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Morphometric Correlations of the Voice Category (VC) in Professional Singers with Oropharyngeal and Laryngeal Anatomy Using Stroboscopy and Cervical Posteroanterior Radiography

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第4期10卷 277-299页

作者： athina zarachi Dionysios Tafiadis Nafsika Ziavra Ioannis Kastanioudakis Efthymis Dimakis Angelos Liontos Maria Argyropoulou Georgios Exarchakos Department of Otorhinolaryngology Head and Neck Surgery Faculty of Medicine School of Health Sciences University of Ioannina Ioannina Greece Department of Speech & Language Therapy School of Health Sciences University of Ioannina Ioannina Greece Department of Health Sciences Speech and Language Therapy European University Cyprus Nicosia Cyprus Division of Biostatistics and Epidemiology Department of Medical School University of Ioannina Ioannina Greece Faculty of Medicine Department of Internal Medicine School of Health Sciences University of Ioannina Ioannina Greece Faculty of Medicine Department of Radiology School of Health Sciences University of Ioannina Ioannina Greece

Objective(s): The aim of this study is to explore if there is a correlation between the typical voice classification and the oropharyngeal and laryngeal morphology, using video laryngeal stroboscopy and cervical posterior-anterior radiography on professional singers in Greece. Methods: 55 professional singers (28 females: 7 sopranos, 12 mezzo-sopranos, and 9 contraltos;27 males: 8 tenors, 12 baritones and 7 basses) were recruited for this study. All participants underwent stroboscopic and cervical posterior-anterior radiographic imaging of their oral pharyngeal and laryngeal area. Additionally, the voice classification and features (e.g., height, weight) of individuals were correlated statistically. Results: Statistically significant correlations were observed between the VC of the participants with the Phonetic Area (PA) (r = −0.451, p = 0.001) and the VC with the Oral-pharyngeal Cavity (OPC) area (r = −0.402, p = 0.001) in the total sample. Specifically, in male singers, the PA and VC correlation was r = −0.319, p = 0.047, and the VC and OPC area was r = −0.328, p = 0.044. Likewise, in female singers, the PA area and VC and PA were r = −0.336, p = 0.041 and the OPC area and VC were r = −0.344, p = 0.039. The analysis confirmed no correlations between VC and height and body weight. Conclusions: The cervical posteroanterior radiography in conjunction with laryngeal stroboscopy provided new morphometric correlations of the VC of professional singers with their Oropharyngeal and Laryngeal Anatomy.

关键词： Laryngeal Anatomy Professional Singers Cervical Posteroanterior Radiography Stroboscopy Voice Classification

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Stroboscopic Evaluation of the Vocal Folds’ Morphometric Characteristics, between the Different Voice Categories on Professional Singers

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第5期10卷 345-358页

作者： athina zarachi Aikaterini Lianou Angelos Liontos Konstantinos Garefis Eleni Litsou Dionysios Tafiadis Efthymis Dimakis Ioannis Kastanioudakis Georgios Exarchakos Department of Otorhinolaryngology Head and Neck Surgery Faculty of Medicine School of Health Sciences University of Ioannina Ioannina Greece Department of Internal Medicine Faculty of Medicine School of Health Sciences University of Ioannina Ioannina Greece 2nd Academic ORL Head and Neck Surgery Department Papageorgiou Hospital Aristotle University of Thessaloniki Thessaloniki Greece Department of Speech & Language Therapy School of Health Sciences University of Ioannina Ioannina Greece Department of Health Sciences Speech and Language Therapy European University Cyprus Nicosia Cyprus Division of Biostatistics and Epidemiology Department of Medical School University of Ioannina Ioannina Greece

Objective(s): The aim of this study is to explore if there is a correlation between the typical voice classification and the morphometric characteristics of the vocal folds, using video laryngeal stroboscopy, on professional singers in Greece. Methods: 70 professional singers, 50% men (35 men) and 50% women (35 women), were recruited for this study. A stroboscopic evaluation was prepared for every participant. Additionally, the voice classification and features of individuals were correlated statistically. Results: Statistically significant difference were observed between the voice categories and the size of stomatopharynx, the shape of the hard palate, the length of the vocal folds, the width and thickness of the vocal folds, as well as the tone of speech, in male singers. Statistically significant differences were also observed between the voice categories and all the variables except the shape of epiglottis, the color of speech and the shape of the vocal folds, in female singers. Conclusions: There is correlation between the morphometric characteristics of the vocal folds and the voice categories.

