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中国生物医学工程学会成立30周年纪念大会暨2010中国生物医学工程学会学术大会

作者： atsuko matsuoka National Institute of Health Sciences Division of Medical Devices

Recently,nanomaterials(NMs) have been used in industry,consequently arriving just around us as many kinds of *** are being used in medical devices as *** the amount of NMs contained in those products may be a little,we may need to pay attention to their safety because it may be different from that of their bulky *** present,not only OECD and ISO but also many other cooperative study groups are trying to establish test methods for NMs’ safety evaluation heading for the international cooperation on development and harmonization of the test *** this presentation,first I will talk about the particle size-dependent toxicity of polystyrene(PS) particles in vitro,and then introduce an in vivo test method performed with colloidal silica,silver and zinc *** particles were tested assuming them to be the aggregates of *** and genotoxicity of eleven size-different PS spheres with defined diameters ranging from 0.1 to 9.2 μm were tested in a Chinese hamster cell line,CHL[1].The 4.45-μm PS particles were most cytotoxic and smaller or larger particles showed less *** was a big toxicity difference between the 4.45-and 5.26-μm particles,although both precipitated and covered cells to the same extent in the *** analysis of particles and chemical analysis of dispersion vehicles did not show any difference between *** particles induced polyploidy in the chromosome aberration test and the intensity was correlated well with their *** images clearly showed the uptake of the 4.45-μm PS particles into CHL *** cytometric analysis seemed to measure the uptake of PS particles *** findings suggest that polyploidy may be induced by cytokinesis block due to particles *** are considering that such a size specific toxicity may be induced in the test with NM *** may need to provide information about aggregate sizes or some parameters indicating dispersion cond

关键词： Biomaterials silica,silver,zinc oxide intratracheal administration a 13-week repeated dose test

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Respiratory Changes in the Superior Vena Cava Area on Inspiratory and Expiratory Chest CT: Comparison between Patients with COPD and with Bronchial Asthma

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Open Journal of Medical Imaging 2016年第4期6卷 123-134页

作者： Akiyuki Kotoku Shin matsuoka Tsuneo Yamashiro Shoichiro Matsushita atsuko Fujikawa Hayato Tomita Kunihiro Yagihashi Yasuo Nakajima Department of Radiology Graduate School of Medical Science University of the Ryukyus Nishihara Town Japan Department of Radiology St. Marianna University School of Medicine Kawasaki City Japan

Purpose: In patients with obstructive lung diseases, alteration of intrathoracic pressure is closely related to hyperinflation and leads to hemodynamic impairments. Both intrathoracic pressure and hemodynamics are affected by the respiratory phase. In fact, a previous study showed that respiratory phasic variations in the superior vena cava (SVC) area significantly correlated with the extent of emphysema. Chronic obstructive pulmonary disease (COPD) and bronchial asthma manifest different pathophysiological changes in hyperinflation and hemodynamics. The current study was conducted to evaluate differences in respiratory variations in the cross-sectional area of the SVC between patients with COPD and with asthma. Materials and Methods: We measured the SVC area and calculated the ratio of the SVC area on inspiratory and expiratory scans (i/e-SVC ratio) in 66 patients with COPD and 16 patients with asthma. The cor-relations of the i/e-SVC ratios with airflow limitation, pulmonary small vessels less than 5 mm2 (%cross-sectional area [%CSA] < 5), and respiratory changes in lung volume (i/e-LV) obtained by inspiratory and expiratory computed tomography (CT) images were evaluated. Results: There was no significant difference in i/e-SVC ratio between COPD and asthma groups. In COPD patients, the i/e-SVC ratio significantly correlated with the %CSA ﹣0.433, P = 0.003), i/e-LV ratio (ρ = ﹣0.371, P = 0.011), and percent of predicted forced expiratory volume in 1 second (FEV1% predicted) (ρ = ﹣0.474, P = 0.001), whereas in asthma patients, there were no significant correlations between the i/e-SVC ratio and those functional parameters. Conclusion: There would be differences in the relationship between intrathoracic pressure and cardiopulmonary hemodynamics between COPD and asthma patients.

关键词： Computed Tomography Hyperinflation Hemodynamics Intrathoracic Pressure Expiration COPD Asthma

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Optimal Minimum Number of CT Slices Required to Measure Cross Sectional Areas of Small Pulmonary Vessels

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Open Journal of Medical Imaging 2015年第2期5卷 71-77页

作者： Shingo Sakamoto Shoichiro Matsushita Akiyuki Kotoku Hayato Tomita Yuki Saito Shinji Saruya Shin matsuoka Tsuneo Yamashiro atsuko Fujikawa Kunihiro Yagihashi Yasuo Nakajima Department of Radiology St. Marianna University School of Medicine Kawasaki Japan Department of Radiology Graduate School of Medical Science University of the Ryukyus Nishihara Japan

The cross-sectional area (CSA) of small pulmonary vessels can be quantified by CT, which is a reliable method of evaluating vascular alterations in such vessels. However, the optimal number of slices required for accurate quantitation remains unknown. We evaluated relationships among all slices at 10-mm interval and all slices at 3-cm interval, 6-cm interval, and 3-slices and found the closest correlation (0.939) between all slices at 10-mm intervals and 3-cm intervals. Thus, all slices at 3-cm intervals are suitable for accurately measuring CSA.

关键词： Computed Tomography Cross-Sectional Area Pulmonary Vessels Quantitative Analysis

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