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A Revised Classification of Primary Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 346-356页

作者： Yasuaki Tatsumi Motoyoshi Yano Shinya Wakusawa Hiroaki Miyajima Tetsuya Ishikawa Shinsaku Imashuku atsuko Takano Wataru Nihei Ayako Kato Koichi Kato Hisao Hayashi Kentaro Yoshioka Kazuhiko Hayashi Department of Medical Biochemistry Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiJapan Department of Medical Technology Shubun UniversityIchinomiyaJapan Department of Medicine and Neurology Tenryu Kohseikai ClinicHamamatsuJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Department of Laboratory Medicine Uji-Tokushukai Medical CenterUjiJapan Department of Medicine Saiseikai Takaoka HospitalTakaokaJapan Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology FNPS Meijo HospitalNagoyaJapan

Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary iron overload syndromes(PIOSs).In 2012,we proposed a classification of PIOSs based on the Hep25/FP system,which consists of prehepatic aceruloplasminemia,hepatic hemochromatosis(HC),and posthepatic FP disease(FP-D).However,in consideration of accumulated evidence on PIOSs,we aimed to renew the ***:We reviewed the 2012 classification and retrospectively renewed it according to new information on ***:Iron-loading anemia was included in PIOSs as a prehepatic form because of the newly discovered erythroferrone-induced suppression of Hep25,and the state of traditional FP-D was remodeled as the BIOIRON *** key molecules responsible for prehepatic PIOSs are low transferrin saturation in aceruloplasminemia and increased erythroferrone production by erythroblasts in iron-loading *** PIOSs comprise four genotypes of HC,in each of which the synthesis of Hep25 is inappropriately reduced in the *** Hep25 synthesis is adequate in posthepatic PIOSs;however,two mutant FP molecules may resist Hep25 differently,resulting in SLC40A1-HC and FP-D,*** phenotypes are diagnosed using laboratory tests,including circulating Hep25,followed by suitable *** sequencing of the candidate genes may be outsourced to gene centers when *** kits for the prevalent mutations,such as C282Y,may be the first choice for a genetic analysis of HC in ***:The revised classification may be useful worldwide.

关键词： Ethnicity Ferroportin Hemochromatosis Hepcidin25 Iron overload syndrome

High-temperature formation phases and crystal structure of hot-pressed thermoelectric compounds with chalcopyrite-type structure

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Rare Metals 2018年第4期37卷 360-368页

作者： atsuko Kosuga Yosuke Fujii Akito Horie Department of Physical Science Graduate School of ScienceOsaka Prefecture University JST PRESTO Department of Electronics Mathematics and PhysicsGraduate School of EngineeringOsaka Prefecture University

In this study, we introduced the temperaturedependent formation phases and crystallographic parameters of hot-pressed silver gallium telluride AgGaTe2 and copper gallium telluride CuGaTe2 with chalcopyrite structure from 300 to 800 K. These two compounds are potential thermoelectric materials in the intermediate temperature range; however, the temperature-dependent formation phases and crystallographic parameters of hotpressed samples have not yet been analyzed in detail. The crystal structure analysis based on synchrotron X-ray diffraction （SXRD） measurements clarifies that impurity phases such as Te and Ag2Te in the AgGaTe2 matrix and Te and CuTe in the CuGaTe2 matrix appear at some temperature regions above 300 K. The existence of such impurity phases could be correlated with the increases of the electrical resistivity and Seebeck coefficient of the samples after multiple measurement cycles of the temperature-dependent transport properties from 300 to 800 K. The tetragonal lattice parameters a and c, tetragonal lattice volume, thermal expansion coefficients, tetragonal distortion, anion displacement parameter, and isotropic displacement parameter of the hot-pressed AgGaTe2 and CuGaTe2 were also analyzed. These crystallographic parameters are expected to substantially affect the thermoelectric properties of AgGaTe2 and CuGaTe2. Our results provide prospect of the long-term high-temperature stability and clues of the detailed analysis on the transport properties of hot-pressed AgGaTe2 and CuGaTe2, which should aid their development for thermoelectric applications.