关键词： Stroboscopy Vocal Folds Professional Singers Voice Category Morphometric Characteristics

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Hazardous Attitude Factors Influence Risk Perception in General Aviation Pilots

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Advances in Aerospace Science and Technology 2024年第3期9卷 85-93页

作者： athina Holmes Aeronautical Science Department College of Aviation Embry-Riddle Aeronautical University Daytona Beach FL USA

This manuscript presents a research proposal to investigate how hazardous attitudes among general aviation pilots influence pilot performance in aviation accidents. General aviation pilots train to maintain safe flying conditions, but accidents still occur, and human factors figure prominently among the causes of aviation accidents. The levels of hazardous attitudes among pilots may influence the likelihood of engaging in risky flight behaviors that can lead to accidents. This quantitative study aims to determine whether dangerous attitudes impact risk perception in general aviation pilots. The study will focus on two specific hazardous attitudes, “Anti-Authority” and Macho” behaviors. Among the hazardous attitudes identified by the Federal Aviation Administration (FAA), the two attitudes often stand out in accident investigations and pilot narratives. While all hazardous attitudes have inherent dangers, these two attitudes tend to be more frequently cited in accident reports and investigations. Despite rigorous training in safe flying conditions, general aviation accidents still transpire due to human factors. This research hypothesizes that the five attitudes from the hazardous attitude model, particularly Anti-Authority and Macho, significantly shape pilots’ risk perception. The insights from this study would benefit stakeholders, like the Aircraft Owners and Pilots Association (AOPA), Air Safety Institute, and aviation training programs, in creating training modules tailored to reduce such attitudes.

关键词： General Aviation (GA) Pilot Aviation Safety Hazardous Attitudes Anti-Authority Macho Risk Perception Flight Training

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Stent A pancreaticojejunostomy after pancreatoduodenectomy:Is it always necessary?

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World Journal of Methodology 2024年第3期14卷 23-29页

作者： Dimitrios Symeonidis Dimitris Zacharoulis Georgios Tzovaras Labrini Kissa athina A Samara Eleana Petsa Konstantinos Tepetes Department of Surgery University Hospital of LarissaLarissa 41110Greece Department of General Surgery University Hospital of LarissaLarissa 41110Greece

The establishment of a postoperative pancreatic fistula(POPF)is considered the most common and,concomitantly,the most serious complication associated with pancreaticoduodenectomy(PD).The search for either technical modifications of the operative technique or pharmaceutical interventions that could possibly aid in decreasing the incidence of this often-devastating complication appears *** stenting of the pancreatic duct,with the use of either internal or external stents,has been evaluated in this *** theory,it is an approach that could eliminate many pathophysiological factors responsible for the occurrence of a *** purpose of the present study was to review the current data regarding the role of pancreatic duct stenting on the incidence of POPF,after PD,by using PubMed and Reference Citation *** general,previous studies seem to highlight the superiority of external stents over their internal counterparts in regard to the incidence of POPF;this is at the cost,however,of increased morbidity associated mainly with the stent ***,the use of an internal stent is a less invasive approach with acceptable results and is definitely deprived of the drawbacks arising through the complete diversion of pancreatic juice from the gastrointestinal *** in mind the scarcity of high-quality data on the subject,an approach of reserving stent placement for the high-risk for POPF patients and individualizing the selection between the use of an internal or an external stent according to the distinct characteristics of each individual case scenario appears appropriate.

