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Combined Effects of Blood Pressure and Aldosterone on Cardiac Left Ventricular Mass Index—Ethnic Differences between Kazakh, Uygur and Han Subjects

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World Journal of Cardiovascular Diseases 2014年第3期4卷 99-105页

作者： Masakatsu Ohta Yuji Kasamaki Yukio Ozawa atsushi hirayama Tomohiro Nakayama Hiroshi Kawamura Dilxat Himit Masayoshi Soma Yoichi Izumi Department of Cardiology Kanazawa Medical University Himi Municipal Hospital Himi Japan Department of Internal Medicine Nippon Dental University Tokyo Japan Department of Science and Research Xinjiang Medical University Urumqi China Division of Cardiology Department of Medicine Nihon University School of Medicine Tokyo Japan Division of General Medicine Department of Medicine Nihon University School of Medicine Tokyo Japan Division of Laboratory Medicine Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan

Previous Background: Hemodynamic factors, like blood pressure, have been established to be major determinants of cardiac left ventricular structure. However, several factors other than blood pressure to influence cardiac mass have been implicated. When we did medical survey, cardiac left ventricular mass index (LVMI) of one ethnic group that had higher blood pressure was found to be smaller than that of the other ethnic groups with a lower blood pressure. Such contradicted data from the present study were analyzed combining blood pressure, LVMI and chemical parameters obtained from blood and urine. Methods: In a medical survey conducted in Xinjiang, China, 279 people (65 - 70 years old) from three ethnic groups (Kazakh, Uygur and Han) from two separated regions provided blood and urine samples and underwent echocardiography and 24-h ambulatory blood pressure monitoring (ABPM). Results: Systolic and diastolic blood pressure obtained from ABPM and urinary sodium excretion values were significantly higher in Kazakh than that in Uygur and Han. However, LVMI in Kazakh was lower than that in other 2 groups. Plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were significantly lowest in Kazakh. The values of LVMI in all ethnic groups were positively related to both blood pressure and PAC. An inverse correlation was identified between PAC and urinary sodium excretion value. Conclusion: Although higher blood pressure in Kazakh subjects, their LVMI was lower than those of Uygur and Han, whose blood pressure was lower than that in Kazakh. These results suggest that blood pressure is not always a determinant for LVMI value. There is a possibility that relatively lower PAC resulted from higher sodium intake suppressed the rise in LVMI caused by higher blood pressure in Kazakh.

关键词： Left Ventricular Mass Aldosterone Blood Pressure Salt Intake

Degradation of dibromophenols by UV irradiation

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Journal of Environmental Sciences 2014年第6期26卷 1284-1288页

作者： Keiko Katayama-hirayama Naoki Toda Akihiko Tauchi atsushi Fujioka Tetsuya Akitsu Hidehiro Kaneko Kimiaki hirayama Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi 4-3-11 Takeda Kofu 400-8511 Japan Technology Development Division Toshiba Lighting and Technology Corporation Asahimachi 5-2-1 Imabari Ehime 794-8510 Japan

We examined the degradation of dibromophenols （DBPs）, i.e. 2,4-DBP, 2,6-DBP and 3,5-DBP by ultraviolet （UV） irradiation and estimated the relationship between degradability and molecular orbital properties of each dibromopbenol. The removal of DBPs under a UV lamp system was successfully performed in an aqueous solution. After 5 min of irradiation, the initial DBPs concentration of 20 mg/L was decreased to below 1 mg/L, and about 60% of bromide ion was released. A decrease in the concentration of dissolved organic carbon （DOC） suggested the mineralization of DBPs, The mineralization may occur after release of bromide ions because the decrease of DOC was slower than the release of bromide ions. The degradability of 3,5-DBP was slightly lower than 2,6-DBP and 2,4-DBE Molecular orbital calculation suggested that the electrophilic frontier density and the highest occupied molecular orbital （HOMO） energy may be related to the degradability of DBPs.

