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Surgical Science 2013年第1期4卷 72-76页

作者： Hajime Uchida Seisuke Sakamoto Ikumi Hamano Takanobu Shigeta Hiroyuki Kanazawa Chiaki Karaki Akinari Fukuda atsuko Nakazawa Mureo Kasahara Department of Clinical Pathology National Center for Child Health and Development Tokyo Japan Department of Transplantation National Center for Child Health and Development Tokyo Japan

Hepatoblastoma is the most common type of malignant liver tumor in children and occurs most frequently in patients two years of age and younger. The outcomes for children with hepatoblastoma have been improving in recent years due to the introduction of cisplatin-based chemotherapy regimens. Recently, performing liver transplantation after neoadjuvant chemotherapy has become increasingly advocated as a primary surgical treatment for children with unresectable hepatoblastoma involving three or four sectors of the liver. Surgical exploration is frequently required to determine which tumors are resectable, which require liver transplantation and timing of resection. When the quality of the remnant liver is in question, the decision for transplantation versus resection should be made by a liver team in experienced center with capability of liver transplantation. This report presents the findings of the patient with hepatoblastoma who successfully underwent extreme resection with a backup for living donor liver transplantation. The patient was discharged home in good condition and the follow-up continued for three years with normal AFP levels observed.

关键词： Hepatoblastoma Unresctable Hepatoblastoma Living Donor Liver Transplantation

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心跳的感觉巧克力王国

国际服装技术 2007年第2期 56-61页

作者： Satomi Okisada atsuko Watanabe Pluto（翻译） Junai Nakagawa（摄影）

一年一度的情人节，借助巧克力带来心跳的感觉吧。一款承载心意的巧克力，一次技压情敌的良机，不管是情义还是本命，成熟的女人都不会忽视！香香甜甜的巧克力会溶化在口中，也会溶化在你的心里！

关键词：巧克力心跳情人节溶化

協働作業における不同意表明の中日比較——構成要素の分析を通して

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日语教育与日本学 2021年第2期 22-35页

作者：张佳楠田崎敦子南京大学东京农工大学

本研究では、中国語母語話者(C)と日本語母語話者(J)がそれぞれの母語で行った協働作業における不同意表明場面の特徴を示すために、使用された構成要素を比較·分析した。その結果、JがCに比べ非言語行為、疑問文を多用し相手に配慮す... 详细信息

本研究では、中国語母語話者(C)と日本語母語話者(J)がそれぞれの母語で行った協働作業における不同意表明場面の特徴を示すために、使用された構成要素を比較·分析した。その結果、JがCに比べ非言語行為、疑問文を多用し相手に配慮するという相違点と、両者が否定や否定理由、代案などを使い迅速に作業を進めるという共通点があることが明らかになった。この結果から、CがJと日本語で協働作業を円滑に行うためには、不同意表明場面において、相手に配慮しつつ、作業を効率的に進めることができる日本語能力の養成が必要であることが示唆された。

关键词：不同意表明協働作業日本語教育中国人日本語学習者日本語母語話者

Effects of UV Irradiation on the Locomotor Activity and Body Temperature Rhythms in Hairless Mice

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Effects of UV Irradiation on the Locomotor Activity and Body...

Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis

The 3rd Asian and Oceanian Conference on Photobiology

作者： Eri Chikamori Tomoko Sudo atsuko Masuda Kanako Muramatsu Morihiro Yoneda Tomoko Wakamura Hiromi Tokura Tadashi Oishi Faculty of Science Faculty of Science Faculty of Science KYOUSEI Science Center for Life and Nature Faculty of Human Life and Environment Nara Women’s UniversityNara 630-8506Japan Faculty of Medicine Kyoto UniversityKyoto 606-8501Japan Institute of Textiles ＆ Clothing The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Faculty of Science Nara Saho College Rokuyaon-cho 806Nara 630-8566Japan

＜正＞Effects of ultra violet light （UV） irradiation on the skin physiology have been studied well. However, other effects than the skin physiology have not been investigated so much. On the other hand, visible light is reported to be most important as a zeitgeber to entrain circadian rhythms in animals. However, effects of UV on the circadian rhythms such as locomotor activity and body temperature rhythms have not been investigated well. Therefore, in this study, we examined the effects of UV irradiation on the circadian rhythms of locomotor activity and body temperature in hairless mice.

