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Screening and Phylogenetic Analysis of Deep-Sea Bacteria Capable of Metabolizing Lignin-Derived Aromatic Compounds

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Open Journal of Marine Science 2012年第4期2卷 177-187页

作者： Y. Ohta S. Nishi T. Haga T. Tsubouchi R. Hasegawa M. Konishi Y. Nagano Y. Tsuruwaka Y. Shimane K. Mori K. Usui E. Suda K. tsutsui A. Nishimoto Y. Fujiwara T. Maruyama Y. Hatada Institute of Biogeosciences Japan Agency of Marine-Earth Science and Technology (JAMSTEC) Yokosuka Japan

Lignin is one of the most abundant biomasses in nature. It is composed of aromatic moieties and has great potential for use in the production of chemical alternatives to petroleum products. Because of increasing interest in biocatalysis, the potential for industrial application of microbial metabolism of lignin-derived compounds has gained considerable recent attention. Functional screenings of culturable bacteria isolated from sediments and sunken wood collected from the deep sea revealed the existence of a number of previously unidentified bacteria capable of metabolizing lignin-related aromatic compounds. Of the 510 isolates obtained in the present study, 208 completely or partially metabolized these compounds. The 208 isolates were classified into diverse phyla, including Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria. Among the 208 isolates, 61 unique 16S rRNA gene sequences were detected including previously unidentified marine lineage isolates. The metabolites of the isolates were analysed using liquid chromatography/mass spectrometry (LC/MS) or gas chromatography/mass spectrometry (GC/MS). Most of the representative 61 isolates non-oxidatively decarboxylated the substrates to produce the corresponding aromatic vinyl monomers, which are used as feed stocks for bio-based plastics production. Oxidative metabolism of the lignin-related compounds for assimilation was frequently observed. Our study showed that the deep-sea environment contains an abundance of microorganisms capable of both non-oxidative and oxidative bioconversion of lignin-derived aromatic compounds. The ability for bio-conversion of aromatic compounds found in this study will facilitate the development of future biotechnological applications.

关键词： Aromatic Compound Bacteria Deep Sea Lignin

Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

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World Journal of Gastrointestinal Pathophysiology 2011年第6期2卷 93-99页

作者： Tsutomu Nishida Shusaku tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan

Treatment strategies,whether as follow-up or"total incisional biopsy"for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic *** on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive ***,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade *** studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness.

关键词： Gastric intraepithelial neoplasia Adenoma Dysplasia Endoscopic submucosal dissection Endoscopic mucosal resection Endoscopic resection Adenocarcinoma

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使用水泥固定氚水的研究(Ⅰ)

武汉理工大学学报 1981年第2期20卷 34-42页

作者：筒井天尊西牧研壮三宅千秋刘士仪日本京都大学原子炉研究所

从原子能设备中产生的放射性废物之一,是含氚废水。氚水的化学性质和物理特性与普通水是相同的,因此要从放射性废水中,象其它放射性核素一样,把氚水分离出来是困难的。我们认为使用水泥水化固定氚水是一个行之有效的方法。一般说来,水... 详细信息

从原子能设备中产生的放射性废物之一,是含氚废水。氚水的化学性质和物理特性与普通水是相同的,因此要从放射性废水中,象其它放射性核素一样,把氚水分离出来是困难的。我们认为使用水泥水化固定氚水是一个行之有效的方法。一般说来,水泥水化主要产生3CaO·2SiO_2·3H_2O和Ca(OH)_2,即每100g水泥中的水将消耗25克水,因此利用这一性能,期待氚水能作为水泥水化后结构中的组份而固定。虽然利用简单的试验,已经发现大量氚水转移到周围水中。但是,使用波特兰水泥的水化,氚水还是被溶合进去了,因此,我们试图了解,用水泥固定氚化水转移现象的机理。本报告中,我们示出了包括下述几方面的基本试验的结果和条件,即:不同水泥的作用,养护期,水中浸渍时间,凝胶水存在时的情况,以及周围水中盐和碱的浓度等。

关键词：波特兰水泥周围构成物质硅酸盐水泥硬化体水化反应

TauH2单体型和额颞痴呆患者发病年龄之间的相关性

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 9-9页

作者： Borroni B. Yancopoulou D. tsutsui M. M.G. Spillantini 江山 Brain Repair Centre Department of Clinical Neurosciences Forvie Site Robinson Way Cambridge CB2 2PY United Kingdom.Dr

