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Enhancing the Surface Properties of a Bioengineered Anterior Cruciate Ligament Matrix for Use with Point-of-Care Stem Cell Therapy

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Engineering 2021年第2期7卷 153-161页

作者： Xiaohua Yu Paulos Y.Mengsteab Ganesh Narayanan Lakshmi S.nair Cato T.Laurencin Connecticut Convergence Institute for Translation in Regenerative Engineering University of Connecticut HealthFarmingtonCT 06030USA Raymond and Beverly Sackler Center for Biological Physical and Engineering SciencesUniversity of Connecticut HealthFarmingtonCT 06030USA department of Orthopedic Surgery University of Connecticut HealthFarmingtonCT 06030USA department of Biomedical Engineering University of ConnecticutStorrsCT 06269USA department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA department of Chemical and Biomolecular Engineering University of ConnecticutStorrsCT 06269USA department of Reconstructive Sciences University of Connecticut HealthFarmingtonCT 06030USA

We have previously developed a poly(L-lactic)acid(PLLA)bioengineered anterior cruciate ligament(ACL)matrix that has demonstrated enhanced healing when seeded with primary ACL cells prior to implantation in a rabbit model,as compared with the matrix *** suggests that improving cell adhesion on the matrix may beneficially affect the healing response and long-term performance of the bioengineered ACL *** regenerative engineering approach involves enhancing the surface properties of the matrix to support cell adhesion and growth in combination with point-of-care stem cell ***,we studied the cell adhesion properties of PLLA braided microfiber matrices enhanced through the physical adsorption of fibronectin and air plasma *** evaluated the kinetics and binding efficiency of fibronectin onto matrices at three time points and three fibronectin *** the matrix for 120 min in a solution of 25 lgmL1 fibronectin achieved the greatest binding efficiency to the matrix and cellular *** the matrices to air plasma treatment for 5 min before fibronectin adsorption significantly enhanced the cell adhesion of rabbit bone marrow-derived mesenchymal stem cells(R-BMMSCs)24 h post cell ***,cellular proliferation was monitored for up to 21 d,the matrices were exposed to air plasma treatment,and fibronectin adsorption was found to result in enhanced cell *** findings suggest that exposure to air plasma treatment and fibronectin adsorption enhances the cellular adhesion of PLLA braided microfiber matrices and may improve the clinical efficacy of the matrix in combination with point-of-care stem cell therapies.

关键词： Anterior cruciate ligament Ligament Poly(L-lactic)acid plasma treatment Fibronectin Stem cells Adhesion

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Bacterial genome mining to advance enzymology for plant cell wall degradation

Bacterial genome mining to advance enzymology for plant cell...

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第七届草食动物营养国际学术研讨会

作者： I.K.O.Cann d.dodd S.K.nair R.I.Mackie A.Spies department of Animal Sciences department of Microbiology University of IllinoisUrbanaIL 61801USA department of Biochemistry department of Animal Sciences department of Biochemistry

＜正＞Strategies for harnessing the energetic potential inherent in cellulosic biomass are confounded by the recalcitrant nature of these complex carbohydrate *** extract nutrients from cellulose,herbivores harbor microbial symbionts within their digestive tracts that are capable of catabolyzing plant cell wall material into a form that is readily metabolized by the ***,these bacteria may hold the key to efficient utilization of plant biomass as a renewable energy source;however,our knowledge of the detailed mechanisms in which cellulolytic/hemicellulolytic microbes hydrolyze complex fibers into their principal carbohydrate components is incomplete. We believe that a multidisciplinary approach merging transcriptional profiling studies, functional genomics,bioinformatics,structure determination and enzyme homology modeling will yield significant insight into the repertoire of degradation enzymes and the catalytic strategies employed by hydrolytic enzymes of plant cell wall degrading *** a bioinformatics approach,we have identified and annotated a cluster of 10 putative glycoside hydrolases from a rumen fiber-degrading bacterium. Additionally,a computational approach was employed to obtain a three-dimensional homology model for a putative family 3 β-glycosidase from *** using the barley β-d-glucan glucohydrelase crystal structure as a *** results revealed that while the two glycosidases shared only 35% sequence homology,the positioning of active site residues about the bound transition-state analog was remarkably *** studies utilizing this multidisciplinary approach will provide an excellent foundation for enhancing the catalytic capacity of hydrolytic enzymes through rational approaches and ultimately to optimize the conversion of biomass to milk and meat in the animal production industry and carbon-based fuels in the emerging biofuels industry.