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Open Journal of Stomatology 2014年第2期4卷 49-55页

作者： Tetsuo Kobayashi Moe Okada Satoshi Ito Daisuke Kobayashi atsuko Shinhara Takahiko Muramatsu Tsuyoshi Kobayashi Ichiei Narita Kiyoshi Nakazono Akira Murasawa Hiromasa Yoshie Division of Clinical Nephrology and Rheumatology Department of Homeostatic Regulation Developments Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Division of Periodontology Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Institute for Innovation Ajinomoto Co. Inc. Kawasaki Japan Niigata Rheumatic Center Shibata Japan

Chronic periodontitis (CP) and rheumatoid arthritis (RA) are chronic inflammatory conditions, and share many pathologic features. Plasma amino acid profiles have been shown to be associated with RA, but their relevance to CP remains unclear. The aim of the present study is to evaluate amino acid profiles in relation to CP and RA. The study participants consisted of 62 patients with RA (RA group), 30 patients with CP (CP group) and 29 healthy controls (H group) in age-, gender-, smoking status-balanced condition. Clinical periodontal and rheumatologic parameter values and plasma levels of 21 amino acids, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were determined. Multiple comparison analyses revealed that the RA group exhibited similar periodontal conditions but significantly higher levels of CRP, IL-6, and TNF-α than the CP group (P < 0.01). A total of four amino acids (glycine, histidine, ornithine, and alpha-aminobutyric acid) were significantly different in the concentrations among the three groups (P < 0.01). The RA group displayed significantly lower levels of glycine and histidine and significantly higher ornithine level than the CP and H groups (P < 0.01). The CP group showed significantly higher alpha-aminobutyric acid level than the RA and H groups (P < 0.01). Of these four amino acids, a significantly positive correlation was found between ornithine level and % of sites with bleeding on probing (P = 0.006) in the RA group. These results suggest a possibility that profiles of four amino acids may play a role in the pathogenesis of CP and RA.

关键词： Amino Acid Chronic Periodontitis Rheumatoid Arthritis Case-Control Study

Optimal Minimum Number of CT Slices Required to Measure Cross Sectional Areas of Small Pulmonary Vessels

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Open Journal of Medical Imaging 2015年第2期5卷 71-77页

作者： Shingo Sakamoto Shoichiro Matsushita Akiyuki Kotoku Hayato Tomita Yuki Saito Shinji Saruya Shin Matsuoka Tsuneo Yamashiro atsuko Fujikawa Kunihiro Yagihashi Yasuo Nakajima Department of Radiology St. Marianna University School of Medicine Kawasaki Japan Department of Radiology Graduate School of Medical Science University of the Ryukyus Nishihara Japan

The cross-sectional area (CSA) of small pulmonary vessels can be quantified by CT, which is a reliable method of evaluating vascular alterations in such vessels. However, the optimal number of slices required for accurate quantitation remains unknown. We evaluated relationships among all slices at 10-mm interval and all slices at 3-cm interval, 6-cm interval, and 3-slices and found the closest correlation (0.939) between all slices at 10-mm intervals and 3-cm intervals. Thus, all slices at 3-cm intervals are suitable for accurately measuring CSA.

关键词： Computed Tomography Cross-Sectional Area Pulmonary Vessels Quantitative Analysis

Expression of Difficult-to-Express Proteins, Human IL-12 and IFN-<i>γ</i>

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American Journal of Molecular Biology 2021年第2期11卷 29-37页

作者： Yoshihito Hosaka Shun Matsutani Shinya Kawate Kei Itoh atsuko Miura Yukaze Mizoura Sayumi Yamada Seiya Uemura Hiroshi Konno Ewa Grave Hideki Wakui Hideaki Itoh Department of Life Science Graduate School and Faculty of Engineering Science Akita University Akita Japan Akita Konno Co. Ltd. 248 Aza Kariwano Daisen-shi Akita Japan Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan

It is known to be that lactic acid bacteria induce the IL-12. IL-12 activates NK cells and promotes the production of IFN-γ. IFN-γ activates macrophages, resulting in enhanced phagocytosis and bactericidal activity. We have been investigating fermented foods that activate the immune function. For that purpose, a specific antibody is required. We tried to express IL-12p35 by the usual method, but IL-12p35 was not expressed at all. In the present study, we constructed, purified human IL-12p35 and obtained a specific antibody against IL-12p35. We also purified human IFN-γ and obtained specific antibody against IFN-γ. We have established a method for expressing poorly expressed proteins. The method we have established can be applied to the purification of poorly expressed proteins and antibody production.

