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Liver Stiffness Measurement Is Useful to Predict Early Recurrence of Hepatocellular Carcinoma after Sustained Virological Responses by Direct Antiviral Agents in Patients with Hepatitis C

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Open Journal of Gastroenterology 2018年第7期8卷 255-268页

作者： Noboru Hirashima Hiroaki Iwase Masaaki Shimada Noboru Urata Etsuko iio Yasuhito Tanaka Department of Gastroenterology National Hospital Organization Nagoya Medical Center Nagoya Japan Department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences Nagoya Japan

Background: Recently, increases in the risk of Hepatocellular carcinoma (HCC) recurrence in patients with hepatitis C virus (HCV) due to the administration of direct antivirals agents (DAA) have been reported. Methods: One hundred and nineteen patients who were treated with DAA and achieved sustained viral response (SVR) were prospectively followed-up for over two years by transient elastography with liver stiffness measurements (LSM). Fourteen out of 119 patients (12%) had a history of being treated for HCC by radiofrequency ablation or resection and achieved complete responses after previous HCC treatments before the initiation of DAA. HCC was diagnosed by contrast-enhanced computed tomography (CT) or enhanced magnetic resonance imaging (MR). CT or MR was performed before the DAA treatment and every 6 months after during the follow-up. LSM was performed at the initiation of DAA (LSM0), at 24 weeks after the start of DAA (LSM24), at 48 weeks after that (LSM48) and at 2 years after that (LSM2y). Results: LSM0, LSM24, LSM48 and LSM2y of 105 patients without HCC were 7.5 (3.027.0), 6.0 (2.5 - 31.6), 4.6 (2.6?- 25.2) and 4.4 (3.1 - 29.9) kPa, respectively, showing significant improvements. Three out of 105 patients (2.9%) subsequently developed HCC and their LSM showed improvements. Eight out of fourteen patients (57%) with a history of HCC treatments subsequently developed HCC recurrence. LSM0 in the eight patients with recurrence increasing from 12.1 to 27.0 kPa, LSM24 from 9.9 to 26.6 kPa and LSM48 from 9.6 to 18.0 kPa. On the other hand, the six other patients without recurrence had LSM values that were less than 12.0 kPa at last. Based on the ROC analysis, LSM0 15.4, LSM24 12.8 and LSM48 9.6 kPa were identified as cut-off values. Conclusion: HCV patients previously treated for HCC with high LSM values before and after DAA have an elevated risk of HCC recurrence, particularly LSM24 >12.8 kPa and LSM48 >9.6 kPa.

关键词： Hepatitis C Virus Infection Direct-Acting Antivirals Hepatocellular Carcinoma Recurrence Liver Stiffness Measurement

Tomato Seed Extract Containing Lycoperoside H Improves Skin Elasticity in Japanese Female Subjects: A Randomized, Placebo-Controlled, Double-Blind Trial

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第3期11卷 217-236页

作者： Tatsuya Izumi Kazuo Yamamoto Naoko Suzuki Shin-ichiro Yamashita Shin-ichiro iio Hayata Noguchi Toshihiro Kakinuma Asami Baba Shogo Takeda Wakana Yamada Hiroshi Shimoda Hiroo Dermatology Clinic & Mentors Inc. 1 & 2F Hiroo Masugi Annex Bldg. Hiroo Shibuya-ku Tokyo Japan ORTHOMEDICO Inc. 2F Sumitomo Fudosan Korakuen Bldg. Koishikawa Bunkyo-ku Tokyo Japan Oryza Oil & Fat Chemical Co. Ltd. 1 Numata Kitagata-cho Ichinomiya Aichi Japan

Background and Objective: Tomato seeds are edible seeds unconsciously ingested with the fruit. However, there are few reports regarding the constituents and biological activities of tomato seed extract (TSE). Recently, we found that saponins are major constituents of TSE including lycoperoside H. Previous reports have described that several plant-derived saponins improve skin diseases such as wounds and microangiopathy. Therefore, to discover the effect of TSE on the skin condition, we conducted a clinical trial of TSE (Tomato Seed Extract-P) standardized with lycoperoside H when orally ingested. Methods: The study was performed as a randomized, double-blind, placebo-controlled study. TSE (200 mg daily) containing 1 mg of lycoperoside H was used as the active sample. We enrolled 44 Japanese women who have concerns about facial elasticity and relatively low facial skin elasticity. All subjects were randomly allocated into either the active group (n = 22) or the placebo group (n = 22) using a computerized random-number generator. Capsules containing either the active sample or a placebo were administered for 8 weeks between October 12, 2020, and January 16, 2021. Facial elasticity, specifically the R7 value, was evaluated as the primary outcome. The remaining facial R parameters, upper arm R parameters, and other skin parameters including epidermal moisture, trans epidermal water loss, dermal parameters, and advanced glycation end products (AGEs) parameters were measured at 0, 4, and 8 weeks of ingestion. Blood, urine, and body parameters were also evaluated for safety. Results: Forty-three subjects completed the trial, and the per protocol set comprised 21 subjects in the TSE group and 22 subjects in the placebo group. After ingesting TSE for 8 weeks, the R7 value was significantly higher in the TSE group compared to the placebo group. Furthermore, the change in R7 values from the baseline at 4 and 8 weeks were also

关键词： Tomato Seed Saponin Lycoperoside Skin Elasticity Cutometer Pentosidine

Gastric and enteric anisakiasis successfully treated with Gastrografin therapy: A case report

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World Journal of Gastrointestinal Endoscopy 2018年第3期10卷 69-73页

作者： Hiroki Fujikawa Toshio Kuwai Toshiki Yamaguchi Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio iio Hiroki Imagawa Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Department of Gastroenterology National Hospital OrganizationKure Medical Center and Chugoku Cancer Center

