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Journal of Cancer Therapy 2017年第4期8卷 341-348页

作者： Masanori Naito Takeo Sato Takatoshi Nakamura Takahiro Yamanashi Hirohisa Miura atsuko tsutsui Masahiko Watanabe Department of Surgery School of Medicine Kitasato University Sagamihara Japan

Introduction: Systematic lymphadenectomy and ligation of the feeding artery is extremely important when performing radical resection in colorectal cancer. However, vascular surgery via laparoscopy requires advanced skills and techniques;thus, this procedure needs to be simplified while maintaining quality of the surgery to make it a preferred technique for the surgeons. Methods: There were 49 patients who underwent laparoscopic sigmoidectomy or anterior resection till T2 level for sigmoid colon cancer and recto-sigmoid colon cancer. We analyzed short-term and long-term outcomes between stapling ligation and clipping ligation techniques used in these surgeries. Results: The mean volume of blood loss in the stapling ligation group was 12.8 ± 12.3 ml, which was significantly lower than 41.9 ± 71.2 ml of mean volume of blood loss in the clipping ligation group. There was no significant difference in the mean duration of surgery, the mean number of harvested lymph nodes, morbidity, recurrence, and 5-year relapse free survival rates between the 2 groups. Conclusions: This study demonstrates a surgical technique using staplers for vascular treatment of tumor-feeding arteries as a new technical improvement in laparoscopic colectomy for the treatment of early-stage colon cancer. We found that the described procedure was technically safe, simple, convenient, and oncologically valid.

关键词： Laparoscopic Surgery Colorectal Cancer Vascular Ligation Linear Stapler

Insights into genetic variation and demographic history of sharpnose rays:examinations of three species of Telatrygon(Elasmobranchii,Dasyatidae)from the Indo-West Pacific

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Integrative Zoology 2022年第6期17卷 1063-1077页

作者： Jiwei QI Fanglei SHI Baowei ZHANG Xiao CHEN Jie XING Keisuke FURUMITSU Joel B.CORUSH atsuko YAMAGUCHI Jie ZHANG Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijingChina School of Life Science Anhui UniversityHefeiAnhuiChina College of Marine Sciences South China Agricultural UniversityGuangzhouChina East China Sea Centre of Standard and Metrology SOAShanghaiChina Faculty of Fisheries Nagasaki UniversityNagasakiJapan Illinois Natural History Survey University of Illinois Champaign-UrbanaChampaignIllinoisUSA State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikouChina

Coastal and demersal chondrichthyans(sharks,rays,and skates)are expected to exhibit high levels of genetic differentiation in areas of complex *** genetic studies investigating the extent to which demographic history shapes the genetic structure of theseﬁshes are ***,we combined mitochondrial DNA(Cytb and ND2)and 8 nuclear microsatellite loci from 244 individuals to examine the population genetic structure and demographic history of the 3 Indo-West Paciﬁc species of sharpnose rays(Telatrygon zugei,Telatrygon biasa,and Trygon crozieri).High levels of genetic variation both within and between species were identiﬁ*** analysis partitioned haplotypes into 2 lineages supporting divergence of *** from *** and *** during the ***,microsatellite-based clustering analyses identiﬁed 4 genetic groups(*** from Japan,*** from coastal China,*** from Gulf of Thailand,and *** from the Andaman Sea).Measurements of genetic differentiation also support these 4 ***,Pleistocene demographic expansions were examined in all genetic *** climate oscillations and current hydrologic cycles in the Indo-West Paciﬁc appear to coincide with the hypothesis regarding speciation and the observed demographic history trends of the sharpnose *** the species group has,until recently,been thought to be one species,these results are critical for deﬁning management units and guiding conservation efforts to preserve stingray biodiversity.

关键词： conservation biodiversity of stingray demographic history genetic variation Indo-West Paciﬁc Telatrygon

High-temperature formation phases and crystal structure of hot-pressed thermoelectric compounds with chalcopyrite-type structure

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Rare Metals 2018年第4期37卷 360-368页

作者： atsuko Kosuga Yosuke Fujii Akito Horie Department of Physical Science Graduate School of ScienceOsaka Prefecture University JST PRESTO Department of Electronics Mathematics and PhysicsGraduate School of EngineeringOsaka Prefecture University

In this study, we introduced the temperaturedependent formation phases and crystallographic parameters of hot-pressed silver gallium telluride AgGaTe2 and copper gallium telluride CuGaTe2 with chalcopyrite structure from 300 to 800 K. These two compounds are potential thermoelectric materials in the intermediate temperature range; however, the temperature-dependent formation phases and crystallographic parameters of hotpressed samples have not yet been analyzed in detail. The crystal structure analysis based on synchrotron X-ray diffraction （SXRD） measurements clarifies that impurity phases such as Te and Ag2Te in the AgGaTe2 matrix and Te and CuTe in the CuGaTe2 matrix appear at some temperature regions above 300 K. The existence of such impurity phases could be correlated with the increases of the electrical resistivity and Seebeck coefficient of the samples after multiple measurement cycles of the temperature-dependent transport properties from 300 to 800 K. The tetragonal lattice parameters a and c, tetragonal lattice volume, thermal expansion coefficients, tetragonal distortion, anion displacement parameter, and isotropic displacement parameter of the hot-pressed AgGaTe2 and CuGaTe2 were also analyzed. These crystallographic parameters are expected to substantially affect the thermoelectric properties of AgGaTe2 and CuGaTe2. Our results provide prospect of the long-term high-temperature stability and clues of the detailed analysis on the transport properties of hot-pressed AgGaTe2 and CuGaTe2, which should aid their development for thermoelectric applications.

