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Frontiers of Architectural Research 2024年第4期13卷 928-943页

作者： Jiankun Liu atsushi deguchi School of Architecture Tianjin UniversityTianjin 300072China Graduate School of Frontier Science The University of TokyoChiba 277-0882Japan

Beijing is a typical traditional city in China,originating from the uniform and conventional grid plan,but transformed diversely,either on purpose or *** research took the diversification process of grid blocks as an angle to understand the transformation process of Beijing’s urban *** took 194 grid blocks within the 3rd Ring Road of Beijing as research ***,the paper proposed a whole view of Beijing’s grid blocks by 1)visualizing their construction process,2)classifying 5 morphological clusters by 7 indicators(Block size,Block shape regularity,Intensity,Coverage,Network density,Plot shape regularity,Standard deviation of plot size),and 3)investigating their ***,the diversification process of grid blocks was clarified from two layers:the block-boundary layer and the inner-space ***,the mechanism of block form diversification was clarified by exploring the connections between elements in each layer,and the influence of urban development on block form *** study re-defined the diversification process in a more quantitative way from both time and spatial *** concluded that the diversification is influenced by changes in urban planning principles and locations,and emerged thorough the long-term transformation and *** interaction between the boundary and the inner space stimulates the *** based on these,it concluded with a discussion of limitations and potentials on grid blocks’construction and renovation.

关键词： Grid block Urban morphology Diversification Morphological quantification

Simple and robust 3D MINFLUX excitation with a variable phase plate

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Light(Science & Applications) 2024年第7期13卷 1354-1363页

作者： Takahiro deguchi Jonas Ries European Molecular Biology Laboratory Cell Biology and BiophysicsHeidelbergGermany. Max Perutz Labs Vienna Biocenter Campus(VBC)ViennaAustria. University of Vienna Center for Molecular BiologyDepartment of Structural and Computational BiologyViennaAustria. University of Vienna Faculty of PhysicsViennaAustria

MINFLUX has achieved extraordinary resolution in superresolution imaging and single fluorophore *** is based on localizing single fluorophores by rapid probing with a patterned beam that features a local intensity *** implementations,however,are complex and expensive and are limited in speed and ***,we show that a combination of an electro-optical modulator with a segmented birefringent element such as a spatial light modulator produces a variable phase plate for which the phase can be scanned on the MHz *** or top-hat phase patterns generate high-contrast compact excitation point-spread functions for MINFLUX localization in the x,y,and z-direction,respectively,which can be scanned across a fluorophore within a microsecond,switched within 60 microseconds and alternated among different excitation *** discuss how to compensate for non-optimal performance of the components and present a robust 3D and multi-color MINFLUX excitation module,which we envision as an integral component of a high-performance and cost-effective open-source MINFLUX.

关键词： excitation phase switched

Urban structure transformation of Lhasa City after the peaceful liberation and democratic reform of Tibet

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Journal of Chongqing University 2017年第3期16卷 124-140页

作者：张樱子 ZHAO Shi-chen atsushi deguchi School of Architecture and Design Southwest Jiaotong University Chengdu 610031 P. R. China

In Tibet, Buddhism coupled with its theocratic history has given its cities and urban areas unique forms and structures. As the political, religious, and economic center of Tibet, Lhasa City has a special urban form and has experienced typical urban transformation processes for a thousand years. The city has been experiencing significant urban structure transformation that has accompanied the socio-economic development in recent decades since the peaceful liberation and democratic reform of Tibet during the 1950 s. Hence, this study presents the time-series of urban structure changes in Lhasa City for the purpose of understanding the characteristics and mechanisms of transformation under the republican political system. First, the study illustrates the urban socio-economic changes of Lhasa City beginning in the 1950 s via statistical data analysis. We then divide the urban development into several stages. Subsequently, we identify the transformation characteristics of urban structure by investigating urban growth, street structure, land-use, and religious facilities via maps of the city from every development stage. This paper ultimately discusses the regulation of city transformation. This study clarifies several probable issues facing Tibetan cities and proposes suggestions for future urban development of Tibetan cities.

关键词： urban structure transformation highland city Tibetan Buddhism theocratic governance

“输入型”城市形态在中国东北地区的本土化演变:以大连市环形-放射状空间为例

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景观设计学（中英文） 2022年第6期10卷 32-47页

作者：刘健琨出口敦天津大学建筑学院天津300072 日本东京大学大学院新领域创成科学研究科柏市277-8563

历史上源自外来文化的“输入型”城市空间形态在被“移植”至中国城市后,由于文化根基缺失,易与现代主流城市建设脱节,其当代价值与城市更新潜力备受质疑。本研究以街区尺度下源于巴洛克城市的“环形-放射状空间为例,以厘清其引入中国... 详细信息

