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Biomechanical characteristics of bone in streptozotocin-induced diabetic rats:An in-vivo randomized controlled experimental study

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World Journal of Orthopedics 2013年第3期4卷 124-129页

作者： Nektarios Korres Eleftherios Tsiridis George Pavlou athanasios mitsoudis Despina N Perrea Aristedes B Zoumbos KAT First Department of Orthopaedics and Trauma 14561 AthensGreece Academic Orthopaedics and Trauma Unit Division of SurgeryAristotle University Medical School54124 ThessalonikiGreece Department of Orthopaedics Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry SY10 7AGUnited Kingdom Department of Biomechanics School of Applied Mathematical and Physical SciencesNational Technical University of Athens14561 AthensGreece Department of Experimental Surgical Research "N.S.Christeas" Athens University Medical School14561 AthensGreece Department of Orthopaedics Academic Orthopaedic Department "Attikon" HospitalAthens University Medical School14561 AthensGreece

AIM: To investigate the in vivo effects of type Ⅰdiabetes on the mechanical strength of tibial bone in a rodent ***: The biomechanical effect of diabetes on the structural integrity of the tibia in streptozotocin induced diabetic Wistar rats was analysed. Induction of diabetes was achieved by an intra-peritoneal injection and confirmed by measuring serial blood glucose levels(> 150 mg/d L). After 8 wk the tibiae were harvested and compared to a control group. Biomechanical analysis of harvested tibiae was performed using a threepoint bending technique on a servo hydraulic MTS 858 MiniB ionix frame. Maximum force applied to failure(N), stiffness(N × mm) and energy absorbed(N/mm) were recorded and plotted on load displacement curves. A displacement control loading mode of 1 mm/min was selected to simulate quasi-static loading conditions. Measurements from load-displacement curves were directly compared between ***: Fourteen streptozotocin induced diabetic Wistar rats were compared against nineteen non-diabetic controls. An average increase of 155.2 g in body weight was observed in the control group compared with only 5 g in the diabetic group during the experimental study period. Levels of blood glucose increased to 440.25 mg/d L in the diabetic group compared to 116.62 mg/d L in the control *** biomechanical results demonstrate a highly significant reduction in the maximum load to failure from 69.5 N to 58 N in diabetic group compared to control(P = 0.011). Energy absorption to fracture was reduced from 28.2 N in the control group to 23.5 N in the diabetic group(P = 0.082). No significant differences were observed between the groups for bending ***: Streptozotocin-induced diabetes in rodents reduces the maximum force and energy absorption to failure of bone, suggesting a predisposition for fracture risk.

关键词： Streptozotocin Rodent Bone Biomechanics

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