关键词： bromide ion dibromophenol DOC mineralization UV irration

Exact Bosonic Solutions of the Truncated Skyrme Model

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Chinese Physics Letters 2010年第6期27卷 35-36页

作者： SHI Chang-Guang hirayama Minoru Department of Mathematics and Physics Shanghai University of Electric Power Shanghai 200090 Department of Physics University of Toyama Gofuku 3190 Toyama Japan

A model defined by half the Lagrangian （the highly nonlinear part） of the Skyrme model is investigated. Two classes of bosonic solutions are obtained. It is shown that, although the field configurations of these two... 详细信息

关键词： Models Solutions Model

Significant Deviations in the Configurations of Homologous Tandem Repeats in Prokaryotic Genomes

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Genomics, Proteomics & Bioinformatics 2009年第4期7卷 163-174页

作者： Shintaro hirayama Satoshi Mizuta Graduate School of Science and Technology Hirosaki University

We explored the possibilities of whole-genome duplication （WGD） in prokaryotic species, where we performed statistical analyses of the configurations of the central angles between homologous tandem repeats （TRs） on the circular chromosomes. At first, we detected TRs on their chromosomes and identified equivalent tandem repeat pairs （ETRPs）; here, an ETRP is defined as a pair of tandem repeats sequentially similar to each other. Then we carried out statistical analyses of the central angle distributions of the detected ETRPs on each circular chromosome by way of comparisons between the detected distributions and those generated by null models. In the analyses, we estimated a P value by a simulation using the Kullback-Leibler divergence as a distance measure between two distributions. As a result, the central angle distributions for 8 out of the 203 prokaryotic species showed statistically significant deviations （P〈0.05）. In particular, we found out the characteristic feature of one round of WGD in Photorhabdus luminescens genome and that of two rounds of WGD in Escherichia coli K12.

关键词： whole-genome duplication statistical analysis tandem repeat Kullback-Leibler divergence prokaryote

Atomic force microscopy imaging of dialyzed single-walled carbon nanotubes dispersed with sodium dodecyl sulfate

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International Journal of Smart and Nano Materials 2013年第2期4卷 119-127页

作者： Shigeyuki hirayama Takuya Hayashida Kazuo Umemura Biophysics Section Department of PhysicsFaculty of ScienceTokyo University of Science1-3 KagurazakaShinjukuTokyo 1628601Japan

The existence of excess sodium dodecyl sulfate(SDS)molecules in a single-walled carbon nanotube(SWNT)solution dispersed by hybridization with SDS leads to unstable atomic force microscopy(AFM)*** this study,we demonstrate sequential dialysis against pure water in order to remove excess SDS molecules from an SDS-SWNT hybrid dispersion.A 1:102 volume ratio of SDS-SWNT dispersion to water in the dialysis was found to be effective in realizing stable AFM observations of the SDS-SWNT hybrids despite imperfect filtering of SDS via *** the other hand,the SDS-SWNT hybrids were stable even when this volume ratio was 1:***,the SDS-SWNT hybrids were present in the solution even when the dialyzed samples were stored for 14 *** results reveal that dialysis under optimal conditions enables improved handling of SDS-SWNT hybrids,particularly for stable AFM observations.

关键词： carbon nanotube atomic force microscopy sodium dodecyl sulfate dialysis

Nanotwin-assisted nitridation of quenched FeNi alloy nanopowders for rare-earth-free magnets

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Journal of Materials Science & Technology 2023年第34期165卷 244-252页

作者： Jian Wang Yusuke hirayama Kazuyuki Suzuki Kwangjae Park Zheng Liu Kenta Takagi Kimihiro Ozaki Innovative Functional Materials Research Institute National Institute of Advanced Industrial Science and Technology4-205SakurazakaMoriyamaNagoya463-8560Japan

L1_(0)-ordered FeNi alloy with a high uniaxial magnetic anisotropy and large magnetic moment is a promising candidate for rare-earth-free permanent magnets ***,the synthesis of this chemically ordered phase remains a longstanding challenge because of its low chemical order-disorder transition temperature(200-320℃).Although a non-equilibrium synthetic route based on a nitrogen topotactic reaction has been proposed as a valid approach,the volume fraction and degree of chemical ordering of the product phase are ***,we propose a promising approach that promotes the efficient formation of L1_(0)-ordered nitride phase in FeNi nanopowders by introducing a quenching treatment during a low-oxygen induction thermal plasma *** quenched FeNi nanopowders possessed much smaller powder sizes(40.4 vs 74.0 nm),exhibited higher number densities of nanotwins(39.8%vs 24.1%)and formed much larger volume fraction(33.6 wt.%vs 0.6 wt.%)of ordered phase than the unquenched ***,quenching-induced high-density nanotwins led to the dominant coverage of serrated{001}crystal facets over the surfaces of the FeNi *** unique features substantially accelerated the formation of the L1_(0)-ordered nitride phase in the FeNi nanopowders because the{001}crystallographic orientation had the highest nitrogen *** work provides not only a valid synthetic approach for mass production of the L10-ordered nitride phase in FeNi nanopowders but also novel insights into the crystal-defect-assisted nitridation of nanomaterials.

