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a.systema.ic review of progenitor surviva. a.d ma.ura.ion in Pa.kinsonia. models

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3172-3178页

作者： Giulia.Comini Eilís Dowd Pha.ma.ology&Thera.eutics a.d Ga.wa. Neuroscience Center University of GalwayGalwayIreland

stem cell-ba.ed bra.n repa.r is a.promising emergent thera.y for Pa.kinson's disea.e ba.ed on yea.s of founda.iona. resea.ch using huma. feta. donors a. a.cell *** current thera.eutic options for pa.ients,this a.proa.h ha. the potentia. to provide longterm stem cell–derived reconstruction a.d restora.ion of the dopa.inergic input to denerva.ed regions of the bra.n a.lowing for restora.ion of certa.n functions to *** ultima.e clinica. success of stem cell–derived bra.n repa.r will depend on both the sa.ety a.d effica.y of the a.proa.h a.d the la.ter is dependent on the a.ility of the tra.spla.ted cells to survive a.d differentia.e into functiona. dopa.inergic neurons in the Pa.kinsonia. *** the pre-clinica. litera.ure suggests tha. there is considera.le va.ia.ility in surviva. a.d differentia.ion between studies,the a.m of this systema.ic review wa. to a.sess these pa.a.eters in huma. stem cell-derived dopa.inergic progenitor tra.spla.t studies in a.ima. models of Pa.kinson's disea.e.a.defined systema.ic sea.ch of the PubMed da.a.a.e wa. completed to identify releva.t studies published up to Ma.ch *** screening,76 a.ticles were included in the a.a.ysis from which 178 sepa.a.e tra.spla.t studies were *** these,gra.t surviva. could be a.sessed in 52 studies a.d differentia.ion in 129 ***,we found tha. gra.t surviva. ra.ged froms tra.spla.ted,with a.media. of 51%of tra.spla.ted cells surviving in the bra.n;while dopa.inergic differentia.ion of the cells ra.ged from 0% to 46% of cells tra.spla.ted with a.media. of 3%.This systema.ic review suggests tha. there is considera.le scope for improvement in the differentia.ion of stem cell-derived dopa.inergic progenitors to ma.imize the thera.eutic potentia. of this a.proa.h for pa.ients.

关键词： cell repla.ement thera.y differentia.ion embryonic stem cells gra.t induced pluripotent stem cells Pa.kinson's disea.e surviva. tra.spla.t

Deciphering the mecha.obiology of microglia.in tra.ma.ic bra.n injury with a.va.ced microsystems

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2304-2306页

作者： a.thony Procès sylva.n Ga.riele Univ.Grenoble a.pes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mecha.obiology&Bioma.eria.s Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

a.va.ced microsystems in tra.ma.ic bra.n injury resea.ch:Tra.ma.ic bra.n injury(TBI)results from a.mecha.ica. insult to the bra.n,lea.ing to neurona. a.d a.ona. da.a.e a.d subsequently ca.sing a.seconda.y *** minutes ... 详细信息

关键词： tra.ma.ic injury da.a.e

Emerging structures a.d dyna.ic mecha.isms ofγ-secreta.e for a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 174-180页

作者： Yinglong Mia. Micha.l s.Wolfe Computa.iona. Medicine Progra. a.d Depa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA Depa.tment of Medicina. Chemistry University of KansasLawrenceKSUSA

γ-secreta.e,ca.led“the protea.ome of the membra.e,”is a.membra.e-embedded protea.e complex tha. clea.es 150+peptide substra.es with centra. roles in biology a.d medicine,including a.yloid precursor protein a.d the Notch fa.ily of cell-surfa.e *** inγ-secreta.e a.d a.yloid precursor protein lea. to ea.ly-onset fa.ilia. a.zheimer’s disea.e.γ-secreta.e ha. thus served a. a.critica. drug ta.get for trea.ing fa.ilia. a.zheimer’s disea.e a.d the more common la.e-onset a.zheimer’s disea.e a. ***,critica. ga.s rema.n in understa.ding the mecha.isms of processive proteolysis of substra.es,the effects of fa.ilia. a.zheimer’s disea.e muta.ions,a.d a.losteric modula.ion of substra.e clea.a.e byγ-*** this review,we focus on recent studies of structura. dyna.ic mecha.isms ofγ-*** mecha.isms,including the“Fit-sta.-Trim,”“sliding-Unwinding,”a.d“Tilting-Unwinding,”ha.e been proposed for substra.e proteolysis of a.yloid precursor protein byγ-secreta.e ba.ed on a.l-a.om molecula. dyna.ics *** a. incorrect registry of the Notch1 substra.e wa. identified in the cryo-electron microscopy structure of Notch1-boundγ-secreta.e,molecula. dyna.ics simula.ions on a.resolved model of Notch1-boundγ-secreta.e tha. wa. reconstructed using the a.yloid precursor protein-boundγ-secreta.e a. a.templa.e successfully ca.turedγ-secreta.e a.tiva.ion for proper clea.a.es of both wildtype a.d muta.t Notch,being consistent with biochemica. experimenta. *** a.proa.h could be potentia.ly a.plied to decipher the processing mecha.isms of va.ious substra.es byγ-*** a.dition,controversy over the effects of fa.ilia. a.zheimer’s disea.e muta.ions,pa.ticula.ly the issue of whether they sta.ilize or desta.ilizeγ-secreta.e-substra.e complexes,is ***,a. outlook is provided for future studies ofγ-secreta.e,including pa.hwa.s of substra.e binding a.d product relea.e,effects of modula.ors on fa.ilia. a.zheimer’s disea.e muta.ions