关键词： Chalcopyrite Silver gallium telluride Coppergallium telluride Thermoelectric Crystal structure

Role of animal models in glaucoma research

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Neural Regeneration Research 2020年第7期15卷 1257-1258页

作者： atsuko Kimura Takahiko Noro Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical Science

Glaucoma is a neurodegenerative disease of the eye,and it presents with visual field defects accompanied by progressive degeneration of the optic nerve and retinal ganglion cells(RGCs).It is one of the major causes of blindness worldwide and affects 1 in 20 people over the age of *** is caused by multiple factors,but it is usually associated with elevated intraocular pressure(IOP).Extensive studies have been carried out to discover therapeutic targets and to develop new drugs to treat ocular hypertension using experimental models of rodents(rats and mice)and non-human primates(e.g.,cynomologus,rhesus,or marmoset monkeys).

关键词： elevated degeneration drugs

A trip of peptides to the brain

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食物生产加工与营养(英文) 2020年第1期2卷 300-307页

作者： Toshiro Matsui atsuko Yoshino Mitsuru Tanaka Department of Bioresources and Biosciences Faculty of AgricultureGraduate School of Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Research and Development Center for Five-Sense Devices Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan

Dietary di/tripeptides elicit preventive effects against lifestyle-related diseases such as hypertension,and hypercholesterolemia,*** there have been evidential reports that the intake of protein hydrolysate improved impaired memory in human,limited studies on bioavailability,in particular,beyond the blood-brain barrier(BBB)of candidates in hydrolysate may prevent their extensive physiological ***,this review discusses the updated studies on BBB transport of peptides showing improved cognitive ***,their accumulation in the brain cerebral parenchyma is also introduced.

关键词： Peptide Blood-brain barrier Transport Cognitive decline

Learning from the Film “Mitorishi (Transition Doula)”—Application to Understanding the End-of-Life in a Gerontological Nursing Practice Course in Japan

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Open Journal of Nursing 2023年第5期13卷 233-248页

作者： Testuko Takaoka atsuko Hatsumi Miho Sugawara Yumi Takenouchi Sugako Fujinaga Department of Nursing Faculty of Human Sciences Hokkaido Bunkyo University Eniwa Japan

Purpose: This study aims to detail what nursing students learned from watching the film “Mitorishi”, which was used among the teaching materials in a gerontological nursing practice course in nursing education in Japan, and demonstrate the applicability of using the film as an element relevant to the teaching of end-of-life care in Japan. Methods: The participants were fourth-year nursing students at University A who had watched the film “Mitorishi” during the course, had submitted a report on what they learned, and provided informed consent to the study participation. The reports submitted by the participants were used as data and analyzed qualitatively using the content analysis approach. Results: The analysis identified the following five categories (number of codes): Characteristics of life during the final days (9), Importance of views on life and death (3), Importance of end-of-life care (3), Assistance in preparation for the final days of life (13), and Understanding the profession of transition doula (9). Discussion: The five categories show that the students have learned about the “role of nurses at the time of end-of-life care” while “visualizing end-of-life care” and learning “preparedness for end-of-life care”. These findings suggest that using the film “Mitorishi” in the teaching curriculum is effective for learning about end-of-life care for older people.

关键词： End-of-Life Care Nursing Students Basic Nursing Education Transition Doula

Using Machine Reading to Understand Alzheimer's and Related Diseases from the Literature

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Journal of Data and Information Science 2017年第4期2卷 81-94页

作者： Satoshi tsutsui Yi Bu Ying Ding School of Informatics Computingand EngineeringIndiana UniversityBloomingtonIN 47408USA School of Information Management Wuhan UniversityWuhan 430072China

Purpose： This paper aims to better understand a large number of papers in the medical domain of Alzheimer＇s disease （AD） and related diseases using the machine reading approach. Design/methodology/approach： The study uses the topic modeling method to obtain an overview of the field, and employs open information extraction to further comprehend the field at a specific fact level. Findings： Several topics within the AD research field are identified, such as the Human Immunodeficiency Virus （HIV）/Acquired Immune Deficiency Syndrome （AIDS）, which can help answer the question of how A1DS/HIV and AD are very different yet related diseases. Research limitations： Some manual data cleaning could improve the study, such as removing incorrect facts found by open information extraction. Practical implications： This study uses the literature to answer specific questions on a scientific domain, which can help domain experts find interesting and meaningful relations among entities in a similar manner, such as to discover relations between AD and AIDS/HIV. Origlnality/value： Both the overview and specific information from the literature are obtained using two distinct methods in a complementary manner. This combination is novel because previous work has only focused on one of them, and thus provides a better way to understand an important scientific field using data-driven methods.