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Multisystem Inflammatory Syndrome-Neonate: Biochemical Parameters as Early Marker of Adverse Neurodevelopmental Outcome

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Open Journal of Pediatrics 2022年第5期12卷 767-782页

作者： Perumalsathya Sankaranarayanan Harshitha Shanmuganathan devika Sanil Kumar Lal devayani Vasudevan nair Santosh Kamalakannan department of Pediatrics Saveetha Medical College and Hospital Chennai India department of Research and development Saveetha Medical College and Hospital Chennai India department of Neonatology Saveetha Medical College and Hospital Chennai India

Background: Pregnant women and newborns are highly susceptible to Covid-19, manifesting as multisystem inflammatory syndrome-New-born (MISC-N) in many babies born to Covid positive mothers. The relationship between Covid-19 infection during pregnancy and neonatal neurodevelopmental outcome, if any, is unclear necessitating a follow-up study in this aspect. Methods: 16 babies with MIS-N, born to symptomatic Covid antibody positive mothers were enrolled. demographic profile, treatment details and biochemical parameters were analyzed with neurodevelopmental follow-up. Results: 25% mothers received 2 doses of Covid vaccine;50% had oligohydramnios and 75% received antenatal steroids. 87.5% were preterm of which 62.5% required surfactant with ventilator support and 75% required ionotropic support. Significant association was found between the antibody level and d-dimer levels with the ferritin and LdH levels of the baby (p 0.05);gestational age with LdH and d-dimer levels (p 0.05) and Covid antibody level of the baby vs the duration of ventilator requirement (P-value-0.0009). d-dimer values of babies were positively associated with both maternal antibody and d-dimer levels. Neurodevelopmental follow-up done at 6 months of corrected gestational age showed 37.5% were normal, 37.5% hypertonic and 25% hypotonic. HINE score was below 60 in 62.5%. development assessment using Bayley-III showed a delay in the motor domain (62.5%), cognitive domain (56.25%) and language domain (62.5%). Conclusion: Neurodevelopmental problems occur in babies born to Covid positive mothers and should be stratified as “high risk”. Anticipatory guidance to prospective mothers for preterm care should be given. Covid antibody titre and d-dimer levels may help to predict the NICU stay, ventilator requirement and the adverse neurodevelopmental outcomes in these babies.

关键词： Neurodevelopment Covid-19 Pregnancy Multisystem Inflammatory Syndrome Biochemical Markers d-dimer HINE Score

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Phase-pure two-dimensional Fe_(X)GeTe_(2) magnets with near-room-temperature Tc

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Nano Research 2022年第1期15卷 457-464页

作者： Govindan Kutty Rajendran nair Zhaowei Zhang Fuchen Hou§ Ali Abdelaziem Xiaodong Xu Steve Wu Qing Yang Nan Zhang Weiqi Li Chao Zhu Yao Wu Heng Weiling Lixing Kang Teddy Salim Jiadong Zhou Lin Ke Junhao Lin Xingji Li Weibo Gao Zheng Liu School of Material Science and Engineering 50 Nanyang Ave639798Singapore division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang Link637371 Singapore department of Physics Southern University of Science and TechnologyShenzhen 518055China Institute of Materials Research and Engineering Agency for Science Technology and Research(A*STAR)2 Fusionopolis WaySingapore 138634Singapore School of Material Science and Engineering School of PhysicsHarbin Institute of TechnologyHarbin 150001China Shenzhen Key Laboratory of for Advanced Quantum Functional Materials and devices Southern University of Science and TechnologyShenzhen 518055China National Institute of Laser Enhanced Sciences(NILES) Cairo UniversityGiza 12613Egypt CINTRA CNRS/NTU/THALES UMI3288Research Techno Plaza637553Singapore School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang Ave639798Singapore