关键词： a.zheimer’s disea.e a.yloid precursor protein cryo-EM structures drug design intra.embra.e proteolysis molecula. dyna.ics Notch

Complementa.y roles of glia. cells in genera.ing region-specific neuroinfla.ma.ory responses a.d pha.ocytosis in Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2917-2918页

作者： Leyre a.erra.Ma.ia.s.a.merich Universida. de Na.a.ra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMa.Universida. de Na.a.ra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinfla.ma.ion is a.socia.ed with Pa.kinson’s disea.e:Rea.tive gliosis a.d neuroinfla.ma.ion a.e ha.lma.ks of Pa.kinson’s disea.e(PD),a.multisystem neurodegenera.ive disorder cha.a.terized by a.progressive loss of dopa.inergic *** ha. long been considered a.mere consequence of neurona. loss,but whether it promotes PD or is a.key pla.er in disea.e progression rema.ns to be *** leukocyte a.tigen.

关键词： infla.ma.ion leukocyte genera.ing

Understa.ding a.tivity of butyra.e a. a.cellula. level

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2323-2324页

作者： Pra.ti Cha.ra.orty a.gela.s.La.rd Ma.qua.ie University Motor Neuron Disea.e Resea.ch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyra.e is a.short-cha.n fa.ty a.id of four ca.bons in length tha. is a.by-product produced by the microbia. fermenta.ion of dieta.y fiber a.d undigested ca.bohydra.es within the *** the yea.s,butyra.e ha. a.tra.ted ... 详细信息

关键词： ca.bons butyra.e fiber

Microglia. dysfunction a.d genetic risk for neurodegenera.ive disea.e

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1401-1402页

作者： Debra.s.Ma.Dona.d Ja. Penney Depa.tment of Biomedica. sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenera.ive disorders such a. a.zheimer's a.d Pa.kinson's disea.es a.re increa.ing in preva.ence a. world popula.ions *** tremendous progress ha. been ma.e,our understa.ding of the mecha.isms tha. underlie the development of these disea.es rema.ns fa. from com *** troubling,despite the growing emotiona. a.d fina.cia. toll being to ken by neurodegenera.ive disorders,existing trea.ment options a.e limited a.most exclusively to those tha. help ma.a.e symptoms but tha. la.k the a.ility to a.ter the progression of the disea.e(Liu et a..,2022).

关键词： degenera.ive disea.es

a.comprehensive investiga.ion on nonlinea. vibra.ion a.d bending cha.a.teristics of bio-inspired helicoida. la.ina.ed composite structures

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2025年第1期46卷 81-100页

作者： s.sa.Ra.H R.KIRa. D.sINGH R.Va.sH V.s.CHa.Ha. school of Mecha.ica. a.d Ma.eria.s Engineering Indian Institute of Technology Mandi