We report a case of a 59-year-old woman who was diagnosed with gastric and small intestinal anisakiasis, which was successfully treated with endoscopic extraction and Gastrografin therapy. She was admitted to our hospital with epigastric pain and vomiting one day after eating raw fish. She exhibited tenderness in the epigastrium without obvious rebound tenderness or guarding. Computed tomography (CT) demonstrated segmental edema of the intestinal wall with proximal dilatation and a small number of ascites. Because enteric anisakiasis was suspected based on the patient's history of recent raw fish consumption and abdominal CT, we performed gastroscopy and confirmed that nine Anisakis larvae were attached to the gastric mucosa. All of the Anisakis larvae were extracted via endoscopy, and the patient was diagnosed with gastric and enteric anisakiasis. Additionally, in the hospital, we performed ileography twice using Gastrografin, which led to shortened hospital stay. Based on the clinical results of this case, we suggest that Gastrografin therapy is a safe, convenient, and useful method to extract enteric Anisakis larvae.

关键词： Enteric anisakiasis Gastrografin Ileus Endoscopic extraction Anisakis larvae

用大量余震震源机制估计2000年鸟取县西部地震区域的应力场

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世界地震译丛 2007年第6期38卷 5-19页

作者： Y. Yukutake Y. iio H. Katao T. Shibutani 万永革（译）吕春来（校）不详防灾科技学院

根据大量震源机制估计了2000年鸟取县西部地震(MW=6.6)前后的区域应力场。为约束主震前的应力场,我们比较了主震产生的静态应力变化与主震后应力场的空间分布。在余震区的北部和中部,推测主震前的偏应力量值太大,不会受到静态应力变化... 详细信息

根据大量震源机制估计了2000年鸟取县西部地震(MW=6.6)前后的区域应力场。为约束主震前的应力场,我们比较了主震产生的静态应力变化与主震后应力场的空间分布。在余震区的北部和中部,推测主震前的偏应力量值太大,不会受到静态应力变化的影响。主震前的最大主应力轴的方向与构造应力场一致。而在余震区南部,主震滑动较大的地区及其周围,发现由于静态应力变化较大,主震后应力场的空间分布很不均匀。在断层南端附近,静态应力变化的空间分布与余震的P轴方位角一致,推测主震前的偏应力量值小到足以受到静态应力变化(5MPa)影响的地步。断层南端原有余震断层面的强度可能特别弱。发现主震前的应力场在小于主震断层长度的尺度上是不均匀的。

关键词：区域应力场地震区域震源机制鸟取县余震西部估计应力变化

由精确震源机制推断的日本海岸地震带的局部应力集中:板内地震断层应力积累过程的意义

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世界地震译丛 2009年第1期40卷 28-41页

作者： R．Kawanishi Y．iio Y．Yukutake T．Shibutani H．Katao 李洁波（译）万永革（校）吕春来（复校）不详防灾科技学院

在日本西南的板内地区发现了最大主应力轴(σ1)方位角的空间变化。根据大量精确震源机制进行应力反演推测,沿日本海岸地震带的σ1轴方位角取向为N110°E～N130°E,而在周边地区几乎为东西方向,即N90°E～N100°E。沿南海海沟内陆板块的... 详细信息

在日本西南的板内地区发现了最大主应力轴(σ1)方位角的空间变化。根据大量精确震源机制进行应力反演推测,沿日本海岸地震带的σ1轴方位角取向为N110°E～N130°E,而在周边地区几乎为东西方向,即N90°E～N100°E。沿南海海沟内陆板块的地壳浅部广泛观测到东西方向的最大水平压应力。然而,在该地震带上仅观测到WNW—ESE方向的最大水平应力。用该地震带之下下地壳中的无震断层或延性断层带的形变解释了该地震带内及其周围应力场的这种空间变化。

关键词：局部应力集中地震断层震源机制地震带积累过程日本板内海岸

Progress in Physics and Technology Developments for the Modification of JT-60

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Plasma Science and Technology 2004年第1期6卷 2141-2150页

作者： H.Tamai M.Matsukawa G.Kurita N.Hayashi K.Urata Y.M.Miura K.Kizu K.Tsuchiya A.Morioka Y.Kudo S.Sakurai K.Masaki T.Suzuki M.Takechi Y.Kamada A.Sakasai S.Ishida K.Abe A.Ando T.Cho T.Fujii T.Fujita S.Goto K.Hananda A.Hatayama T.Hino H.Horiike N.Hosogane M.Ichimura Tsuji-iio S.Itoh M.Katsurai M.Kikuchi A.Kohyama H.Kubo M.Kuriyama M.Matsuoka Y.Miura N.Miya T.Mizuuchi K.Nagasaki H.Ninomiya N.Nishino Y.Ogawa K.Okano T.Ozeki M.Saigusa M.Sakamoto M.Satoh M.Shimada R.Shimada M.Shimizu T.Takagi Y.Takase T.Tanabe K.Toi Y.Ueda Y.Uesugi K.Ushigusa Y.Yagi T.Yamamoto K.Yatsu K.Yoshikawa Japan Atomic Energy Research Institute Naka Ibarahi 311-0193 Japan Tohoku University University of Tsukuba Osaka University Kyushu University Keio University Hokkaido University Tokyo Institute of Technology the University of Tokyo Kyoto University Mie University Hiroshima University Central research Institute of Electric Power Industry Ibaraki University ITER JCT Nagoya University National Institute for Fusion Science Kanazawa University National Institute of Advanced Industrial Science and Technology

Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme, physics design for the MHD control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.

关键词： modification of JT-60 physics design technology developments