关键词： Difficult-to-Express Proteins IL-12 IFN-γ Purification Antibody Production

Efficacy and Tolerability of Second-Line Metronidazole Triple Therapy Using Vonoprazan for Helicobacter pylori Eradication in Japan—Comparative Study: Vonoprazan vs. Proton Pump Inhibitors

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Open Journal of Gastroenterology 2018年第1期8卷 27-38页

作者： Masahiko Ohtaka Mika Miura Mitsuhiko Hanawa Yuichi Hirose atsuko Kitahashi Naoki Imamura Ikko Watanabe Kazuhiko Takaso Naoki Shimura Yoshioki Yoda Ichiro Takayama Mitsuharu Fukasawa Nobuyuki Enomoto Yamanashi Koseiren Health Care Center Yamanashi Japan First Department of Internal Medicine Graduate School of Medical and Engineering Science University of Yamanashi Yamanashi Japan Health Care Center University of Yamanashi Yamanashi Japan

Aim: To investigate the efficacy and tolerability of second-line metronidazole triple therapy with vonoprazan (VPZ) for Helicobacter pylori (H. pylori). Methods: We retrospectively reviewed medical records of patients who experienced clarithromycin triple therapy failure and were treated with second-line (20 mg VPZ (n = 274)/30 mg lansoprazole (n = 323) or 10 mg rabeprazole (n = 141) twice daily, 750 mg amoxicillin twice daily, 250 mg metronidazole twice daily for 7 days) eradication therapies. Successful eradication rates were compared between two groups: those receiving VPZ and those receiving a proton pump inhibitor (PPI). Adverse events were also investigated. Results: Successful second-line eradication rates according to ITT analysis and PP analysis, respectively, were 79.9% and 92.4% for VPZ therapy and 83.6% and 93.3% for PPI therapy. There were no significant differences between treatment groups. The eradication rates in those who had received first-line VPZ therapy previously according to ITT and PP analysis were 75.2% and 88.1%, respectively;in contrast, values were 82.5% and 95.4%, respectively, for those who had received first-line PPI therapy previously. In second-line therapy, the overall adverse event rate for VPZ therapy was the same as for PPI therapy. Conclusions: The efficacy and tolerability of metronidazole-containing second-line triple therapy with VPZ or a PPI were equivalent.

关键词： Vonoprazan Metronidazole Proton Pump Inhibitor Second-Line Eradication Helicobacter pylori

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全球化下日本公民馆的发展及其社会影响

现代远程教育研究 2011年第2期23卷 52-58页

作者：新保敦子[日] 早稻田大学教育部日本东京

公民馆是日本社会环境下独特的产物,在日本的社会教育中居于相当重要的地位,对日本社会的影响至为深远。公民馆是一种从小区中发展出来的自发性组织,是集综合社会教育、社交娱乐、自治区振兴、产业振兴、青年养成等目的于一体的中心机... 详细信息

公民馆是日本社会环境下独特的产物,在日本的社会教育中居于相当重要的地位,对日本社会的影响至为深远。公民馆是一种从小区中发展出来的自发性组织,是集综合社会教育、社交娱乐、自治区振兴、产业振兴、青年养成等目的于一体的中心机构。公民馆以《社会教育法》为推动的政策依据,自战后以来,历经设置期、稳定期、探索期、改革期至停滞期等阶段。近年日本地方自治体出现发展新动向,即指定管理者制度的产生和非营利性组织的参与,这给公民馆运营带来变化,社会教育的小区共同体意识出现瓦解。因此继承公民馆理念,实现小区共同体再生,是日本终身教育今后发展值得关注的问题。

关键词：终身教育日本公民馆发展历程社会意义

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一种辐射固化树脂组合物及其涂料的制备

涂料技术与文摘 2016年第4期37卷 55-55页

作者： Konishi atsuko

201604007一种辐射固化型聚氨酯丙烯酸酯树脂及其抗粘性优异的涂料：W02015 152 110[国际专利申请，日]日本：The Nippon Synlhetic Chemical Induslry Co．，Ltd．（***等）．-2015．10．08．-76页．-JP2014／263375（2014．12．26）

关键词：聚氨酯树脂涂料丙烯酸酯树脂专利申请固化型 Ltd