关键词： Pancreaticoduodenectomy Postoperative pancreatic fistula Pancreatic stent Pancreaticojejunostomy

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Morphometric Correlations of the Voice Category (VC) in Professional Singers with Oropharyngeal and Laryngeal Anatomy Using Stroboscopy and Cervical Posteroanterior Radiography

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International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2021年第4期

作者： athina zarachi Dionysios Tafiadis Nafsika Ziavra Ioannis Kastanioudakis Efthymis Dimakis Angelos Liontos Maria Argyropoulou Georgios Exarchakos

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Stroboscopic Evaluation of the Vocal Folds’ Morphometric Characteristics, between the Different Voice Categories on Professional Singers

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International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2021年第5期

作者： athina zarachi Aikaterini Lianou Angelos Liontos Konstantinos Garefis Eleni Litsou Dionysios Tafiadis Efthymis Dimakis Ioannis Kastanioudakis Georgios Exarchakos

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Detecting community structure using label propagation with consensus weight in complex network

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Chinese Physics B 2014年第9期23卷 594-601页

作者：梁宗文李建平杨帆 athina Petropulu School of Computer Science and Engineering University of Electronic Science and Technology of China Electrical and Computer Engineering Department RutgersThe State University of New Jersey

Community detection is a fundamental work to analyse the structural and functional properties of complex networks. The label propagation algorithm （LPA） is a near linear time algorithm to find a good community structure. Despite various subsequent advances, an important issue of this algorithm has not yet been properly addressed. Random update orders within the algorithm severely hamper the stability of the identified community structure. In this paper, we executed the basic label propagation algorithm on networks multiple times, to obtain a set of consensus partitions. Based on these consensus partitions, we created a consensus weighted graph. In this consensus weighted graph, the weight value of the edge was the proportion value that the number of node pairs allocated in the same cluster was divided by the total number of partitions. Then, we introduced consensus weight to indicate the direction of label propagation. In label update steps, by computing the mixing value of consensus weight and label frequency, a node adopted the label which has the maximum mixing value instead of the most frequent one. For extending to different networks, we introduced a proportion parameter to adjust the proportion of consensus weight and label frequency in computing mixing value. Finally, we proposed an approach named the label propagation algorithm with consensus weight （LPAcw）, and the experimental results showed that the LPAcw could enhance considerably both the stability and the accuracy of community partitions.

关键词： label propagation algorithm community detection consensus cluster complex network

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The Secret Life of Chloroplast Precursor Proteins in the Cytosol

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Molecular Plant 2020年第8期13卷 1111-1113页

作者： athina Hristou Julia Grimmer Sacha Baginsky Biochemistry of Plants Faculty of Biochemistry and BiotechnologyRuhr University BochumUniversit(a)tsstrasse 15044801 BochumGermany Institute of Biochemistry and Biotechnology Martin-Luther-University Halle-WittenbergCharles Tanford ProteinzentrumKurt-Mothes-Str.3a06120 Halle(Saale)Germany

Eukaryotic cells contain semi-autonomous organelles that have lost most of their coding capacity for essential proteins to the ***,their functioning depends on the cytosolic translation products of nuclear-encoded genes that must be imported by a specialized protein import *** import between 2500 and 3500 proteins for their functioning,demonstrating that the bulk of the chloroplast proteome is shuttied through the cytosol as precursor *** proteins usually contain an N-terminal transit peptide that is cleaved off by a signa/processing peptidase(SPP)and degraded by the chloroplast protease network upon *** the cytosol,precursors can be co-and post-translationally modified,interact with a set of chaperones,co-chaperones,14-3-3 proteins,and/or E3 ligases before they are either imported or degraded by the cytosolic proteasome *** is now clear that precursors are not only a transient transport form of functional proteins but that their cytosolic transition is of regulatory importance.

