性能,并比较各方法优劣;简介现行菌株鉴定方法,分析菌种种性劣化的原因,指出菌种种性维持是待研究课题。

关键词：食用菌工厂化栽培菌种保藏种性维持品种鉴定

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Non-invasive gene delivery across the blood-brain barrier:present and future perspectives

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Neural Regeneration Research 2022年第4期17卷 785-787页

作者： Seigo kimura Hideyoshi Harashima Laboratory for Molecular Design of Pharmaceutics Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan Laboratory of Innovative Nanomedicine Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan

The aging of society has arrived,and is accompanied by an increase in the absolute numbers of patients with neurological disorders,such as Alzheimer's and Parkinson's diseases(Feigin et al.,2020).Such diseases,particularly Alzheimer's disease and other forms of dementia,affect not only the patients themselves,but also the people around them,including family members and care *** a result,such neurological disorders are thought to carry a larger social burden compared to other *** most critical point in the current situation is that there is no effective treatment despite the fact that the number of patients increase with the aging of the population.

关键词： diseases Alzheimer carry

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MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury

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Neural Regeneration Research 2023年第2期18卷 311-312页

作者： Tetsu kimura Yuta Horikoshi Department of Anesthesia and Intensive Care Medicine Akita University Graduate School of MedicineAkitaJapan

Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa *** frequently occurs due to traffic accidents,falls,slips,violence,sports,and medical accidents in today's *** initial mechanical damage triggers a secondary injury cascade that induces more intractable damage(Silva et al.,2014).Secondary injury mechanisms have been postulated,including neuronal apoptosis,inflammation,oxidative stress,and excitotoxicity.

关键词： damage injury emotional

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Reconstruction of power spectrum of primordial curvature perturbations on small scales from primordial black hole binaries scenario of LIGO/VIRGO detection

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Science China(Physics,Mechanics & Astronomy) 2023年第6期66卷 87-93页

作者： Xinpeng Wang Ying-li Zhang Rampei kimura Masahide Yamaguchi School of Physics Science and Engineering Tongji UniversityShanghai200092China Institute for Advanced Study of Tongji University Shanghai200092China Kavli Institute for the Physics and Mathematics of the Universe(WPI) Chiba277-8583Japan Center for Gravitation and Cosmology Yangzhou UniversityYangzhou225009China Waseda Institute for Advanced Study Waseda UniversityTokyo169-8050Japan Department of Physics Tokyo Institute of TechnologyTokyo152-8551Japan

As a candidate bound for the Binary Black Hole(BBH) merger events detected by LIGO/Virgo, Primordial Black Holes(PBHs)provide a useful tool to investigate the primordial curvature perturbations on small scales. Using the GWTC-1 to GWTC-3 catalogs, under the scenario that PBHs originate from large primordial curvature perturbations on small scales during infiationary epoch, we for the first time reconstruct the power spectrum of primordial curvature perturbations on small scales. It is found that the value of the amplitude of the primordial power spectrum is enhanced to O(10-2)on scales O(1) pc. This may imply the validity of PBH as a possible BBH merger candidate.

关键词： primordial black hole primordial curvature perturbation gravitational wave inflation

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Comparative evaluation of acute phase proteins by C-reactive protein(CRP)and serum amyloid A(SAA)in nonhuman primates and feline carnivores

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Animal Diseases 2022年第4期2卷 258-268页

作者： Tohru kimura Laboratory Animal Science Joint Faculty of Veterinary MedicineYamaguchi University1677-1YoshidaYamaguchi-cityYamaguchi 753-8515Japan

The feasibility of a commercially available assay for C-reactive protein(CRP,CRP for humans:hCRP,and CRP for dogs:vCRP)and a trial reagent of serum amyloid A(SAA,vSAA for animals)were applied to the measurement of acute phase proteins in zoo animals,particularly in nonhuman primates and feline carnivores was *** showed that hCRP and vSAA methods were applicable to measure CRP and SAA in *** was a highly signifcant correlation between both parameters with remarkably high correlation coefcient.A higher proportion of Bonnet macaques in Haplorhini,and the linear regression with good correlation between hCRP and vSAA levels were *** values in healthy Bonnet macaques were hCRP(46.86±30.97 nmol/L)and vSAA(9.06±1.95μg/mL).Although Ring-tailed lemur,which belonging to Strepsirrhini,showed low vSAA concentrations(reference values:1.08±0.47μg/mL),vSAA in patients was apparently *** vCRP and vSAA methods were applicable to measurements of CRP and SAA in feline carnivores for highly signifcant correlation between both *** two methods were also been deteded in lions,tigers and *** assays can be applied to measure SAA levels in other carnivores and *** conclusion,vSAA systems have potential utility as diagnostic tools for health screening and prediction in zoo animals.

关键词： Acute phase proteins C-reactive protein Feline carnivores Nonhuman primates Serum amyloid A Zoo animal

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