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Numerical modelling of spatially and temporally distributed on‑fault induced seismicity:implication for seismic hazards

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International Journal of Coal Science & Technology 2023年第1期10卷 108-123页

作者： atsushi Sainoki Adam Karl Schwartzkopf Lishuai Jiang Hani Mitri Faculty of Advanced Science and Technology KumamotoUniversityKumamotoJapan School of Engineering The University of Western AustraliaPerthAustralia State Key Laboratory of Mining Disaster Preventionand Control Shandong University of Scienceand TechnologyShandongChina Department of Mining and Materials Engineering McGillUniversityMontrealCanada

Induced seismicity is strongly related to various engineering projects that cause anthropogenic in-situ stress change at a great ***,there is a need to estimate and mitigate the associated *** the past,various simulation methods have been developed and applied to induced seismicity analysis,but there is still a fundamental diference between simulation results and feld observations in terms of the spatial distribution of seismic events and its *** present study aims to develop a method to simulate spatially distributed on-fault seismicity whilst reproducing a complex stress state in the fault ***,an equivalent continuum model is constructed,based on a discrete fracture network within a fault damage zone,by employing the crack tensor theory.A fault core is simulated at the center of the model as a discontinuous *** the model,a heterogeneous stress state with stress anomalies in the fault zone is frst simulated by applying tractions on the model outer ***,the efective normal stress on the fault plane is decreased in a stepwise manner to induce *** simulation result is validated in terms of the b-value and other seismic source parameters,hence demonstrating that the model can reproduce spatially and temporally distributed on-fault *** analysis on the parameters shows the variation of frequency-magnitude distribution before the occurrence of large seismic *** variation is found to be consistent with feld observations,thus suggesting the potential use of this simulation method in evaluating the risk for seismic hazards in various engineering projects.

关键词： Induced seismicity Fracture network Fault damage zone Crack tensor theory

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A Rare Case of Small Bowel Intussusception Due to Metastatic Malignant Melanoma

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Journal of Cosmetics, Dermatological Sciences and Applications 2019年第2期9卷 107-112页

作者： Yuma Hanaoka atsushi Tanemura Mari Tanaka Madoka Takafuji Eiji Kiyohara Mari Wataya-kaneda Manabu Fujimoto Naotsugu Haraguchi Department of Dermatology Osaka University Graduate School of Medicine Suita Osaka Japan Department of Gastroenterological Surgery Osaka University Graduate School of Medicine Suita Osaka Japan

The small intestine is sometimes metastasized by malignant melanoma. While small intestinal involvement is asymptomatic or usually nonspecific, intussusception causing intestinal obstruction is very rare. Herein we report the case of a 68-year-old man with small bowel intussusception due to metastatic malignant melanoma. Although he has been comprehensively treated with surgery, radiation, and immunotherapies, the disease rapidly progressed and consequently severe life-threatening intussusception developed on the small bowel. Because surgical resection of the obstructive melanoma lesions was successful, his quality of life was dramatically improved followed by the resumption of treatment with anti-PD-1. Several effective treatments for metastatic melanoma, including immune checkpoint inhibitors and targeted therapy, have been developed within the past decade. However, given the present case, surgical approaches to symptomatic metastatic melanoma lesions should still be considered as a treatment option for improving not only patients’ critical condition but also their survival.

关键词： Intussusception Bowel Obstruction Metastatic Melanoma Palliative Surgery Sequential Anti-Tumor Immunotherapy

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Asian Case of Metastatic Melanoma in Which a Complete Response Was Maintained after Discontinuation of Dabrafenib and Trametinib

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第2期10卷 55-58页

作者： Rikako Deno atsushi Tanemura Madoka Takafuji Yuma Hanaoka Eiji Kiyohara Noriko Arase Mari Wataya-kaneda Manabu Fujimoto Department of Dermatology Graduate School of Medicine Osaka University Suita Osaka Japan

A 54-year-old man diagnosed with metastatic melanoma of the right inguinal node with occult primary developed liver and bone metastases. The combination of dabrafenib plus trametinib was initiated, and a complete response (CR) was achieved 24 months after starting treatment. One month later, the target therapy was discontinued at the patient’s decision, and he has remained free from progression for 21 months since discontinuation. To the extent of our knowledge, real-world data in Asian melanoma concerning the discontinuation of dabrafenib plus trametinib after achieving CR have not been published;therefore, our case is a meaningful one for considering to cease target drugs and to rescue their financial toxicity.