Two-dimensional(2d)ferromagnets with out-of-plane(OOP)magnetic anisotropy are potential candidates for realizing the next-generation memory devices with ultra-low power consumption and high storage ***,a scalable approach to synthesize 2d magnets with OOP anisotropy directly on the complimentary metal-oxide semiconductor(CMOS)compatible substrates has not yet been mainly explored,which hinders the practical application of 2d *** work demonstrates a cascaded space confined chemical vapor deposition(CS-CVd)technique to synthesize 2d FexGeTe_(2) *** weight fraction of iron(Fe)in the precursor controls the phase purity of the as-grown *** a result,high-quality Fe_(3)GeTe_(2) and Fe_(5)GeTe_(2) flakes have been grown selectively using the CS-CVd *** temperature(Tc)of the as-grown FexGeTe2 can be up to-280 K,nearly room *** thickness and temperature-dependent magnetic studies on the Fe_(5)GeTe_(2) reveal a 2d Ising to 3d XY ***,Terahertz spectroscopy experiments on Fe_(5)GeTe_(2) display the highest conductivity among other FexGeTe_(2) 2d *** results of this work indicate a scalable pathway for the direct growth and integration of 2d ternary magnets on CMOS-based substrates to develop spintronic memory devices.

关键词： cascaded space confined chemical vapor deposition(CVd) van der Waals(vdW) ferromagnetism out of plane anisotropy iron germanium telluride terahertz

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Modeling and analysis of bio-prinitng process-induced local environment for cells

Modeling and analysis of bio-prinitng process-induced local ...

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中国力学大会——2013

作者： Karen Chang Yan Kamila Paluch Kalyani nair Wei Sun Biomanufacturing Engineering Research Laboratory Department of Mechanical EngineeringGraduate School at ShenzhenTsinghua University department of Mechanical Engineering Drexel University

The aim of this study is to develop a computational model to determine detailed local hydrodynamic environment to which cells are exposed during the printing process and establish a linkage between the microenvironment and cell damage.3d computational models were created for the pressure driven flow system with different nozzle diameters and computational fluid dynamics(CFd) analyses were performed to characterize the local environment that the living cells are experiencing due to

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Two-photon polymerization lithography for imaging optics

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International Journal of Extreme Manufacturing 2024年第4期6卷 21-60页

作者： Hao Wang Cheng-Feng Pan Chi Li Kishan S Menghrajani Markus A Schmidt Aoling Li Fu Fan Yu Zhou Wang Zhang Hongtao Wang Parvathi nair Suseela nair John You En Chan Tomohiro Mori Yueqiang Hu Guangwei Hu Stefan A Maier Haoran Ren Huigao duan Joel K W Yang College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082People's Republic of China Engineering Product development Singapore University of Technology and DesignSingapore 487372Singapore Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronomy Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of Material Research FSU Jena07745 JenaGermany Institute of Materials Research and Engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayama Prefecture Wakayama 6496261Japan School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore department of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical imaging systems have greatly extended human visual capabilities,enabling the observation and understanding of diverse *** technologies span a broad spectrum of wavelengths from x-ray to radio frequencies and impact research activities and our daily *** glass lenses are fabricated through a series of complex processes,while polymers offer versatility and ease of ***,modern applications often require complex lens assemblies,driving the need for miniaturization and advanced designs with micro-and nanoscale features to surpass the capabilities of traditional fabrication ***-dimensional(3d)printing,or additive manufacturing,presents a solution to these challenges with benefits of rapid prototyping,customized geometries,and efficient production,particularly suited for miniaturized optical imaging *** 3d printing methods have demonstrated advantages over traditional counterparts,yet challenges remain in achieving nanoscale ***-photon polymerization lithography(TPL),a nanoscale 3d printing technique,enables the fabrication of intricate structures beyond the optical diffraction limit via the nonlinear process of two-photon absorption within liquid *** offers unprecedented abilities,***-free fabrication,micro-and nanoscale capabilities,and rapid prototyping of almost arbitrary complex 3d *** this review,we emphasize the importance of the criteria for optical performance evaluation of imaging devices,discuss material properties relevant to TPL,fabrication techniques,and highlight the application of TPL in optical *** the first panoramic review on this topic,it will equip researchers with foundational knowledge and recent advancements of TPL for imaging optics,promoting a deeper understanding of the *** leveraging on its high-resolution capability,extensive material range,and true 3d processing,alongside advances in materials,fabrication,and design,we en