关键词： Chalcopyrite Silver gallium telluride Coppergallium telluride Thermoelectric Crystal structure

Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease

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World Journal of Gastroenterology 2007年第42期13卷 5581-5593页

作者： Mayumi Kawada atsuko Arihiro Emiko Mizoguchi Gastrointestinal Unit Department of Medicine Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States

Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal *** the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are *** studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative *** investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for *** models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been *** this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(*** sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD.

关键词： Inflammatory bowel disease Experimental colitis Dextran sodium sulfate Trinitrobenzene sulfonicacid Oxazolone Pathogenesis

Role of animal models in glaucoma research

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Neural Regeneration Research 2020年第7期15卷 1257-1258页

作者： atsuko Kimura Takahiko Noro Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical Science

Glaucoma is a neurodegenerative disease of the eye,and it presents with visual field defects accompanied by progressive degeneration of the optic nerve and retinal ganglion cells(RGCs).It is one of the major causes of blindness worldwide and affects 1 in 20 people over the age of *** is caused by multiple factors,but it is usually associated with elevated intraocular pressure(IOP).Extensive studies have been carried out to discover therapeutic targets and to develop new drugs to treat ocular hypertension using experimental models of rodents(rats and mice)and non-human primates(e.g.,cynomologus,rhesus,or marmoset monkeys).

关键词： elevated degeneration drugs

A trip of peptides to the brain

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食物生产加工与营养(英文) 2020年第1期2卷 300-307页

作者： Toshiro Matsui atsuko Yoshino Mitsuru Tanaka Department of Bioresources and Biosciences Faculty of AgricultureGraduate School of Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Research and Development Center for Five-Sense Devices Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan

Dietary di/tripeptides elicit preventive effects against lifestyle-related diseases such as hypertension,and hypercholesterolemia,*** there have been evidential reports that the intake of protein hydrolysate improved impaired memory in human,limited studies on bioavailability,in particular,beyond the blood-brain barrier(BBB)of candidates in hydrolysate may prevent their extensive physiological ***,this review discusses the updated studies on BBB transport of peptides showing improved cognitive ***,their accumulation in the brain cerebral parenchyma is also introduced.

关键词： Peptide Blood-brain barrier Transport Cognitive decline

Inflammatory myoglandular polyp causing hematochezia

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World Journal of Gastroenterology 2008年第34期14卷 5353-5355页

作者： Shoji Hirasaki Masato Okuda Kenichiro Kudo Seiyuu Suzuki atsuko Shirakawa Department of Internal Medicine Sumitomo Besshi Hospital Department of Pathology Sumitomo Besshi Hospital

A case of inflammatory myoglandular polyp (IMGP) causing hematochezia is reported. The patient was a 33-year-old man who visited our hospital for further evaluation of hematochezia. Colonoscopy revealed a red, hard, spherical peduncular polyp with erosion and mucous exudation, about 20 mm in diameter, in the descending colon. Excluding the polyp, there was no lesion in the colorectum. Endoscopic polypectomy was performed. Histological examination of the specimen revealed inflammatory granulation tissue in the lamina propria, proliferation of smooth muscle, and hyperplastic glands with variable cystic changes. This polyp was diagnosed as an IMGP. The symptom of hematochezia was resolved after endoscopic resection. Our case shows that treatment is necessary for IMGP if intestinal bleeding occurs and endoscopists should be aware of the endoscopic characteristics of IMGP.