关键词： Machine reading Alzheimer's disease Knowledge discovery Data mining

Curvature derived from LiDAR digital elevation models as simple indicators of debris-flow susceptibility

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Journal of Mountain Science 2019年第1期16卷 95-107页

作者： atsuko NONOMURA Shuichi HASEGAWA Hideo MATSUMOTO Mari TAKAHASHI Mina MASUMOTO Kazuhito FUJISAWA Faculty of Engineering and design Kagawa University Institute of Education Research and Regional Cooperation for Crisis Management Shikoku Kagawa University Faculty of Engineering Graduate school of Engineering Kagawa University

To mitigate the damage caused by debris flows resulting from heavy precipitation and to aid in evacuation plan preparation, areas at risk should be mapped on a scale appropriate for affected individuals and communities. We tested the effectiveness of simply identifying debris-flow hazards through automated derivation of surface curvatures using LiDAR digital elevation models. We achieved useful correspondence between plan curvatures and areas of existing debris-flow damage in two localities in Japan using the analysis of digital elevation models(DEMs). We found that plan curvatures derived from 10 m DEMs may be useful to indicate areas that are susceptible to debris flow in mountainous areas. In residential areas located on gentle sloping debris flow fans, the greatest damage to houses was found to be located in the elongated depressions that are connected to mountain stream valleys. Plan curvaturederived from 5 m DEM was the most sensitive indicators for susceptibility to debris flows.

关键词： Digital elevation model LiDAR Gridspacing Debris flow Geological hazard Curvature

Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 464-469页

作者： atsuko Ohkubo Tomomi Chida Hidetomo Kikuchi Tadashi Tsuda Katsuyoshi Sunaga Laboratory of Pharmacotherapy Department of Clinical Dietetics and Human Nutrition Faculty of Pharmaceutical Sciences Josai University

We previously demonstrated that tomato juice(TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice(GFJ)on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine(NFP) and midazolam(MDZ), in male Wistar rats. Oral administration of GFJ 90 min before the intraduodenal administration of NFP or MDZ increased the area under the concentration–time curves(AUCs)of NFP and MDZ by 32.4% and 89.4%, respectively. TJ increased MDZ blood concentrations and AUC after intraduodenal MDZ administration;however, it had no effect on NFP. When MDZ and NFP were intravenously administered, GFJ significantly increased the AUC of MDZ,but only slightly increased that of NFP. In contrast, TJ only slightly increased the AUC of *** results suggest that, similar to GFJ, TJ influences the pharmacokinetics of CYP3A4-substrate drugs;however, it may be a drug-dependent partial effect.

关键词： Food–drug interactions Tomato juice Grapefruit juice Nifedipine Midazolam Pharmacokinetic interactions

Prevalence of nonalcoholic fatty liver disease and its association with age in patients with type 2 diabetes mellitus

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World Journal of Hepatology 2022年第6期14卷 1226-1234页

作者： Ryosuke Yamane Kentaro Yoshioka Kazuhiko Hayashi Yuko Shimizu Yuki Ito Komei Matsushita Michiyo Yoshizaki Go Kajikawa Taro Mizutani atsuko Watarai Kosuke Tachi Hidemi Goto Department of Gastroenterology and Hepatology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Center for Liver Diseases Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Department of Diabetes and Endocrinology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan

BACKGROUND Type 2 diabetes mellitus(T2DM)is a risk factor for nonalcoholic fatty liver disease(NAFLD).AIM To determine the prevalence and clinical correlates of NAFLD in a large cohort of patients with *** Four hundred thirty-seven participants with T2DM who consulted at Meijo Hospital from April 2019 to September 2020 and underwent computed tomography(CT)were *** mean age was 74±13 years,and 269 were *** attenuation minus splenic attenuation(CTL−S)less than 1 Hounsfield unit was considered fatty *** was defined as fatty liver in the absence of significant alcohol consumption and hepatitis virus infection.A multiple logistic regression was used to assess the independent factors associated with *** NAFLD was identified in 25.2%of the *** age(odds ratio[OR]=−0.945;95%confidence interval[CI]:0.922–0.969),higher hemoglobin levels(OR=1.501,95%CI:1.278–1.764),lower high-density lipoprotein(HDL)cholesterol levels(OR=0.971,95%CI:0.953–0.989),and the absence of dialysis(OR=0.109,95%CI:0.014–0.856)were independent predictors of *** NAFLD was detected with CT in 25.2%of the *** was associated with younger age,higher hemoglobin levels,lower HDL cholesterol levels,and an absence of dialysis.

关键词： Age Computed tomography Dialysis Hemoglobin Nonalcoholic fatty liver disease Type 2 diabetes mellitus