关键词： two-photon polymerization lithography 3d printing additive manufacturing imaging optics and nanophotonics

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平台抗震设计中反应谱和时程曲线法的比较

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世界地震工程 1983年第5期 8-14页

作者： d.nair J.B.Valdivieso C.M.Johnson 谢君斐

前言推荐用于近海平台抗震设计的主要方法是时程曲线法和反应谱法。在时程曲线法中,结构物承受随时间变化的地面运动,而结构的反应则通过对运动方程的逐步积分来确定。一旦建立了结构模型和输入运动,时程曲线分析本身就被认为是精确的,... 详细信息

前言推荐用于近海平台抗震设计的主要方法是时程曲线法和反应谱法。在时程曲线法中,结构物承受随时间变化的地面运动,而结构的反应则通过对运动方程的逐步积分来确定。一旦建立了结构模型和输入运动,时程曲线分析本身就被认为是精确的,并给出可靠的数据。然而这种分析是十分复杂的,

关键词：反应谱法弯矩弯曲力矩杆件内力地面运动地壳运动时程曲线导管架振型组合法组合应力 GMR 水平支撑轴向荷载结构设计抗震设计防震设计

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Sediment Characteristics of Tidal deposits at Mandvi, Gulf of Kuchchh, Gujarat, India: Geophysical, Textural and Mineralogical Attributes

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International Journal of Geosciences 2012年第3期3卷 515-524页

作者： deshraj Trivedi Mani Christy Raicy Koravangatt devi devender Kumar Ilya Buynevich P. Srinivasan Nagesh R. Iyer R. Guin d. Sengupta Rajesh R. nair department of Earth and Environmental Science Temple University 1901 N. 13th Street Philadelphia PA 19122 USA department of Geology and Geophysics Indian Institute of Technology Kharagpur-721302 department of Ocean Engineering Indian Institute of Technology Madras-600036 National Geophysical Research Institute Hyderabad 500606 India Structural Engineering Research Centre Chennai-600113 Variable Energy Cyclotron Centre Kolkatta 700064

The textural and mineralogical characteristics of subsurface sediments along with Ground Penetrating Radar (GPR) data collected along the Western margin of India were used to understand the depositional environments and the provenance of sediments. Textural attributes such as mean, standard deviation, skewness and Kurtosis show fluctuations due to fluvio-marine interaction and it is well understood that the bottom sediments are enriched with muddy sand, which may be deposited by mean of tidal invasion. The abundance of very coarse silt to very fine sand indicates the prevalence of low energy environment. The Linear discriminate Function analysis indicates the fluvio marine deposition of sediments under low energy condition. GPR data upto a depth of 5 m shows the stratigraphic sequences of very fine sands and coarse silt. Optically Stimulated Luminescence (OSL) dating of sediments implies that the tidal sediments had deposited between ~30 ± 1 and ~90 ± 4 years before Present. XRd studies results the dominance of K-feldspar and deficiency of clay minerals, indicating that most of the sediments are derived from hinterland. Studies indicate that the Provenance of sediments in the Mandvi area is not related to Indus delta even though a considerable part of Gulf sediments are deposited by the Indus River.