Background: The frontotemporal dementia (FTD) syndromes have been associated with the microtubule-associated tau protein since tau gene mutations have been demonstrated to be the cause of FTD and parkinsonism linked to chromosome 17. In cases of FTD without tau gene mutations, however, it is unclear whether genetic variability in the tau gene is associated with the development or modulation of FTD. Objective: To determine whether genetic variability in tau and apolipoprotein E (ApoE)-modulates and contributes to the development of FTD. Design and Patients: The distribution of tau gene haplotypes and the ApoE genotype were investigated in 86 patients with well-characterized FTD and 50 control subjects. Results: No difference in the distribution of the tau H1 and H2 haplotypes between FTD cases and controls was observed, whereas the ApoE∈4 allele was more frequent in FTD cases. The presence of at least 1 tau H2 allele was found to be significantly associated with an earlier age of onset in patients with FTD. The association between the H2 allele and age at onset was not related to family history, clinical presentation, or ApoE genotype. Conclusion: These findings support a role of tau protein in modulating disease phenotype by influencing the age at onset in these FTD cases.

关键词：额颞痴呆发病年龄年龄因素单体型患者相关性

多巴酚丁胺负荷超声心动图过程中早期应用阿托品与传统方法安全性与有效性的比较

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 28-28页

作者： tsutsui J. M. Osório A. F. F. Lario F. C. 郭宁

Although dobutamine-atropine stress echocardiography (DASE) is an established method for evaluating patients who have coronary artery disease(CAD), it can in crease test duration and a patient’s exposure to large doses of dobutamine. New protocols, including the early injection of atropine during dobutamine stress e chocardiography (EA-DSE), have been proposed to decrease test duration. This st udy compared the safety, efficacy, and accuracy of EA-DSE with those of DASE. W e retrospectively evaluated 3,163 patients who underwent DASE and 1,664 patients who underwent EA-DSE over a period of 12 years. In EA-DSE, atropine at a dose ≤2mg was started with 20 μg/kg/min of dobutamine if heart rate was 50%stenosis) was assessed in pati ents who underwent quantitative angiography ≤3 months of stress testing. The do butamine dose used in EA-DSE was smaller than that used in DASE(31±6vs 36±6 μg/kg/min, p< 0.0001), although the atropine dose was larger(0.8±.0.5 vs 0.5± .0.25 mg, p< 0.0001). EA-DSE resulted in a significantly shorter duration of do butamine infusion(12.4±.2.0 vs 14.6±.2.5 minutes, p < 0.0001), more diagnostic studies(88%vs 81%, p< 0.0001), and a lower incidence of minor adverse effects than did DASE. The rate of major adverse effects was similar in the 2 protocols . Sensitivities, specificities, positive predictive values, negative predictive values, and accuracies for detecting CAD were 84%, 90%, 93%, 76%, and 86%fo r EA-DSE and 86%, 78%, 84%, 79%, and 82%for DASE, respectively(p=NS). Ther efore, EA-DSE is a safe and effective alternative to DASE and had a similar acc uracy for the detection of CAD.

关键词：负荷超声心动图多巴酚丁胺无冠状动脉替代方法阴性预测值阳性预测值血管造影特异性

喂食中长期缺乏亚硝酸盐和硝酸盐可导致小鼠代谢综合征、内皮功能障碍及心血管病死亡

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中华高血压杂志 2017年第6期25卷 507-507页

作者：刘莉叶鹏 Kina-Tanada M Sakanashi M Tanimoto A Kaname T Matsuzaki T Noguchi K Uchida T Nakasone J Kozuka C Ishida M Kubota H Taira Y Totsuka Y Kina SI Sunakawa H Omura J Satoh K Shimokawa H Yanagihara N Maeda S Ohya Y Matsushita M Masuzaki H Arasaki A tsutsui M

一氧化氮不仅通过一氧化氮合成酶（nitric oxide synthases,NOS）由L-精氨酸合成,还可由其惰性代谢物,亚硝酸盐和硝酸盐合成。绿叶蔬菜中含有丰富的硝酸盐。但是膳食中亚硝酸盐/硝酸盐的缺乏是否导致疾病的发生还有待澄清。该研究人员假... 详细信息

一氧化氮不仅通过一氧化氮合成酶（nitric oxide synthases,NOS）由L-精氨酸合成,还可由其惰性代谢物,亚硝酸盐和硝酸盐合成。绿叶蔬菜中含有丰富的硝酸盐。但是膳食中亚硝酸盐/硝酸盐的缺乏是否导致疾病的发生还有待澄清。该研究人员假设,喂食中长期缺乏亚硝酸盐/硝酸盐会诱导小鼠发生代谢综合征。

关键词：亚硝酸盐和硝酸盐代谢综合征内皮功能障碍心血管病一氧化氮合成酶小鼠喂食死亡