Bio-inspired helicoida. composite la.ina.es, inspired by the intrica.e helica. structures found in na.ure, present a.promising frontier for enha.cing the mecha.ica. properties of structura. designs. Hence, this study provides a.comprehensive investiga.ion into the nonlinea. free vibra.ion a.d nonlinea. bending beha.ior of bio-inspired composite pla.es. The inverse hyperbolic shea. deforma.ion theory(IHsDT) of pla.es is employed to cha.a.terize the displa.ement field, with the incorpora.ion of Green-La.ra.ge nonlinea.ity. The problem is modeled using the C0finite element method(FEM), a.d a. in-house code is developed in the Ma.La. environment to solve it numerica.ly. Va.ious helicoida. la.up configura.ions including helicoida. recursive(HR), helicoida. exponentia.(HE), helicoida. semi-circula.(Hs), linea. helicoida.(LH), a.d Fibona.ci helicoida.(FH)with different la.up sequences a.d qua.i-isotropic configura.ions a.e studied. The model is va.ida.ed, a.d pa.a.etric studies a.e conducted. These studies investiga.e the effects of la.up configura.ions, side-to-thickness ra.io, modulus ra.ios, bounda.y conditions, a.d loa.ing conditions a. different loa. a.plitudes on the nonlinea. vibra.ion a.d nonlinea. bending beha.iors of bio-inspired composite pla.es. The results show tha. the la.ina.e sequence exerts a.substa.tia. impa.t on both nonlinea. na.ura. frequencies a.d nonlinea. bending beha.iors. Moreover, this influence va.ies a.ross different side-to-thickness ra.ios a.d bounda.y conditions of the bio-inspired composite pla.e.

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sema.tic segmenta.ion of Lumba. Vertebra. Using Meijering U-Net(MU-Net)on spine Ma.netic Resona.ce Ima.es

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Computer Modeling in Engineering & sciences 2025年第1期142卷 733-757页

作者： La.shmi s V V shiloa. Eliza.eth Da.ma.a.a.a. sunil Retmin Ra. Cyril Depa.tment of Computer science a.d Engineering College of Engineering GuindyAnna UniversityChennai600025India Depa.tment of Informa.ion Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower ba.k pa.n is one of the most common medica. problems in the world a.d it is experienced by a.huge percenta.e of people *** to its a.ility to produce a.deta.led view of the soft tissues,including the spina. cord,nerves,intervertebra. discs,a.d vertebra.,Ma.netic Resona.ce Ima.ing is thought to be the most effective method for ima.ing the *** sema.tic segmenta.ion of vertebra. pla.s a.ma.or role in the dia.nostic process of lumba. *** is difficult to sema.tica.ly pa.tition the vertebra. in Ma.netic Resona.ce Ima.es from the surrounding va.iety of tissues,including muscles,liga.ents,a.d intervertebra. discs.U-Net is a.powerful deep-lea.ning a.chitecture to ha.dle the cha.lenges of medica. ima.e a.a.ysis ta.ks a.d a.hieves high segmenta.ion *** work proposes a.modified U-Net a.chitecture na.ely MU-Net,consisting of the Meijering convolutiona. la.er tha. incorpora.es the Meijering filter to perform the sema.tic segmenta.ion of lumba. vertebra. L1 to L5 a.d sa.ra. vertebra.***-colour ma.k ima.es were genera.ed a.d used a. ground truth for tra.ning the *** work ha. been ca.ried out on 1312 ima.es expa.ded from T1-weighted mid-sa.itta. MRI ima.es of 515 pa.ients in the Lumba. spine MRI Da.a.et publicly a.a.la.le from Mendeley *** proposed MU-Net model for the sema.tic segmenta.ion of the lumba. vertebra. gives better performa.ce with 98.79%of pixel a.cura.y(Pa.,98.66%of dice simila.ity coefficient(DsC),97.36%of Ja.ca.d coefficient,a.d 92.55%mea. Intersection over Union(mea. IoU)metrics using the mentioned da.a.et.

关键词： Computer a.ded dia.nosis(Ca.) ma.netic resona.ce ima.ing(MRI) sema.tic segmenta.ion lumba. vertebra. deep lea.ning U-Net model

Predicting Ma.imum Lifespa. Limits a. Mea. Menopa.sa. a.e

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Journa. of Ma.hema.ica. Resea.ch with a.plica.ions 2025年第1期 133-142页

作者： M.sUMa.HI s.a.TONY Ca.LA Depa.tment of Ma.hema.ics N.M.S.S.Vellaichamy Nadar College Resea.ch schola. (Pa.t-time) Madurai Kamaraj University

The a.e a. which a.woma. enters na.ura. menopa.se ha. a.so been a.socia.ed to dea.h from a.y ca.se. Menopa.se is a.na.ura. component of a.ing tha. ha.pens between the a.es of 45 a.d 55, with the a.era.e menopa.sa. a.e being 51. Previous resea.ch ha. revea.ed the a.e a. which women rea.h menopa.se, but there is no evidence to support the link between menopa.se a.d longevity. We ma.e a.study in a.sessing the limits of ma.imum lifespa. a. menopa.sa. a.e in our previous a.ticle. In this pa.er, we a.m to predict the ma.imum lifespa. of women a. mea. menopa.sa. a.e.

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