关键词： Tidal Currents Mandvi Grain Size Analysis XRd GPR data OSL Ages

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Clinical outcomes for nasopharyngeal cancer with intracranial extension after taxanebased induction chemotherapy and concurrent chemo-radiotherapy in the modern era

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 25-33页

作者： Sarbani Ghosh-Laskar Avinash Pilar Carlton Johnny Kumar Prabhash Amit Joshi Jai Prakash Agarwal Tejpal Gupta Ashwini Budrukkar Vedang Murthy Monali Swain Vanita Noronha Vijay Maruthi Patil Prathamesh Pai deepa nair.d.vendra Arvind Chaukar Shivakumar Thiagarajan Gouri Pantvaidya Anuja deshmukh Pankaj Chaturvedi Sudhir nair Anil d’Cruz department of Radiation Oncology Tato Memorial HospitalHomi Bhobho National InstituteMumbaiIndia department of Medical Oncology Tata Memorial HospitalHomi Bhobha Notional InstituteMumbaiIndia department of Surgical Oncolosy Tota Memorial HospitalHomi Bhabha Notional InstituteMumbait India

Objective:To evaluate the survival outcomes for a cohort of nasopharyngeal cancer with intracranial extension(ICE)treated with induction chemotherapy(ICT)followed by chemo-intensity-modulated radiotherapy(CTRT)at a tertiary cancer ***:We retrospectively analyzed 45 patients with histologically proven,non-metastatic NPC with ICE treated at our institute between October 2008 and October *** were classified as minor ICE or major ICE,based on the extent of *** the patients received 2-3 cycles of a taxane-based ICT regimen followed by *** was delivered with"riskadapted"intensity-modulated radiotherapy(IMRT)technique in all ***:After a median follow up of 45 months(range:8-113 months),the estimated 5-year dFS,LRFS,dMFS,and OS of the entire cohort was 58%,82%,67%and 74%*** multivariate analysis,histological subtype was an independent predictor of LRFS,and age was an independent predictor of *** extent of ICE showed only a trend towards worse dFS(P=0.06).None of the factors significantly predicted for dMFS or ***,N-stage,and response to ICT did not significantly affect any of the *** 2 or worse subcutaneous fibrosis was seen in 22%of patients and grade 2 or worse xerostomia was seen in 24%of patients at last follow ***-three percent of the patients developed clinical hypothyroidism at last follow *** of the patients experienced any neurological or vascular ***:Taxane-based induction chemotherapy followed by chemo-intensity modulated radiotherapy resulted in excellent locoregional control and survival with acceptable toxicities in patients of nasopharyngeal cancer with intracranial *** metastasis continues to be the predominant problem in these patients.

关键词： Nasopharyngeal cancer Intracranial extension Clinical outcomes Induction chemotherapy and intensity-modulated radiotherapy

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d-Aminoacid Oxidase-Fe<sub>2</sub>O<sub>3</sub>Nanoparticle Complex Mediated Antitumor Activity in Swiss Albino Mice

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Journal of Cancer Therapy 2011年第5期2卷 666-674页

作者： Saratchandran A. divakaran K. M. Sreekanth K. V. Rao Cherupally Krishnan Krishnan nair 不详

d-Aminoacid oxidase (dAO) was isolated from fresh porcine kidney;its cytotoxic potential was studied under in vitro and in vivo conditions. The isolated dAO was complexed with Fe2O3 nanoparticles and its potential as an oxidation therapeutic agent was analysed. The ability of the complex in eliciting H2O2 mediated cytotoxicity was studied on dalton’s lymphoma ascites cells (dLA). The induction of apoptosis in dLA cells by Fe2O3-dAO complex was studied by morphological examination and alkaline single cell gel electrophoresis (comet assay). The antitumor activity of the complex was investigated by oral administration of the complex and the substrate d-alanine to tumor bearing Swiss albino mice and by targeting the complex to the tumor site, using an externally applied magnetic field. Fe2O3-dAO along with d-alanine showed remarkable cytotoxicity in a substrate concentration-dependent manner. Both morphological examination and comet assay revealed that Fe2O3-dAO/d-alanine induced apoptosis. Oral administration of Fe2O3-dAO and d-alanine along with magnetic targeting significantly suppressed tumor growth in mice. The present report provides the first evidence for the promising application of enzyme bound nanoparticles for targeted oxidation therapy.

关键词： d-Aminoacid Oxidase Oxidation Therapy Fe2O3 Antitumor Nanoparticles Comet assay Apoptosis

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