关键词： Metastatic Melanoma Dabrafenib Trametinib Complete Response Discontinuation

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Hemobilia due to hepatocellular carcinoma： cholangioscopicfindings and novel endoscopic hemostasis

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 275-277页

作者： takeshi ogura atsushi okuda kazuhide higuchi second department of internal medicine osaka medical college2-7 DaigakuchouTakatsukishiOsaka 569-8686Japan

To the Editor：Trauma, inflammation, iatrogenic procedures such as liverbiopsy and percutaneous transhepatic biliary drainage （PTBD）, vascularanomalies, coagulopathy status, and malignancy can causehemobilia [1]. Malignant causes of hemobilia include cholangiocarcinoma,pancreatic cancer, gallbladder tumor, and liver metastasis,but rarely hepatocellular carcinoma （HCC）. Here, we describeachieving endoscopic hemostasis for hemobilia caused by HCC,which was visualized using the single-operator, SPY-DS cholangioscope（Boston Scientific, Tokyo, Japan） under endoscopic retrogradecholangiopancreatography （ERCP） guidance. This scope is a dramaticimprovement over the SpyGlass system in that it is easier to insert into the biliary tract due to a tapered tip, a 120° digitalfield-of-view provides favorable visualization, and new injection and suction functions have been added via a two-port adaptor.

关键词： COVERED METALLIC STENT

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Fulminant hepatic failure resulting from small-cell lung cancer and dramatic response of chemotherapy

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World Journal of Gastroenterology 2006年第15期12卷 2466-2468页

作者： Kyoichi Kaira atsushi Takise Rieko Watanabe Masatomo Mori Department of Respiratory Medicine Maebashi Red Cross Hospital 3-21-36 Asahi-choMaebashiGunma 371-0014Japan Department of Medicine and Molecular ScienceGunma University Graduate School of MedicineShowa-machiMaebashiGunma 371-8511Japan Department of Respiratory Medicine Maebashi Red Cross Hospital 3-21-36 Asahi-choMaebashiGunma 371-0014Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Showa-machiMaebashiGunma 371-8511Japan

Prompt treatment in tumor-associated encephalopathy may prolong survival. We describe a 69-year-old male patient who was presented with fulminant hepatic failure, secondary to small-cell lung carcinoma with rapidly progressing encephalopathy. Both symptoms remitted following chemotherapy, suggesting swift diagnosis and administration of chemotherapy to be effective in treatment of fulminant hepatic failure and encephalopathy.

关键词： Small-cell lung carcinoma Fulminant hepatic failure Chemotherapy

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Salt effects on formation of microcrystallites in poly(vinyl alcohol) gels prepared by cast-drying method

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Progress in Natural Science:Materials International 2011年第5期21卷 375-379页

作者： Shin KOMIYA Emiko OTSUKA Yumiko HIRASHIMA atsushi SUZUKI Graduate School of Education Yokohama National University79-2 TokiwadaiHodogaya-kuYokohama240-8501 Japan Graduate School of Environment and Information Sciences Yokohama National University79-7 TokiwadaiHodogaya-kuYokohama240-8501 Japan Graduate School of Environment and Information Sciences、Yokohama National University 79-7 TokiwadaiHodogaya-kuYokohama240-8501 Japan

The preparation method of poly(vinyl alcohol)(PVA) gels by a simple cast-drying technique using salt solutions was reported in the present *** effects of the salt concentration on the macro- and microscopic properties were examined in detail,and the relationships between macroscopic properties,such as swelling ratio,mechanical strength,and the network microstaicture were *** was found that the swelling ratio of PVA cast gel increased largely by adding a small amount of salt, and decreased rapidly,hereafter it increased with increasing the salt concentration above 2%(mass fraction).The changes in the breaking stress and strain corresponded to the changes in the swelling *** macroscopic properties were found to be correlated with the microcrystallites and hydrogen bonds,which were characterized by the measurements using X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR).

关键词： poly(vinyl alcohol) phase separation microcrystallite hydrogen bond

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Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

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Cellular & Molecular Immunology 2020年第1期17卷 50-63页

作者： atsushi Takahashi-Kanemitsu Christopher T.Knight Masanori Hatakeyama Department of Microbiology Graduate School of MedicineThe University of TokyoTokyoJapan

Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for gastric *** cagA gene product,CagA,is delivered into gastric epithelial cells via the bacterial type IV secretion *** CagA then undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala(EPIYA)motifs in its C-terminal region and acts as an oncogenic scaffold protein that physically interacts with multiple host signaling proteins in both tyrosine phosphorylation-dependent and-independent *** of CagA using in vitro cultured gastric epithelial cells has indicated that the nonphysiological scaffolding actions of CagA cell-autonomously promote the malignant transformation of the cells by endowing the cells with multiple phenotypic cancer hallmarks:sustained proliferation,evasion of growth suppressors,invasiveness,resistance to cell death,and genomic *** expression of CagA in mice leads to in vivo oncogenic action of CagA without any overt *** in vivo oncogenic activity of CagA is further potentiated in the presence of chronic *** Helicobacter pylori infection triggers a proinflammatory response in host cells,a feedforward stimulation loop that augments the oncogenic actions of CagA and inflammation is created in CagA-injected gastric *** that Helicobacter pylori is no longer colonized in established gastric cancer lesions,the multistep nature of gastric cancer development should include a“hit-and-run”process of CagA ***,acquisition of genetic and epigenetic alterations that compensate for CagA-directed cancer hallmarks may be required for completion of the“hit-and-run”process of gastric carcinogenesis.