关键词： Rare-earth-free Permanent magnet FeNi Nitridation Nanotwin

A new scorpion polypeptide enhances the binding of radiolabeled-ryanodine on ryanodine receptor in sarcoplasmic reticulum of rabbit skeletal muscle

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Chinese Science Bulletin 1997年第2期42卷 147-151页

作者： Seiko Kawano Yoshiyuki hirayama Masayasu Hiraoka Akihiko Kuniyasu Hitoshi Nakayama Department of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanFaculty of Pharmaceutical Science Hokkaido University Japan Faculty of Pharmaceutical Science Kumamoto University Japan

RYANODINE is a toxic alkaloid from the plant Ryania speciosa Vahl. It selectively binds to the Ca2+ release channel on skeletal and cardiac heavy sarcoplasmic reticulum （HSR） and has

关键词： scorpion Buthus martensi Karsch ryanodine receptor toxic polypeptide.

Reactive lymphoid hyperplasia of the liver:A case report and review of literature

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World Journal of Gastroenterology 2007年第40期13卷 5403-5407页

作者： Takuro Machida Toshiyuki Takahashi Tomoo Itoh Michiaki hirayama Takayuki Morita Shoichi Horita Department of Internal Medicine Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan Department of Pathology Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan Department of Pathology Hokkaido University HospitalSapporoHokkaido060-8648Japan Department of Surgery Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan

A case of a 53-year-old female patient with reactive lymphoid hyperplasia （RLH）, clinically designated as pseudolymphoma of the liver is described in this article. The patient was admitted to our hospital for further evaluation of hepatic tumors incidentally discovered at another hospital. Various diagnostic methods, including ultrasonography （US）, computerized tomography （CT）, magnetic resonance imaging （MRI） and hepatic angiography displayed three small lesions in the liver with outstanding findings consistent with hepatocellular carcinoma （HCC）. Surgical resection was performed and the three lesions were microscopically diagnosed as RLH of the liver. The lesions comprised a massive infiltration of lymphoid cells with follicles and hyalinized inter- follicular spaces. Immunohistochemical examination revealed that infiltrating lymphocytes had no prominent nuclear atypia and polyclonality. RLH of the liver is a very rare condition and only twelve cases have been reported in the English literature. Majority of the reported cases were middle-aged women and about half of them had some immunologic abnormalities such as autoimmune thyroiditis, Sjogren＇s syndrome, primary immunodeficiency, primary biliary cirrhosis. Since they are olden clinically misdiagnosed as HCC, surgery is the choice of treatment for these patients. Although their pathology resembles malignant lymphoma, the clinical course is completely benign. The authors propose that RLH of the liver can be discriminated from HCC by its clinical features.

关键词： Reactive lymphoid hyperplasia Pseudo lymphoma Hepatocellular carcinoma Autoimmunethyroiditis Immunohistochemistry

Steering performance of an inverted pendulum vehicle with pedals as a personal mobility vehicle

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Theoretical & Applied Mechanics Letters 2013年第1期3卷 71-76页

作者： Chihiro Nakagawa Kimihiko Nakano Yoshihiro Suda Yuki hirayama Mechanical Engineering Osaka Prefecture University Interdisciplinary Information Studies University of Tokyo Institute of Industrial Science University of Tokyo

From the viewpoints of environmental protection, support for the aged and ensuring the right to mobility, there is a need to develop a new type of mobility vehicle that provides more effective transportation. The authors propose an inverted pendulum vehicle with pedals as one of the forms of personal mobility vehicles （PMVs）. In this paper, the steering performance of the inverted pendulum vehicle with pedals is discussed based on experiments on a prototype. From the experimental results, it was confirmed that the errors from the five subjects for the target trajectory and the five-grade evaluation of the maneuverability were similar. Finally, we created an inverted pendulum vehicle with pedals to which was added a reaction actuator for the steering system. From the experimental results, it was found that setting appropriate feedback gains for the handle steering angle and its rate of rotation, which control the right and left wheel driving torques, resulted in greatly improved maneuverability. C 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301309]

关键词： steering control stability inverted pendulum vehicle