关键词： specialized autonomous imported

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Diffusion-weighted MR imaging of normal and abnorma scrotum： preliminary results

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Asian Journal of Andrology 2012年第4期14卷 649-654页

作者： athina C Tsili Maria I Argyropoulou Dimitrios Giannakis Stavros Tsampalas Nikolaos Sofikitis Konstantinos Tsampoulas Department of Clinical Radiology University Hospital of Ioannina Ioannina 45500 Greece Department of Urology University Hospital of Ioannina Ioannina 45500 Greece

Magnetic resonance （MR） imaging of the scrotum represents an important supplemental diagnostic tool in the evaluation of scrotal diseases. Diffusion-weighted （DW） MR imaging is a developing technique, proved to improve tissue characterization. We evaluated the feasibility and diagnostic performance of DW MR imaging in the detection and characterization of scrotal lesions. We retrospectively evaluated 31 scrotal lesions （23 intratesticular and 8 extratesticular） in 26 men. All MR examinations were performed on a 1.5-T unit, using a pelvic-phased array coil. DW sequences were obtained using a single shot, multislice spin echo planar diffusion pulse sequence and a b factor of 0 and 900 s mm-2. The DW MR characteristics and the apparent diffusion coefficient （ADC） values of normal scrotal contents and scrotal diseases were evaluated. Comparison between the ADC values of normal scrotum, benign lesions and scrotal malignancies was performed. The accuracy of conventional sequences, DW images alone and DW imaging combined with conventional images in differentiating benign from malignant scmtal lesions was calculated. The ADC values of testicular malignancies were different from those of normal testis and benign intratesticular lesions, and the ADC values of benign extratesticular lesions from those of normal epididymis （P〈0.05）. The overall accuracy of conventional imaging, DW imaging alone and DW MR combined with conventional sequences in the characterization of intratesticular lesions was 91%, 87% and 100%, respectively. Our findings suggest that DW MR imaging and ADC values may provide valuable information in the diagnosis and characterization of scrotal diseases.

关键词： diagnosis epididymis male genital neoplasms scrotum testicular neoplasms testis

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Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine

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Cell Research 2004年第5期14卷 415-422页

作者： Evangelos KONTARGIRIS,Evangelos KOLETTAS,athina VADALOUCA,Ioannis P. TROUGAKOS,Efstathios S. GONOS,Vasiliki KALFAKAKOU Laboratory of Experimental Physiology University of Ioannina Medical School 45110 Ioannina Greece Laboratory of Experimental Physiology University of Ioannina Medical School 45110 Ioannina Greece Department of Anesthesia Pain Relief and Palliative Care University Clinic Areteion Hospital Athens Greece Laboratory of Molecular and Cellular Aging Institute of Biological Research and Biotechnology National Hellenic Research Foundation 11635 Athens Greece Laboratory of Molecular and Cellular Aging Institute of Biological Research and Biotechnology National Hellenic Research Foundation 11635 Athens Greece Laboratory of Experimental Physiology University of Ioannina Medical School 45110 Ioannina Greece

Local anesthetics inhibit cell proliferation and induce apoptosis in various cell types. Ropivacaine, a unique, novel tertiary amine-type anesthetic, was shown to inhibit the proliferation of several cell types including keratinocytes. We found that Ropivacaine could inhibit the proliferation and induce apoptosis in an immortalized human keratinocyte line, HaCaT, in a dose- and time-dependent manner and with the deprivation of serum. The dose-dependent induction of apoptosis by ropivacaine was demonstrated by DNA fragmentation analysis and the proteolytic cleavage of a caspase-3 substrate — poly (ADP-ribose) polymerase (PARP). In addition, ropivacaine downregulated the expression of clusterin/ apoliporotein J, a protein with anti-apoptotic properties, in a dose-dependent manner, which well correlated with the induction of apoptosis of HaCaT cells. To investigate the role of clusterin/apoliporotein J in ropivacaine-induced apoptosis, HaCaT cells overexpressing clusterin/apoliporotein J were generated and compared to cells expressing the well estab- lished anti-apoptotic Bcl-2 protein. Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression. Furthermore, the downregulation of endogenous clusterin/apolipoprotein J levels by ropivacaine suggested that this might be one mechanism by which ropivacaine induced cell death in HaCaT cells. In conclusion, the ability of ropivacaine to induce antiproliferative responses and to suppress the expression of the anti-apoptotic protein clusterin/apolipoprotein J, combined with previ- ously reported anti-inflammatory activity and analgesic property of the drug, suggests that ropivacaine may have poten- tial utility in the local treatment of tumors.

关键词： keratinocytes ropivacaine clusterin/Apolipoprotein J Bcl-2 apoptosis.

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