历史上源自外来文化的“输入型”城市空间形态在被“移植”至中国城市后,由于文化根基缺失,易与现代主流城市建设脱节,其当代价值与城市更新潜力备受质疑。本研究以街区尺度下源于巴洛克城市的“环形-放射状空间为例,以厘清其引入中国东北地区城市的背景与动因,并以大连市为例,明晰其移植后在形式与功能上的适应性变化,继而提出城市更新建议。研究发现,各种几何形式环形-放射状空间的引入,虽然在不同程度上受到欧、美、日等地区城市规划与理论的影响,但都强调象征性与功能性并重。环形-放射状空间在大连的城市规划建设具有时空连续性,但受地形、交通、规划理念等变化影响,形态与功能趋向独立,关联性减弱,重要程度退居街道网络之后;其延承与变化在城市更新中需辩证考量。最后,研究重新提出“输入型”城市空间的“本土化”概念,并构建了普适性研究模式,为理解相似类型城市形态的演变提供了崭新视角。

关键词： “输入型”城市形态环形-放射状空间本土化跨文化城市景观中国城市语境大连

Role of ultrasound in the treatment of pediatric infectious diseases:case series and narrative review

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World Journal of Pediatrics 2023年第1期19卷 20-34页

作者： Takahiro Hosokawa Yutaka Tanami Yumiko Sato Kuntaro deguchi Haruka Takei Eiji Oguma Department of Radiology Saitama Children's Medical Center1-2 Shintoshin Chuo-kuSaitama 330-8777Japan Department of Infectious Diseases and Immunology Saitama Children's Medical CenterSaitamaJapan

Background Infectious diseases are common in pediatric *** these patients,ultrasound is a useful imaging modality that involves no irradiation or sedation and can be performed repeatedly at the patient's *** purpose of this review was to show pediatric cases with infectious disease that used ultrasound to decide the methods of *** sources Literature review was performed using Pubmed as the medical database *** year-of-publication restric-tion was *** mesh terms used were:"ultrasound","sonography","infectious disease","treatment","antibiotics","surgical intervention","pediatric","children","deep neck abscess","pyothorax","empyema","pneumonia","urinary tract infection","intra-abdominal abscess","soft tissue infection","septic arthritis","osteomyelitis",and"surgical site infection".Results We presented pediatric case series with infectious diseases,including deep neck abscess,pyothorax and empyema,pneumonia,urinary tract infection,intra-abdominal abscess,soft tissue infection,septic arthritis and osteomyelitis,and surgical-site *** was useful for evaluating the extent and location of inflammation and abscess and for decision-making concerning surgical *** Knowledge of these sonographic findings is important for sonographers during examinations and for physicians when determining the treatment plan and period of antibiotic therapy for infected lesions.

关键词： Infectious diseases Intra-abdominal abscess Osteomyelitis Pyothorax Ultrasound

Performance Improvements in Temperature Reconstructions of 2-D Tunable Diode Laser Absorption Spectroscopy(TDLAS)

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Journal of Thermal Science 2016年第1期25卷 84-89页

作者： Doo-Won Choi Min-Gyu Jeon Gyeong-Rae Cho Takahiro Kamimoto Yoshihiro deguchi Deog-Hee Doh Tokushima University 2-1 Minamijyosanjima TokushimaJapan Korea Maritime&Ocean University Dongsam-dong 1 Youngdo-guBusan 606-791Korea

Performance improvement was attained in data reconstructions of 2-dimensional tunable diode laser absorption spectroscopy(TDLAS). Multiplicative Algebraic Reconstruction Technique(MART) algorithm was adopted for data reconstruction. The data obtained in an experiment for the measurement of temperature and concentration fields of gas flows were used. The measurement theory is based upon the Beer-Lambert law, and the measurement system consists of a tunable laser, collimators, detectors, and an analyzer. Methane was used as a fuel for combustion with air in the Bunsen-type burner. The data used for the reconstruction are from the optical signals of 8-laser beams passed on a cross-section of the methane flame. The performances of MART algorithm in data reconstruction were validated and compared with those obtained by Algebraic Reconstruction Technique(ART) algorithm.

关键词：可调谐二极管激光吸收光谱性能温度二维代数重建技术可调谐激光器数据重构测量原理

Laser-induced breakdown spectroscopy in Asia

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Frontiers of physics 2016年第6期11卷 231-255页

作者： Zhen-ZhenWang Yoshihiro deguchi Zhen-Zhen Zhang Zhe Wang Xiao-Yan Zeng Jun-Jie Yan State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University Xi'an 710049 China Graduate School of Advanced Technology and Science Tokushima University Tokushima 770-8501 Japan State Key Lab of Power Systems Department of Thermal Engineering Tsinghua-BP Clean Energy Center Tsinghua University Beijing 100084 China Wuhan National Laboratory for Optoelectronics (WNLO) Huazhong University of Science and Technology Wuhan ~3007~ China

Laser-induced breakdown spectroscopy (LIBS) is an analytical detection technique based on atomic emission spectroscopy to measure the elemental composition. LIBS has been extensively studied and developed due to the non-contact, fast response, high sensitivity, real-time and multi-elemental detection features. The development and applications of LIBS technique in Asia are summarized and discussed in this review paper. The researchers in Asia work on different aspects of the LIBS study in fundamentals, data processing and modeling, applications and instrumentations. According to the current research status, the challenges, opportunities and further development of LIBS technique in Asia are also evaluated to promote LIBS research and its applications.