关键词： cagA/CagA Helicobacter pylori SHP2 PAR1 inflammation “hit-and-run”carcinogenesis

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Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsy

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World Journal of Gastroenterology 2007年第15期13卷 2179-2182页

作者： atsushi Minami Shinji Hirose Tomohiro Nomoto Shoichiro Hayakawa Internal Medicine Kawasaki Kyodo Hospital 2-1-5 Sakuramoto Kawasaki City 210-0833Japan

AIM： TO introduce a new method： small endoscopic sphincterotomy （ES） combined with endoscopic papillary large balloon dilation （SES ＋ EPLBD） to treat patients with large biliary stones.METHODS： Retrieval of large biliary stones was performed in 88 patients. Mean stone size was 14 ± 3 mm and mean number of stones was 2.5 ± 3.5. Firstly, ES with a small incision was performed. Next, endoscopic papillary dilation was performed with a large balloon to slowly match the size of the bile duct. Stones were then retrieved from the biliary duct with a balloon and a basket.RESULTS： Stone retrieval was successful in all cases except one cystic duct stone case without the need to crush large stones. Mean procedure time was 30 ± 5 min. Dilating the papillary orifice with a large balloon made it possible to remove large stones smoothly without crushing them. After dilation with the large balloon, there were some instances of oozing, but no perforations. One instance of post-procedural pancreatitis （1%） occurred. CONCLUSION： SES ＋ EPLBD was effective for the retrieval of large biliary stones without the use of mechanical lithotripsy.

关键词： Endoscopic sphincterotomy Endoscopic papillary dilation Bile duct stone

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Experimental Observation of Two Phase Flow of R123 Inside a Herringbone Microfin Tube

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Journal of Thermal Science 2003年第3期12卷 270-274页

作者： Akio Miyara Mohammad ArifulIslam Yoshihiko Mizuta atsushi Kibe Department of Mechanical Engineering Saga University1 HonjomachiSaga-shi840-8502 JapanGraduate School of Science and EngineeringSaga University1 HonjomachiSaga-shi840-8502 JapanGraduate School of Science and EngineeringSaga University1 HonjomachiSaga-shi840-8502 JapanGraduate School of Science and EngineeringSaga University1 HonjomachiSaga-shi840-8502 Japan

Vapor-liquid two phase flow behavior of R123 inside herringbone microfin tubes has been studied. Herringbone microfin tube is a kind of internally finned tube in which microfins are installed inside the tube where the microfins form multi-V-shape in flow direction. For the present experiment three different types of herringbone microfin tubes with helix angle B = 8, 14 and 28 are used. Experimental observations showed how flow diverges and converges inside herringbone microfin tube due to fin arrangement. The effect is more remarkable for larger helix angle. From the measurements of the cross-sectional liquid flow rate distribution, the liquid removal and collection and the entrained droplet are discussed. Quantity of liquid droplets is increased with increase of helix angle. The tube with helix angle B = 28 shows higher quantity of liquid droplets than others.

关键词： two phase flow herringbone microfin tube flow pattern R123

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Risk of hepatitis B virus reactivation in patients with autoimmune diseases undergoing non-tumor necrosis factor-targeted biologics

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World Journal of Gastroenterology 2021年第19期27卷 2312-2324页

作者： Shintaro Akiyama Thomas G Cotter atsushi Sakuraba Section of Gastroenterology Hepatology and NutritionDepartment of MedicineUniversity of ChicagoChicagoIL 60637United States

Hepatitis B virus reactivation(HBVr)can occur in patients treated with immunosuppressive *** stratification for HBVr based on hepatitis B virus(HBV)serology and viral load is an important strategy to determine appropriate HBV monitoring and antiviral prophylaxis *** advances in the understanding of pathophysiology of autoimmune diseases have led the development of cytokine-targeted *** necrosis factor(TNF)-αinhibitors have been widely used for patients with inflammatory bowel disease,psoriasis,and rheumatic ***,the clinical benefits of interleukin(IL)-12/23,IL-17,or Janus kinases inhibitors have been demonstrated in these *** is well known that TNF-αinhibitor use can lead to HBVr,however,the risk of HBVr in patients undergoing non-TNF-targeted biologics have not been fully *** this review,we discuss the risk of HBVr in patients treated with non-TNF-targeted biologics,and immunological mechanisms of these medications causing HBVr.

关键词： Hepatitis B virus Autoimmune diseases Biological therapy Interleukin-23 Interleukin-17 Janus kinases

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