关键词： Inflammatory myoglandular polyp Colonoscopy Endoscopic polypectomy Gastrointestinal bleeding

Curvature derived from LiDAR digital elevation models as simple indicators of debris-flow susceptibility

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Journal of Mountain Science 2019年第1期16卷 95-107页

作者： atsuko NONOMURA Shuichi HASEGAWA Hideo MATSUMOTO Mari TAKAHASHI Mina MASUMOTO Kazuhito FUJISAWA Faculty of Engineering and design Kagawa University Institute of Education Research and Regional Cooperation for Crisis Management Shikoku Kagawa University Faculty of Engineering Graduate school of Engineering Kagawa University

To mitigate the damage caused by debris flows resulting from heavy precipitation and to aid in evacuation plan preparation, areas at risk should be mapped on a scale appropriate for affected individuals and communities. We tested the effectiveness of simply identifying debris-flow hazards through automated derivation of surface curvatures using LiDAR digital elevation models. We achieved useful correspondence between plan curvatures and areas of existing debris-flow damage in two localities in Japan using the analysis of digital elevation models(DEMs). We found that plan curvatures derived from 10 m DEMs may be useful to indicate areas that are susceptible to debris flow in mountainous areas. In residential areas located on gentle sloping debris flow fans, the greatest damage to houses was found to be located in the elongated depressions that are connected to mountain stream valleys. Plan curvaturederived from 5 m DEM was the most sensitive indicators for susceptibility to debris flows.

关键词： Digital elevation model LiDAR Gridspacing Debris flow Geological hazard Curvature

Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 464-469页

作者： atsuko Ohkubo Tomomi Chida Hidetomo Kikuchi Tadashi Tsuda Katsuyoshi Sunaga Laboratory of Pharmacotherapy Department of Clinical Dietetics and Human Nutrition Faculty of Pharmaceutical Sciences Josai University

We previously demonstrated that tomato juice(TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice(GFJ)on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine(NFP) and midazolam(MDZ), in male Wistar rats. Oral administration of GFJ 90 min before the intraduodenal administration of NFP or MDZ increased the area under the concentration–time curves(AUCs)of NFP and MDZ by 32.4% and 89.4%, respectively. TJ increased MDZ blood concentrations and AUC after intraduodenal MDZ administration;however, it had no effect on NFP. When MDZ and NFP were intravenously administered, GFJ significantly increased the AUC of MDZ,but only slightly increased that of NFP. In contrast, TJ only slightly increased the AUC of *** results suggest that, similar to GFJ, TJ influences the pharmacokinetics of CYP3A4-substrate drugs;however, it may be a drug-dependent partial effect.

关键词： Food–drug interactions Tomato juice Grapefruit juice Nifedipine Midazolam Pharmacokinetic interactions

Isolation and characterization of polymorphic microsatellite loci from pale-edged stingray,Telatrygon zugei(Elasmobranchii,Dasyatidae)

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Integrative Zoology 2019年第3期14卷 318-322页

作者： Fanglei SHI Hui WANG atsuko YAMAGUCHI Baowei ZHANG Jie ZHANG Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina School of Life Science Anhui UniversityHefeiChina Faculty of Fisheries Nagasaki UniversityNagasakiJapan

INTRODUCTION Sharks,skates and rays originated 400 Ma,with a further radiation throughout every ocean,and play a vital role in maintaining the balance of marine ecosystems as top predators(Weigmann 2016).There are more than 1000 species of sharks,skates,rays and chimaeras in the world,244 of which are distributed in Chinese *** is,Chinese chondrichthyan fauna make up at least one-fifth of the world’s extant *** habitat degradation and overexploitation have caused sharp declines in many populations of elasmobranchs(White 2007;Dulvy et al.2017).Environmental changes and loss of oceanic apex predators due to overfishing could affect the migration routes and distribution of batoids(rays),resulting in community restructuring in the coastal ecosystem(Yamaguchi et al.2005;Myers et al.2007).Despite the combination of known high biodiversity and heavy exploitation of elasmobranchs in China,there is little reliable information on the population genetics of many shark and ray ***ly,clarification of the population structure is crucial for conservation and management,especially for endangered elasmobranchs.

关键词： originated coastal branch