关键词： laser-induced breakdown spectroscopy (LIBS) quantitative analysis signal enhancement applications challenges

Simulation of Human Phonation with Vocal Nodules

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American Journal of Computational Mathematics 2011年第3期1卷 189-201页

作者： Shinji deguchi Yuki Kawahara 不详

The geometric and biomechanical properties of the larynx strongly influence voice quality and efficiency. A physical understanding of phonation natures in pathological conditions is important for predictions of how voice disorders can be treated using therapy and rehabilitation. Here, we present a continuum-based numerical model of phonation that considers complex fluid-structure interactions occurring in the airway. This model considers a three-dimensional geometry of vocal folds, muscle contractions, and viscoelastic properties to provide a realistic framework of phonation. The vocal fold motion is coupled to an unsteady compressible respiratory flow, allowing numerical simulations of normal and diseased phonations to derive clear relationships between actual laryngeal structures and model parameters such as muscle activity. As a pilot analysis of diseased phonation, we model vocal nodules, the mass lesions that can appear bilaterally on both sides of the vocal folds. Comparison of simulations with and without the nodules demonstrates how the lesions affect vocal fold motion, consequently restricting voice quality. Furthermore, we found that the minimum lung pressure required for voice production increases as nodules move closer to the center of the vocal fold. Thus, simulations using the developed model may provide essential insight into complex phonation phenomena and further elucidate the etiologic mechanisms of voice disorders.

关键词： Aerodynamics Flow–Structure Interaction Self-Excited Oscillation Phonation Vocal Fold Larynx Vocal Tract Speech Production Voice Production Vocal Nodules Vocal Cord Polyp Voice Disorder

Carbohydrate Intake Is Correlated with the Glycated Albumin to Glycated Hemoglobin Ratio in Drug-Naive Patients with Type 2 Diabetes

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Journal of Diabetes Mellitus 2016年第1期6卷 10-15页

作者： Satoru Sumitani Yoshihiko Utsu Shuhei Nishina Kenta Okuro atsushi Kogetsu Seigo Ishii Akiko deguchi Bunzo Sato Isao Tachibana Soji Kasayama Masafumi Koga Center for Diabetes and Endocrinology Nissay Hospital Osaka Japan Department of Medicine Nissay Hospital Osaka Japan Department of Internal Medicine Kawanishi City Hospital Hyogo Japan

Background: The glycated albumin (GA) to HbA1c ratio (GA/HbA1c ratio) has been reported to reflect postprandial hyperglycemia. Carbohydrate is the primary dietary macronutrient that causes postprandial hyperglycemia. Thus, we investigated whether carbohydrate intake was associated with the GA/HbA1c ratio in patients with type 2 diabetes. Methods: Daily energy intake and carbohydrate intake were estimated in twenty-two patients with type 2 diabetes who received no pharmacological therapy (18 men and 4 women, age 53 ± 11 years old). The energy index and the carbohydrate index were defined as the ratio of daily energy intake to body weight and daily carbohydrate intake to body weight, respectively. Results: The energy index was significantly correlated with the GA/HbA1c ratio (r = 0.451, p = 0.035), but not with fasting plasma glucose (FPG), HbA1c and GA. The carbohydrate index was significantly correlated with GA (r = 0.461, p = 0.031) and the GA/HbA1c ratio (r = 0.554, p = 0.007), but not with FPG and HbA1c. Multivariate analysis revealed that the carbohydrate index was independently associated with the GA/HbA1c ratio (β = 0.397, p = 0.046). Conclusions: The carbohydrate index was significantly correlated with GA and the GA/HbA1c ratio in the patients with type 2 diabetes. These results suggest that carbohydrate intake may be associated with the GA/HbA1c ratio through postprandial hyperglycemia.

关键词： Glycated Albumin HbA1c Type 2 Diabetes Mellitus Carbohydrate Postprandial Hyperglycemia

Measuring surface geometry of adherent cells using oblique transillumination

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Advances in Bioscience and Biotechnology 2011年第5期2卷 359-363页

作者： Shinji deguchi Haruhisa Bamba 不详

We present a new technique for estimating cell surface geometry. A dish supporting adherent cells is observed using oblique transillumination and rotated in the horizontal plane using a stepping motor. The stage rotation-dependent movements of the start and end points of a shadow formed behind the illuminated cells uniquely determine the relative height differences between points along the cell surface. Thus, using custom-made apparatuses and living endothelial cells, we demonstrate that the combination of a rotating stage and oblique lighting allows for the evaluation of three-dimensional surface geometry of adherent cells. As compared to confocal microscopy and atomic force microscopy, which are commonly used for measuring cell surface geometry, this approach can be performed rapidly and is especially suitable for the observation of unstained cells over a large surface covering multiple cells at a time.

关键词： 3D Cell Morphology Oblique Illumination Rotating Stage Microscopy